Program Plan and Budget Bioscience II BuildingI. Introduction and Project Overview.....1 II....

Program Plan and Budget Bioscience II Building

PROGRAM PLAN | AUGUST 26, 2013

Office of Institutional PlanningUniversity of Colorado Anschutz Medical Campus

University of Colorado Anschutz Medical Campus

Bioscience II Program Plan | August 26, 2013

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Table of Contents

I. Introduction and Project Overview.........................1II. Bioscience II Building Project................................3 a. Building Location...................................................................3 b. Building Size and Height.......................................................5 c. Parking..................................................................................6 d. Facility Overview...................................................................8 e. Facility Cost.........................................................................10 f. Source of Funds...................................................................10 g. Schedule............................................................................10 h. Consistency with the Strategic Plan and Sustainability.......10 i. Relationship to the 2012 Anschutz Medical Campus Facilities Master Plan...........................................................10 j. Building Data/Telecom System Information..........................11III. Program Plan Information....................................13 a. Project Description..............................................................13 i. Bioengineering Program................................................13 ii. iC42 Clinical Research and Development....................21 iii. ClinImmune....................................................................27 iv. FRA Future Tenant Space.............................................34IV. Alternatives............................................................35V. Appendices.............................................................37 a. Appendix A - Opinion of Probable Cost (CC-C Form - FY 2013-2014)..............................................................................38



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1Bioscience II Program Plan | August 26, 2013

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The Anschutz Medical Campus.

I. Introduction and Project OverviewAs a successful world class academic health center, the University of Colorado Anschutz Medical Campus continues to experience programmatic growth and the introduction of new initiatives that require additional space on campus. As part of the 2012 Facilities Master Plan, three areas were identified as growing or new programs that require additional space on campus to meet their goals and objectives.

The three groups identified in this program plan that will occupy space in the Bioscience II Building are the Bioengineering program (3rd and 4th year and graduate), ClinImmune Labs, and iC42 Clinical Research and Development (iC42). Also included in the building program plan is future tenant space that will be leased to the Fitzsimons Redevelopment Authority (FRA) for private/third party future tenants who may benefit by being in close proximity to the translational and university research efforts that exist on the Anschutz Medical Campus. Each of the identified programs has unique working relationships with the university, University of Colorado Hospital (UCH) and Children’s Hospital of Colorado (CHCO). The future Veterans Affairs Eastern Colorado Medical Center (VA Hospital) will also likely have a contributing effect on the working relationship of these three programs when the new facility opens in 2016/2017.

Due to the lack of space allowing expansion for ClinImmune and iC42, and the need for dedicated Bioengineering space to address the educational needs of the new degree program, the Bioscience II Building will be designed to meet these programmatic needs and plans for future growth. The unique location of the building allows the occupants to benefit by being in close proximity to the university but also the development of private company entities on the FRA property.

The unique site location of this project will also help foster further development of translational research between the university academic research programs and third party/

private companies. The property is located along the north side of East Montview Boulevard directly adjacent to the university and between Scranton and Ursula Street in an area that is being developed as the Colorado Science and Technology Park by the Fitzsimons Redevelopment Authority.

Bioscience II will be a four story building of 120,000 Gross Square Feet (GSF) with the ground level dedicated to the university’s Bioengineering academic program. ClinImmune Labs, iC42, and FRA will occupy space on the upper floors of the building. The site will be designed to complement and align with the existing roadway and pedestrian routes of the university, Pauls’ Development to the north and other FRA buildings to the west of the new building.

The building is to be designed to offer flexibility within each program to provide the most optimal collaborative environment for students, clinicians, and researchers. This document will define in further detail the proposed building location, occupant program space needs, and some of the required adjacencies that need to be considered in the design of the building.



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II. Bioscience II Building Project

a. Building LocationThe Bioscience II building will be located on property purchased by the University that is immediately north of the CU Anschutz Medical Campus along East Montview Boulevard between Scranton and Ursula Street. The site is directly north of the existing CU Henderson Parking Garage and the Skaggs School of Pharmacy Building on the university’s campus. The proposed building lot is currently an open site that is squared off on three sides. The fourth side of the property on the south, follows the curvature of East Montview Boulevard for a small section in the southeast corner. There is some roadway, utility and site work beyond the property lines that will be done as a part of the scope of work.

Bioscience IIProposed Footprint

The future Bioscience II site. Looking north from Montview Blvd.

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This includes roadwork on Scranton, 21st Street, 22nd Street and other items shown on the Colorado Science and Technology Park at Fitzsimons Subdivision Filing No. 4 and the Site Plan No. 4 R.O.W. (right of way) blueprint documents.

See the Conceptual Site graphic below and surrounding area map that highlight some of these items.

The exact building position on the site and the main exterior entrances should be designed to easily align with the existing flow of university pedestrians and the flow of pedestrians from the various vehicle parking locations. It is anticipated that a large number of pedestrian crossings of E. Montview Boulevard and 21st Avenue will take place each day and design considerations of street crossings will need to be incorporated into the site planning to determine appropriate crossing amenities and crossing locations for this project to maintain appropriate safety of pedestrians.

The site is uniquely located at the edge of what is considered a transition zone between the university and private

companies specializing in health science technology. This site serves as a strategic transition point for further development of translational research opportunities as research projects move from the university to private third party companies. The site plan graphic on the next page shows in red the proposed building footprint and the approximate walking distances to other university and FRA buildings. The graphic shows several key building entrances and their approximate walking time to this site. Creating a convenient pedestrian connection to the university campus with this building will set a precedence for future development on both university and FRA property.

All necessary utilities are available for the project in this location. Except for the telecommunications connection to the university, all utility systems for Bioscience II will be stand alone and will not be tied into the university’s utility systems. For connection to the university’s computer network system, conduits will be installed under Montview Boulevard allowing for a direct tie-in to the university fiber/cabling network. The electricity supply and HVAC systems will be specific to this building and will not be connected

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to the university’s Central Utility Plant (CUP). However, excessive trenching and/or costly extensions of existing utilities are not required to reach this proposed building site.

From a pedestrian standpoint, new sidewalk and landscaping should be designed to create cohesive connections to existing university and FRA pedestrian/bicycle pathways and other multimodal circulation zones. Common site furnishings and design elements that exist on campus will also be a positive amenity of the exterior design to help make for a consistent environment that is complimentary to the adjacent university and FRA buildings.

The exterior of the building should have an outdoor landscaped patio space directly adjacent and accessible to the buildings break/lunch room. This provides a place for the building occupants to take a break, relax, converse, or eat lunch with friends/colleagues in an outdoor space. Similar spaces exist on the university campus that are popular exterior spaces. Photos of a couple university

outdoor patios with tables and chairs are provided on the following page. Incorporation of these types of outdoor landscaped amenities on new building projects also aligns with the 2012 Facilities Master Plan document and recommendations.

b. Building Size and HeightThe overall building is planned at 120,000 GSF with a ground floor building footprint that may be slightly larger than the upper floors. This preliminary program allocated approximately 30,000 gross square feet (GSF) per floor level and envisioned a four (4) story structure on the site. The GSF for each floor level may vary depending upon the programmatic assignment and layout of space throughout the building. A massing study should be conducted in the early phases of the building design to determine the best geometrical configuration of the building so that it appropriately addresses the surrounding streets, future planned street sections and adjacent existing buildings. Setbacks as defined by the FRA property guidelines are to be incorporated into the site planning. Programmatic space assignment in the building may dictate that the ground floor

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is the largest area and upper floor levels step-back to a smaller footprint. The conceptual massing diagram graphic shows a possible definition of the building on the site that should be explored further for the most appropriate fit of the building. Any on-site plazas or courtyards should take into consideration the building height and how it will relate to the daylighting angles throughout the four Colorado seasons. The height of the existing Paul’s Development buildings, the CU Anschutz Medical Library, the Chapel, the Skaggs School of Pharmacy building, and the Henderson Parking Garage should all be included in the massing study to ascertain the full effect of the proposed building massing on this site. It is important that the facility proportionally fit with the adjacent buildings and have a pleasing presence as it relates to its surrounding environment.

c. ParkingThe site design on the north side of the building includes accessible parking spaces, dock access for deliveries and some convenient short term metered parking spaces for visitors. These short term parking spaces are only for visitors and will not be for the daily building occupants. For full time building occupants, parking will be provided through two parking venues. For the university’s Bioengineering

ED 2 west side patio near the Fulginiti Center.

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program, parking is available in the Henderson Parking Garage. The other parking option is the construction of a new surface parking lot immediately north of the building site that will provide approximately 160-175 parking spaces. These two parking venues together will address all the required parking requirements of the building. The parking proximity map below shows the general location of parking that will be used by the occupants in the building.

Pedestrian crossings of the streets and alignment of entrances into the building should take the flow of pedestrians into consideration as they access the building from campus and the two parking areas. Of utmost importance is the crossing of East Montview Boulevard which has a heavy vehicle load throughout the day. A main building lobby with multiple points of access may need to be considered on the ground level to help accommodate the flow of people coming to the building.

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University of Colorado Denver|Anschutz Medical Campus

Bioscience II 8/26/2013

Summary of Building Program Space

# Program/Unit Space Name

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Percent of Building GSF

Allocation

A Bio-Engineering Program and Academic Space 17,871 25,735 28,594 23.8%B iC42 Clinical Research & Development 10,178 14,656 16,284 13.6%C ClinImmune Labs 17,576 25,309 28,122 23.4%

CU Anschutz Total 45,625 65,700 73,000 60.8%D Fitzsimons Redevelop'mt Auth. (leased space) 29,375 42,300 47,000 39.2%

FRA Total 29,375 42,300 47,000 39.2%

Building Totals 75,000 108,000 120,000 100.0%

draft only for discussion purposes -MEB



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d. Facility Overview The proposed building will be 120,000 gross square feet and the proposed allocation by floor level is as follows:

Bio-Engineering Program 28,122 GSF (1st Floor)iC42 Clinical Research & Development 16,284 GSF (2nd Floor)ClinImmune Labs 28,594 GSF (3rd Floor)Fitzsimons Redevelopm’t Authority Space 47,000 GSF (2nd & 4th Floor) Total 120,000 GSF

The below chart shows a breakdown of square footage by assignable, rentable, and gross square feet. Also shown are the percentages of building allocation for each of the programs/units as compared to the gross square footage of the building.

The first floor will house the new Bio-Engineering Program spaces. These spaces consist of educational classrooms, teaching/open labs & service, faculty & staff offices and other support spaces required of the educational program. The 70 person classroom will be located on the first floor and will be considered shared space to be utilized by others on campus through advanced reservation requests when not being used by the Bioengineering program. A large shared lounge and kitchenette for all building occupants will be located on the first floor with access to an exterior patio. The second floor will be



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Although the exact placement of each program/group in the building and the exact floor level they would occupy will need more exploration, a conceptual placement has been defined for the basic layout analysis of this program plan. As the first phase of building design takes place, there may be some shifting of programmed spaces to best fit the needs, adjacencies and work flow of the occupants to the overall fit of the building. The current proposed arrangement of programs by floor is based upon the information gathered from each unit. The design phase will analyze each floor allocation to create an efficient and optimal solution for each program. The final number of floor levels, the overall footprint size, and the massing of the building will all dictate some massaging of programmed space on each level to appropriately fit the users.

occupied by iC42, and some of the future tenant leasable FRA space. The iC42 space includes all offices, labs and support spaces required to meet their needs. The space allocated to the FRA on the 2nd floor will be core and shell space only so the leasing tenant can tailor the build out to their specific needs. The third floor will be occupied by ClinImmune Labs with offices, labs and all support spaces required to meet their programmatic needs. The fourth floor will be completely reserved for the FRA as future tenant space and will be constructed as core and shell with no tenant finishes which will allow the future tenants to customize the build out to best meet their facility needs. Basic building systems will be provided to the core & shell spaces allowing future tenants access and tie-in to the planned building utility systems.

If additional funding is available, additional floor levels would be possible on the site while keeping the building appropriately scaled in its surrounding. During the design phase, review of the building structure should include an investigation of a possible 5th and 6th floor that could be shelled space for future use. However, current economic constraints and funding availability may not allow for consideration of additional floors at this time.



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e. Facility CostBased upon detailed projections and utilizing cost data from similar projects recently constructed on the CU Anschutz Medical Campus, the FRA property and local construction companies familiar with this type of building and the systems required in it, a building of this size constructed with the specific amenities for the defined users will have a total cost of $33,712,665.00. There will be an additional cash expenditure by the university of $4,838,916.00 for equipment, furnishings, and other items specific to the university programs. The total budgeted amount includes all property, site costs, design, engineering, permitting, construction, equipment, furnishings and project management required of the project. It should be noted that $500,000 of the cost estimate budget has been allocated to asbestos clean-up of the property based upon historic records and past projects on the CU Anschutz campus requiring abatement of hazardous materials. See Appendix A for a breakdown of the above costs into their respective budget categories.

f. Source of FundsFunding for the Bioscience II Building will come from a mixture of debt financing and cash from institutional reserves and gifts/donations. The university treasury will submit a financing plan that includes a future bond issuance for action with the program plan. The financing rate will be determined and based upon the financial market at the time of the draws.

g. ScheduleThe schedule for this project is for design work to commence immediately upon approval of this program plan and Board of Regents approval. The conceptual and building design phases will start in late September 2013 and are envisioned to take 10 months due to the complex engineering needed for the building systems to meet the occupant needs. The construction would then take 14 months with the facility opening for use by August 1, 2015. The first cohort of 3rd year Bioengineering students will arrive on campus in August 2015.

h. Consistency with the Strategic Plan and SustainabilityThe CU Anschutz Medical Campus is committed to sustainable practices in order to insure the longevity of our facilities and institutional accomplishments. To this end, the university is a signatory to the American College and University President’s Climate Commitment (ACUPCC) which requires a comprehensive plan to significantly reduce greenhouse gas emissions over incremental periods through 2050. Energy conservation measures such as those already completed on the campus in the R1

South Tower as well as other sustainable measures are helping the university attain its goal of a 20% reduction in emissions by the year 2020, as well as saving the university $900k per year in utility expenditures. The University of Colorado Board of Regents also supports the goals of the ACUPCC and has formalized in a resolution that all University of Colorado campuses will adhere to the goals of the ACUPCC and that they will support projects that result in natural resource and greenhouse gas emissions reductions. The new Bioscience II Building would be constructed to a LEED-Gold standard and may implement the available energy savings infrastructure needed to meet this certification. It is anticipated that the heat generated from the freezer farm spaces will be captured for a second reusable function or heat transfer in the building. It is also anticipated that the recent grey-water use approval by the State of Colorado Legislature will allow this building to implement a grey-water re-use program to help reduce overall water consumption. Grants may be available for creative grey water use projects and the intention is to submit a grant application directly related to this project for funding to assist in the design of a creative grey water re-use method throughout the building and or site.

i. Relationship to the 2012 Anschutz Medical Campus Facilities Master PlanThe CU Anschutz Medical Campus 2012 Facilities Master Plan documents the space deficiency that will exist for the Bioengineering Department and the auxilliary enterprise operations of ClinImmune and iC42. The development schedule and space needs analysis of the 2012 Facilities Master Plan sets the initial direction and approach for the building to address the defined programmatic need on the campus. “Section IV - Education Program” of the master plan addresses the need for more collaboration on campus between disciplines and inter-professional programs and research. This building project is in direct relation to the master plan recommendations.

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j. Building Data/Telecom System InformationThe Bioscience II building project will have modern communications including voice, high-speed data, and wireless connectivity from the universities existing system to new embedded university office spaces, classrooms, teaching labs and other support spaces. The telecommunications spaces and pathways will be designed to provide secure administration to university units and unaffiliated tenants. University occupants will be on the UCD campus voice and data networks. Bioscience II tenants who are not affiliated with the university will receive telecommunications services from the carrier of their choosing but can be in the same pathway/conduit system as the university. All manholes, infrastructure, pathways, raceways, cable trays, conduits, j-boxes, IDF/MDF closets, mechanical & electrical systems, grounding bars, and necessary sprinkler systems are to be provided by the general contractor. The cabling and Telco equipment in the IDF/MDF closets (racks, UPS, servers) will be provided by the university for all university tenants. All future tenants who are not affiliated with the university will be required to provide their cabling and equipment

for their tenant spaces. However, the general contractor is to include conduits, pathways, cable-trays through the building from the main De-mark room to each IDF/MDF closet for the building tenants.

To create seamless connectivity, the general contractor will connect Bioscience II to the university’s backbone network via outside plant duct banks, as portrayed in the sketch below showing the general pathway connection across East Montview Boulevard. The new duct bank extension and pathway to the new main building De-mark location is required to tie-in to the existing campus network backbone and will allow those university customers in Bioscience II the same voice and data capabilities that on-campus network users experience. This arrangement will enhance data security and avoid costly carrier circuit charges.



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III. Program Plan Information

a. Project DescriptionThere are four units that are programmed into the Bioscience II Building. These include three university programs; Bioengineering, iC42, ClinImmune, with the fourth unit being future tenant leased space for the FRA. As the building design progresses, the following square footage information may adjust depending upon the exact layout, space efficiencies, and space adjacencies needed by the building occupants.

The following sections of this program plan will explain in detail the spaces associated with each of the departments/units identified for occupancy in the building.

i. Bioengineering Program

A new degree program under the Department of Bioengineering was approved in September of 2012 and the interdisciplinary program spans both the Denver and Anschutz Medical Campuses for this Bachelor of Science degree. Students in the Bioengineering program will spend the first two years on the CU Denver Campus focusing

on general education requirements and introduction to biology, and then their 3rd and 4th years on the CU Anschutz Medical Campus where the focus of instruction will shift to core bioengineering and laboratory instruction. The first cohort of 3rd year students will arrive on the CU Anschutz campus in August of 2015 which is coordinated with the opening of this new facility.

Bioengineering combines the concepts of engineering, mathematics, physics, and health sciences including biology and chemistry. The students will be involved in comprehensive training including all of these disciplines and will be able to continue on to advanced research in the graduate programs upon completion of their bachelor’s degree. The Department of Bioengineering is the only bioengineering program to offer in Colorado the full spectrum of degrees from bachelor’s to PhD. The Bioengineering academic spaces will include flexibility to allow for exposure to the field of bioengineering, guest lectures, clinical research, and hands-on design projects created by the students in the new Biomechanics, Bioinstrument, and Bio-Prototyping labs. The spaces will be designed and constructed to allow students to engage in active learning and to construct projects that have

Bioengineering - Space Arrangement

# Space NameNumber/Quantity

Number ofStations

SpaceFactor

SubtotalASF Notes

A1.0 Office SuiteA1.01 Department Chair Office 1 1 180 180

A1.02 Academic Faculty Office 7 1 120 840

A1.03 Future Growth Academic Faculty Offices (2) 2 1 120 240

A1.04 Fellow Offices (2 Post Doc/Fellows) 2 1 120 240

A1.05 File Area 2 1 60 120

A1.06 Break Rm kitchenette w/ sink (is not required as separate rm)

1 1 120 120 Fridge, microwave, no dishwasher

A1.07 Office Storage 1 1 140 140 Shelving at walls

A1.08 Reception/Waiting Area w/ secure night drop 1 1 180 180 Includes a full time person workstation

A1.09 Workroom, copier, scanner, mail, supplies 1 1 120 120 Cabinetry for supplies storage

TOTAL ASF 2,180

Page 1 draft for discussion purposes only-MEB



DRAFT

potential for real-world impact. A university or a private company may want to develop further. This facility will not only allow students to design but also build prototypes and interact with health professionals to better understand the biomedical implications of their projects for future patients.

The new Bioengineering academic program is to be located on the ground floor of the building and is anticipated to have the most frequent number of users accessing the building from a pedestrian mode. Appropriate placement of the main building entrance to correspond with the existing Anschutz Medical Campus pedestrian path network is an important consideration of the first floor arrangement for this program.

A variety of spaces will be required for the new Bioengineering program and consist of Classrooms, Group Study Rooms, Teaching Laboratories, Research Laboratories, various support spaces and faculty and staff offices for the department which will be further detailed in this program plan.

Bioengineering Office SuiteThe faculty and staff offices along with the required support spaces are envisioned to be located within an office suite in close proximity to the academic areas. This space will be visible and easily accessible to the students of the Bioengineering program but the office suite will be designed to be a secured space after hours that is only accessible with a security card reader. The office spaces

consist of an office for the department chair, nine faculty offices which includes two as future growth office spaces, two Fellow Offices, an office filing area, an office storage room, a workroom that can accommodate a copier/scanner/printer machine, a small break area kitchenette with a sink, and a room or cabinet storage space to hold typical supplies, mail and general office materials. The entrance to the bioengineering office suite will need an area for a receptionist workstation and four to six chairs in a waiting area. A section of the front office entry needs to have access to a secured night drop box that will allow after hour deliveries of packages. The proposed room sizes and square footages programmed for these office suite spaces is as follows:

Dr. Robin Shandas meets with students in the Bioengineering program.


Number of Stations

SpaceFactor

SubtotalASF Notes

A2.0 Classrooms/Group Study/Meeting SpacesA2.01 Classroom/Meeting Rm 1 70 23.5 1,645 Mov. tables/chrs,mobile lctrn, remote

speaker/video conf.,A/V lecture capt.mobile A2.02 Executive Conf./Meeting Rm w/ technology 1 20 32 640 flat panel LCD, laptop connection, whiteboard

A2.03 Conf. Rm w/ technology (Faculty Office Suite) 1 10 28 280 Projector, laptop connection, screen, spkr phone

A2.04 Large Group Study Area w/ technology 2 12 30 720 flat panel LCD, laptop connection, whiteboard

A2.05 Small Group Study Area w/ technology 6 6 30 1,080 flat panel LCD, laptop connection, whiteboard

A2.06 A/V Equipment Closet in 70-Seat Classroom 1 1 50 50

A2.07 Storage for Classroom & Conf. Rm (adjacent to the spaces)

1 1 140 140 Addl chairs/tables, rolling whiteboard

TOTAL ASF 4,555




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Bioengineering Classrooms / Group Study / Meeting SpacesThe bioengineering program requires one 70 station multi-purpose classroom with movable tables and chairs. This room is a flat floor space but is large enough to allow for multiple arrangements of furniture to have team teaching, group teaching, front facing lectures, or other room arrangements to accommodate the teaching pedagogy. Flexibility of the room is key and the audio visual components of the room will have the appropriate equipment for video conferencing or distance learning. The Educational Support Services department of the university will specify the standard A/V equipment for projectors, screens, speakers and other required equipment in this room. This classroom space may serve as a meeting room for other groups on campus after hours or for special weekend seminars related to bioengineering.

There will be one conference room with 20 seats. It may be advantageous for this room to be directly adjacent to the classroom space with a moveable partition divider that allows it to be used in conjunction with the classroom for certain events or overflow situations. Also in close proximity to the classroom space will be eight group study rooms. Two study rooms will accommodate twelve (12) seats and six will accommodate six (6) seats for group study sessions that are a vital component of the bioengineering program.

The office suite area will require one conference room large

enough for 10 people that is only accessible from the office suite. All conference rooms and group study rooms will have either LCD flat screens or projectors and screens for presentations along with the required controls and cabling connections for use with laptop computer technology. The lighting levels for these rooms will require appropriate switching to view presentations.

An A/V equipment closet will be needed with direct access to the classroom space. If the other rooms require control equipment for their A/V systems, it may be advantageous to place that equipment in this room also. Adjacent and accessible to the classroom and near the large conference room is a storage space for additional chairs and tables to help accommodate multiple arrangements of furniture for various classroom settings and meeting functions. The proposed room sizes and square footages programmed for the Bioengineering General Purpose Classroom, Group Study and Meeting spaces is as follows:


Number of Stations

SpaceFactor

SubtotalASF Notes

A3.0 Open Student and Campus Community AreasA3.01 Open Student Lounge/Mov. tables/chairs, lounge furniture 52 1 23 1,200 2 Flat panel LCD

A3.02 Café, vending area w/ Kitchenette, two bay sink 1 1 220 220 microwave, refrigerator, counter/prep area, two bay sink

A3.03 Student coat/backpack cubbies storage (250 lockers, 148LF)

1 250 1.35 336 2-tier half lockers

TOTAL ASF 1,756




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Bioengineering Open Student and Campus Community AreasThe bioengineering program is intensive and often will have students working on projects in the building for long periods of time. Appropriate spaces to break for lunch or relax with others in the program will be designed near the academic area. It is envisioned that this space will have a kitchenette or café type space with microwaves, a refrigerator and counter top space. Access to various vending machines near this space would also be helpful to let students dine, meet, relax, study or partake in group study activities. This open space will incorporate several different types of furniture from moveable lunch style tables and chairs that can also serve as study tables to comfortable lounge furniture that can be arranged into collaborative type settings. This space will be adjacent to an exterior patio or courtyard landscaped area to allow easy movement from indoors to outdoors when weather permits. The collaborative nature of this space will be reflected in the layout and architecture so that private conversations can place between individuals yet larger groups are comfortable to share the space at the same time.

The students of the bioengineering program will have a locker space assigned to them and it is envisioned that these lockers will be incorporated into spaces that are easily accessible in the academic area of the program. The proposed room sizes and square footages programmed for the Open Student and Campus Community Areas is as follows:

A student in the Bioengineering program works on computer modeling.


Number of Stations

SpaceFactor

SubtotalASF Notes

A4.0 Dry Labs and Support SpacesA4.01 Design Space/Think Tank w/ tech. (28 LF bench, mov.

tables)1 1 620 620 whiteboards, comp. air, 110V, vacuum, sink

A4.02 Prototyping Lab/Lt Machine Shp (64 LF bench,4 mov.tables)

1 1 780 780 snorkel, comp. air, vac., overhead 110V, 220V, 440V, acoustic. separ., sink

A4.03 Stock Rm w/Vacuum Compressor (adjac. to Prototyping Lab)

1 1 150 150 vacuum compressor and other req.'d equip.

A4.04 Gen. Dry Research Lab (56 LF bench/upper cabs) 2 1 500 1,000 upper and lower cabinets, tables

A4.05 Biophotonics Lab (45 LF bench, 25 LF lockers, 4 mov. tables)

1 12 45 540 4 mobile optical benches, dark room capable

A4.06 Clean Rm - Class 10,000 (30 LF bench) w/ HEPA filters/hood

1 1 210 210 120V, 220V, compressed air, dark rm capable

A4.07 Deliveries Storage space (adjac. to delivery dock) 1 1 140 140

A4.08 Biomed. Instrumentat.Lab (40 LF lockers, 35 LF bench, 18 mov. table)

1 36 45 1,620 2 chemhoods, whtboards, comp air, vac, 110/220V

TOTAL ASF 5,060




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Bioengineering Dry Labs and Support SpacesThe Dry Labs and Support Spaces for the bioengineering program are unique in that some will be typical bench style lab spaces while others are more flexible and may require changing the layout or arrangements of lab equipment to accommodate the needs of the program. A key component of the lab space will be the Design Space/Think Tank where technical collaboration among students, faculty, and researchers can take place. This space requires white boards to help foster brainstorming or creating new prototype ideas. This space is to be designed as a highly collaborative area where current boundaries of bioengineering can be pushed, new ideas explored, and creative thinking developed for new bioengineered concepts/prototypes.

Directly adjacent to this Think Tank space is a Prototyping Lab/Light Machine Shop where an idea can be explored by machining components for review and further research. This space will have specialty machines, work benches, 3D printers, parts and tools that are useful in creating prototypes. Even though this is considered a light machine shop, it will still require overhead snorkels (fixed and movable) for exhaust of fumes, vacuum compressed air outlets, various electrical power capacity for 110V, 220V and possibly 480V 3 phase for certain pieces of machinery. Some of the shop machinery in this prototyping lab is a bandsaw, circular saw, combination mill/lathe, 3D printer and a laser cutter. This space is not considered a manufacturing shop but more of a space to invent and create new bioengineering prototypes and will require equipment and tools to assist in those creations.

In close proximity but easily accessible to the Prototyping Lab is a Stock Room for materials and parts where the compressor for the vacuum system could also be located. A separate storage room in close proximity to the building main loading dock is required for the delivery of various bioengineering materials and supplies.

There are four dry lab spaces required by the program. Two of these labs are typical General Dry Research Labs with work benches and cabinetry. One of the labs is a Bio-photonics Lab with 4 movable optical benches. This lab will have dark room capabilities for optics education. Adjacent and with direct access to the Bio-photonics lab is a small clean room (10,000 Class), which will also need darkroom capabilities incorporated into the space. The clean room will require a 72” wide fume hood in the space and the required HEPA filtering of the mechanical system.

The fourth dry lab is a Biomedical Instrumentation Teaching Lab with 36 stations. This space will need two 72” chemical fume hoods, white boards, and accessible drop cords for utility supplies to all stations. Access to a sink will also be required in this lab. The Biomedical Teaching Lab will have a projector and screen as part of its A/V package and the room layout should consider the appropriate sight lines for all the student stations.

All four of the dry lab spaces will require compressed air supply, 120V and 220V electrical for equipment, vacuum lines, and access to de-ionized water supply. The proposed room sizes and square footages programmed for the Bioengineering Dry Labs and Support Spaces is as follows:


Number of Stations

SpaceFactor

SubtotalASF Notes

A5.0 Wet Labs and Support Spaces

A5.01 Gen. Wet Research Lab 2 1 1,000 2,000 sink, tables, upper and lower cabs

A5.02 Biomaterials Cell/Tissue Culture (1 sink, 36 LF bench, 10 mov. tables) 1 20 45 900 2 chemhoods, incubator, vacuum, 6 lamin.

flow hoods, Emerg. Power, projector

A5.03 Biological Prep Rm - Attached to Biomaterials (1 sink, 48 LF bench) 1 1 420 420 acid/base cabs, compressed air, vacuum,

110V, fridge, freezer, autoclave

A5.04 Vacuum Compressor Closet (adjac. to Biomedical/Biomaterials) 1 1 40 40 vacuum compressor

TOTAL ASF 3,360




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Bioengineering Wet Labs and Support SpacesThere will be three wet lab spaces for the Bioengineering program. Two labs are for faculty members to conduct research. These two research labs are proposed at 1,000 ASF each and will have the necessary utility drops to the benches for gas, compressed air, vacuum and electrical. The third lab will be a Biomaterials teaching laboratory space with 20 student stations. This lab will have 6 Laminar flow hoods and 2 chemical fume hoods that students can access. The lab requires an incubator for cell and tissue cultures and will need to have emergency back-up power in the event of power failure.

To support the Biomaterial teaching lab is a Biological Prep Room that is directly accessible to the lab. This prep room will have certified cabinets for storing acids/bases, refrigerators, freezers, and an autoclave for sterilization of medical instruments. The prep room will also have the necessary utility drops for gas, compressed air, vacuum, and electrical. A sink and benches for preparation of educational lab kits/experiments is also planned in this room. A separate closet for a vacuum compressor and other equipment needed in the lab and prep room is programmed, however, depending upon the space layout, the prototype lab vacuum and air compressor could share the same closet space. The proposed room sizes and square footages programmed for the Bioengineering Wet Labs and Support Spaces are as follows:


Number of Stations

SpaceFactor

SubtotalASF Notes

A6.0 Building Support SpaceA6.01 Bio-Engineering IT Network Closet and Server Room 1 1 80 80

A6.02 Machine and Equipment Repair shop (spare parts room) 1 1 260 260 Adjacent to Biomechanics/Bioinstruments Lab

A6.03 General Facilities Storage Room and Maintenance Supplies Room

1 1 450 450

A6.04 New Mother's Room (Lactation Room prorated at 25% of 120asf)

1 1 30 30 1 sink, comfortable seating, u/c refrig. & cabinets

A6.05 Main De-mark MDF Room (prorated at 25% of 120asf) 1 1 30 30 ground level room

A6.06 Delivery Dock (prorated at 25% of 440asf) 1 1 110 110 dock height or with lift platform.

TOTAL ASF 960

17,871 28,594Total ASF Gross Sq Feet




DRAFT

Bioengineering Building Support SpaceThere are several spaces that are considered building support type spaces that will help serve the Bioengineering program needs. A small dedicated IT Network Closet and Server Room will be needed for those computer and IT items that are specific to the Bioengineering academic program. Complex computation models are expected to be discussed and reviewed with the students and will require dedicated services. With multiple pieces of equipment and unique machinery being used in the program, a Machine and Equipment Repair Room is programmed that will have specific tools and parts for the specified machinery in the prototyping, research and teaching labs. This repair shop will be small and only used for emergency repairs when immediate repairman, technicians and parts are not readily available. A General Facilities Storage Room is programmed near the delivery dock and may be used by all the CU units in the building. Due to the number of freezers utilized by the bioscience programs, a spare freezer will typically be stored and ready to replace a non-functioning unit. Other supplies and equipment used by the CU program occupants in the building can also be stored in this space. This will allow for a more efficient use of space rather than dedicated spaces allocated throughout the building on each floor.

Other space that the Bioengineering program may utilize periodically is a Mother’s Room, network and phone distribution panels in the main De-mark/MDF closet, and

the delivery dock that is truck height or has a lift platform to accommodate local delivery truck or long-haul semi-trucks. A proration of these three spaces is included in the program but only at the percentage of ASF that will be allocated to the Bioengineering program. The proposed room sizes and square footages programmed for the Bioengineering Building Support Spaces are as follows:



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DRAFT

Storage/Staging

Mass Spectrometry

ResearchMass

Spectrometry

Research Prep

Prep

Offices

IC42

iC42- Space Arrangement

ii. iC42 Clinical Research and Development

iC42 Clinical Research and Development is a regulatory compliant laboratory and an extension of the University of Colorado Department of Anesthesiology that falls under the School of Medicine located on the Anschutz Medical Campus. Although iC42 has full access to the resources and expertise of the University of Colorado, it operates an auxilliary enterprise and operation. First established in 2001, iC42 created a service center to help carry out pre-clinical and clinical drug development programs, to assist basic science departments to bring drug candidates into clinical development, to support clinicians/scientist in the planning, conduct, bioanalytics, pharmacokinetics and static analysis, reporting/publishing, and to serve as a resource for the biotech and pharmaceutical industry. iC42’s laboratories are GLP, CAP, and CLIA certified and were created to provide evaluation of pharmacokinetics, drug metabolism and the development of clinical diagnostic tools. The use of mass spectrometry is essential to the analysis of clinical samples provided to iC42. Vibration and EMI (electro-magnetic interference) levels will need to be addressed and minimized in the building systems to

Adjacency Diagram

not affect test results and meet the sensitivity requirements of the laboratory equipment. Specifications for the triple and single stage quadrupole instruments, various mass spectrometers, extractors, autosamplers and other equipment used in the laboratories will be provided to the architects and engineers during the building design phases to address electrical, HVAC cooling, and other environmental factors required of the laboratory spaces. It should be noted that the existing space that iC42 currently occupies lacks the appropriate HVAC cooling and electrical capacity for future growth. Their existing systems have been maximized and the appropriate future capacity is to be planned into the new Bioscience II building for iC42. iC42 Office SuiteThe iC42 offices and office support spaces will be located with-in a single office suite and will include a Directors office, ten staff offices of which two are future office spaces. Cubicle type workstations are needed for 12 Post Doctorates and two additional workstations for administrative assistants. One of the administrative assistants should be located at the front desk or with


ofStations

SpaceFactor

SubtotalASF Notes

B1.0 Office SuiteB1.01 Directors Office 1 1 180 180

B1.02 IC42 Private Offices 8 1 120 960

B1.03 IC42 Future Growth Offices 2 1 120 240

B1.04 Post Doctorate Work Stations (open office) 12 1 45 540

B1.05 Admin. Assistants - Shared (open office) 2 1 70 140 1 station at reception area

B1.06 CLARO Private Offices 3 1 120 360

B1.07 Storage Rm - adjacent to copy/mail room 1 1 140 140

B1.08 Reception/Waiting Area 1 1 160 160

B1.09 Workrm/Copier/Supplies 1 1 120 120

B1.10 Break rm w/ kitchenette 1 1 280 280 1 sink, refrigertor, microwave, counter

B1.11 Conf. Rm - in office suite w/ technology 1 10 34 340

B1.12 Conf. Rm Storage closet 1 1 30 30

TOTAL ASF 3,490




DRAFT

visible sight of the front door entrance. Minimal space is needed for a reception and waiting area but a space designed to let visitors know they cannot proceed into the space unaccompanied is required. A centrally located workroom with a copier/scanner/printer and storage for office supplies and mail distribution is programmed. This can be a separate room but could also be designed into open areas of the office suite.

A secured storage room for archives and Good Lab Practice (GLP) manuals should be located in close proximity to the workroom/copier space. A break room with a kitchenette (microwave, sink, toaster, coffee maker) located in a convenient section of the office is programmed and should accommodate seating for six to eight persons on break.

Also included in the office suite but potentially designed as a separate grouping is three offices for CLARO employees who are a separate entity but work closely with iC42. The proposed room sizes and square footages programmed for these office suite spaces are listed below.

As part of the office suite, a conference/meeting room with ten seats is programmed. This space will require video conferencing technology with a projector, screen and

appropriate speakers. White boards should be installed on three of the four walls to accommodate brainstorming and working sessions of the iC42 staff, technicians, and researchers. This conference/meeting room will be shared by all in the office suite. A separate conference room is not required for the CLARO employees. Adjacent to the conference/meeting room will be a storage closet for additional chairs and meeting supplies.



DRAFT

iC42 Laboratories and Support SpacesThere are two laboratory spaces, the Research Mass Spectrometry Lab and the Clinical Spectrometry Lab required for iC42 and each lab has an associated prep lab programmed. The Research Mass Spectrometry Lab will have individual benches to accommodate 10 separate mass spectrometers. Each Mass Spectrometer bench will require two 20 AMP dedicated 208V outlets, two 20 AMP 110V dedicated 4 plex outlets, and a computer cable connection jack. Access is needed to two sides of the equipment as it sits on the benches and the accessible end of the mass spectrometer must be in the open portion of the room for the insertion and extraction of samples. The Clinical Mass Spectrometry Lab is similar in that each bench requires two 20 AMP dedicated 208V outlets, two 20 AMP 110V dedicated 4 plex outlets, and a computer cable connection jack. However, this space will have twelve benches to accommodate various spectrometer equipment. Access is needed to two sides of the equipment as it sits on the benches and the accessible end of any mass spectrometer must be facing the open portion of the room for easy insertion and extraction of samples.

Each of the Mass Spectrometry labs have a prep room associated with them and include back to back lab benches,

counter top work space, chemical fume hoods, a bio hood, and a sink. The prep rooms will also have the necessary utility drops for gas, compressed air, vacuum and electrical. Included in the Research Prep Lab is a Cell Culture Lab with two bio safety cabinets, countertop & cabinet space, and a sink. Each of the mass spectrometry labs, prep rooms, and cell culture lab require an emergency shower with eye wash station.

Appropriate access to liquid nitrogen “Dewars” (mobile storage tanks) will be needed for the mass spectrometers.

A dedicated freezer room for sixteen -80 (minus 80 degrees Celsius) units and space for six future freezers is needed. This room should be in close proximity to both mass spectrometry labs and the prep rooms but does need to be directly adjacent to them. Each freezer requires a 20 AMP dedicated 208V circuit and outlet per freezer. A computer cable connection jack is also required per each freezer for 24/7 temperature monitoring. The freezer room will also have a centrifuge, freezer dryer and ice machine located in the room. The complete circulation pathway from the delivery dock to the freezer room must include oversized doors to accommodate the larger height and width of the


ofStations

SpaceFactor

SubtotalASF Notes

B3.0 Laboratories and Support SpacesB3.01 Freezer rm w/ 16 frzr, centrifuge, freezer dryer, ice 1 16 28 448 Requires oversized door for -80 Refrig

B3.02 Freezer space for 6 future frzr 1 6 28 170 Requires oversized door for -80 Refrig

B3.03 Consumables storage rm (near freezer rm) 1 1 100 100

B3.04 Nitrogen strge w/ 5 lg tanks, 10 sm tanks 1 1 140 140 need space for 8 high pressure cylinders

B3.05 Chem. stor. attached to nitrogen stor. w/ 6 cabs approx. 30"x30"

1 1 90 90 upper and lower cabs

B3.08 Clinical mass spec. rm (shared w/ CLARO) 12 tables 30x180

1 1 1,400 1,400

B3.09 Clinical prep lab (shared with CLARO) with tables 30x288

1 1 650 650 1 snk, 2 hoods,1 biohood, 4 wkstn, 4 tables

B3.10 Research Prep Lab, prep robot, 32 LF bench, 6 tables 30x288

1 1 1,200 1,200 1 biohood, 2 chemhoods, 4 wkstn, 1 sink

B3.11 Cell cultre lab in research prep lab - 26 LF bench w/ upper cabs

1 1 260 260 1 sink, upper and lower cabs

B3.12 Research Mass Spectrometry - 10 tables 30x216 1 1 1,000 1,000

B3.13 Utility rm 1 1 100 100

B3.14 Storage rm adjac. to clinical prep lab and research prep lab

1 1 90 90

B3.17 Solvent Rm for 500L w/ 300L of this Flammable (10x12) 1 1 120 120

B3.18 LC/MS Equipment tables (already have 8 existing tables) 1 8 0 0 need 10 new LC/MS Tables-$10k total

TOTAL ASF 5,768




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freezer units. The access door must be 8’-0” tall and 6’-0” wide with no center astragal in the door opening.

Appropriate mechanical cooling and venting will need to be engineered for the laboratory, support spaces and freezer room.

Other support rooms required include a consumables storage space for supplies, a chemical storage room with approved flammable storage cabinets, a liquid nitrogen and tank storage room, a utility room for a vacuum compressor and a separate space for a liquid nitrogen generator with exhaust venting to the exterior. A separate storage space for solvents is needed near the delivery area also. The proposed room sizes and square footages programmed for the Laboratories and Support Spaces is as follows:


ofStations

SpaceFactor

SubtotalASF Notes

B4.0 Building Support SpacesB4.01 IT Network Closet and Server Rm 1 1 80 80

B3.16 Delivery staging area (access to main building delivery dock)

1 1 240 240

B3.15 Pallet Loading Space (Deliveries) 1 1 90 90

B3.06 Staging/Courier delivery entrance area 1 1 220 220 Requires oversized door for -80 Refrig

B3.07 Sample rec'g area with wkstnn attached to staging/courier area

1 1 120 120 Requires oversized door for -80 Refrig

B4.02 New Mother's Rm (Lactation Room prorated at 25% of 120asf)

1 1 30 30 1 sink, seating, u/c refrig. & cabinets

B4.03 Main De-mark MDF Rm (prorated at 25% of 120asf) 1 1 30 30 Ground Level Rm

B4.04 Delivery Dock (prorated at 25% of 440asf) 1 1 110 110 dock height or with lift platform

TOTAL ASF 920





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iC42 Building Support SpacesThere are several spaces that are considered building support type spaces that will help serve the iC42 Clinical Research and Development program needs. A small dedicated IT Network Closet and Server Room will be needed for those computer and IT items that are specific to the iC42 program and operations. Other space that iC42 may utilize periodically is a Mother’s Room, network and phone distribution panel in the main De-mark/MDF closet, and access to a main building delivery dock that is truck height or has a lift platform for truck deliveries. A proration of these three spaces is included in the program but only at the percentage of ASF that will be allocated to the iC42 program. The proposed room sizes and square footages programmed for iC42 Building Support Spaces are as follows:



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DRAFT

Reception

Lounge

Offices

ClinImmune

KitAssembly

Storage/Prep

Prep

CleanRooms

CleanRooms

HLA

ClinImmune- Space Arrangement

iii. ClinImmune

ClinImmune Labs is an auxilliary enterprise laboratory of the Division of Allergy and Clinical Immunology, a group within the University of Colorado Anschutz Medical Campus’ School of Medicine. ClinImmune offers both educational and consultative expertise to research and medical communities on stem cell processing and storage, histocompatibility, analysis and sequencing issues. As an academic biotechnology auxilliary company, it is currently located in the Bioscience Park Center building next to the Anschutz Medical Campus. It integrates a scholarly mission to contribute to the science of and education about stem cell therapy, histocompatibility and immunogenetics with high-quality laboratory services and products. The University of Colorado Cord Blood Bank has worked with ClinImmune for over 17 years, including the collection, processing, banking, and distribution of cord blood for human transplantation. ClinImmune also provides hematopoietic stem cell processing for the University of

Colorado Hospital Bone Marrow Transplantation Program and works with the Flow Cytometry and Cell Sorting Facility in the Research 2 Building on the Anschutz Medical Campus. ClinImmune is accredited with the College of American Pathologists (CAP), Clinical Laboratory Improvements Amendments (CLIA), American Society for Histocompatibility and Immunogenetics (ASHI), American Association of Blood Banks (AABB), and the Foundation for Accreditation of Cell Therapy (FACT).


ofStations

SpaceFactor

Subtotal ASF Notes

C1.0 Office SuiteC1.01 Directors Office 1 1 200 200

C1.02 Reception/Waiting area 1 1 280 280 Receptionist work station plus 6 to 8 seats

C1.03 Offices - General 12 1 120 1,440 includes 1 future office space

C1.04 Graduate Student Office (shared space w/ work stations in one office space)

1 4 50 200 4 workstations

C1.05 QA Office - small 1 1 120 120

C1.06 QA Office - large 1 1 240 240

C1.07 Project space cubicle workstations - Open Office 9 1 45 405 includes 2 future wkstns

C1.08 File room 1 1 180 180

C1.09 HLA workstations - Open Office 9 1 50 450

C1.10 COO Office (HLA) 1 1 120 120

C1.11 Future HLA room 2 1 120 240

C1.12 Workroom, copier, scanner, mail, supplies 1 1 120 120 cabinetry for supplies storage

C1.13 Conf. Rm w/ Technology (adjac. to recep. in office suite)

1 14 32 448 projector, screen, video conference capabilities

TOTAL ASF 4,443




DRAFT

ClinImmune Labs Office SuiteSome of the ClinImmune Lab office spaces will be located with-in a single office suite. Other offices and work stations will be located closer to their respective work areas and work functions. Included in the main office suite is a small reception/waiting area that includes a receptionist work station and enough seating for four to six chairs, a Directors office, twelve staff offices of which one is a future office space. There will be one larger office space with 4 shared work stations for graduate students. Part of the office suite is an open office area with 9 cubicles which includes two future workstations.

Adjacent and easily accessible to the office suite is a workroom with a copier/scanner/printer and cabinetry for office supplies/mail and a separate file room for required files that must be kept on-site per FDA protocol and certifications.

Separate office areas that may be located closer to their work functions but may be part of the overall office suite is an office for the Chief Operating Officer, one large and one small office for the Human Leukocyte Antigen

(HLA) Quality Analyst offices. The small HLA office will have 1 workstation and the large office will have 2 work stations. There will also be an open office area for nine HLA cubicle workstations and two individual offices for future positions. The optimal layout of the office space will need to be reviewed during the design phase of the project to determine proper adjacencies and proximity to the lab spaces.

As part of the office suite, a conference/meeting room with fourteen seats is programmed. This space will require video conferencing technology with a projector, screen and appropriate speakers. White boards should be installed on three of the four walls to accommodate brainstorming and working sessions of the ClinImmune staff, technicians, and researchers. This conference/meeting room will be shared by all in the ClinImmune office suite. The proposed room sizes and square footages programmed for these office suite spaces are listed below.


Number of Stations

SpaceFactor

SubtotalASF Notes

C3.0 Research Space - Labs & support spaceC3.01 Clean Rms (adjac. to hematology rm) Secure access

req'd4 1 400 1,600 sepax, sealer, fridge/ freezer, biosaf. cabs

C3.02 Hematology Rm w/ 68 LF bench 1 1 640 640 Access security card required

C3.03 Gown-Up rm between hematology/access to 4 clean rms

1 1 160 160 Access security card required

C3.04 Clean Rm Exit Spaces 2 1 80 160 Access security card exit required

C3.05 HLA Pre Lab including adjac. 120 SF Freezer Space 1 1 2,000 2,000

C3.06 HLA Post Lab w/ small interior incubator rm 1 1 1,100 1,100 CO2 incubator, EM incubator, microscopes

C3.07 Cryo Rm adjac. to hematology 1 1 140 140

C3.08 Material Office 1 1 120 120

C3.09 Materials Mgmt Space adjac. to deliveries corridor 1 1 300 300 scale, sealer

C3.10 Bio Hazard Space adjac.to material mgmt space 1 1 120 120 cabinets?

C3.11 Freezer Rm adjac. to HLA Post Lab/LN2 Manifold Freezer

1 1 785 785 LN2 freezers (4), 2 CRF's, -80 rm

C3.12 HLA Storage Rm adjac. to Materials Mgmt 1 1 240 240

TOTAL ASF 7,365




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ClinImmune Research Space - Labs and Support SpacesClinImmune will have four GMPc (Good Manufacturing Practice current) facilities as part of their tenant space. Two gown-up areas and two exit rooms will be needed. One gown up area and one exit area can be shared between two Clean-room Labs. As a central space between the four clean rooms, a Hematology Cord Blood Bank (CBB) lab space is needed. Access into the two gown-up rooms can be directly from the Hematology Lab. Adjacent and with direct access to the Hematology Lab is a Cryogenics Freezer room.

There are two separate lab spaces for HLA. One lab space is a Pre-Lab that will include lab bench work stations and individual lab work stations with lab equipment. Access to six stand-up freezers in a separate space will be needed directly adjacent to beginning work flow end of the HLA Pre-Lab space. Each of the freezers will require a 20 AMP dedicated 208V outlet and the room will require the appropriate venting to expel heat from the compressors. A computer cable connection jack is also required per each freezer for 24/7 temperature monitoring. Next to the HLA-Pre Lab is the Post Lab area however between the two lab spaces is a buffer zone that includes a supervisor office and 7 small work stations for data entry from the lab work.

The HLA Post-Lab space will have lab bench workstations and equipment throughout the lab space. De-ionized water is required in the HLA Post-Lab space. Near the HLA Post-Lab is a Freezer Room with four LN2 and two CRF freezers tied into the liquid nitrogen manifold or building liquid nitrogen tank system. If mobile liquid nitrogen tanks (Dewar tanks) are anticipated, floor space will be needed for maneuvering and parking the liquid nitrogen tanks to tie into a manifold system. As a result of the frequent deliveries of liquid nitrogen, this freezer room and tank storage space should be located close to the building’s freight elevator. The spaces designed for the freezers will also need to have a path of travel from the building freight elevator that includes oversized doors to change out freezers periodically. An 8’-0” tall door with no center astragal allowing for a full 72” wide opening is required for the movement of freezers.

Other support rooms that should be in close proximity to the HLA Labs is a Materials Management room, a Materials office, and a HLA Storage Room. These are not required to be directly accessible from the HLA labs, but should be reasonably close for everyday access to materials. The proposed room sizes and square footages programmed for the Research Space – Labs and support spaces are as follows:


Number of Stations

SpaceFactor

SubtotalASF Notes

C4.0 Kit Building Suite - adjac. COO Office/HLA Workstns (optional space)C4.01 Kit Building Rm - Entry 1 1 240 240

C4.02 Kit Building Rm - adjac. to entry 1 1 320 320

C4.03 Kit Building Rm - adjac. to entry 1 1 180 180

TOTAL ASF 740




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ClinImmune Kit BuildingClinImmune has a kit building area that processes incoming and outgoing packages daily. The space has three processing work stations, materials storage and space for maneuvering of employees as kit building progresses to each work station. Each work station requires a computer terminal and adjacent open counter top space of approximately 6’-0” ( 3’-0” on either side). The following spaces are separated out to help allow for quiet environments for the employees working in the kit building areas. Although the spaces are separated into individual rooms, an open space plan could be possible if the work flow, equipment and furniture were arranged appropriately. The kit building site is best located near the deliveries entrance to the tenant space due to the amount of supplies and incoming/outgoing packages each day. The proposed room sizes and overall square footages programmed for the Kit Building Suite are as follows:


Number of Stations

SpaceFactor

SubtotalASF Notes

C5.0 Cord Blood Bank Office SuiteC5.01 Cord Blood Bank wkstns 1 6 45 270

C5.02 Cord Blood Bank Rm 2 1 210 420 Security access card for entry

C5.03 Cord Blood Bank File Area (in CBB wkstn area) 1 1 80 80 Access security card required

TOTAL ASF 770




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ClinImmune Cord Blood Bank OfficeDepending upon the layout of the office suite area for ClinImmune Labs, a space for the Cord Blood Bank offices should be allocated as a separate suite but with-in the overall office area. This separate Cord Blood Bank Office Suite should be a secured work area accessible by security card reader only and will include two larger office spaces that accommodate two full size work stations in each space, an open office area for six cubicle work stations, and a secured file room or file cabinet area directly adjacent and accessible from this office suite. The proposed room sizes and overall square footages programmed for the Cord Blood Bank Office Suite are as follows:


Number of Stations

SpaceFactor

SubtotalASF Notes

C6.0 Cord Blood BankC6.01 Cord Blood Bank Freezer Farm from Bioscience East 1 1 2,078 2,078 Requires oversized door for -80 Refrig.

Security access card for entryC6.02 Future Freezers space needed 1 12 100 1,200 Requires oversized door for -80 Refrig.

Security access card for entryTOTAL ASF 3,278




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ClinImmune Cord Blood BankSpace is dedicated in the program for a freezer farm which is an open floor area space in the building set up to accommodate multiple -80 (minus 80 degrees Celsius) freezer units. Access to the room will require oversized doors with a minimum height of 8’-0” tall and a full width of 6’-0” wide and no center astragal in the door opening. Each freezer requires a 20 AMP dedicated 208V circuit and outlet per freezer. A computer cable connection jack is also required per each freezer for 24/7 temperature monitoring. The overall room is to have a security system with card reader access badges and will be monitored for entry and exit of occupants. The temperature of the overall space will also be monitored 24/7 in the event the mechanical cooling/venting system to the room fails.

The complete circulation pathway from the delivery dock to the freezer room and circulation pathways throughout the freezer room need to be wide enough to accommodate the change out of freezer units. Periodically a freezer unit will fail and a replacement unit brought in. Maneuvering this replacement unit through the circulation path, and removal of the non-functioning unit must be planned into the space accordingly. Due to the weight of the freezer units (800 lbs up to 1500 lbs when fully loaded) , it is anticipated this space will be located on the first floor slab on grade. It is preferred that daylight windows not be part of this space, however, higher clearstory windows may be considered if required daylight is needed to help meet LEED or other environmental requirements. The finishes in this freezer

farm space can be minimal. Exposed ceiling and utility lines are acceptable. Wall surfaces do not need to be of a finished material but should have enough protection to meet code requirements. Plywood, fire taped drywall, FRP, or a similar type material may be acceptable for this space. The floor is to have an exposed sealed concrete floor and the lighting is anticipated to be exposed fluorescent or LEDlight fixtures.

The room will have a workstation along one wall for an employee to recorded incoming and outgoing samples. A computer terminal and phone jack will be required at this work station.

There is currently 26 freezer units that need to be accommodated in the program for this space and an additional 12 future freezer units need to be planned into the space. The proposed room size and overall square footages programmed for the Cord Blood Bank freezer farm area are as follows:


Number of Stations

SpaceFactor

SubtotalASF Notes

C7.0 Building Support SpaceC7.01 Break rm with kitchenette and 1 sink 1 1 330 330 1 sink, refrigerator, counters, microwave

C7.02 Locker rm (mens and womens) 2 1 150 300 Lockers, seat benches

C7.03 Server/IT Bench Rm 1 1 180 180

C7.04 New Mother's Rm (Lactation Rm prorated at 25% of 120asf)

1 1 30 30 1 sink, seating, u/c refrig. & cabinets

C7.05 Main De-mark MDF Rm (prorated at 25% of 120asf) 1 1 30 30 Ground Level Rm

C7.06 Delivery Dock (prorated at 25% of 440asf) 1 1 110 110 Dock height or with lift platform.

TOTAL ASF 980

17,576 28,122Total ASF Gross Sq Ft




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ClinImmune Building SupportA breakroom area with a kitchenette along one wall is programmed into the ClinImmune Lab tenant office area. The kitchenette should include a sink, refrigerator, micro-wave, and counter top space. Moveable tables and chairs for up to ten people should be part of this space where employees can take a break or enjoy their lunch. It is preferred that this space have large amounts of daylight and views to the outdoors. This space should also be separate enough to allow conversations and activities to take place that do not affect the other workers in close proximity. A separate room is programmed for this space unless an open environment can contain the casual noise that may be generated during a lunch hour or break period.

A separate Men’s and Women’s Locker room is to be provided. Each room is to have 10 full height lockers and a small bank of eight ½ tier lockers. A bench should be provided for an employee to sit and change shoes. A hand sink in each locker room is to be provided but restroom fixtures are not required.

For ClinImmune’s IT services, a Server room with a separate IT Bench work area is to be provided for the servicing of computers and technology equipment. This area will allow the set up and burn-in of computers and other equipment used in the facility. Storage of some computer parts and cables may be kept on shelves and cabinets in this space also.

There are several spaces that are considered building support type spaces that will help serve the ClinImmune Lab employees and work functions. Spaces that may be utilized periodically are a Mother’s Room, network and phone distribution panel in the main De-mark/MDF closet, and access to a main building delivery dock that is truck height or has a lift platform for truck deliveries. A proration of these three spaces is included in the program but only at the percentage of ASF that will be allocated to the ClinImmune program. The proposed room sizes and square footages programmed for ClinImmune Building Support Spaces are as follows:


Number of Stations

SpaceFactor

SubtotalASF Notes

D1.0 Building SpaceD1.01 FRA Future Leased Space 1 1 29,205 29,205 unfinished core & shell space

D1.02 New Mother's Rm (Lactation Rm prorated at 25% of 120asf)

1 1 30 30 1 sink, seating, u/c refrig. & cabs

D1.03 Main De-mark MDF Rm (prorated at 25% of 120asf) 1 1 30 30 ground level room

D1.04 Delivery Dock (prorated at 25% of 440asf) 1 1 110 110 dock height or with lift platform

TOTAL ASF 29,375





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iv. FRA Future Tenant SpaceAs development of space continues on the Colorado Science and Technology Park at Fitzsimons, the FRA has agreed to lease a portion of the building from the university for future development/build-out by tenants. These future tenants may be associated with the various fields of health science and would be private companies or third party companies who work closely with the university or other Site-wide entities like UCH, CHCO, or the VA Hospital. Having private companies in the building to help support efforts toward translational research and/or collaboration of university programs is positive in creating a vibrant building community. The space allocated for the FRA for future tenants may be one single tenant or could be multiple tenants depending upon the size of space needed and the allowable building code requirements needed for design and build out of the future tenant’s space.

In addition to the tenants space, there are several spaces that are considered building support type spaces that will help serve the future tenant employees and work functions. Spaces that may be utilized periodically are a Mother’s Room, network and phone distribution panel in the main De-mark/MDF closet, and access to a main building delivery dock that is truck height or has a lift platform for truck deliveries. A proration of these three spaces is included in the program but only at the percentage of ASF that will be allocated to the FRA future tenant program spaces. The proposed room sizes and square footages programmed for future tenant Building Support Spaces are as follows:



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IV. AlternativesIf the project and program plan for Bioscience II is not approved for funding, there are several alternatives that would need to be activated to address the critical space needs on campus. The new Bioengineering Program would need to lease space in an off-campus building and build out space to accommodate the classrooms, labs, offices and support spaces required to offer the educational program. It is critical that the Bioengineering Program be located on the Anschutz Medical Campus to be adjacent to the existing medical and health science programs that currently exist between the university and other site-wide entities as well as the existing teaching spaces that are used in the Education 2 and Research 2 buildings. Given the collaborative and translational research opportunities that are present on the Anschutz Medical Campus, it is critical that the program be located in close proximity to the university, UCH and CHCO.

If space in the Bioscience II building is not available for iC42, this company will need to find new space to lease in another building. The current building they are located in, Bioscience East, will most likely be sold in the next 24 to 36 months. The existing space is also under sized for electrical and mechanical cooling capacity. iC42 has had to supplement these building systems to maintain their operations. No other space is available on the university campus or FRA property that would be comparable space for iC42 to relocate. With their close association with UCH and CHCO, it is preferable to be in close proximity to the Anschutz Medical Campus. If another location is found in the Denver metro area to house iC42, transportation between sites is expected to add a significant hurdle to their operations. Although this is a potential option, it is not expected to be a cost savings to iC42’s operations and would most likely stifle their growing developments with UCH and CHCO by being located further away.

ClinImmune currently leases space from the FRA in a building located ¼ mile from the proposed Bioscience II building site. Although ClinImmune has an option to stay in their existing facility, they are currently in 3 separate leases and are challenged in their operations with space that is not contiguous. Part of ClinImmune’s space, the freezer farm, is located in the same building where iC42 leases space, Bioscience East. With the potential sale of the building, new space will need to be secured for this freezer farm. ClinImmune’s existing space is in two different suites of the Bioscience I building and employees frequently need to travel down common building corridor space to access the other functions and operations of their business. If ClinImmune were to stay in their existing space of

Bioscience I, additional space for growth is limited and capacity to expand would require taking on a 4th leased space adding to their logistical operation challenges of non-contiguous space.



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VI. Appendices

a. Appendix A - Option of Probable Cost (CC-C Form - FY 2013-2014)The following is a copy of the CC-C state budget estimate form showing the project Probable Cost not including the bridge connections.



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Agency or Institution:

Project Title

Project Year(s):

Agency or Institution Priority Number:

Total Project Costs

Total Prior Year Appropriations

Current RequestFY 2013-14 Year 2 Request Year 3 Request Year 4 Request Year 5 Request

A. Land Acquisition(1) Land /Building Acquisition 1,724,679$ -$ 1,724,679$ -$ -$ -$ -$ B. Professional Services

(1) Master Plan/PP 100,000$ -$ 100,000$ -$ -$ -$ -$ (2) Site Surveys, Investigations,

Reports, Materials Testing, Geotech, Traffic Survey

211,000$ -$ 211,000$ -$ -$ -$ -$

(3) Architectural/Engineering/ Basic Services

1,270,000$ -$ 1,270,000$ -$ -$ -$ -$

(4) Code Review/Inspection 82,250$ -$ 82,250$ -$ -$ -$ -$ (5) Construction Management 120,000$ -$ 120,000$ -$ -$ -$ -$ (6) Advertisements -$ -$ -$ -$ -$ -$ -$

(7a) Developer fees, Title, Insurance 1,016,931$ -$ 1,016,931$ -$ -$ -$ -$ (7b) Inflation Percentage Applied 0.00% 0.00% 0.00% 0.00% 0.00% 0.00%(8) Other (LEED consulting &

commissioning)174,000$ -$ 174,000$ -$ -$ -$ -$

(9) Total Professional Services 2,974,181$ -$ 2,974,181$ -$ -$ -$ -$ C.

(1) Infrastructure 1,400,000$ -$ 1,400,000$ -$ -$ -$ -$ (a) Service/Utilities (power) 192,000$ -$ 192,000$ -$ -$ -$ -$ (b) Site Improvements 1,028,040$ -$ 1,028,040$ -$ -$ -$ -$

(2) Structure/Systems/ Components(a) New (GSF): 120,000 24,986,600$ -$ 24,986,600$ -$ -$ -$ -$ New $ 448 / GSF(b) Renovate GSF: -$ -$ -$ -$ -$ -$ -$ Renovate $ /GSF

(3) Other (Site Clean-Up-Asbestos) 500,000$ -$ 500,000$ -$ -$ -$ (4) High Performance Certification

Program -$ -$ -$ -$ -$ -$ -$

(5a) Inflation for Construction 466,800$ -$ 466,800$ -$ -$ -$ -$ (5b) Inflation Percentage Applied 2.00% 0.00% 2% 0.00% 0.00% 0.00% 0.00%(6) Total Construction Costs 28,573,440$ -$ 28,573,440$ -$ -$ -$ -$ D.

(1) Equipment 845,000$ -$ 845,000$ -$ -$ -$ -$ (2) Furnishings 640,220$ -$ 640,220$ -$ -$ -$ -$ (3) Communications 1,263,696$ -$ 1,263,696$ -$ -$ -$ -$

(4a) Inflation on Equipment and Furnishings

-$ -$ -$ -$ -$ -$ -$

'(4b) Inflation Percentage Applied 0.00% 0.00% 0.00% 0.00% 0.00% 0.00%(5) Total Equipment and Furnishings

Cost2,748,916$ -$ 2,748,916$ -$ -$ -$ -$

E. Miscellaneous

(1) Art in Public Places=1% of State Total Construction Costs (see SB 10-94)

-$ -$ -$ -$ -$ -$ -$

(2) Annual Payment for Certificates of Participation

-$ -$ -$ -$ -$ -$ -$

(3) Relocation Costs -$ -$ -$ -$ -$ -$ -$ (4) Other Costs [TAP fees] 660,000$ -$ 660,000$ -$ -$ -$ (5) Other Costs [CoA Permit/Inspect] 25,000$ -$ 25,000$ -$ -$ -$ -$ (6) Other Costs [moving] 240,000$ -$ 240,000$ -$ -$ -$ -$ (7) Other Costs [specify] -$ -$ -$ -$ -$ -$ -$ (8) Total Misc. Costs 925,000$ -$ 925,000$ -$ -$ -$ -$ F. Total Project Costs 36,946,216$ -$ 36,946,216$ -$ -$ -$ -$ G. Project Contingency

(1) 5% for New 1,605,365$ -$ 1,605,365$ -$ -$ -$ -$ (2) 10% for Renovation -$ -$ -$ -$ -$ -$ -$ (3) Total Contingency 1,605,365$ -$ 1,605,365$ -$ -$ -$ -$ H. Total Budget Request [F+G(3)] 38,551,581$ -$ 38,551,581$ -$ -$ -$ -$ I. Source of Funds

CCF -$ -$ -$ -$ -$ -$ -$ CF 38,551,581$ -$ 38,551,581$ -$ -$ -$ -$ RF -$ -$ -$ -$ -$ -$ -$ FF -$ -$ -$ -$ -$ -$ -$

check (should = H) $38,551,581 $0 $38,551,581 $0 $0 $0 $0

Date

Date

Mark Berthold [email protected]

Date

CC-C: CAPITAL CONSTRUCTION REQUEST FOR FY 2013-14

Construction or Improvement

University of Colorado Denver|Anschutz Medical Campus

Signature Department or Institution Approval:

Equipment and Furnishings

Revision? Yes NoIf yes, last submission date:

Name and e-mail address of preparer:

Bioscience II

1

SignatureCCHE Approval:

FY 2013-15 SignatureOSPB Approval:

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