Program. Genetics Epigenetics Environmental «triggers» You Nutrition Lifestyle Stress Infections...
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Transcript of Program. Genetics Epigenetics Environmental «triggers» You Nutrition Lifestyle Stress Infections...
16.00 Innregistrering og servering
17.00 Innledning
17.10 Nytten av diettbehandling i klinisk praksis – kasuistikk. Geir Flatabø, lege, Medisinsk Helsesenter AS
17.30 Gluten sensitivitet fra et klinisk perspektiv. Knut Lundin, Overlege, dr. med., førsteamanuensis, Rikshospitalet
18.00 En pasient forteller om sin erfaring med diettbehandling
18.10 Utvikling av en ny metode for påvisning av gluteneksorfiner og casomorfiner i Urin. Dag Tveiten, laboratorieleder, Lab1/Adrian Finvold, kjemiingeniør Lab1/stud. NTNU
18.30 Kulturelt innslag og pause
19.00 Probiotika ved diettbehandling. Gunnar Brønstad, dr.med, Neurozym Biotech AS
19.25 Omega-3 fettsyrer (EPA) og/eller vitamin E+C mot schizofreni. Et randomisert forsøk. Håvard Bentsen, Overlege, dr.med. Senter for Psykofarmakologi, Diakonhjemmet Sykehus.
19.50 Pause
20.00 Food antigens, intestinal inflammation and complement dysregulation in psychiatric disorders. Emily G. Severance, Ph.D. Stanley Division of Developmental Neurology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, USA
20.40 “Kalles time”
Program
Genetics
Epigenetics
Environmental «triggers»
You
• Nutrition• Lifestyle• Stress• Infections • Microbiota• ++++
Interactions
S
Neuropeptides in urineLC- MS/MS
Dag TveitenAdrian Finvold
2013
Peptides to nervous system
Incomplete breakdown of gluten and casein
Permeability – “Leaky gut syndrome”
Pathway
Diet and effect
UV- spectrum of urine
UV-spectrum of urine with given wavelengths
Derek - 27
Difficult birth – normal weight
Reduced weight soon after birth
9,5 kg when 2,5 years old
Diagnosed with Infantile Autism - 4 years old
Often GI symptoms – pain, diarea
Angry often/aggressive behaviour
Derek
Derek 2005 – 50 kgDerek 2007 – 64 kg
?
With permission from parents
DerekBefore GFCF diet:
Rigid, stiffness, unrelaxed
Hardly no eye contact Aggressive Tramping with his feet Biting and kicking
After GFCF diet: More relaxed Smiling more often More happy Eyecontact More communicative
Parents say: One hour after ingestion of ”forbidden” food – marked increased aggressive behaviour
Gluten- and casein free diet
Publications
Project LC-MSMS
• Autumn 2011• Investment Ms• Cooperation with HIOA, RH
(Medinova)• 4 students Bachelor in Chemistry
Peptide structures
Casomorphine 1-4 Gluten exorphine C
- Mass: 522,2 g/mol - Mass: 591.3 g/mol
Enzymatic degrading effects
Calibration curveRelation between signal and concentration
C - 5 Levels, 5 Levels Used, 15 Points, 15 Points Used, 0 QCs
Relative Concentration0 0.2 0.4 0.6 0.8 1 1.2 1.4 1.6 1.8 2 2.2 2.4 2.6 2.8 3 3.2 3.4 3.6 3.8 4 4.2
Rela
tive R
esp
onse
s 1x10
00.1
0.20.30.40.5
0.60.70.80.9
11.11.2
1.31.41.51.6
1.71.81.9
2
2.12.22.32.4
2.5y = 5.727725 * x + 0.581928R^2 = 0.99745320Type:Linear, Origin:Ignore, Weight:None
Mass spectrometry Conclusions
Fast
Selective
Sensitive
Reliable
Mass spectrometry Patient - LC-MsMs
ID/RID
Reel krea. Kons.
(mmol/L)Kasomorfi
n 1-3Kasomorfi
n 1-4Kasomorfi
n 1-4AKasomorfin
1-5Kasomorfi
n 1-5AKasomorfi
n 1-7Kasomorfin
1-8Gluteneksorfi
n A4Gluteneksorfi
n A5Gluteneksorfi
n B4Gluteneksorfi
n B5Gluteneksorf
in C26305 13,7 239,7 139,1 1269,7 307,5 4807,1 110,1 0 0 0 0 0 0
Mass spectrometry Patient
Patient example
Patient lab results – Antibodies/Peptides
IgG cowmilk 68 U/mL (<20)IgG casein 40 U/mL (<20)IgA casein 13 U/mL (<12)
Casomorphin 1-4 41,4 nmol/L/kreatininCasomorphin 1-5 45,2 nmol/L/kreatininCasomorphin 1-7 200,1 nmol/L/kreatininCasomorphin 1-8 145,2 nmol/L/kreatinin
Hurra.hurraDet er bra .bra .bra.Dette går veien Som tosken og skreien . VH K
Vi får ta en tittPå det som er blittEt enigma i en gåte Som nålen i en såte.Hi ,hi Kalle
Hipp hurraDette var bra.Nå har vi seiret ,Og dette må feires VH kalle den nå helgale
E-mails from Kalle