Products refresher webinar - Igennus

Igennus Product Refresher Webinar

What is inflammation?

• The normal response of a tissue to injury

• Triggered by a number of causes including infection, invading pathogens (such as bacteria or viruses), trauma or compromised blood flow

• Three defined phases:- Initiation- Resolution- Termination

Resoleomics - the process of inflammation resolution In

flam

mat

ory

resp

onse

Initiation Resolution Termination

PGE2

LTB4

Eicosanoid switch Stop signal

Time

Pro-inflammatory reduced

Anti-inflammatory increased

The role of diet in modulating inflammation

Many modern food types are new in regard to human evolution

Triggers from chronic altered diet and psycho-emotional stress negatively influence the resolution step of the inflammatory response

Failure to resolve inflammation increases susceptibility to the development of chronic, low-grade, inflammation-based diseases due to the constant activation of both the HPA-axis and innate immune system

Bosma-den Boer MM, van Wetten ML, Pruimboom L: Chronic inflammatory diseases are stimulated by current lifestyle: how diet, stress levels and medication prevent our body from recovering. Nutrition & metabolism 2012, 9:32.

The key to regulating inflammation is through the modulation of eicosanoids:

⁻ pro-inflammatory eicosanoids drive the immune and inflammatory processes

⁻ anti-inflammatory eicosanoids act to end the process through resolution

Overproduction of pro-inflammatory products or reduced production of anti-inflammatory products can result in continued production of inflammatory products – the hallmark of silent inflammation

The role of lipid mediators

• Pro-inflammatory lipidarachidonic acid (AA)

• Anti-inflammatory/pro-resolving lipids dihomo-gamma-linolenic acid (DGLA) eicosapentaenoic acid (EPA)

docosahexaenoic acid (DHA)

• AA and EPA are the significant eicosanoid precursors

• AA to EPA ratio is a direct biomarker of inflammatory status

AA to EPA ratio is a direct measure of inflammationBy modifying diet we can influence the ratio of pro-inflammatory (from AA)

to anti-inflammatory eicosanoids (from EPA)

• Depression• Bipolar disorder• Schizophrenia• Myalgic encephalomyelitis• Fibromyalgia• Chronic pain syndromes• Diabetes• Cardiovascular disease• Cancer

• Inflammatory disorders• Inflammatory bowel disease:

(Crohn’s disease, ulcerative colitis)• Neurodevelopmental disorders:

(autism, dyslexia, dyspraxia, ADHD)• Alzheimer’s disease• Huntington’s disease• Skin conditions:

(eczema, psoriasis, dermatitis)

Conditions associated with a high AA to EPA ratio

Shifting the balance

⁻ AA and EPA contents of cell membranes can be altered through consumption of omega-3 EPA (marine products/marine oils)

⁻ Changing the fatty acid composition of cell membranes affects• changes in membrane structure• products involved in immune function and the inflammatory cascade• cell signalling• gene expression and cell cycle

EPA as a therapeutic agent

⁻ Cod liver oil benefits to health long established

⁻ Key protective and beneficial aspects are the essential fatty acids: EPA and DHA

⁻ Only recently discovered, these two important EFAs have very different roles within the body

⁻ EPA = anti-inflammatory, immune function, neuron and brain function support

⁻ DHA = main structural fat for cells and brain development

EPA reduces the activity of AA in two ways

• EPA (but not DHA) is an inhibitor of the enzyme delta-5-desaturase that produces AA

• EPA also competes with AA for the enzyme PLA2 necessary to release AA from the membrane phospholipids

Therapeutically, fish oils are not all equal

Restore & Maintain® treatment protocol

Restore with pure EPA

Introduce GLA for long-term maintenance

Step 1Pharmepa 90

Step 2Pharmepa 80

3-6 months

Pharmepa®Restore & Maintain™ anti-inflammatory protocol

• Igennus is the only independent manufacturer of specialist Fatty Acid in the UK. Based in Cambridge the medical innovation hub for the UK:

- Seven Seas Merck Pharma Germany- Minami Atrium Pharma Canada- Biocare Elder Pharma India- Eskimo 3 Bringwell Pharma Sweden- Equizen Vifor Pharma Swiss

Step 1: Restore

Pharmepa E-EPA 90 provides 1000 mg EPA with just two easy-to-swallow capsules daily. This product provides a loading dose of super strength EPA and is ideal for people who have never supplemented with pure EPA or those who have taken a break from omega-3 EPA supplementation



Step 2: Maintain

Pharmepa E-EPA 80 combines 80% ethyl-EPA concentrate with GLA and triterpenes from organic virgin evening primrose oil and vitamins B5, D3 & E

This product balances and maintains the omega-6 to omega-3 ratio and is suitable for long-term use after supplementing with pure EPA. Alternatively, long-term users of omega-3 supplements may skip step 1 and take step 2 as a maintenance supplement



Pharmepa® Restore & Maintain™ Benefits summary

Allows high concentrations of EPA to be achieved Maintains DHA levels:

• raises both EPA and DHA levels (if DHA is needed) thus improving 'omega-3 index’

• protects DHA loss from cell membranes Enhances mitochondrial function Maintains cell integrity including neuronal systems Counteracts inflammation/oxidative stress Powerful antidepressant Improves immune function Prevents the death of healthy cells Induces 'programmed cell death' of damaged, genetically mutated cells Improves cardiovascular function

Vegan therapeutic alternative?



Echiomega

• Derived from Echium plantagineum • Echium seed oil is a novel food approved source of SDA and ALA • SDA is the precursor to EPA

• 25-30% of SDA converts to EPA• 5-8% of ALA • Echiomega is naturally rich in SDA• SDA directly increases cellular EPA levels• Echium seed oil provides standalone health benefits



Provides the building blocks to restore optimum omega-3 and omega-6 levels

Favourable omega-6 to omega-3 ratio of 1:1.8 Naturally high in SDA and GLA Vegetarian precursor to EPA Supports immune function Naturally anti-inflammatory Supports cardiovascular health Lowers triglycerides Early studies show enhanced glycaemic control

and reduced atherosclerosis in animal models

Echiomega

Nutritional co-therapeutics

Mood disorders

Pharmepa®

Homocysteine ControlTM

Neurodevelopmental disorders

Vegepa E-EPA 70 + Chewables

NeurobalanceTM

Cardiovascularhealth

Pharmepa®


VESIsorb® Ubiquinol




• folic acid, vitamin B6 and vitamin B12

• formulated to prevent and reduce elevated plasma homocysteine

• slow-release delivery system

• most bioavailable forms of each ingredient

• ensures optimal blood plasma levels are maintained throughout the day




Highly bioavailable nutrients Easy-to-swallow tablets Split-dosing for optimal bioavailability Sustained-release tablets for

enhanced absorption & optimal tissue distribution

Offers benefits for cardiovascular health, brain function and mood balance

Lowers homocysteine levels Supports cardiovascular function Supports healthy mood Supports methylation pathways Supports neurotransmitter

metabolism Supports red blood cell formation Supports neurological function Supports DNA and protein synthesis

0 6.0 9.0 15+

Homocysteine clinical levels 0.0 – 15 mmol

Desirable

Optimal

Critical

Role and benefits of a healthy methylation cycle Neurotransmitter production:

o Mood o Memory o Learning o Gut function

Antioxidant activity: o Increased glutathione production o Reduced free radical production

Cardioprotection: o Reduced risk of cardiovascular disease and

stroke

Detoxification: o Improved liver function o Increased energy o Improved sleep

Neuroprotection Improves cell signalling Anti-inflammatory Normal cell cycle Reduced risk of bone loss and fracture Improved fertility Anti-ageing

Therapeutic application for Homocysteine ControlTM

Cardiovascular disease o Heart attacko Strokeo Vascular disease o Atherosclerosis

Mood disorderso Depressiono Schizophreniao Bipolar syndrome

Neurodegenerative diseases o Huntington’s disease o Parkinson’s disease o Alzheimer’s disease

Neuromuscular diseases o Muscular dystrophyo Multiple sclerosis

Migraine Cell cycle control Diabetes Liver disorders Thyroid disease/low thyroid function Infertility Pregnancy complications Macular degeneration Chronic fatigue syndrome


IngredientsBulking agent: calcium carbonate; emulsifier: microcrystalline cellulose; thickener: hydroxypropyl methylcellulose; vitamin B6 (pyridoxal-5-phosphate); anti-caking agents: magnesium stearate, stearic acid; folic acid; vitamin B12 (methylcobalamin); glycerol.

Nutritional information Serving size: 1 tablet Amount per tablet % RDA

Vitamin B6 (as pyridoxal-5-phosphate) 8 mg 570%

Vitamin B12 (as methylcobalamin) 300 µg 12,000%

Folic acid 300 µg 150%

NeurobalanceTM



NeurobalanceTM

• magnesium, zinc and vitamin B6

• formulated to aid in normal neurotransmitter production and function

• scientifically formulated supplement

• synergistic benefits to optimise the functioning of the nervous system

• slow-release delivery system ensures optimal blood plasma nutrient levels are maintained throughout the day

• most bioavailable forms of each ingredient



NeurobalanceTM

Highly bioavailable nutrients Synergistic relationship between Mg

and B6 Easy-to-swallow tablets Split-dosing for optimal bioavailability Sustained-release tablets for enhanced absorption & optimal tissue distribution Offers benefits for brain function and

mood balance

Supports neurotransmitter metabolism

Supports neurological function Supports hormone balance Supports immune function Supports DNA and protein synthesis Aids in the production of sleep

modulators Supports a healthy mood Anti-anxiety benefits

Neurotransmitter Functions

Dopamine Movement, memory, pleasurable, reward, behaviour, cognition, attention, inhibition of prolactin production, sleep, mood, learning

Serotonin Mood, appetite, sleep, memory, learning, body temperature, pain

Melatonin Libido, sleep, immune function

Norepinephrine ‘Fight or flight’ response, attentiveness, mood, mental arousal, emotions, sleep, dreaming, learning

Epinephrine ‘Fight or flight’ response, mental focus, attention

GABA Muscle tone, sleep, anxiety modulator

Therapeutic application for Neurobalance

Neurodevelopmental disorderso Attention-deficit hyperactivity-disorder (ADHD)o Autistic spectrum disorders (ASD)o Dyspraxiao Dyslexia Mood disorderso Depressiono Schizophreniao Bipolar syndrome

Neurodegenerative diseases o Huntington’s disease o Parkinson’s disease o Alzheimer’s disease Women’s healtho Premenstrual syndrome

(PMS)o Menopausal symptoms

NeurobalanceTM

IngredientsMagnesium citrate; bulking agent: calcium carbonate; emulsifier: microcrystalline cellulose; zinc methionine; vitamin B6 (pyridoxal-5-phosphate); thickener: hydroxypropyl methylcellulose; anti-caking agents: stearic acid, silicon dioxide, magnesium stearate.

Nutritional information

* from 376 mg magnesium citrate

Serving size: 2 tablets Amount per tablet % RDA

Zinc methionine 14 mg 140 %

Magnesium (elemental)* 60 mg 16 %

Vitamin B6 (pyridoxal-5-phosphate) 10 mg 714%

VESIsorb® Ubiquinol-QH



VESIsorb® Ubiquinol-QH• VESIsorb® Ubiquinol-QH

• most bioavailable source of the activated form of coenzyme Q10 (CoQ10)

• patented VESIsorb® delivery system provides colloidal, highly solubilised ubiquinol

• passes easily through the water layer barrier in the gut and into the bloodstream

• unprecedented absorption

• optimal blood CoQ10 levels

• 1 a day provides therapeutic, sustained action



Energy production Antioxidant activity Cardioprotection Neuroprotection Anti-inflammatory Promotes thermogenesis Cellular communication & gene

expression Supports organ metabolism Supports normal cell cycle


Patented VESIsorb® delivery system Mimics natural intestinal transport easily absorbed into the bloodstream for

optimal tissue distribution Pre-digested solubilised ubiquinol for faster

absorption Reaches therapeutic plasma concentrations Sustained action Unprecedented bioavailability 1-a-day dosing

Coenzyme Q10

• CoQ10 is a powerful, fat-soluble, vitamin-like substance

• Two main functions:• Energy production – cellular respiration• Antioxidant/antioxidant recycling

• Two main forms• Ubiquinone – oxidised form• Ubiquinol – reduced form

• 96% of CoQ10 within the body is in the form of ubiquinol• Ubiquinol is the active form of CoQ10

CoQ10 production and intake

• Endogenous CoQ10 synthesis is a complex multi-step process

• Tissue CoQ10 levels generally peak around the age of 20-30 and decline with age

• The conversion of ubiquinone to ubiquinol also declines with age

• Majority of dietary CoQ10 is in the form of ubiquinone

• Found in foods such as fish, organ meats and germ of whole grains, the average diet is estimated to provide approximately 10 mg/day of CoQ10

Free radical damage and

oxidative stressSkin

LungsInflammation

Cardiovascular

BrainImmunity

Ageing

Ubiquinol deficiency alters mitochondria function and lowers antioxidant status, leading to increased free radical generation

Acetyl-CoA

Cholesterol

HMG-CoA

Mevalonate

HMG-CoA reductase inhibitors (statins)

Coenzyme Q10(ubiquinone)

HMG-CoA reductase

HMG-CoA synthase

• Absorption occurs in the small intestine directly into the lymphatic system followed by absorption into the bloodstream

• Absorption is generally poor (large lipophilic molecule) and fat soluble molecules must cross the ‘unstirred’ water layer for effective uptake

• ~60% of oral supplements may be excreted via the faeces

• High variability with absorption depending on the dosage form

• Highest bioavailability when taken with lipid-containing food

VESIsorb® technology

• The aqueous diffusion layer or 'unstirred' water layer adjacent to the intestinal membrane has long been regarded as a potential barrier for intestinal absorption of compounds, especially large fat-soluble molecules

• The task of naturally formed bile salt-mixed micelles, having a size <10 nm, is to transport the lipophilic molecules through the aqueous environment of the gastrointestinal tract and across the unstirred water layer to the absorptive epithelium

• VESIsorb® is a novel delivery technology that mimics this natural absorption process to improve bioavailability of large lipophilic molecules

Time (hours)

Plas

ma

CoQ

10 (m

g/m

L)

VESIsorb®

Therapeutic level

120mg single dose of VESIsorb® delivered CoQ10 reaches therapeutic levels within 2 hours, reaching maximum blood plasma levels (6.89 mg/mL) (Cmax) within around 4 hours (Tmax)

In contrast, 120mg single dose of oil-based CoQ10 reaches maximum blood plasma levels (2.44 mg/mL) within 5 hours and fails to achieve therapeutic levels

VESIsorb® increases the bioavailability of CoQ10 by 622%

0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 240

0.51

1.52

2.53

3.54

4.55

5.56

6.57

7.5

Oil-based

Cmax

Tmax

VESIsorb® delivered CoQ10 is absorbed FASTER, reaching concentrations that are STRONGER and stay in the body LONGER than generic delivery methods


Serving size: 1 capsule Amount per capsule

Ubiquinol (Kaneka QHTM – activated coenzyme Q10) 100 mg

Vitamin E ( α-tocopherol) 6.7 mg α-TE*

IngredientsUbiquinol activated coenzyme Q10 (Kaneka-QH™); capsule shell (emulsifier: gelatine; glycerol: colour: caramel); medium chain triglycerides; emulsifiers: non-ionic surfactant, polyglycerol fatty acid esters; antioxidant: vitamin E.

Nutritional information

*56% EU RDA

Therapeutic applications for VESIsorb® Ubiquinol-QH Cardiovascular disease

o Cardiomyopathy o Congestive heart failureo Angina o Arrhythmias o Hypertension o Atherosclerosis

Neurodegenerative diseases o Huntington’s disease o Parkinson’s disease o Alzheimer’s disease

Neuromuscular diseases Chronic fatigue syndrome

Statin-associated myopathy Mitochondrial disease Muscular dystrophy Chronic fatigue conditions Diabetes Cell cycle regulation Chronic obstructive pulmonary disease Migraine Immune disorders HIV/AIDS Periodontal disease Male infertility



www.igennus.com01223 421434

[email protected]

Sophie TullyNutrition education manager

[email protected]@igennus.com

07908683174

http://www.igennus.com/

mailto:[email protected]



Products refresher webinar - Igennus

Health & Medicine

Transcript of Products refresher webinar - Igennus