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Fil lers catalogue

Technologyof 21st century

serving medicine

Fil lers catalogue

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CompanyFil lers catalogue

01

whowe are

Neauvia, present in morethan 70 countries worldwide,

is the main licensor of Matex Lab:the filler and cosmeceutical company headquartered in

Lugano, with subsidiariesin Italy and Poland.

Neauvia has been operating

since 2012 with expertise in

the areas of:

• Injectable, such as dermal fillers and biorevitalizers

• Anti-aging and lenitive creams

• Tissue regeneration systems and healing serums with sterile masks.

Neauvia stands for

innovation and safety and

the high quality standards

are guaranteed by the use

of the highest quality raw

materials and advanced

manufacturing technology.

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The core business of the company consists of a range of fillers Polyethylene glycol (PEG) crosslinked - an outstanding new technology able to give the products a high safety and tolerability profile.

Each reference of the filler line has a specific rheology, due to the particular chemical geometry and the real polymeric technology, to be effective and perfectly integrated in different anatomical planes.

To complete the treatment with fillers, Neauvia offers a complete range of professional skin care products that prolong the effects of filler therapy.

Thanks to its wide portfolio of products, the brand is able to satisfy the need of the most demanding doctors and patients.

Company

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vision &MISSION

Company

To create valuefor the science, the society, our team

and our company.

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Fil lers catalogue

the new 2nd

g e n e r at i o nof ha fillers

Neauvia range of fillers are biomimetic. Thanks to the

PEG-cross-linked technology, they have an high

safety and tolerability profile.

Each Neauvia filler reference is based on a specific

combination of HA and PEG for different indication

and injection planes.

Neauvia fillers bring many benefits:

• High level of biocompatibilty;• Optimal biointegration;• Optimal rheological ratio.

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Neauvia fillers are biomimetic.

Company

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neauviais highly

biocompatible(1,2)

Neauvia fillers are based onPEG-cross-linked technology.

Biocompatibility depends on how fillers are stabilized. The scientists working on Neauvia

fillers decided to apply not a common molecule, but a new crosslinker: PEG polymer.

Polyethylene glycol is a gold standard of a biocompatible polymer for pharmaceutical,

cosmetic and medical use.

Biocompatibil ity

(1) Zerbinati N, Rauso R, Gonzalez P et al. In vitro evaluation of collagen production on human fibroblasts treated with hyaluronic acid PEG cross-linked with micromolecules

of calcium hydroxyapatite in low concentration.Journal of biological regulators & homeostatic agents 2017; 31(2): 87-90.

(2) Lam J,Truong NF, Segura T. Design of cell-matrix interactions in Hyaluronic acid hydrogel scaffolds. Acta Biomater. 2014; 10 (4): 1571-1580.02

13

PEG OUTSTANDING ADVANTAGES

FOR SAFETY AND LONGEVITY

PEG is recognized as a

biodegradable low molecular

weight polymer(<400 Da), so

in vivo can be degraded by alcohol dehydrogenase (3,4,5).

Metabolism studies with PEG

have demonstrated that there

is no evidence of ethylene

glycol formation in animals

and humans (6).

metabolismof peg

• Non-toxic (7)

• Reduces the action of the proteolytic

enzymes (e.g. hyaluronidase),

increasing the duration of the implant (8)

• Reduces the immunological response,

the implant is not recognized as a foreign body (7)

• Non-immunogenic polymer (7)

• It has been proven that the products

have not pro-sensitization activity (9)

• Less edema than BDDE (10)

• Lower need to repeat injection

after the first treatment

(3) Webster R, Didier E, Harris P et al. PEGylated proteins: evaluation of their safety in the absence of definitive metabolism studies.Drug Metab Dispos 2007; 35: 9-16.

(4) Baumann A, Tuerck D, Prabhu S et al. Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins:quo vadis? Drug Discov. Today 2014; 10: 1623-1631.

(5) Markovsky E, Baabur-Cohen H, Eldar-Boock A et al. Administration, distribution, metabolism and eliminationof polymer therapeutics. J. Control. Release 2012; 161: 446-460.

(6) Fruijtier-Pölloth C. Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products. Toxicology 2005. 214; 1-38.

(7) Lam J. Truong Nf, Segura T. Design of cell matrix interation in Hyaluronic Acid hydrogel scaffolds. Acta Biomater. 2014; 10 (4): 1571-1580.

(8) Comparison of the sensitivity of 11 cross-linked Hyaluronic Acid gels to bovine testis hyaluronidase. Ibrahima Sall, Georges Férard. Laboratoire de Biochimie Appliqueé, Faculté de Pharmacie, Université Louis Pasteur, 74 Route du Rhin, BP 60024, F-67401 Illkirch Cedex, France” + data on file

“In vitro evaluation of the sensitivity of Hyaluronic Acid PEG-cross-linked to bovine testes hyaluronidase” UB-Care, Spinoff University of Pavia.

(9) In Vitro Evaluation Of The Pro-Sensitisation Activity Of An Injectable Medical Device (Intense e Intense Flux). UB-Care, Spinoff University of Pavia.

(10) Mechanical Improvement of Hyaluronic Acid (HA) Hydrogels and Incorporation of Polyethylene Glycol (PEG) Ho-Yong Lee, Seol-Ha Jeong,Jae-Uk Baek, Ju-Ha Song, Hyoun-Ee Kim*Department of Materials Science and Engineering, Seoul National University, Seoul, Republic of Korea.

Biocompatibil ityFi l lers catalogue

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B IOCOMPAT IB I L I T YOF NEAUVIA F ILLERS IS SCIENT IF ICALLY PROVEN

Test report by UB-Care Spin-off of University Pavia (Italy).

Biocompatibil ity

Cytotoxicity evaluationof an injectable medical device on a cell

culture of human keratinocytes.

Test report MTT/16/ML2P5

Not cytotoxic activitywere observed.

Evaluation of cell morphologyon human keratinocytes cell culture

after treatment with an injectable

medical device.

Test report EE/16/ML2P5

The product does not induce alterations in cell morphology.



Test report KB/16/ML2P5


Evaluation of cell viabilityof an injectable medical device on a cell

culture of human keratinocytes through

the live/dead assay.

Test report LAD/16/ML2P5

The product does not determine an alteration of cell viability under the experimental conditions.



Test report NRU/16/ML2P5


Measurement of collagen synthesison a cell culture of human fibroblast

after treatment with an injectable

medical device.

Test report CLG/16/ML2P4

The product induced a statistically increase in the collagen production after treatment with the two concentrations tested after 24h treatment in human fibroblasts.

EVALUATIONS Test report OUTCOMES

cohesivityCompression Test

The ability of a gel to stick together and thereby to mantain gel integrity. It depends on the crosslinking used.

elastic modulusFrequency Sweep Test

The tendency of solid material to return to their original shape after being deformed.

viscosous modulusFrequency Sweep Test

It is a measure of resistance to flow in a fluid/semifluid. Adiacent layers move to parallel to eachother with different speeds.

plasticityStrain Sweep Test

The property to undergo permanent deformation under load.

optimalRHEOLOGICAL

RATIO (11,12,13,14)

The most common and most cited values to identify rheological property of an aesthetic hydrogel

are shown in the table below:

The optimal rheological ratio: soft gel for superficial injection layers and stiffer gel for deep injection layers.

17

Rheological ratio

03 (11) La Gatta A, De Rosa M, Frezza AM, Catalano C, Meloni M, Schiraldi c. Biophysical and biological characterization of a new line of hyaluronan-based dermal fillers:A scientific rationale to specific clinical indications . Materials Science and Engineering C 68 (2016) 565–572.

(12) Pierre S, Liew S, and Bernardin A. Basics of Dermal Filler Rheology. Dermatol Surg (2015);41:S120–S126.

(13) La Gatta A, Schiraldi C, Papa A, De Rosa M. Comparative analysis of commercial dermal fillers based on crosslinked hyaluronan: Physical characterization and in vitro enzymatic degradation. Polymer Degradation and Stability 96 (2011) 630 e 636.

(14) Santoro S, Russo L, Argenzio V, Borzacchiello A. Rheological properties of cross-linked hyaluronic acid dermal fllers. J Appl Biomater Biomech 2011; Vol. 9 no. 2, 127-136.

1918

Strain Sweep Test

Linear Domain Crossover Point

G’(Pa) G”(Pa) tan ð y(%) τ (Pa) G’=G”(Pa)

INTENSE RHEOLOGY

270-320 80-100 0.30-0.40 1690-2070 1750-2150 70-80

INTENSE LIPS

320-380 100-120 0.30-0.40 1880-2200 2100-2500 75-85

INTENSE LV 370-430 110-140 0.30-0.40 1500-1880 1600-1970 70-80

SIMULATE 370-430 110-140 0.30-0.40 1500-1880 1600-1970 70-80

INTENSE 420-480 140-160 0.30-0.40 1940-2380 1600-1970 85-95

INTENSE ROSE

420-480 140-160 0.30-0.40 1940-2380 2300-2850 85-95

INTENSE FLUX

233-276 129-142 0.56-0.51 272-292 390-441 101-106

G*, the complex module, can

be divided into two variables:

G’ (elastic module) and G’’

(viscous module).

Thanks to the high G* and high coesivity of Neauvia products we can obtain many benefits.

Fillers with an high G* allow to achieve a better result using less product.

Fillers with an high G’ and

G’’ allow to obtain an higher

resistance to deformation

when implanted under the

skin while gels remain more

stable in volume: therefore

they have lower migration in the skin allowing much more natural results.

Fillers with high coesivity

allow to obtain a better

resistance to mechanical

chemical degradation and

prevent gel migration: thus

they have a better duration in the skin and maintain the initial shape of gel deposit.

Neauvia Intense for eg. has the highest coesivity compared to the other Neauvia products

besides having an optimal viscoelasticity.

Thanks to PEG features and to a precise techniqueof determining the molecular weight of HA,

Neauvia fillers have an optimal rheological ratio.

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21

Our research team have published several

papers on the evolution over time of Neauvia

implant showing how Neauvia fillers have an

optimal distribution and integration in the

connective tissue of the skin.

Neauvia fillers distribute finely in the interstitial

tissue among constitutive structures of the

hypodermis and dermis, even into the smallest

spaces between collagen fibers, always

preserving the structural integrity of the skin.

Moreover, our research team have demonstrated both in vitro and in vivo the

absence of any adverse reaction.

Inflammatory cells surrounding the implant or closely associated with it have never

been found.

optimal tissue biointegration(15)

Morphological evidences have demonstratedthat Neauvia fillers have a great biointegration.

Figure 1

The common histological stain (H&E) is showing the filler implant (light blue) perfectly integrated in the connective tissue with collagen fibers, adipose tissue and ducts of sweat glands. No immunoreactions are present.

Figure 2

The implant,is clearly visible in the Alcian blue stained preparation. It appears finely distributed in the interstitial tissue, closely associated with dermis and hypodermis structures as gland ducts (encircled) and collagen fibres.

(15) Zerbinati N, D’Este E, Farina A et al. Morphological evidences following PEGylated filler treatment in human skin.Journal of biological regulators & homeostatic agents 2017; 31(S2): 79-85.

Tissue biointegration

04

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2322

The aging process gradually

deprives skin not only of

hyaluronic acid, but also of

collagen.

A solution that really prevents

the aging process is Neauvia

Stimulate: a unique product

which combines pure

hyaluronic acid of probiotic

origin (Bacillus Subtilis) cross-

linked with PEG (poly-ethylen

glycol) and micromolecules (8-12 microns only) of calcium

hydroxyapatite (CaHA), in low

concentration (1%).

The product could be

considered an “hybrid” filler (completely biocompatible

and biodegradable) with both volumizing effect and a

collagenesis activity.

Calcium hydroxyapatite

stimulates the skin self-

production of collage.

Thanks to the small size and low concentration of CaHA

molecules, Neauvia Stimulate fillers are extremely safe.

During the natural degradation

of the product, there is a release

of small particles of CaHA, few at times, that have the right

size to stimulate fibroblasts in producing not only collagen, but also elastin, glycosaminoglycans

and hyaluronic acid (16).

NEAUVIA FILLERS INTEGRATE SO WELL THAT A BIOLOGICAL

SCAFFOLD IS OBTAINED

Using Neauvia Stimulate skin density and elasticity are both improved and, in the meantime, there is a natural, continuous and long-lasting collagen

production thanks to the small size of the particles.

(16) Zerbinati N, Rauso R, Gonzalez P, Cherubino M, D’Este E, Calligaro A, Sommatis S, Maccario C, Mocchi R.In vitro evaluation of collagen production on human fibroblasts treated with hyaluronic acid PEG cross-linked with micromolecules of calcium hydroxyapatite

in low concentration. J Biol Regul Homeost Agents. 2017 APR-JUN;31(2 Suppl. 2):87-90.


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25

The maximum size of phagocytes is

around 55 microns, so they can’t eat

CaHA in particle fillers but create a

capsule around the particles. This does

not happen with Stimulate, thanks to its

small size of CaHA.

Moreover, Stimulate makes the CaHA

gradually available in 9 to 12 months,

stimulating collagen production by

signaling, after that phagocytes eat

CaHA particles.

IMAGE ANALYSIS AND COMPUTERIZED MORPHOMETRY

OF THE COLLAGEN PRODUCED

31,66

Control FollowingStimulate

2,18

26,06

10,52

0

5

10

15

20

25

30

35

Old Collagen Newly formed Collagen

ORIGINAL

Follo

win

g s

timul

ate

tre

atm

ent

Co

ntro

l

RED/ORANGE GREEN/YELLOW


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INTENSE

INTENSE LV

INTENSE Flux

Stimulate

Intense Lips

INTENSE RHEOLOGY

Intense Rose

hydro deluxe

VOLUMIZATION

LIFTING

BIOSTIMULATIONand lifting

shaper

Deep HydratIon

other

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f i l l e rf o r h e r

26

Each reference of Neauvia filler line has a specific

rheology, due to the particular chemical geometry

and the real polymeric technology, to be effective and

perfectly integrated into different anatomical planes.

Thanks to its wide portfolio of products, the brand

is able to satisfy the need of the most demanding

doctors and patients.

Products

28 29

BENEFITS

• High concentration of HA and high viscoelasticity;• It gives fantastic volumetric results shapingthe injected area in the natural way.

CONCENTRATION

26 mg/ml of HA, PEG polymer cross-linked

SYRINGE

1 x 1 ml

CONTAINS

Glycine and L-Proline

INDICATION

Deep tissue restoration of volume & correction.It is suitable especially to deep filling of skin depression (included deep wrinkles and nasolabial folds), cheeks, chin and nose modelling, face contouring, in moderate and strongly aged skin.

BENEFITS

• Slow biodegradation and long lasting results;• Thanks to unique rheological properties,Intense is highly adaptive to the tissue; • Intense gives fantastic lift effect.

CONCENTRATION


SYRINGE

1 x 1 ml

CONTAINS


INDICATION

Deep tissue restoration of volume & correction.It is suitable especially to deep filling of skin depression (included deep wrinkles and nasolabial folds), cheeks, chin and nose modelling, face contouring and temples, in moderate and strongly aged skin.

EPIDERMAL EPIDERMAL

DERMAL DERMAL

SUBCUTANEOUS SUBCUTANEOUS

PERIOSTEUM PERIOSTEUM

This product contains a high concentration of hyaluronic acid - 26 mg/ml.

This product contains the highest available concentration of hyaluronic acid - 28 mg/ml.

INJECTION PLANENEEDLE ANGLE: 45°DEPTH: SUBCUTANEOUS


intense lvintensEHigh viscoelasticity and high modelability. High viscoelasticity and high modelability.

| LIFTING | | LIFTING |

NEEDLE

21 GCANNULA

22 G

NEEDLE

21 GCANNULA

22 G

extrusion force

highextrusion force

medium/high

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Fil lers catalogue Products

30 31

| biostimulation and lifting |

BENEFITS

• Multi task filler: possibility of use in different anatomical areas;• High concentration of HA and low viscoelasticity;• It gives fantastic volumetric results shaping the injected area in the natural way;• Thanks to the balanced crosslinking degree. It is highly adaptive to the tissue which helps to volumize the anatomic area.

CONCENTRATION


SYRINGE

1 x 1 ml

CONTAINS


INDICATION

Deep tissue restoration of volume in moderate and strongly aged skin. It is suitable for injection into the intradermal layer. Thanks to its viscoelastic properties, this product can correct areas of different consistency.

Intense Flux contains a high concentration of hyaluronic acid - 26 mg/ml.

EPIDERMAL

DERMAL

SUBCUTANEOUS

PERIOSTEUM

INJECTION PLANENEEDLE ANGLE: 45°DEPTH: DERMAL

NEEDLE

27/30 G

intensE fluxLow viscoelasticity high biointegration.

extrusion force

low

| volumization |

BENEFITS

• Significant improvement in skin density level;• The product immediately fills the tissue deficits giving the desired shape and volume, gradually improving the quality of the skin;• Increment in neocollagenesis;• The neocollagenesis process permits a longer lasting correction.

CONCENTRATION


SYRINGE

1 x 1 ml

CONTAINS

1% CaHA; Glycine and L-Proline

INDICATION

Deep filling of skin depression (included deep wrinkles and nasolabial folds), biostimulation and revitalisation.Stimulate is a perfect choice every time a patient is suffering from the lack of volume and density.

stimulateDouble action: combination of filling and biostimulation.

Neauvia Stimulate is a unique product, the only one which offers not only great filling effect but also a long term biostimulation. The 26 mg/ml of hyaluronic acid is complemented with 1% of calcium hydroxyapatite. Calcium hydroxyapatite used in Neauvia fillers has small particle size (8-12 microns) and is well spread in the cluster of the hydrogel. This assures stability of the particles that have no possibility to migrate. The small sizes of CaHA particles do not interfere with phagocytes activities and are gradually released during the degradation of the implant, not all at once. The safe and optimal concentration of CaHA is able to provide excellent results without creating side effects.

EPIDERMAL

DERMAL

SUBCUTANEOUS

PERIOSTEUM

INJECTION PLANENEEDLE ANGLE: 45°DEPTH: DEEP DERMAL

NEEDLE

21 GCANNULA

22 G

extrusion force

medium/high

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3535

BENEFITS

• Optimal amount of HA for natural effectand patient’s comfort;• This dedicate preparation gives special elasticity to the polymer’s chains and permit it to overcome the mechanical stress the lips are submitted to; • This improvement gives a natural touch perception.

CONCENTRATION


SYRINGE

1 x 1 ml

CONTAINS


INDICATION

Lips augmentation and modelling. Suitable for augmentation, contouring and revitalization of lips.

Intense Lips contains 24 mg/ml of hyaluronic acid to provide optimal results in delicate lips area.

| shaper |

EPIDERMAL

DERMAL

SUBCUTANEOUS

PERIOSTEUM


NEEDLE

27 G

intensE lipsHighly elastic and resistant.

extrusion force

medium

| SHAPER |

BENEFITS

• Natural correction of superficial and moderate wrinkles;• Specific rheological features to treat specificand difficult areas.

CONCENTRATION


SYRINGE

1 x 1 ml

CONTAINS


INDICATION

Fine line reduction, lip contouring, orbital area, glabella.It is dedicated to correct the first signs of aging: fine lines and superficial wrinkles especially in young skin. It is also suitable for lip’s barre code correction, light lips correction and hands rejuvenation.

Developed for difficult areas.

Intense Rheology contains 22 mg/ml of hyaluronic acid.

EPIDERMAL

DERMAL

SUBCUTANEOUS

PERIOSTEUM

INJECTION PLANENEEDLE ANGLE: 45°DEPTH: DERMAL

NEEDLE

27 G

extrusion force

mediumintense rheology

34

Products

3736

BENEFITS

• High concentration of HA and high viscoelasticity level for great volume effects;• Particular rheology to correct lipoatrophy and tissue augmentation.

CONCENTRATION


SYRINGE

1 x 1 ml

CONTAINS


INDICATION

Soft tissue correction, tissue augmentation, lipodistrofy correction.

It is characterized by the highest amount of hyaluronic acid - 28 mg/ml - and high viscoelasticity of the hydrogel to guarantee 100% satisfaction for the patient.

| other |

EPIDERMAL

DERMAL

SUBCUTANEOUS

PERIOSTEUM


NEEDLE

22 GCANNULA

21 G

intense roseDelicate and pure.

extrusion force

medium/high hydro deluxeCombination of deep hydration and biostimulation.

BENEFITS

• Specific concentration of HA for great hydration;• Improvement in skin density level thanks to calcium hydroxyapatite.

CONCENTRATION

18 mg/ml of HA, non cross-linked

SYRINGE

2 x 2,5 ml, 2 x 1 ml

CONTAINS

0,01% of CaHA; Glycine and L-Proline

INDICATION

Hydration, revitalization, collagen stimulation.Regeneration, superficial wrinkles correction,hands rejuvenation.

EPIDERMAL

DERMAL

SUBCUTANEOUS

PERIOSTEUM

Hydro Deluxe contains 18 mg/ml of pure hyaluronic acid, enriched with 0,01% of calcium hydroxyapatite. This unique composition activates and supports natural processes of collagen production, thanks to which skin becomes thicker and firmer. A series of 4 treatments with 3 week intervals between all treatments should be performed to achieve optimal results. At the end of the series, in order to maintain results, it is worth offering to a patient a follow-up treatment scheduled for half a year later.

INJECTION PLANENEEDLE ANGLE: 45°DEPTH: EPIDERMAL

| deep hydration |

NEEDLE

30 G

extrusion force

low

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Products

39

crow’s feet REDUCTIONHydro Deluxe

fine linesIntense Rheology

TEAR TROUGHIntense Rheology

templesIntense

FACE CONTOURS LIFTINGIntense , Stimulate , Intense Flux

NOSE MODELING Intense

cheek MODELING Intense , Stimulate ,

Intense Flux

CHIN MODELINGIntense , Stimulate , Intense Flux

NASO-LABIALFOLDS FILLING

Intense , Stimulate ,Intense Flux , Intense LV

LIPS AUGMENTATIONIntense Lips , Intense Rheology , Intense Flux

ACNE SCARS REDUCTIONStimulate , Intense Rheology

neck and shoulders regenerationHydro Deluxe

skin firmingHydro Deluxe

elbows and knees regenerationHydro Deluxe

strech marks reductionHydro Deluxe

HANDS REJUVENATIONFilling: Stimulate , Intense Rheology Mesotherapy: Hydro Deluxe

modeling of intimate partsIntense Rose

effectivesolutions

Fil lers catalogue

INTENSE MAN

STIMULATE MAN

HYDRO DELUXE MAN


LIFTING

DEEP HYDRATION

f i l l e rf o r h I M

4140 4140 06

Being aware of the differences in men and women tissue as well as

their subjective expectation from the aesthetic medicine. Neauvia is

proud to present the first and unique product line dedicated to men.

Processes of aging and skin structure of men differs from woman’s

and the results are different with the aging. Their ticker skin lose

volume, density and elasticity of tissue. To reduce the signs of

passing years and keep the young, energetic appearance it is

important to treat it holistic.

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4342

BENEFITS

• High viscoelasticity of the hydrogelfor better adaptation to man’s tissue;• The product immediately fills the tissue deficitsgiving the desired shape and volume graduallyimprovingthe quality of the skin;• Increment in neocollagenesis;• The neocollagenesis process permitsa longer lasting correction.

CONCENTRATION


SYRINGE

1 x 1 ml

CONTAINS

1% CaHA; Glycine and L-Proline

INDICATION

Restoration of volume, filling of skin depression (included deep wrinkles and nasolabial folds), collagen stimulation.

BENEFITS

• Slow biodegradation and long lasting results;• Thanks to unique rheological properties, Intense is highly adaptive to the tissue; • Intense gives fantastic lift effect.

CONCENTRATION


SYRINGE

1 x 1 ml

CONTAINS


INDICATION

Restoration of volume, filling of skin depression (included deep wrinkles, nasolabial folds and temples). Intense Man can be used to add volume in the sagging area and to fill the folds and deep wrinkles.

EPIDERMAL EPIDERMAL

DERMAL DERMAL

SUBCUTANEOUS SUBCUTANEOUS

PERIOSTEUM PERIOSTEUM

A specific formula with the highest concentration of hyaluronic acid (28 mg/ml) and high viscoelasticity of this product suits perfectly for thicker skin and more rapid process of aging.

Stimulate Man is the first filler dedicated to help fighting the time in two ways. 28 mg/ml of hyaluronic acid and high viscoelasticity of the hydrogel fill tissue deficits for a long time. The addition of 1% of calcium hydroxyapatite gives extra stimulation effect by activating fibroblasts to collagen stimulation. Calcium hydroxyapatite used in Neauvia fillers has small particle size (8-12 microns) and is well spread and crosslinked in the hydrogel. This assure stability of the particles that have no possibility to migrate.



| LIFTING | | BIOSTIMULATION and lifting |

NEEDLE

21 GCANNULA

22 G

NEEDLE

21 GCANNULA

22 G

extrusion force

highextrusion force

medium/highintensE manHigh viscoelasticity and high modelability.

stimulate manDouble action: combination of filling and biostimulation.

ProductsFil lers catalogue

44

BENEFITS

• Specific concentration of HA for great hydration;• Improvement in skin density levelthanks to calcium hydroxyapatite;• Visible results in quality of the skin;• Ultra-safe profile thanks to Bacillus subtilis.

CONCENTRATION

18 mg/ml of HA, non cross-linked

SYRINGE

2 x 2,5 ml, 2 x 1 ml

CONTAINS

0,01% of CaHA; Glycine and L-Proline

INDICATION

Hydration, revitalization, collagen stimulation. Regeneration, superficial wrinkles correction.

Hydro Deluxe Man contains 18 mg/ml of pure hyaluronic acid, enriched with 0,01% of calcium hydroxyapatite. This unique composition activates and supports natural processes of collagen production, thanks to which skin becomes thicker and firmer. A series of 4 treatments with 3 week intervals between all treatments should be performed to achieve optimal results. At the end of the series, in order to maintain results, it is worth offering to a patient a follow-up treatment scheduled for half a year later.

| deep hydration |

EPIDERMAL

DERMAL

SUBCUTANEOUS

PERIOSTEUM

INJECTION PLANENEEDLE ANGLE: 45°DEPTH: EPIDERMAL

NEEDLE

30 G

extrusion force

lowhydro deluxe manCombination of deep hydration and biostimulation.

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47

effectivesolutions

crow’s feet REDUCTION

Hydro Deluxe Man

frown linesIntense Rheology

face revitalisingHydro Deluxe Man

templesIntense Man

filling of skin depressionIntense Man

face volumisingIntense Man , Stimulate Man

nose modellingIntense Man

sagging skinStimulate Man

vertical lips linesIntense Rheology


4948

intense intenseLV

intenserose

intenseman

stimulateman

hydrodeluxe man

specifications

stimulate intenserheology

LIFTING LIFTINGvolumization shapershaper BIOSTIMULATIONand liftingother deep

Hydration

hydrodeluxe

deepHYdration

intense flux

intenselips



1 x 1 ml 1 x 1 ml

hyaluronicacid content

28 mg/ml 26 mg/ml 28 mg/ml 28 mg/ml 28 mg/ml 18 mg/ml





1% CaHA,Glycine and

L-Proline

0,01% CaHA,Glycine and

L-Proline

21 G22 G

High

21 G22 G

Medium/High

1 x 1 ml

22 G21 G

Medium/High

1 x 1 ml

21 G22 G

High

1 x 1 ml

21 G22 G

Medium/High

2 x 2,5 ml2 x 1 ml

30 G

Low

Deep tissue restoration

of volume & correction

Deep tissue restoration

of volume & correction

Soft tissuecorrection, tissueaugmentation,

lipodistrofycorrection

Restoration of volume, filling

skin depression

Restoration of volume, filling

skin depression, collagen

stimulation

Hydration, revitalization,

collagenstimulation

amino acidsand calciumhydroxiapatite

syringe

needle/cannula

extrusionforce

indication

Injectionplane

26 mg/ml

1% CaHA,Glycine and

L-Proline

1 x 1 ml

21 G22 G

Medium/High

Deep filling of skin depression, biostimulation

and revitalisation

1 x 1 ml

22 mg/ml


27 G

Medium

Fine linereduction,

lip contouring, orbital area,

glabella

18 mg/ml

0,01% CaHA,Glycine and

L-Proline

2 x 2,5 ml2 x 1 ml

30 G

Low

Hydration, revitalization,

collagenstimulation

1 x 1 ml

26 mg/ml


27-30 G

Low

Deep tissuerestoration

of volume inmoderate and strongly aged

skin

1 x 1 ml

24 mg/ml


27 G

Medium

Lipsaugmentation and modelling

50

before& after

51

before after

LIPS AUGMENTATIONINTENSE LIPS

before after

LIPS AUGMENTATIONINTENSE

before after

Upper Lips augmentationINTENSE RHEOLOGY

before after

BiorevitalizationHYDRO DELUXE

before after

Marionette linesSTIMULATE

before after

Nasolabial foldsINTENSE LV

LIPS ANGULAR FOLDSINTENSE RHEOLOGY

before after

Before & AfterFi l lers catalogue

neauvia meansmany benefits

NeAUvia fillers are BIOMIMETICwith an HIGH TOLERABILITY

AND SAFETY PROFILE

07OPTIMAL

RHEOLOGICAL RATIO

HIGHBIOCOMPATIBILITY

optimalbioINTEGRATION

Key Messages

high biocompatibility

Neauvia fillers are based on PEG-cross-linked technology.

PEG has scientifically proven oustanding advantages

Neauvia preservesthe skin natural integrity

It distributes finely in the interstitial tissue among constitutive structures of the

hypodermis and dermis.

Neauvia does not bring inflammatory cells surrounding the implantor close

Demonstrated both in vitro and in vivo.

It adapts perfectly to the receiving anatomic structures having optimal distribution in the tissue over time.

optimal biointegrationMorphological evidences have demonstratedthat Neauvia fillers have a great biointegration.

Better resultswith less product(HIGH G*)

Neauvia fillersallow natural results (HIGH G’)

Neauvia Fillers have long duration in the skin (HIGH cohesivity)

OPTIMAL RHEOLOGICAL RATIOOptimal gels for each injection plane: soft gel for superficial injection and stiffer gel for deep injection layers.

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Fil lers catalogue

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Products

MATEX LAB SAVia Maggio 1C | CH-6900 Lugano | Switzerland

MATEX LAB S.P.A.Via Carlo Urbani 2 ang. Via Enrico Fermi | 72100 Brindisi | Italy

© Copyright Matex Lab SA. 2018All rights reserved

Concept and design by: Emporio ADV

www.neauvia.com

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Fil lers catalogue

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