Chemical Process Industry - 2

Arham Veerayatan Institute of Engineering, Technology &

Research

Presentation OnProduction of

Aspirin

Name : Bhatt Milan L.Branch : Chemical 2nd YearEn. No. : 140920105002Roll No. : 03

INDEX

1. About Aspirin

2. Production Of Salicylic Acid

3. Production Of Aspirin

4. Uses Of Aspirin

5. Side Effects

What is

Aspirin

• its IUPAC name is: 2- Acetyloxybenzoic Acid and

It is also commonly known by the name Acetyl Salicylic Acid.

• Aspirin is in group of drugs called salicylates

Aspirin

• Structural

Formula of

aspirin is :

• Its molecular formula is: C9H8O4

• molecular weight is: 180.157 g/mole

Raw Materials

• Phenol

• Caustic Soda

• Carbon Dioxide.

For Salicylic Acid :

Chemical Reaction

2 2NaOH 2H2O

OH

ONa

ONaCO2Na

H2SO4+

+ CO2

Sodium Phenolate

ONa

OH

OHCO2Na

ONa

Sodium Salicylate

+ Na2SO4

CO2H

+

+ +

Salicylic Acid

2

100* C

130* C

Phenol

Mixer

Autoclave

130* C

Caustic Soda

Precipitation

Carbon Dioxide100* C

Sulphuric acid

Packing

Salicylic Acid

Production Of Salicylic Acid

Phenol Recovery

Decoloriser

Raw Materials

• Salicylic Acid

• Toluene

• Acetic Anhydride

Chemical Reaction

OHCO2H

Salicylic Acid

O2CCH3CO2H

Aspirin

+ H2O(CH3CO)2O

For Aspirin :

90* C

Reactor90* C

Cooling Tank

Packing

Salicylic Acid

Acetic AnhydrideIn toluene

Filter

Aspirin

Production Of Aspirin

Uses Of Aspirin

• It is used to treat pain and fever.

• Aspirin is also used long-term, at low doses, to

help prevent heart attacks, strokes, and blood

clot formation in people at high risk of developing

blood clots.

• Aspirin may be effective at preventing certain types

of cancer, particularly colorectal cancer.

• Over-the-counter pain relief, especially for

headaches.

SIDE Effects :

• Risk of increase in gastrointestinal bleeding.

• It inhibits the ability of kidney to excrete uric acid

and exacerbate these conditions.

• Large dosages results in tinnitus (ringing in ears).

• May result in fatty liver and acute encephalopathy.

• May cause swelling of skin tissues.

• It increases the risk of cerebral microbleed.