Product Presentation Metris
Transcript of Product Presentation Metris
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Product Presentation
Instruments for AnimalBehavioral Research
© Metris b.v. 2009
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ContentContent
Company overviewCompany overview
ProductsProducts
Importance of the energy parameter in Importance of the energy parameter in Behavioral PharmacologyBehavioral Pharmacology
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Company overviewCompany overviewGoalGoal
Provide turnkey solutions / expertise in the area ofProvide turnkey solutions / expertise in the area ofautomatic animal behavior analysis.automatic animal behavior analysis.
ProductsProducts MarketsMarketsLABORASLABORAS Pharmaceutical industry Pharmaceutical industrySonoTrackSonoTrack Research institutes/CRO’s Research institutes/CRO’sThird Party productsThird Party products Universities/ Academic Hospitals Universities/ Academic Hospitals
ActivitiesActivities Product Development, Product Development, Marketing / Sales , Marketing / Sales , Assembly and Product support. Assembly and Product support.
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HistoryHistory 5/19995/1999 Metris BV startMetris BV start 9/20019/2001 Delivery of first LABORAS for Delivery of first LABORAS for
Windows systemsWindows systems 2/20052/2005 Introduction SONOTRACK (Ultrasound Introduction SONOTRACK (Ultrasound
recording and analysis)recording and analysis) 7/20057/2005 Distributor SleepSign for Animals Distributor SleepSign for Animals
(EU)(EU) 8/20068/2006 Introduction LABORAS 2.0Introduction LABORAS 2.0 12/200812/2008 Introduction SonoTrack USV PlaybackIntroduction SonoTrack USV Playback 1/20091/2009 Introduction SonoTrack 2.0Introduction SonoTrack 2.0
Since 2001 Since 2001 ± 400± 400 platforms are delivered and platforms are delivered and over 50 references on our website support the over 50 references on our website support the value of LABORAS as experienced by researchersvalue of LABORAS as experienced by researchers
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Company RelationsCompany Relations
DistributorsDistributors Neuroscience Inc. (Japan)Neuroscience Inc. (Japan) Kuo Yang Scientific Corporation (Taiwan)Kuo Yang Scientific Corporation (Taiwan) Mirae Korea Inc. (South Korea) Mirae Korea Inc. (South Korea) Medi Analytika Ltd. (India)Medi Analytika Ltd. (India) AH Medical Supply (China) AH Medical Supply (China) Radon Medical (Turkey)Radon Medical (Turkey)
CooperationsCooperations DataSciences – Telemetry (USA)DataSciences – Telemetry (USA) Kissei (Japan)Kissei (Japan) Porsolt (France)Porsolt (France) National Instruments (USA, NL, Armenia)National Instruments (USA, NL, Armenia)
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LABORASLABORAS
LABORAS is a fully automatic LABORAS is a fully automatic system for continuous behavior system for continuous behavior recognition and tracking of small recognition and tracking of small rodents (mice and rats)rodents (mice and rats)
LABORASLABORAS replaces, reduces replaces, reduces and refines behavioral scoring by and refines behavioral scoring by human observershuman observers
LABORAS sets a new standard LABORAS sets a new standard in the area of behavioral in the area of behavioral observation instrumentsobservation instruments
What is LABORAS?What is LABORAS?
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1980 1990 2000 2010
Infrared beammatrix (8x5) Infrared beam
matrix (3D)
LABORAS2.0
Infrared beammatrix (4x3)
ANIMEX
Video tracking(single point) Video tracking
(multi point)
LABORAS1st. generation
Low
resolution
XY
track h
igh
0 no. of b
ehaviors >
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Evolution of automatic tracking & behavioral observation systems
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LABORAS techniqueLABORAS technique (1/3)(1/3)
Main Main componentscomponents
LABORASLABORAS
Measurement Measurement platform(s)platform(s)
ElectronicsElectronics(e.g. amplifiers & (e.g. amplifiers & control & A/D control & A/D conv.)conv.)
LABORAS softwareLABORAS softwarefor Windowsfor Windows
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x
y
t
Behaviors
Behavior
Track
AdministrationA/D
conv.
Am
p. Ctr.
&Tracking
Results
ctr
ctr
Measurement platform(s)
Electronics(@ platform) PC + software
Graphs Tables
t behav
0
t x y
0.500.75
0.2510
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3 10688
05.259.7515.5
immobeatdrinkgroom
Export
ASCII
e.g. MS-Excel
SPSS
SAS JMP
ElectronicControl
Unit
LABORAS technique LABORAS technique (2/3)(2/3)
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LABORAS technique LABORAS technique (3/3)(3/3)
Locomotion
Scratching
Example of recognition of behavioral Example of recognition of behavioral featuresfeatures
Fast up and down movement of the hindfoot, rubbing the side of the body, neck and face.
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Tracking measurementTracking measurement
Tracking information provided by LABORASTracking information provided by LABORAS
High resolution XY position trackHigh resolution XY position track Velocity data (average, max.)Velocity data (average, max.) Distance traveledDistance traveled Position distribution (details like favorite spots)Position distribution (details like favorite spots) Circling / turning (Clockwise and counter-clockwise circle Circling / turning (Clockwise and counter-clockwise circle
count, avg. circle size, avg. circling speed, avg. time in count, avg. circle size, avg. circling speed, avg. time in circle)circle)
Sociality Cage (preference to visit specific compartments Sociality Cage (preference to visit specific compartments in cage)in cage)
Estimation of energy use Estimation of energy use (in development)(in development)
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Detection of behaviorsDetection of behaviors
LABORAS distinguishes more than 16 LABORAS distinguishes more than 16 different rat and mouse behavioursdifferent rat and mouse behaviours
Normal behavioursNormal behaviours LocomotionLocomotion ImmobilityImmobility RearingRearing ClimbingClimbing EatingEating DrinkingDrinking GroomingGrooming
Special behavioursSpecial behaviours Scratching (mice)Scratching (mice) Seizures - tonic-clonic convulsions, Seizures - tonic-clonic convulsions,
barrel-rolls, Racine P4 and P5 barrel-rolls, Racine P4 and P5 (mice)(mice)
Hind limb licking / Formalin test Hind limb licking / Formalin test (rat)(rat)
Purposeless chewing (rat)Purposeless chewing (rat) Wet dog shakes (rat)Wet dog shakes (rat) Headshakes (rat)Headshakes (rat) Head twitches (rat)Head twitches (rat)
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LABORASLABORAS configurationsconfigurations
Configuration variablesConfiguration variables Up to to 8 measurement platforms connected to one Up to to 8 measurement platforms connected to one
computercomputer Species: mice, rat or bothSpecies: mice, rat or both Tracking and Behavior software modules:Tracking and Behavior software modules:
– TrackingTracking– Normal behaviors Normal behaviors – Special behaviors Special behaviors
Integration with Telemetry (Behavior & Psychology)Integration with Telemetry (Behavior & Psychology) Sociality Cage (special cage that enables sociability test)Sociality Cage (special cage that enables sociability test) User interface specialsUser interface specials
– GLPGLP– Independent start of the platformsIndependent start of the platforms
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Examples of resultsExamples of results
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Examples of resultsExamples of results
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LABORAS QualificationLABORAS Qualification (1/6)(1/6)
Operational Validation:Operational Validation:– Does LABORAS performs as advertisedDoes LABORAS performs as advertised– Explained in the following sheetsExplained in the following sheets
Pharmacological ValidationPharmacological Validation– Does LABORAS assist me with my researchDoes LABORAS assist me with my research– Metris role to assistMetris role to assist– E.g. new experiments or new algorithmsE.g. new experiments or new algorithms
CertificatesCertificates– GLP (Laboratory req.) , CE / FCC (electrical req.)GLP (Laboratory req.) , CE / FCC (electrical req.)
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LABORAS QualificationLABORAS Qualification (2/6)(2/6)
Camera
Platform
Electronics
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timet
durationTestT
TatobserverstimecumulativeofmeancumTObs
tatobserverstimecumulativeofmeancumtObs
tatLABORAStimecumulativecumtLab
cumcumobscumcum TObsTtObsttObstLab
)(
)(
)(
)(%4%1)(%5)(5.1)()(
Grooming (Rat14) : 90%
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mu
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LABORAS
Alex
Lee
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Boundary-
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LABORAS Qualification LABORAS Qualification (3/6)(3/6)
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LABORAS QualificationLABORAS Qualification (4/6)(4/6)
Immobility (Rat01): 90%
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Alex
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Heleen
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Bound -10%
Bound +10%
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LABORAS QualificationLABORAS Qualification (5/6)(5/6)
Validation ResultsValidation Results● Correlation with human observers (according Correlation with human observers (according
to validation criterion)to validation criterion)– Locomotion, ClimbingLocomotion, Climbing > 95%> 95%– Immobility, Grooming Immobility, Grooming > 90%> 90%– Eating, Drinking, RearingEating, Drinking, Rearing > 80%> 80%
– Special behaviorsSpecial behaviors > 80-90%> 80-90%
● Since 2001 Since 2001 ± 400± 400 platforms are delivered and platforms are delivered and over 50 references on our website support the over 50 references on our website support the value of LABORAS as experienced by value of LABORAS as experienced by researchersresearchers
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LABORAS QualificationLABORAS Qualification (6/6)(6/6)
Development of new algorithmsDevelopment of new algorithms• Good animal behavior definitionGood animal behavior definition• Proper definition of the experiment protocolProper definition of the experiment protocol
- and use of the LABORAS experiment administration- and use of the LABORAS experiment administration• Choice of pharmacological relevant behaviorsChoice of pharmacological relevant behaviors• Good correlation with the real behavior (acceptation Good correlation with the real behavior (acceptation
criterion)criterion)- Not always human observer reference- Not always human observer reference
• Results presentationResults presentation- Recording and Presentation of result data- Recording and Presentation of result data- Use of previous raw data/ result summaries- Use of previous raw data/ result summaries
Enabling the full benefit of LABORASEnabling the full benefit of LABORAS
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Examples of Examples of performanceperformance
Normal BehaviourNormal Behaviour (rat) (rat)
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Examples of Examples of performanceperformance
Wet Dog Wet Dog ShakesShakes (rat) (rat)
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Examples of Examples of performanceperformance
Head Head Twitches Twitches (rat) (rat)
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Examples of Examples of performanceperformance
Circling Circling (rat)(rat)
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Examples of Examples of performanceperformance
Sociality Cage (mice)Sociality Cage (mice)
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Applications LABORASApplications LABORAS LABORAS application areas are:LABORAS application areas are:
(behavioral assessment in)(behavioral assessment in)– Drug DevelopmentDrug Development –– Phenotyping Phenotyping – Safety PharmacologySafety Pharmacology –– Lab. animal science Lab. animal science– ToxicologyToxicology
Typical customers areTypical customers are::– Pharmaceutical CorpPharmaceutical Corp –– CRO’s (Contract Research Org.) CRO’s (Contract Research Org.)– Academic institutesAcademic institutes –– Lab. animal suppliers Lab. animal suppliers– HospitalsHospitals – – Governmental Governmental
Organizations Organizations
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Applications LABORASApplications LABORAS
Monitoring of behavioral changes and effects in:Monitoring of behavioral changes and effects in:
Drug Development Drug Discovery researchDrug Development Drug Discovery research– Efficacy studies of new compoundsEfficacy studies of new compounds– Long term observation tests (e.g. circadian rhytm,eat-Long term observation tests (e.g. circadian rhytm,eat-
drink patterns)drink patterns)– Experimentally induced behaviors (e.g. grooming, Experimentally induced behaviors (e.g. grooming,
drinking, movement patterns, hindlimb-licking / formalin-drinking, movement patterns, hindlimb-licking / formalin-test, scratching, WDS, Head Shakes)test, scratching, WDS, Head Shakes)
Safety PharmacologySafety Pharmacology ToxicologyToxicology Phenotyping researchPhenotyping research
– High Capacity Phenotyping with transgenic miceHigh Capacity Phenotyping with transgenic mice
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Applications LABORASApplications LABORAS Animal models based on behavioral assessment Animal models based on behavioral assessment
in home cage environmentin home cage environment– Normal behaviorsNormal behaviors– Drug induced behaviorsDrug induced behaviors
Pain studiesPain studies– Automated Formalin TestAutomated Formalin Test
Social InteractionSocial Interaction– Preference studies (with stranger and familiar mouse – Preference studies (with stranger and familiar mouse –
Sociality cage)Sociality cage) Animal welfare studiesAnimal welfare studies
– Cage enrichment studiesCage enrichment studies– Behavioral effects of manipulation of animalBehavioral effects of manipulation of animal
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Applications LABORASApplications LABORAS
Examples of LABORAS applications in drug discoveryExamples of LABORAS applications in drug discovery
TESTTEST RESULTRESULT
Behavioral phenotyping Behavioral phenotyping transgenic micetransgenic mice
Target discovery for future drug Target discovery for future drug developmentdevelopment
Primary observation testPrimary observation test Adverse drug effectsAdverse drug effects
Open field testOpen field test E.g. sedative, stimulant, E.g. sedative, stimulant, anxiolytic, anxiogenic propertiesanxiolytic, anxiogenic properties
Pain test (formaline induced Pain test (formaline induced hindlimb licking)hindlimb licking)
Analgesic propertiesAnalgesic properties
Dermatology test (scratching)Dermatology test (scratching) Skin protective effectsSkin protective effects
Telemetry & BehaviorTelemetry & Behavior Integrated cardiovascular, CNS Integrated cardiovascular, CNS and behavioral dataand behavioral data
Sociability TestSociability Test Analysis of social behavior (for Analysis of social behavior (for amongst other Autism research)amongst other Autism research)
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Applications LABORASApplications LABORAS
TESTTEST RESULTSRESULTS
Effect on Pharmacologically Effect on Pharmacologically induced effects, such as induced effects, such as • m-CPP hypolocomotion and m-CPP hypolocomotion and hypophagia hypophagia• 8-OH-DPAT hyperlocomotion8-OH-DPAT hyperlocomotion• d-Amphetamine hyperactivityd-Amphetamine hyperactivity• Angiotensin II polydypsiaAngiotensin II polydypsia• Orexin-A induced groomingOrexin-A induced grooming• Excessive climbingExcessive climbing• Turning/circling behaviorTurning/circling behavior• Wet Dog Shakes (WDS)Wet Dog Shakes (WDS)• Head Shake & Head TwitchHead Shake & Head Twitch• SeizureSeizure
Pharmacological efficacy of Pharmacological efficacy of (potential) leads(potential) leadsPharmacological antagonist Pharmacological antagonist efficacy, eg. anticonvulsant efficacy, eg. anticonvulsant activityactivity
Examples of LABORAS applications in drug discoveryExamples of LABORAS applications in drug discovery
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Applications LABORASApplications LABORAS
NEAR FUTURE APPLICATIONSNEAR FUTURE APPLICATIONS
Antagonism of pharmacologically Antagonism of pharmacologically induced effects, such as induced effects, such as DyskinesiaDyskinesia Startle responseStartle response
FUTURE APPLICATIONSFUTURE APPLICATIONS
RespirationRespiration Adverse effectsAdverse effects
Heart beatHeart beat Efficacy and safety issuesEfficacy and safety issues
Sniffing, Digging, JumpingSniffing, Digging, Jumping Detailed Exploration/Anxiety Detailed Exploration/Anxiety measuremeasure
Energy spendEnergy spend Metabolic effectsMetabolic effects
Disturbed feeding / drinking Disturbed feeding / drinking patterns (Eating / Drinking)patterns (Eating / Drinking)
Hypo- or hyperphagia; Hypo- or Hypo- or hyperphagia; Hypo- or polydipsiapolydipsia
Examples of LABORAS applications in drug discoveryExamples of LABORAS applications in drug discovery
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Overall benefits LABORASOverall benefits LABORAS
General benefits for customerGeneral benefits for customer● Standard and objective methodStandard and objective method
− Eliminates inter- and intra observer deviationEliminates inter- and intra observer deviation− Does not require trained or experienced ratersDoes not require trained or experienced raters
● Reduces time & costs (>75% reduction)Reduces time & costs (>75% reduction)● Results are almost immediately availableResults are almost immediately available● Many independent parameters can be Many independent parameters can be
measured with just one system (Tracking & measured with just one system (Tracking & behavior recognition combined in single behavior recognition combined in single system)system)
● Growth potential to determine several new Growth potential to determine several new behavioral and tracking parametersbehavioral and tracking parameters
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Overall benefits LABORASOverall benefits LABORAS
Important benefits for experimentImportant benefits for experiment● Independent of light conditionsIndependent of light conditions● Home cage environment and non-invasive Home cage environment and non-invasive
method (stress minimized)method (stress minimized)● Large scale observational experiments Large scale observational experiments
possiblepossible● Long test periods possibleLong test periods possible● More consistent resultsMore consistent results
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SONOTRACKSONOTRACK
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What is SONOTRACK?What is SONOTRACK? ● SONOTRACK records, visualizes and plays back SONOTRACK records, visualizes and plays back
Ultrasound CallsUltrasound Calls
● SONOTRACK records the SONOTRACK records the full spectrumfull spectrum from from 15kHz up to 100kHz 15kHz up to 100kHz
● SONOTRACK records SONOTRACK records 4 independent4 independent ultrasound ultrasound channelschannels
● SONOTRACK can easily be adjusted to SONOTRACK can easily be adjusted to experimental environment and is experimental environment and is easy to useeasy to use
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Ultrasonic VocalizationsUltrasonic Vocalizations Hearing range of Animals
ch
inch
illa
sh
eep
ho
rse
co
w racco
on
rab
bit
ferr
et d
og
hed
geh
og
gu
ineap
ig
gerb
il
cat
op
ossu
m
rat
mo
use
bat
belu
ga w
hale
po
rpo
ise
mo
th
1
10
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10000
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1000000
chin
chill
a
shee
p
hors
e
cow
raccoo
n
rabbit
ferr
et
dog
hedge
hog
guin
eapig
gerb
il
cat
opossum
rat
mouse
bat
belu
ga w
hale
porp
ois
e
moth
Fre
q. ra
ng
e (
Hz)
Log
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What is SONOTRACKWhat is SONOTRACK
● SONOTRACK can be used for long term SONOTRACK can be used for long term experimentsexperiments
● SONOTRACK recognizes and counts Ultrasonic SONOTRACK recognizes and counts Ultrasonic Vocalizations in user definable frequency Vocalizations in user definable frequency bandsbands
● SONOTRACK offers a new approach for SONOTRACK offers a new approach for characterization of animal behavior characterization of animal behavior
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SONOTRACK ApplicationsSONOTRACK Applications ● SONOTRACK can be used to monitor animal SONOTRACK can be used to monitor animal
welfare and interaction between animals welfare and interaction between animals based on the ultrasonic vocalizations of the based on the ultrasonic vocalizations of the animalsanimals
● Typical research areas:Typical research areas:– PainPain– AnxietyAnxiety– StressStress– DepressionDepression– Social interactionSocial interaction– Animal WelfareAnimal Welfare
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SONOTRACK ApplicationsSONOTRACK Applications ● Playback of Ultrasounds to the animal (stimulus)Playback of Ultrasounds to the animal (stimulus)
- playing back parts or complete recordings- playing back parts or complete recordings- playing back specific (artificial) frequency patterns- playing back specific (artificial) frequency patterns
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Examples of resultsExamples of results
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Examples of resultsExamples of results
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Examples of resultsExamples of results
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Examples of ResultsExamples of Results
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Examples of resultsExamples of results
MarmosetMarmoset
Rats, Mother & PupRats, Mother & Pup
Ultrasound VocalizationsUltrasound Vocalizations
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Example of resultsExample of results
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What isWhat is SleepSign?SleepSign? Software for scoring of sleep stagesSoftware for scoring of sleep stages
Based on EMG and EEG signalsBased on EMG and EEG signals
Sleep stages can be scored in a manual mode Sleep stages can be scored in a manual mode as well as well as automaticallyas well as well as automatically
Scores pre-assigned sleep stages (such as REM, Scores pre-assigned sleep stages (such as REM, WAKE, SWS) and up to 3 user defined vigilance WAKE, SWS) and up to 3 user defined vigilance stagesstages
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Special featuresSpecial features Works with wireless or wired EMG and EEG Works with wireless or wired EMG and EEG
signalssignals In depth analysis using Hypnograms and Trend In depth analysis using Hypnograms and Trend
GraphsGraphs Various analysis functions, incl. Stage Graphs, Various analysis functions, incl. Stage Graphs,
Vigilance State Parameter Display, FFT analysisVigilance State Parameter Display, FFT analysis Integrated with VideoIntegrated with Video
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Application areasApplication areas
Pharmaceutical ResearchPharmaceutical Research
Sleep Disorder Studies and Sleep Sleep Disorder Studies and Sleep pattern Analysispattern Analysis
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Integration of SystemsIntegration of SystemsIntegration of systems such as LABORAS, Video, Integration of systems such as LABORAS, Video, DSI Telemetry, SonoTrack & SleepsignDSI Telemetry, SonoTrack & Sleepsign Less Experiments & Experimental lead timeLess Experiments & Experimental lead time
Less Resources (animals, researchers & money)Less Resources (animals, researchers & money)
Integrated analysis of parameters from different Integrated analysis of parameters from different domains collected from the same experiment domains collected from the same experiment
- Behavioral data and Tracking dataBehavioral data and Tracking data
- Psychological dataPsychological data
- SoundsSounds
- Sleep stagesSleep stages
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Integration of SystemsIntegration of Systems
With With SonotrackSonotrack
LABORASLABORAS With With SleepSignSleepSign
Example of integration in Laboras Example of integration in Laboras
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ENERGY & ENERGY & PHARMACOLOGYPHARMACOLOGY
Behavior and external / internal conditionsBehavior and external / internal conditions
Environment Environment -- External condition External condition
Process in the Body – Internal conditionProcess in the Body – Internal condition
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ENERGY & ENERGY & PHARMACOLOGYPHARMACOLOGY
Basic structureBasic structure
BEHAVIOR = BEHAVIOR = Function { Internal stimulus, external stimulus} Function { Internal stimulus, external stimulus}
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ENERGY & ENERGY & PHARMACOLOGYPHARMACOLOGY
Animal behavior and environmentAnimal behavior and environment
BEHAVIOR= Function {BEHAVIOR= Function {Process in the BodyProcess in the Body, nervous nervous system structure, nervous function, hormonal effects , system structure, nervous function, hormonal effects , biological clocks, perceptual mechanisms, Genes, biological clocks, perceptual mechanisms, Genes, stimulus filtering}stimulus filtering}
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ENERGY & ENERGY & PHARMACOLOGYPHARMACOLOGY
External factor and environmental variables Temperature = function { temperature control Unit , CV }Temperature = function { temperature control Unit , CV }
Airflow = function air-conditioning}Airflow = function air-conditioning}Barometric pressure = function { place, time }Barometric pressure = function { place, time }
Humidity = function { office level or place }Humidity = function { office level or place }Visual effect = function { walking researchers in the laboratory}Visual effect = function { walking researchers in the laboratory}
Light = function { lights control unit}Light = function { lights control unit}Sounds = function { sounds generating equipment, voices } Sounds = function { sounds generating equipment, voices }
Vibration = function { refrigerators, ventilators, PCs, specific equipment } Vibration = function { refrigerators, ventilators, PCs, specific equipment } Elektromagnetic waves = function{ transmitting equipment, magnets}Elektromagnetic waves = function{ transmitting equipment, magnets}
Smell = function {specific gases, parfums, etc,}Smell = function {specific gases, parfums, etc,}
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ENERGY & ENERGY & PHARMACOLOGYPHARMACOLOGY
Rule of energy preservation of the Rule of energy preservation of the bodybody
E = K + P = constantE = K + P = constant (Formula (Formula of energetic balance)of energetic balance)
Potential Energy of the BodyPotential Energy of the Body
P = ∆U+ P = ∆U+ δδ((εε − − TTηη + + PPνν))
-∆U -∆U is the change in biochemical energy is the change in biochemical energy - Ε- Ε is the internal energy is the internal energy
- T- Tηη is the entropy energy is the entropy energy - Pv - Pv is the thermodynamic energy is the thermodynamic energy
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THE IMPORTANCE OF THE THE IMPORTANCE OF THE ENERGYENERGY PARAMETER IN PARAMETER IN
BEHAVIORAL PHARMACOLOGYBEHAVIORAL PHARMACOLOGY
Kinetical energy of bodyKinetical energy of body
E (Locomotion) = Mv²/2E (Locomotion) = Mv²/2V V = velocity, M = total mass of body= velocity, M = total mass of body
E (Oscillation) = δm ω²R²/2E (Oscillation) = δm ω²R²/2ω = radial frequency, R = radius of oscillation,ω = radial frequency, R = radius of oscillation,δm = mass of oscillating body part δm = mass of oscillating body part
Mv²/2Mv²/2 δδmm²R²/2²R²/2++ E k =E k =
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THE IMPORTANCE OF THE THE IMPORTANCE OF THE ENERGYENERGY PARAMETER IN PARAMETER IN
BEHAVIORAL PHARMACOLOGYBEHAVIORAL PHARMACOLOGY Kinetical energy of bodyKinetical energy of body E (E (LocomotionLocomotion) ) is the kinetic energy is the kinetic energy
resulting from:resulting from: Locomotion, Walking, Rearing, ClimbingLocomotion, Walking, Rearing, Climbing
E (E (OscillationOscillation) ) is the kinetic energy is the kinetic energy resulting from different repetitive resulting from different repetitive movements:movements:
Scratching, Grooming , Chewing, Sniffing, Wet Dog Scratching, Grooming , Chewing, Sniffing, Wet Dog
Shakes, Head Shakes, Head Twitches, TremorsShakes, Head Shakes, Head Twitches, Tremors
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Detection, Detection, recognitionrecognition and and registration ofregistration of behaviorbehavior
Locomotion
ScratchingFast up and down movement of the hindfoot, rubbing the side of the body, neck and face.
Detection of behavioral featuresDetection of behavioral features
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LABORAS HS SignalLABORAS HS Signal
AnalogAnalog DigitalDigital
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E (E (OscillationOscillation) ) // E (E (LocomotionLocomotion) ) spectrogramspectrogram
Energy spectrogram
0123456789
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HTHS
WDS
Paw L
ickin
g
Scrat
chin
g
Seizu
re
Gro
oming
Eating
Drinkin
g
Chewin
g
Loco
mm
otio
n
Rearin
g
Imm
obility
Climbi
ng
Behavior
En
erg
y
Energy
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Kruisweg 825Kruisweg 8252132 NG Hoofddorp2132 NG Hoofddorp
Phone:+31 23 5623400Phone:+31 23 5623400Fax:Fax: +31 23 5623425+31 23 5623425
www.metris.nlwww.metris.nl
Questions?Questions?
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