Product Name: Lymphoma Tissue Array - 70 cases of various types of nodal and extranodal lymphoma all in duplicates together with 5 cases of non-malignant lymphoid tissues Catalog No.: Z7020070 Lot No.: B110078 Species: Human Tissue Type: Tumor Tissue Array Diagram: Cores Size Cut Format QA/QC

150 1.1 mm 4 µm 10X15 H&E, IHC anti-LCA

Recommended applications: For research use only. RNA or protein analyses using IHC or ISH suitable for general lymphoma tissue profiling. Description: This tissue array contains 75 cases of various types of nodal and extranodal lymphoma in duplicates. All the tissues were from surgical resection. They were fixed in 10% neutral buffered formalin for 24 hours and processed using identical SOPs. Sections were picked onto Superfrost Plus or APES coated Superfrost slides. They all have a guaranteed six months' shelf-life at 4°C from the date of shipment. Each slide has >95% tissue core retention. Array position Age Sex Histology Anatomic site

A1,B1 26 M Reactive Lymph node A2,B2 47 M Reactive Lymph node A3,B3 31 M Reactive Tonsil A4,B4 14 M Reactive Tonsil A5,B5 21 F Normal Spleen A6,B6 77 F MALT B cell lymphoma Thyroid A7,B7 62 M Non-Hodgkin B cell lymphoma Stomach

A8,B8 53 M Peripheral T cell lymphoma, unspecified

Small intestine

A9,B9 41 M Hodgkin lymphoma Neck lymph node

A10,B10 55 M Peripheral T cell lymphoma, unspecified?

Neck lymph node

A11,B11 54 M Non-Hodgkin B cell lymphoma Shoulder A12,B12 29 M Non-Hodgkin B cell lymphoma Neck lymph node A13,B13 5 M Anaplastic large cell lymphoma? Lymph node A14,B14 40 M Hodgkin lymphoma Lymph node A15,B15 48 M Non-Hodgkin B cell lymphoma Colon C1,D1 60 M Non-Hodgkin B cell lymphoma Colon C2,D2 42 M Non-Hodgkin B cell lymphoma Axillary lymph node C3,D3 7 M Hodgkin lymphoma Lymph node C4,D4 66 M Non-Hodgkin lymphoma Lymph node C5,D5 40 M Non-Hodgkin B cell lymphoma Ilium-cecum

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C6,D6 33 M Non-Hodgkin B cell lymphoma Neck lymph node C7,D7 51 M Anaplastic large cell lymphoma? Neck lymph node C8,D8 48 M Non-Hodgkin B cell lymphoma? Lung lymph node C9,D9 72 M Non-Hodgkin B cell lymphoma Testis C10,D10 71 F Non-Hodgkin B cell lymphoma Lymph node

C11,D11 43 M MALT B cell lymphoma, high grade

Stomach

C12,D12 52 F Diffuse large B cell lymphoma Neck lymph node C13,D13 60 M MALT B cell lymphoma? Colon C14,D14 30 M Hodgkin lymphoma Peritoneal cavity C15,D15 40 F Non-Hodgkin B cell lymphoma Peritoneal cavity

E1,F1 33 F MALT B cell lymphoma, high grade

Stomach

E2,F2 70 F Non-Hodgkin B cell lymphoma Mesenteric lymph node E3,F3 43 F Non-Hodgkin B cell lymphoma Neck lymph node E4,F4 65 M Non-Hodgkin B cell lymphoma Lymph node E5,F5 76 M Diffuse large B cell lymphoma Tonsil E6,F6 32 F Non-Hodgkin B cell lymphoma Pelvic Cavity E7,F7 39 M Non-Hodgkin B cell lymphoma Neck lymph node E8,F8 50 M Hodgkin lymphoma Neck lymph node E9,F9 43 M Non-Hodgkin lymphoma Ilium E10,F10 53 F Mantle cell lymphoma Neck lymph node E11,F11 72 F Non-Hodgkin B cell lymphoma Lymph node E12,F12 53 M Diffuse large B cell lymphoma Neck lymph node E13,F13 55 F Non-Hodgkin lymphoma Mesenteric lymph node E14,F14 55 F Non-Hodgkin B cell lymphoma Breast E15,F15 13 M Diffuse large B cell lymphoma Shoulder G1,H1 35 M Non-Hodgkin B cell lymphoma Lymph node G2,H2 40 M Non-Hodgkin B cell lymphoma Tonsil G3,H3 54 F Hodgkin lymphoma Lymph node G4,H4 24 M Non-Hodgkin B cell lymphoma Ilium-cecum G5,H5 64 M Non-Hodgkin B cell lymphoma Lymph node G6,H6 49 M Hodgkin lymphoma Neck lymph node

G7,H7 65 M MALT B cell lymphoma, high grade

Stomach

G8,H8 73 M Non-Hodgkin B cell lymphoma Kidney G9,H9 4 M Non-Hodgkin B cell lymphoma Neck lymph node G10,H10 70 F Non-Hodgkin B cell lymphoma Ilium G11,H11 52 F Non-Hodgkin lymphoma Lung G12,H12 51 M Non-Hodgkin B cell lymphoma Stomach G13,H13 28 M Non-Hodgkin B cell lymphoma Ilium

G14,H14 58 F MALT B cell lymphoma, high grade

Stomach

G15,H15 38 M Non-Hodgkin B cell lymphoma Lymph node

I1,J1 58 F MALT B cell lymphoma, high grade

Stomach

I2,J2 67 M Non-Hodgkin lymphoma Lymph node

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I3,J3 53 F MALT B cell lymphoma, high grade

Stomach

I4,J4 73 M Hodgkin lymphoma Lymph node I5,J5 17 M Non-Hodgkin B cell lymphoma Small intestine I6,J6 43 M Non-Hodgkin B cell lymphoma Brain I7,J7 43 M Non-Hodgkin B cell lymphoma Neck lymph node I8,J8 76 M Non-Hodgkin B cell lymphoma Neck lymph node I9,J9 51 F Hodgkin lymphoma Neck lymph node I10,J10 74 F Non-Hodgkin lymphoma Neck lymph node I11,J11 57 M Hodgkin lymphoma Neck lymph node I12,J12 42 F Non-Hodgkin B cell lymphoma Breast I13,J13 42 F Hodgkin lymphoma Neck lymph node I14,J14 38 F Hodgkin lymphoma Neck lymph node I15,J15 44 F Anaplastic large cell lymphoma Peritoneal cavity Notes: Bake at 60°C for 30 minutes before use. If antigen retrieving is needed, it is always a good idea to start with a protocol with weak to mild strength. Clinical Staging: Malignant lymphoma

Stage I - Involvement of a single lymph node region (I), or localized involvement of a single extrahepatic organ or site (IE)

Stage II - Involvement of two or more lymph node regions on the same site of the diaphragm (II), or localized involvement of a single extralymphatic organ or site and its regional lymph node(s) with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). The number of lymph node regions involved may be indicated by a subscript (e.g. II3)

Stage III - Involvement of lymph node regions on both sides of the diaphragm (III), which may also be accompanied by localized involvement of an associated extralymphatic organ or sites (IIIE), or by involvement of spleen (llls) or both (llle+s)

Stage IV - Disseminated (multifocal) involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement with distant (non-regional) nodal involvement

A and B Classification

Each stage should be divided into A and B according to the absence or presence of defined general symptoms. These are: 1. Unexplained weight loss of more than 10% of the usual body weight for the 6 months prior to first attendance. 2. Unexplained fever with temperature above 38 degree 3. Night sweat

Pathological Staging

Splenectomy, liver biopsy, lymph node biopsy and marrow biopsy are mandatory for the establishment of pathological staging TNM classification of malignant tumours, Fifth Edition (1997)