NUTRITIONAL SUPPLEMENTSAN INTRODUCTION DOCUMENT

NEED FOR SUPPLEMENTS.............................................................................................2Supplements – Uses and Advantages..............................................................................3Requirement of Minerals; Benefits and Deficiency Symptoms......................................4

NUTRILITE: BRAND STRENGTH................................................................................10

PRODUCT TESTIMONIALS...........................................................................................14

USAGE OF SUPPLEMENTS FOR SPECIFIC AILMENTS...........................................26About Hair Health..........................................................................................................26Salmon Omega-3 for Heart health.................................................................................30

RESEARCH PAPERS & OTHER REFERENCES..........................................................34Glucosamine for Osteoarthritis......................................................................................34Glucosamine - Supplements..........................................................................................40Soy protein ingredients and their health benefits..........................................................42Rediff News: Protein Powder as a cure for Hair Loss...................................................45

Updated: Aug 2007

NEED FOR SUPPLEMENTS

Source : www.heart-health.org

Supplements – Uses and Advantages

Supplement Uses and AdvantagesVitamin E Antioxidant; protects blood fats; keeps

cholesterol "happy". Prevents blood sticking, clots and artery damage.

Three very large studies found 40% heart disease risk reduction with supplements.

Vitamin C

C, easy to take for granted, hard to underestimate!

Antioxidant. Works with and recycles vitamin E; prevents artery infection; strengthens blood vessels; raises good & lowers Lp(a) cholesterol; speeds up bowel, removing excess cholesterol. Improves general health & effects of diabetes

Vitamin B’s They help digest fats and sugars, lower homocysteine (-best in higher than RDA amounts) and reduce plaque.

Very high dose plain B3 niacin (about 0.7g taken after each of meals) is by far the best & cheapest cholesterol "modifying" drug, raising HDL while lowering LDL, Lp(a), fibrinogen and triglycerides -must take with a daily multi. B3 is also good for your liver and brain.

The B's are needed for 100's of processes in the body.

B2, B6, B12 & folic acid will lower artery toxic homocysteine in anyone.

Calcium Calcium is heart healthy, helps in Bone, heart, general, blood pressure

Magnesium Crucial for heart function; it, and potassium regulate heart beat. Mg is needed for 325 reactions, not least the lowering of toxic blood homocysteine

Helps in irregular heart beat, heart failure, bone, PMS, cramps, fatigue, diabetes, stroke, diuretic use.

Selenium Antioxidant, works with vitamins E and C. A lack causes heart disease, some virus diseases & cancer which are, in part, selenium deficiency diseases

Helps in cancer, heart muscle, muscle cataracts, BP, ageing

Vitamin F (Omega fatty acids) True Vitamins, which the body cannot make it by itself.

Silicon Helps for bones, joints, heart, skin, poor collagen

Chromium Diabetes; helps insulin, cholesterol, acne, sugar use

Vanadium Diabetes; higher doses replace insulinBoron Bone health, diabetes, infection,

arthritisManganese Bone, cartilage, heart, epilepsy,

diabetes, cataractsCopper Helps for Heart, arthritis, hair color,

artery bursts (aneurysm, stroke), bad collagen, high LDL, poor clotting, Parkinson's

Zinc Arthritis, skin, infection, bad collagen, vision, prostate, diabetes,

Molybdenum Organs, enzymes, cancerPotassium Heart, heart failure, stroke,

hypertension, cell function, sweating, diuretics, irregular heart beat, muscle, fatigue, nerves

Sodium Cell function, always sufficient; raises blood pressure

Iron Blood; meno-pausal women; some infants, teens & elderly

Requirement of Minerals; Benefits and Deficiency Symptoms

Minerals are elements that originate in the soil and cannot be created by living things, such as plants and animals. Yet plants, animals and humans need minerals in order to be healthy. Plants absorb minerals from the soil, and animals get their minerals from the plants or other animals they eat. Most of the minerals in the human diet come directly from plants, such as fruits and vegetables, or indirectly from animal sources. Minerals may also be present in your drinking water, but this depends on where you live, and what kind of water you drink (bottled, tap). Minerals from plant sources may also vary from place to place, because the mineral content of the soil varies according to the location in which the plant was grown.  

Note that I have listed only those foods which contain the listed vitamins in significant quantities. For more detailed information, please visit the United States Department of Agriculture (USDA) Food & Nutrition Center.

Nutrient - Estimated Amounts

Needed

Benefits/Deficiency Symptoms

Fruit Sources

VegetableSources

Nut/SeedSources

Adults need 1000 mg/day.Children need 800 to 1300 mg/day.Recommended supplement: Calcium

Calcium eases insomnia and helps regulate the passage of nutrients through cell walls. Without calcium, your muscles wouldn't contract correctly, your blood wouldn't clot and your nerves wouldn't carry messages. If you don't get enough calcium from the food you eat, your body automatically takes the calcium needed from your bones. If your body

Most fruits contain some calcium:

Orange Blackberries Kiwi Tomatoes Watermelon Lime Strawberry Lemon Grapes Apples Cantaloupe

Bananas Peach

Artichoke Peas Squash - summer Broccoli Kale Lima Beans Squash - winter Spinach Carrots Avocado Asparagus

Almonds Brazil Nuts Pistachios Peanuts Walnuts Chestnuts Macadamias Pecans Sunflower Seeds Filberts/Hazelnuts Pumpkin Seeds Cashews Pine Nuts/Pignolias

continues to tear down more bone than it replaces over a period of years in order to get sufficient calcium, your bones will become weak and break easily. Deficiency may result in muscle spasms and cramps in the short term and osteoporosis.

The estimated safe and adequate intake for copper is 1.5 - 3.0 mg/day. Many survey studies show that Americans consume about 1.0 mg or less of copper per day

Copper is involved in the absorption, storage and metabolism of iron and the formation of red blood cells. It also helps supply oxygen to the body. The symptoms of a copper deficiency are similar to iron-deficiency anemia.

Most fruits contain a small amount of copper, but kiwi fruit has a significant amount. Apples Bananas Blackberries Cantaloupe

Grapes Kiwi   Fruit Lemon Lime Orange Peach Strawberry Tomatoes watermelon

Most vegetables have some copper, but Lima Beans have a significant amount. Artichoke Avocado Broccoli Carrots Cauliflower Corn Cucumber Green   Pepp er Kale Lima Beans Mushrooms Onions Peas Potatoes Spinach Squash   - Summer Squash   - Winter Sweet   Potat o

Most nuts contain a trace amount of copper.

Adults should get 150 mcgs per day.The children's recommendation for iodine is 70 to 150 mcg (that is micrograms).

Iodine helps regulate the rate of energy production and body weight and promotes proper growth. It also promotes healthy hair, nails, skin and teeth. In countries where

Fruits grown in iodine-rich soils contain iodine.

Vegetables grown in iodine-rich soils contain iodine.

Nuts grown in iodine-rich soils contain iodine.

iodine is deficient in the soil, rates of hypothyroidism, goiter and retarded growth from iodine deficiency are very high. In developed countries, however, because iodine is added to table salt, iodine deficiencies are rare.

Women and teenage girls need at least 15 mg a day, whereas men can get by on 10.It is important that children get about 10 to 12 mg of iron per day, preferably from their diet. Breastfeeding is the best insurance against iron deficiency in babies.

Most at risk of iron deficiency are infants, adolescent girls and pregnant women. Iron deficiency in infants can result in impaired learning ability and behavioral problems. It can also affect the immune system and cause weakness and fatigue. To aid in the absorption of iron, eat foods rich in vitamin C at the same time you eat the food containing iron. The tannin in non-herbal tea can hinder absorption of iron. Take iron supplements and your vitamin E at different times of the day, as the iron supplements will tend to neutralize the vitamin E. Vegetarians need to get twice as much dietary iron as meat eaters.

While most fruits have some iron, probably the best source of iron for children is raisins, which are rich in iron. Other fruits which have a good amount of iron are: Blackberries Kiwi Strawberry Tomatoes watermelonBananas Grapes

Vegetables: Lima Beans Peas Avocado Kale Spinach Broccoli Squash - summer Potatoes Sweet potato

Squash - winter Corn Carrots Mushrooms

Most nuts contain a small amount of iron.

Adults need 310 to 420 mg/

Magnesium is needed for bone, protein, making new cells,

Fruits: Kiwi Bananas

Vegetables: Avocado Artichoke Peas

Nuts: Brazil Nuts Cashews Pumpkin Seeds

day.Children need 130 to 240 mg/day.

activating B vitamins, relaxing nerves and muscles, clotting blood, and in energy production.Insulin secretion and function also requires magnesium. Magnesium also assists in the absorption of calcium, vitamin C and potassium. Deficiency may result in fatigue, nervousness, insomnia, heart problems, high blood pressure, osteoporosis, muscle weakness and cramps.

Tomatoes Blackberries Strawberry Orange

Squash - summer Potatoes Corn Spinach Kale Broccoli Squash - winter Sweet potato

Pine Nuts/Pignolias Peanuts Walnuts Macadamias Sunflower Seeds Pecans Pistachios Chestnuts Filberts/Hazelnuts

2.0-5.0 mg/day for adults 2.0-3.0 mg for children 7 - 10 1.5-2.0 mg for children 4 - 6

1.0-1.5 mg for children 1 - 3

0.6-1.0 mg for children 6 mo - 1yr0.3-0.6 mg for infants 0-6 months

The functions of this mineral are not specific since other minerals can perform in its place. Manganese does function in enzyme reactions concerning blood sugar, metabolism, and thyroid hormone function. Deficiency is rare in humans.

Most fruits contain manganese, but the following fruits have a significant amount: Blackberries Strawberry

Most vegetables have some manganese, but these have a significant amount: Peas Lima Beans Sweet potato

Kale Squash - summer

Most nuts contain manganese, but the following nuts have a significant amount: Pine Nuts/Pignolias Pecans Walnuts Chestnuts

Adults need 700 mg/day.Children need 500 to 1250 mg/day.

In combination with calcium, phosphorus is necessary for the formation of bones and teeth and of the nerve cells.Phosphorus is second to calcium in abundance in the body. It is very widely distributed in both plant and animal foods so it is unlikely that

Fruits: Kiwi Tomatoes Blackberries Bananas Strawberry

Orange Peach Lime Cantaloupe

Vegetables: Lima Beans Peas Artichoke Avocado Corn Potatoes Asparagus Broccoli Kale Mushrooms Sweet potato

Nuts: Sunflower Seeds Brazil Nuts Cashews Pine Nuts/Pignolias Pistachios Almonds Peanuts Walnuts Chestnuts Pecans Macadamias Filberts/Hazelnuts

deficiency would be a problem.

Pumpkin Seeds

Estimated Minimum Requirements 2000 mg/day for adults and adolescents.

Potassium is essential for the body's growth and maintenance. It is necessary to keep a normal water balance between the cells and body fluids. Potassium plays an essential role in proper heart function. Deficiency may cause muscular cramps, twitching and weakness, irregular heartbeat, insomnia, kidney and lung failure.

Fruits: Bananas Tomatoes

Blackberries Strawberry Orange Cantaloupe

Peach Grapes Apples Lemon Lime

Vegetables: Avocado Lima Beans Potatoes Peas Artichoke Squash - summer Kale Sweet potato

Broccoli Corn Squash - winter Carrots Spinach Asparagus Green   Pepp er Mushrooms Onions Cauliflower Cucumber

Nuts: Chestnuts Sunflower Seeds Pistachios Pumpkin Seeds Almonds Brazil Nuts Peanuts Cashews Pine Nuts/Pignolias Walnuts Pecans Macadamias Filberts/Hazelnuts

Men need 70 mcgs/day. Women need 55 mcgs/day.

Selenium is a part of several enzymes necessary for the body to properly function. Generally, selenium functions as an antioxidant that works in conjunction with vitamin E. Selenium deficiency is rare in humans.

Fruits: Bananas Kiwi Strawberry Blackberries Tomatoes Orange Peach Apples

Grapes

Vegetables: Lima Beans Peas Mushrooms Kale Corn Sweet potato

Potatoes Squash - winter Onions Squash - summer Spinach

Most nuts contain selenium, but the following nuts have a significant amount: Brazil Nuts Sunflower Seeds Cashews Pistachios Peanuts Walnuts Almonds Chestnuts Pecans

500 mg/day for adults 120 mg for infantsDaily Value recommendation - no more than 2,400 to 3,000 mg/day

Sodium is required by the body to regulate blood pressure and blood volume. It helps regulate the fluid balance in your body. Sodium also helps in the proper functioning of muscles and nerves.

Sodium occurs naturally in almost all fresh, whole fruits.

Sodium occurs naturally in almost all fresh, whole vegetables

Nuts: Peanuts Pumpkin Seeds Cashews Pistachios Chestnuts Macadamias Almonds

Many people get far more sodium than they need, which tends to cause health problems.Different body types need different amounts of sodium.

Men need 15 mgs/day.Women should get 12 mg/day.Children need 10 to 15 mg/day.Vegetarians need about 50 percent more zinc in their diet than meat eaters.

This metal is important in a number of key activities, ranging from protein and carbohydrate metabolism to the immune system, wound healing, growth and vision.Severe deficiency can contribute to stunted growth. Deficiency can sometimes be seen in white spots on the fingernails.

Most fruits contain a small amount of zinc, but the following have a significant amount: Blackberries Kiwi

Most vegetables have some zinc, but these have a significant amount: Peas Lima Beans Squash - summer Potatoes Corn Sweet potato

Most nuts have some zinc, but these have a significant amount: Pumpkin Seeds Pine Nuts/Pignolias Cashews Sunflower Seeds Pecans Brazil Nuts Almonds Walnuts

NUTRILITE: BRAND STRENGTH

---------- Forwarded message ----------From: navin_honavar@amway.com < navin_honavar@amway.com>Date: Jul 8, 2006 10:45 AMSubject: NUTRILITE - MOST TRUSTED BRAND IN ASIATo:

Dear ABO Leader

There is GOOD NEWS for us. What more do we need - NUTRILITE VOTED AS MOST TRUSTED GOLD BRAND IN ASIA BY CONSUMERS.

The May  issue of READERS DIGEST proudly carries the NUTRILITE BRAND withthem as Asia's most trusted brand in Health and Personal Care  - Vitaminand Health Supplement category

Given below is the background for this:

Readers Digest had conducted their 8th annual survey of the brandsconsumers say have earned a trusted place in their everyday lives. TRUST -key ingredient in the relationship between consumers and products they embrace.Brands most trusted are voted by readers in 7 Asian markets - HongKong,Malaysia, India, Philippines, Singapore, Taiwan, Thailand. There are twocategories of brands - GOLD AND PLATINUM

GOLD TRUSTED BRAND - AWARD GOES TO BRAND THAT SCORE WELL ABOVE THEIR COMPETITORS.PLATINUM TRUSTED AWARD - FOR TRULY OUTSTANDING ACHIEVEMENT AND GOES TOCOMPETITORS THAT HAVE SCORED AT LEAST DOUBLE THAT OF THEIR NEAREST RIVAL

They assigned a score for each brand for 6 core qualities: trustworthiness, credibility of image, value, brand ability to innovate, whether brandunderstands consumer needs.

Attaching a scanned copy of the same for your use.

PRODUCT TESTIMONIALS

---------- Forwarded message ----------From: mohammed shafiDate: Sep 12, 2006 3:34 PM Subject: Thanks to NUTRILITE!!To: manoj66866, Priyamanoj

Hi Vijai/Manoj/Priya,

I really really missed the Open meeting this month. I could imagine how great it would had been to hear from the awesome leaders like Sooryah & Geeta.

I write this mail to express the endless joy what my family is undergoing in which NUTRILITE had a great role to play.       Four months back my sister gave birth to a baby girl.Our joy didn't last long after Doctor said that he could hear some noise from the baby's heart.Seeing the scan report we got socked to learn that the baby's heart had 2 holes One was small 0.3 mm but the other one was 3mm which is very big. The Doctor said that this was because of my sister who didn't take care of her health and food while she was pregnant.She always used to be very careless in her health.

During her pregnancy I tried a lot to make my sister take Nutrilite products. Even Priya talked with her about Nutrilite products & how it helps in tissues growth in the baby & everything.But my sister was too careless & lazy.   The doctor said that we should take utmost care and should not let the baby to get cold & should not let her expose to pollution through out her life until the holes gets closed by itself which may or may not happen.Even if it happens, it may take take a minimum of ten years.He said that we can try a surgery.The doctor also said that the baby should take only mother's milk.

 What happened after this was unbeleivable.Now my sister was very conscious about what she eats and she was very religious in taking Nutrilite products. She took 2.5 scoops of Protein powder,a daily, a calmag & an ironfolic everyday religiously in the exact timings which Priya recommended.Thanks to all the nutrilite sessions arranged by Ankur & Taru and all the PASE meetings which made me beleive the product very much and recommend it very very strongly to my sister.

In these four months the baby took only mother's milk & my sister didnot take any medicine for this purpose as there were none discovered yet :(

In four months the improvement the baby shown was phenomenal.Her weight rose to 4.5 kgs which the doctor said was extraordinary.The baby was no more looking pale & my sister could notice that the little noise that used to come while she breaths wasn't there.You would remember that I shared this in the PASE meeting three weeks back!.The doctor by seeing the looks of the baby asked us to scan once again to check for any improvement.

 I had the most pleasant surprise in my life that day when my sister came to me with tears and said that both the holes had been closed!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

 Even the doctors are very much surprised, in the Doctor's experience it took five years for a 2mm hole to  close for a boy's heart & that had been the fastest!!..... It surprised them very much they asked us to repeat the scan in some other DIAGNOSTIC center. The result was the same!!! MASHA ALLAH!

 With whatever food the baby would take, it may take a min 10 years for the tissues to grow in that hole.But with Nutrilite, 4 months had been more than enough!!!!!!

 And for me the doctor have said that it would take 2 months for my broken hand to get back to normal with whatever calcium supplements he had given.He doesn't know that I am taking NUTRILITE (protein powder, daily,calmag ) and would come to Bangalore in a month & will have a huge team to take to FED!!!

Super Excited!!,Shafi,

---------- Forwarded message ----------From: kashyap <kashyap@dypatil.edu>Date: Sep 14, 2006 4:39 PMSubject: Nutrilite Triple Guard Achinacea TestimonyTo: ankur66866@gmail.com

Hi CAM,

3-4 weeks back, I overheard a colleague of mine mentioning "WBC..." :-) music :-) I discovered his mother was not in a position to take 3rdChemotherapy dose for Breast Cancer due to abysmally low WBC count (WBCcount reduces to ~4000 upon dose administration and has to come back to ~9000 before subsequent doses are administered). I asked him to type"Echinacea" in Google and he got good relevant information on benefits ofEchinacea on WBC count improvement. He sent 1 Triple Guard Echinacea to his mother in Kerala. After one week of use, the doctors were speechless to seea WBC count of ~9000, nothing else was working and Nutrilite Triple Guardproved magical ! The doctors actually got the WBC checked again in a different lab to verify the results !

Human body is God's handywork, if it's not cheated (read "given rightNutrition"), it is miraculously self-healing.

Cheers!Kashyap and Pranati..

---------- Forwarded message ----------From: Anshul < anshul.khare@gmail.com>Date: Sep 15, 2006 12:00 PMSubject: Another Nutrilite magic !!To: Gaurav Gupta < gauravgupta66866@gmail.com>

Hi Gaurav/Divya,

After reading Kashyap and Shafi's mail I thought I should share my magical Nutrilite experience also. I have been taking antioxidants i.e. Parse-E(1) and Bio-C(2-4) everyday since last 8 months regularly, supplemented by protein powder and Daily. Although I dint have any specific health issues but i was regulary taking all the supplements to make sure that I am always in good health.

Two weeks back I suddenly had problems in my eyes (I have a power of -2.75 in the right eye and -2.5 in the left eye and it hasnt changed since last 6 years) followed by Redness and headache. WHen the problem persisted for 2 days I consulted an eye specialist in koramangala. I was surprised when he told me that you have been wearing an overpowered lense. After thorough check up he informed me that my eye power is -2.0 in right eye and -1.5 in left eye which is significantly lower than the earlier power. It's absolutely impossible that one can keep on using a high power for 6 years without any complain. The only logical conclusion is that my eye sight has improved in last few months and come down to the current readings. Once I told this to my father (he's also a Doctor), he consulted the eye specialist again who had given me the specs 6 yrs back. He was also not ready to believe and told that there is some mistake in the eye checkup. I got my eye check up done again with refractor and manual check up also twice each. Every time the result was same...reduced power.

In the words of medical science it's impossible. If you ask any Eye specialist he will tell you that Myopic vision (negative power) cannot be cured at all. But again as Kashyap said, "Human body is God's handywork, if it's not cheated (read "given right Nutrition"), it is miraculously self-healing"

Now I believe that with Nutrilite, I can not only improve my eye sight but can get rid of my specs completely !

Anshul

---------- Forwarded message ----------From: murali hebbar <murali1384@yahoo.co.in>Date: Sep 28, 2006 8:11 PM Subject: The magic of Bone Health.To: manoj66866@gmail.com

Hi Manoj/Priya, I dont know about Medically proven statement "Bone Mass Density cannot increase but can only be sustained", but i know one thing, that is the magic of Nutrilite's Bone health with Epriflavone Magic. My mom has osteoporosis (now it is "had osteoporosis"). about a month ago, when i had been to home, i put my mother on Bone health and calmag, she finished one course of bone health just a week before (60 tablets) and had checked her Bone Mass Density check up, the result was unbelievable. Before taking nutrilite she had BMD of -2.6, which is the osteoporosis stage,now it is -1.2 (normal is -1.0), it was so surprising for my dad who called me in the afternoon today, excitedly telling me how well it has helped my mom. I am happy that i am in this business because its not only helping me, its helping my parents and other people because of the quality amway products they use. People who think the products are costly, just think again.its not the cost that should matter you, its whether you want to help others with such quality products or not. God has presented me with that chance, i am no way gonna loose it. Thanks Manoj/Priya for giving me immense support and knowledge about the products and business. Going Eagle......Murali M.S

> Date: Mon, 30 Oct 2006 10:41:41 +0530> From: "arvind mishra" <arvind66866@gmail.com>> To: "Mohit Maheshwari" <m_9512@yahoo.com>> Subject: Nutrilite Magic>> Mohit, This is the Nutrilite magic that vinit has to> share.>> ---------- Forwarded message ---------->>  Hi Arvind !>>>> Here  I have  a good news  to share . I am very> happy after taking> Neutrilite. It's really amazing and wondeful> healthcare products brand .>> I 've a small thing to share . I  am wearing  spects> from last 7 years> because  I always had the eyes infection  and  weak> eyesight.>> But I started using Protein powder and Daily tablets> since last 4-5 months .> My right eye's power got decresed up to .25  ,> Earlier it  was -1.0 D .>> Now it is -.75 D . Day before yesterday I went to> optician for my  eye check> up  , because I  was feeling some problem in eyes, I> thought may be my power> is increased   so  after the complete check –up> doctor told me  the good> news that vinit , it is a rare case after a long> time that somebody 's eye> power is getting down , he said , it only happens> because  of proper> neutritious diet. He told you are working in> software & you already have> infection in your  eyes , even then it got improved> .>> I am now very happy , It all became  possible by the> help of Neutrilite's> Protein powder and Daily tablets.My hair falling is> also stopped now due to> these  amazing  products…>> I really want to thank God  and Neutrlite  for my> health care .. I am very> very  happy after taking these products  ..>> Please forward this message to all our fired-up> leaders…>> CheersVinit

---------- Forwarded message ----------From: samarjit chowdhury <sam_is_cam@yahoo.com>Date: Feb 27, 2007 4:27 PM Subject: testimony about Nutrilite PPTo: minati.panda@gmail.comCc: ankur66866@gmail.com

Hi All,Pls find the mail below abt' the testimony of Protein Powder.  Luv,Sam and MinatiGold Feb 2007 Done Deal  Hi all

I have read so many testimonies about the products from so many people thatyou have forwarded me but to be very frank , i thought that at least some ofthem were exaggerated. Not any more though..

My QA manager in Oracle who is pregnant has already bought 2 PP from me andtoday she asked for the 3rd one. i was suprised because its just 10-15 dayssince she had got her last bottle and that too a 500gm one. Out of curiousity i asked her how she is finishing it so fast.Thats when she saidthat she is taking the powder 2 times a day.Her baby's growth was very lesstill the day her doctor asked her to take Nutrilite PP. its like magic,there is a tremendrous improvement in her baby's growth now and thats whyshe is taking it 2 times a day now..she was telling me that she should havestarted taking this earlier as her date is just a month away now. Hope everything goes fine.

i felt really bad after hearing this.We had this pdt in our hand and eventhen people who we know and who need it are not getting the right info andright access to these pdts. I was late in telling her because she was in our office and so i did not want to let others in office know that i am in biz.finally i send her a mail saying that my friend is distributing Nutrilite.She does not know that i am in the business even now.

i feel so happy that i could do something so great in their lives.

regardsjoe

---------- Forwarded message ----------From: amit sharma <>Date: Mar 23, 2007 9:16 AMSubject: I've improved my eyesight with Nutrilite To: bharat_Cc: ashish_, ratishcam, akglobalmarketing, khusbucam

 Hi Bharat, How r u? This mail is to share my personal experience about Nutrilite, which happened last month. I improved my eyesight significantly. The power of lenses decreased by - 0.25 spherical in both eyes, and - 0.5 cylindrical in right, - 0.25 cylindrical in left eye. I've been taking Nutrilite Daily and Protein powder on a regular basis for the last 7-8 months. It's all been possible because of this. I'm really excited about this, earlier i'd read some mails, and heard it from Vikram, but personal experience is something extra special. Because of my excitement, my younger brother also has started taking these on a regular basis.  And one more thing, we're not able to receive any mails related to Business from you all. Vikram told me that he's not able to forward mails from office as his seating arrangement doesn't allow that. So, for the mean time can we have the mails directly from you?  And i'm switching my business mail id to akglobalmarketing. Please add this to your address book instead of er_amit Fired up !!Eagles Amit & Khushbu

---------- Forwarded message ----------From: Mohammed Fayaz <mfayazu@rediffmail.com>Date: 8 Jun 2007 11:54:04 -0000 Subject: Re :Start to get as many blessings, take the help of Nutrilite Food supplementsTo: ankur668661 <ankur66866@gmail.com>, kashyap1 < kashyap@dypatil.edu>Cc: jnanesh.raghavaiah@fmr.com

Hi Ankur/Kashyap,

Here is some more magic's from Nutilite products which will force people to believe in it. After this incident Jnanesh and Leela are super fired up about the business and they already sponsored 3 people. They are personally sponsored by Charles who is going to be with us in Aug 07 Eagle club.

75 People to Chennai Summer Conference from 9 Legs/ 5 Eagle to Eagle club Aug 07/Starting Platinums Aug 07 with 15 Growing working legs.

Fayaz Fayiza

On Fri, 8 Jun 2007 16:27:54 +0530 "Raghavaiah, Jnanesh" wrote

Greetings,

I am Jnanesh Raghavaiah, Software engineer, working in Bangalore.

I am glad to share with team about the magiccreated by Nutrilite products to my family. I take this opportunity to thank my class mate Charles through whom I came to know about this Amway business and this incredible brand Nutrilite. We will be surely big in this business because ofthe kind of help and support we are getting from Charles. Really I thank godfor making us meet each other in our life.

First of all I would like to tell about the great help I got from Charles.

In the month of March my mother got into aserious body injury due to an accident for which doctors' estimate around2 months to recover to normal stage. During that time her whole body had blood clots, her muscles had been liquefied & also she had many fractures. Alongwith this she was running short of blood.

That was the time, for god's graceCharles came into picture and suggested us to try this Food supplements. He made us to understand that; extra food supplement is requiring to reconstructall her muscles, bone & to improve hemoglobin level.

Hence we dint look behind to get thisproduct. 

As per his instruction she started to consume 4 products Protein powder, Daily, Cal-Mag, and Iron-Folic on daily basis.

Surprisingly within 3 weeks the Nutrilitefood supplements started showing its result. She started to walk without anyone's help, she started feeling healthy, blood clots started disappearing and her hemoglobin level went normal. She got discharged by 20 days instead of

2 months of doctors' expectation. We were really happy, & moreover mymom is happy about these products. And we got back our mom's life.

So, why can't you also go ahead and helppeople who are in danger, who are in need of more food supplement to lead goodhealth, instead of taking chemicals from medical shop?

Now we are so confident of Nutrilite products and want to help as many people as possible to accumulate the blessings fromthem as it happened to my mother.

Next mail will be followed by my wife LeelaJnanesh, where she writes about, how her sister lost 11 KGs of weight within 6 weeks of time.

Regards,

JnaneshRaghavaiah

Off (: - 91 80 66916940 |Mobile (: -9880406803

                                                    

From: Jnanesh, Leela (GE Indust,ConsInd, consultant) [mailto:Leela.Jnanesh@ge.com]

Sent: Friday, June 08, 2007 12:41PM

To: Raghavaiah, Jnanesh

Subject: FW: Positrim WeightManagement – A Success story:

Greetings,

I am Leela Jnanesh, Software engineer,working in Bangalore.

I would like to share a success story with team.

Two months back I came to know about theNutrilite Positrim Weight Management Program, which helps to lose weight scientifically.

Just to brief about Positrim WeightManagement, it is a scientific, comprehensive and easy to follow program. This program provides a simple plan for weight management, which

 comprises of losing weight sensibly andsafely and thereafter maintaining the ideal weight.

 

I thought it might help my sister, as she weighs 74kilos, and also she wanted to reduce her weight at the least 20Kilos.

I suggested her Nutrilite Positrim WeightManagement Program. She started it and found positive results. After 1 month 15

days she saw a downfall in weight by 11 Kilos. That is she

weighs 63kilos now. And she wants to continueit for 1 more month.

With this my family is very much happy &looking for a handsome guy.

 

Positive results:

·       She is healthy & active than earlier,

·       No shrink marks on skin, even on face,an evenly reduce of weight all over the body.

·       Now my sister is so confident aboutthis product and she wants to help as many people as possible to accumulate the blessings from them as it helped her.

So, why can't you also go ahead and helpthose people who wants to lose their weight & want to lead a healthy life, insteadof taking other X branded chemical based weight reducing program?

Regards,

Leela Jnanesh

---------- Forwarded message ----------From: Mohammed Fayaz <mfayazu66866@rediffmail.com>Date: 15 Jun 2007 07:10:47 -0000 Subject: Take the help of Nutrilite Food supplementsTo: ankur668661 <ankur66866@gmail.com>Cc: kashyap1 <kashyap@dypatil.edu >

Hi Ankur and Kashyap,

We are in the deal of accumulating the blessings of our family, friends and relatives and many more people because of this crazy business. Here is  one more testimony from Nutilite products from Sharada's mom.

Sharada and Dilip's faith in the products and business helps them to retail 500 PV each and every months before we even realize it. We believe they will set a trend of 20 people like them in their group to have 10000 pv volume.

75 People to Chennai Summer Conference from 9 Legs/ 5 Eagle to Eagle club Aug 07/Starting Platinums Aug 07 with 15 Growing working legs.Fayaz Fayiza

sharada shenoy <atiyashenoy@yahoo.co.in> wrote:

hi FAYAZ/FAYIZAi just read Jnanesh & leela's experience about the magic nutralite products have done in their life i would like to add to this.... my mom was having untollerable pain in the ankles 3months ago we had been to 6 doctors and they dint know what the reason was for the pain as well how to reduce it.....it was so bad that she couldnt walk without support and she started being at home all day her outdoor activities got reduced.... it was the same time dilip n me got into the business because of u and fayiza. we started with nutralite with the faith that it would reduce my mom's pain but now no one can tell she was going through all this.....with the help of protien powder her pain is reduced to the extent that she doesnt have them at all and now she is more active in her day today work as well she goes for her regular walk!! not only her leg pain decreased her DIABITIES is reduced to normal...... she is soo happy about the product that she helped me retail a nutralite protien powder to two of her friends yesterday!!now my mom has started taking iron folic and call mag too....... thanks to u both for being there with us all the timesharada dilip!!

USAGE OF SUPPLEMENTS FOR SPECIFIC AILMENTS

About Hair Health

Healthy hair is not only a pleasure to behold, it is pleasing to the person that has it. A single follicle on the human scalp produces approximately .35 millimeters of hair shaft per day. The cycles of growth of each follicle consist of the building up and tearing down of the structure. After a period of rest the follicle is built anew from raw materials and each hair follicle goes through these identical processes as it grows longer and stronger. A high-quality liquid multivitamin supplies the body with the proper amino acids, vitamins and minerals that you may not be receiving in your diet to help create beautiful hair.

It is important to point out at this point that many of the metabolic requirements of the cells of the hair follicle must be met at this time or adequate and optimal hair growth will not occur. This means that certain vitamins and minerals must be present in adequate proportions or there will be faulty or nonexistent hair growth. Research has shown that in our hurry up world of fast food, and extreme work schedules we have developed extraordinarily poor eating habits. This extremely poor diet affecting our general health and energy levels and makes our fingernails weaker and our hair thinner and far less healthier.

Along with stress, toxins in the environment, exposure to the sun, cigarette smoke (actively or passively inhaled), excess alcohol consumption and lack of sleep sometimes makes our bodies work overtime to maintain a standard of marginal health - not optimal.

These factors may lead to a decline in our cosmetic appearance, including our hair, being compromised and weakened. Because we consider our hair to be expendable and not needed to maintain your health, at least our physical health, it tends to be the last part of us to receive attention.

The result of this is dull, lifeless hair, or even retarded (slowed) hair growth. What should enhance our best features has become a deterrent to our beauty as individuals and the way others possibly perceive our health and how attractive we appear to them. This does not have to be so. Remember, people subconsciously use triggers like how healthy your face or hair is to make a subconscious judgment about your overall health.

Taking proper, daily vitamins and minerals plays a huge role in keeping your hair healthy. Any nutritional deficiencies can lead to thinning hair or even total baldness. It is a well-known fact that an under-active thyroid can result in frizzy or brittle hair while an overactive thyroid turns hair greasy and limp. The goal is proper supplementation and proper nutritional balance.

In an older person the total number of the capillary loops (blood source) supplying the hair follicles is considerably diminished. This diminution (reduction) of blood supplied to the hair follicle would require either greater blood flow through these follicles or an increased amount of nutrients of various types such as vitamins, minerals and amino acids in order to supple the hair follicle with the same amount of these materials. Since the former is unlikely, as blood vessels are decreasing instead of increasing, it appears that the latter course, mainly supplying more nutrients, would be the most logical way to keep the hair follicle in its “younger” state.

Your hair ultimately reflects the overall condition of your body. If your body is healthy and well-nourished, your hair will be your shining glory. If you are having any health problems or suffering from any nutritional deficiencies, your hair may stop growing or show damage or become brittle. If your body is in good health, you can maximize your genetic growth cycle through taking the

proper blend of amino acids and B-vitamins.

It is also important to include B-6, biotin, inositol and folic acid in the supplemental program. It has been found that certain minerals including magnesium, sulfur, silica and zinc are also very important toward maintaining healthy hair.

Beta-carotene is also important to hair growth. This is so because beta-carotene is converted to vitamin A as the body needs it, helps maintain normal growth and bone development, protective sheathing around nerve fibers, as well as promoting healthy skin, hair and nails.

Besides making lifestyle changes, taking the following supplements every day is recommended to boost your hair growth:

Certain vitamins, minerals and amino-acids are crucial to the metabolic pathways involved in keratin protein (hair) metabolism. Without the nutrients cited, it is well known that the hair growth process will slow or cease, leading to a potential loss of hair and substantial degradation of hair health. There is a rather adequate research basis to justify product effectiveness claims for a vitamin, mineral and amino-acid complex designed to supply the nutrients needed by healthy growing hair. Think about it. How many sick people do you know with a full head of healthy hair?A good multivitamin is the foundation of health and nutrition

Healthy Hair Vitamins

Vitamin A - Antioxidant that helps produce healthy sebum in the scalp. o Food sources: Fish liver oil, meat, milk, cheese, eggs, spinach, broccoli,

cabbage, carrots, apricots and peaches. o Daily Dose: 5,000 IU. o Warnings: More than 25,000 IU daily is toxic and can cause hair loss and other

serious health problems. Vitamin C - Antioxidant that helps maintain skin & hair health.

o Food sources: Citrus fruits, strawberries, kiwi, cantaloupe, pineapple, tomatoes, green peppers, potatoes and dark green vegetables.

o Daily Dose: 60 mg. Vitamin E - Antioxidant that enhances scalp circulation.

o Food sources: Cold-pressed vegetable oils, wheat germ oil, soybeans, raw seeds and nuts, dried beans, and leafy green vegetables.

o Daily dose: Up to 400 IU. o Warnings: Can raise blood pressure and reduce blood clotting. People taking

high blood pressure medication or anticoagulants should check with their doctors before taking Vitamin E supplements.

Biotin - Helps produce keratin, may prevent graying and hair loss. o Food sources: Brewer's yeast, whole grains, egg yolks, liver, rice and milk. o Daily dose: 150-300 mcg.

Inositol - Keeps hair follicles healthy at the cellular level. o Food sources: Whole grains, brewer's yeast, liver and citrus fruits. o Daily Dose: Up to 600 mg.

Niacin (Vitamin B3) - Promotes scalp circulation. o Food sources: Brewer's yeast, wheat germ, fish, chicken, turkey and meat. o Daily dose: 15 mg. o Warnings: Taking more than 25 mg a day can result in "niacin flush" - a

temporary heat sensation due to blood cell dialiation. Pantothenic Acid (Vitamin B5) - Prevents graying and hair loss.

o Food sources: Whole grain cereals, brewer's yeast, organ meats and egg yolks. o Daily dose: 4-7 mg.

Vitamin B6 - Prevents hair loss, helps create melanin, which gives hair its color. o Food sources: Brewer's yeast, liver, whole grain cereals, vegetables, organ

meats and egg yolk.

o Daily dose: 1.6 mg. o Warnings: High doses can cause numbness in hands and feet.

Vitamin B12 - Prevents hair loss. o Food sources: Chicken, fish, eggs and milk. o Daily dose: 2 mg.

All the suggested Vitamins and the quantities are present in one Daily tablet

Healthy Hair Minerals

Calcium - Essential for healthy hair growth. o Food sources: Dairy, tofu, fish, nuts, brewer's yeast, beans, lentils and sesame

seeds. o Daily dose: Up to 1,500 mg. o Warnings: Too much calcium can inhibit the absorption of zinc and iron; An acid

found in chocolate can inhibit calcium absorption. Chromium - Helps prevent hyperglycemia and hypoglycemia, both of which can cause

hair loss.. o Food sources: Brewer's yeast, liver, beef and whole wheat bread. o Daily dose: Up to 120 mg. o Warnings: People who are allergic to yeast should not take chromium

supplements. Copper - Helps prevent hair loss as well as defects in hair color and structure.

o Food sources: Shellfish, liver, green vegetables, whole grains, eggs, chicken and

beans. o Daily dose: Up to 3 mg. o Warnings: High levels can lead to dry hair, hair loss and sever health problems.

Iodine - Helps regulate thyroid hormones and prevents dry hair and hair loss.o Food sources: Fish, seaweed, kelp, iodized salt, garlic. o Daily dose: 150 mcg.

Iron - Prevents anemia and hair loss. o Food sources: Liver, eggs, fish, chicken, whole grains, green vegetables and

dried fruits. o Daily dose: 15 mg.o Warnings: Too much can lead to malfunctions of the liver and spleen.

Magnesium - Works with calcium to promote healthy hair growth. o Food sources: Green vegetables, wheat germ, whole grains, nuts, soy beans,

chickpeas and fish. o Daily dose: 280 mg.

Manganese - Prevents slow hair growth. o Food sources: Whole grain cereals, eggs, avocados, nuts, seeds, beans, peas,

fish, meat and chicken. o Daily dose: 3-9 mg.

Potassium - Regulates circulation and promotes healthy hair growth. o Food sources: Avocados, bananas, lima beans, brown rice, dates, figs, dried

fruit, garlic, nuts, potatoes, raisins, yams and yogurt. o Daily dose: 3,500 mg.

Selenium - Keeps skin and scalp supple and elastic. o Food souces: Brewer's yeast, meat, fish, grains, tuna and broccoli. o Daily dose: 55 mcg. o Warnings: An excess of Selenium can be toxic, leading to the loss of hair, nails

and teeth. Silica - Strengthens hair and prevents hair loss.

o Food sources: Seafood, rice, soybeans, green vegetables. o Daily dose: 55 mcg. o Warnings: An excess of Selenium can be toxic, leading to the loss of hair, nails

and teeth.

Sulfur (methyl-sulfonyl-methane or MSM) - Sulfur is a main component to hair's structure.

o Food sources: Onions, garlic, eggs, asparagus, meat, fish and dairy products. o Daily dose: 1-3 g.

Zinc - Zinc and Vitamin A work together; a deficiency in either can lead to dry hair and oily skin.

o Food sources: Spinach, sunflower seeds, mushrooms, whole grains, red meat and brewer's yeast.

o Daily dose: 12 mg. o Warnings: Too much can interfere with iron absorption.

Recommendation:Daily, Parselenium E, Salmon Omega and Cal-Mag combined have all the ingredients in necessary quantities.Except for the ones marked in blue.

Looking at the above vitamins/minerals and quantities, Nutrilite Daily is must for any one who wants to maintain healthy hair and for people suffering for Hair loss.

Salmon Omega-3 for Heart health

Currently 170 million people in India are suffering from heart diseases. That’s close to 17% of the population now.

60% of heart patients across the world would be Indian by 2010 – WHO

By looking at the above facts and results, it becomes obvious that we need to take care of our heart and make sure that we are less prone to heart related problems. To take care of heart, we need to check and maintain the levels of fatty acids present in our body.

Human body has two types of fatty acids. a. Poly unsaturated fatty acidsb. Saturated fatty acids

Poly unsaturated fatty acids are not synthesized in the body and they need to come through our food. They are also called essential fatty acids. They are of two types Omega-6 fatty acids and omega 3 fatty acids.

Omega-6 fatty acids come through sunflower oil, corn flower oil etc.

Omega-3 refers to a category of long-chain polyunsaturated fats in which the first unsaturated bond, a double bond, is in the third position from the first carbon. There are three main types of these fatty acids:

Alpha-Linolenic acid (ALA) Eicosapentaenoic acid (EPA) Docosahexaenoic acid (DHA)

Studies have shown that omega-3 fatty acids reduce cardiovascular disease incidence. People at a risk for coronary heart disease benefit from consuming omega-3 fatty acids from plants and marine sources. Sources that contain high amounts of Omega-3 fatty acid include fish and fish oil.

Evidence from prospective secondary prevention studies suggests that taking EPA+DHA ranging from 0.5 to 1.8 grams per day (either as fatty fish or supplements) significantly reduces deaths from heart disease and all causes.  For alpha-linolenic acid, a total intake of 1.5–3 grams per day seems beneficial.

The AHA Dietary Guidelines recommendation is to include at least two servings of fish (particularly fatty fish) per week. Fish is a good source of protein and doesn’t have the high saturated fat that fatty meat products do.  Fatty fish like mackerel, lake trout, herring, sardines, albacore tuna and salmon are high in two kinds of omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).

Randomized clinical trials have shown that omega-3 fatty acid supplements can reduce cardiovascular events (death, non-fatal heart attacks, non-fatal strokes).  They can also slow the progression of atherosclerosis in coronary patients.  However, more studies are needed to confirm and further define the health benefits of omega-3 fatty acid supplements for preventing a first or subsequent cardiovascular event.

Increasing omega-3 fatty acid intake through foods is preferable.  However, coronary artery disease patients may not be able to get enough omega-3 by diet alone.  These people may want to talk to their doctor about taking a supplement.  Supplements also could help people with high

triglycerides, who need even larger doses.  The availability of high-quality omega-3 fatty acid supplements, free of contaminants, is an important prerequisite to their use.

Source: American Heart Association (AHA)

Omega-3 fatty acid deficiency symptomsDry +/- scaly +/- flaky +/- lackluster skin

Dry, lackluster or unruly hair

Dandruff or hair loss

Soft, fraying or brittle fingernails

Slow growing fingernails

Cracking/peeling skin (e.g. fingertips)

Patchy dullness on skin

Raised nodules on the back of the upper arm

Menstrual cramps & premenstrual breast pain

Excessive ear wax

Frequent urination & excessive thirst

Impaired memory

Vision impairment

Depression

Crave fatty foods

People with conditions such as autism and schizophrenia often have abnormalities in fatty acid metabolism, in which case the optimum intake of fatty acids would be different to that of the general population. Any one with a serious health condition would ideally work with a health professional who can give individualized nutritional advice. It is not enough to simply increase omega-3 fats, omega-6 fats must also be reduced for an optimum effect. Omega-3 and omega-6 fatty acids compete for sites in cell membranes where they play an important role in regulating cellular function.

=======================================================================Heart Vitamins

An essential part of maintaining your health, heart vitamins contribute to the well-being of your cardiovascular system as well as the rest of your body. Therefore, you have to be sure to include them in your diet to prevent heart disease and the onset of other preventable conditions.

What are heart healthy vitamins?Of all the essential nutrients that our bodies need on a regular basis, vitamins are perhaps the most researched and well-known. Ever since we were children, we were told of the importance of taking our vitamins. These nutrients help our body perform hundreds of different functions and without we simply cannot survive.

Heart vitamins are specific vitamins which contribute to overall heart health and function, while helping prevent heart disease and other cardiovascular issues.

The most important group of vitamins specifically for heart health is the B Vitamin Family. These vitamins serve specific functions that can significantly reduce your risk of developing heart disease.

The B Vitamins, specifically folic acid (Vitamin B9), Vitamin B6 and Vitamin B12 are all

responsible for helping the body remove homocysteine from the blood. High levels of homocysteine can cause artery damage. Meat is a good source of B vitamins, which is why vegetarians have an increased risk of dangerous homocysteine levels. It is especially important that they supplement these important heart healthy vitamins.

Vitamin B3, known more commonly as niacin, may also reduce cholesterol in high concentrations, although further testing is needed to prove this conclusively. As far as other heart vitamins are concerned, Vitamin E and Vitamin C work in conjunction with each other to prevent heart disease and other ailments through their antioxidant abilities.

Antioxidants are substances that remove toxic byproducts of chemical reactions in the body. That's why you hear so much about antioxidants - they are responsible for clearing out highly reactive chemicals that circulate in the body, making sure they don't cause cell and tissue damage. It is this damage that is believed to cause heart disease, cancer and premature aging.

Although these are extremely important, there are many other nutrients that you need to maintain the health of your heart.

Remember that your heart is responsible for delivering oxygen and nutrients to your entire body, so not only do you need nutrients that strengthen the heart but also nutrients for the rest of your body.

These include heart vitamins as well as minerals, amino acids, Omega 3 fatty acids and herbal extracts, many of which offer more potent health benefits than vitamins.

Soy and Cholesterol

The link between soy and cholesterol has been a hot topic in recent years, as nutritionists have been comparing soy-based diets of Asian cultures with non soy-based diets of the West. Recent research suggests that soy may play a role in the fact that the cardiovascular disease death rate in Americans is more than double that in Japan.

What is soy and how are soy and cholesterol related?Soy comes from the soy bean, which is a member of the pea family. Soy is a legume, meaning it takes in nitrogen and converts this nitrogen into protein.

Soy protein contains all of the amino acids the body needs, and has become very popular in recent years as a substitute for animal protein. In 1999, the FDA boosted soy protein's popularity by allowing manufacturers to indicate that these products may help reduce the risk of heart disease.

In terms of the link between soy and cholesterol, 27 clinical studies pointed to soy protein's ability to lower LDL cholesterol levels. One of the studies published in the New England Journal of Medicine in 1995 concluded that soy protein can significantly lower total and LDL (bad) cholesterol as well as triglycerides (fats), another leading risk factor of heart disease.

What are soy isoflavones?Soy, like all plants, contains many different chemical components. One of these components is a class of phytoestrogens called isoflavones, which are a relatively weak form of estrogen. Isoflavones have been the topic of much recent debate, as evidence of their effect on the body is mostly inconclusive.

Many believe the benefits of soy isoflavones are as follows:

Some say soy isoflavones may help protect against cancer. They can suppress the production of stress proteins, which facilitate cancer cell survival. Soy isoflavones also have antioxidant abilities, meaning they can help rid the body of toxic chemicals called free radicals, therefore warding off disease, illness, and premature aging.

For women, soy isoflavones have been shown to prevent estrogen-related bone loss and can

reduce some of the symptoms of menopause.

However, much more research has to be conducted regarding soy isoflavones' role in cancer prevention and menopause alleviation.

Pls refer to for detailed info:

http://www.healthy-heart-guide.com/ http://www.healthy-heart-guide.com/heart-nutrients.html

RESEARCH PAPERS & OTHER REFERENCESDate: Wed, 20 Dec 2006 20:04:42 -0800 (PST)From: Madhu Ramanna < madhu.ramanna@yahoo.com>Subject: Arthritis papers and gifs + glucosamineTo: Sapna <nsapna.b@gmail.com >

Hi Sapna,

Glucosamine is a supplement that is known to help arthritis. In some cases it has reversed osteo arthritis. Its use has resulted in marked decrease of knee replacement surgeries as reported in Annual European Congress of Rheumatology 2005 in Vienna by Karel Pavelka, M.D.,

I'm attaching a paper published in British Society of Rheumatology about taking glucosamine for arthritis. Have attached pictures showing healthy joint, arthritis joint and info about glucosamine. Have also attached abstract by Karel Pavelka.

regards,

Madhu

Glucosamine for Osteoarthritis

Rheumatology 2004;43:100–101 doi:10.1093/rheumatology/keg458Advance Access publication 16 July 2003Debates in RheumatologyThis house believes that we should adviseour patients with osteoarthritis of the kneeto take glucosamineJ. J. Manson and A. RahmanIntroductionGlucosamine is a natural aminomonosaccharide, which is a normalconstituent of glycosaminoglycans in cartilage matrix and synovialfluid. Oral glucosamine is taken by patients with osteoarthritis inthe belief that it can improve symptoms and act as a diseasemodifyingagent. It is not available for prescription as a drug, sothat patients generally have to buy it. This can represent asignificant cost. Rheumatologists have not reached a consensus asto whether the evidence in favour of glucosamine is strong enoughto justify our advising patients to take it [1]. This issue was debatedat the Centre for Rheumatology, University College HospitalsLondon NHS Trust on 6 February 2003. The debate is summarizedbelow.PropositionOsteoarthritis of the knee is very common, and patients with thiscondition often suffer greatly from symptoms that may respondpoorly to the available treatments. Some of those treatments,notably non-steroidal anti-inflammatory drugs (NSAIDs), havemajor adverse effects. Therefore, any new medication which issafe and which shows evidence of even mild beneficial effectsshould be welcomed. Glucosamine is the most convincing productof this type.There are good biological reasons to believe that glucosaminecould have beneficial effects on cartilage in osteoarthritis.Experiments on cultured human chondrocytes have shown thatglucosamine increases the production of aggrecans [2], and reducesthe formation of nitric oxide and interleukin 6 in response tointerleukin 1_ [3]. It may therefore exert both chondroprotectiveand anti-inflammatory effects. Furthermore, experiments inanimals have suggested that circulating glucosamine can localizein cartilage.Although early trials were often of short duration and hadmethodological flaws, a meta-analysis by McAlinden et al. [4]showed that the evidence favoured a modest beneficial effect.Subsequently, two large trials of approximately 200 patients,followed for 3 yr in each case, have confirmed that impression.Both Pavelka et al. [5] and Reginster et al. [6] carried outmethodologically sound, randomized, placebo-controlled doubleblindstudies. In each case, the group of patients treated withglucosamine showed reduced narrowing of the tibiofemoral jointspace at 3 yr compared with the placebo group. This supports thehypothesis that glucosamine acts as a disease-modifying drug inosteoarthritis of the knee. Pavelka’s group also reported that fewerpatients in the glucosamine group reached a cut-off value of 0.5mmjoint space narrowing during the period of the study. This level wasconsidered to represent severe narrowing of the tibiofemoral jointspace.Furthermore, the glucosamine-treated group in each study hadsignificantly better functional outcomes than the placebo group, asmeasured on the Western Ontario and McMaster Universities

(WOMAC) index.Although mild adverse effects such as abdominal pain anddyspepsia were reported, these tended to be transient. There was noconvincing evidence that glucosamine causes severe adverse effectssuch as diabetes mellitus.In conclusion, glucosamine is a safe drug for which a body ofevidence suggests effectiveness in relieving symptoms, increasingfunction and modifying disease progression in osteoarthritis of theknee. We should recommend it to our patients.OppositionGlucosamine is unproven as a treatment in osteoarthritis of theknee. Advising patients to buy it on the basis that it will improvetheir osteoarthritis cannot be justified on the basis of the availableevidence, much of which is flawed.The evidence from the study of cultured chondrocytes in vitro isof dubious relevance to the treatment of osteoarthritis in vivo. Noevidence was advanced in these studies to suggest that osteoarthriticcartilage is deficient in glucosamine, or that the particularfunctional changes demonstrated in the cultured cells couldreverse the changes found in cartilage of osteoarthritic joints.A more important criticism is that the concentrations of glucosamineused in these experiments probably exceed those whichcould be achieved in cartilage following oral administrationof glucosamine. For this reason, the author of a paper on culturedchondrocytes stated that his results could not be applied forexplanation of the therapeutic efficacy of glucosamine [3].Although the systematic review of McAlinden et al. [4] of earlytrials of glucosamine in osteoarthritis concluded that there was amodest beneficial effect, these authors raised a number of seriousconcerns about the six trials that they reviewed. In particular, fourwere funded by drug manufacturers, five had inadequate evidenceof allocation concealment and there was a suspicion of publicationbias in view of the absence of small trials with negative results.Despite the plea of McAlinden et al. for further studiesindependent of pharmaceutical industry funding, the three majorplacebo-controlled studies carried out since that systematic reviewwere all supported by drug manufacturers.Although the studies of Pavelka et al. [5] and Reginster et al. [6]did show statistically significant differences between groups ofpatients treated with glucosamine and with placebo, the clinicalimplications of these differences are not clear. Patients recruited tothese studies had mild to moderate osteoarthritis (Kellgren andLawrence grades 2 and 3 on radiographs). The mean scores on theWOMAC index at baseline were below the midpoints of the scalesand many patients were not complaining of symptoms severe100Centre for Rheumatology, Department of Medicine, University College London, London, UK.Rheumatology Vol. 43 No. 1 _ British Society for Rheumatology 2003; all rights reservedenough to require analgesia; 51% of the patients studied byReginster et al. [6] had not required any pharmacological treatmentfor osteoarthritis in the 6 months prior to enrolment. It is thereforeunclear whether the patients in this trial are representative ofthe majority of patients referred to rheumatology clinics withosteoarthritis of the knee.It is also unclear whether the differences in tibiofemoral jointspace between the glucosamine and placebo groups represent anoutcome that is relevant to the progression of disease in thesepatients. There was no correlation between radiological outcomeand symptoms in either trial. Furthermore, neither trial demonstratedany difference in the use of rescue medications (paracetamol

and/or NSAIDs) between the glucosamine and placebo groups.This argues against the use of glucosamine as a drug that can reducethe need for NSAIDs in osteoarthritis of the knee.In contrast, a third placebo-controlled trial studied an outcomeof immediate clinical relevance in a less circumscribed population.The patients studied by Hughes and Carr [7] had a wide range ofdegrees of severity of osteoarthritis (including some with Kellgrenand Lawrence grade 4 disease) and all of them had suffereddiscomfort in the affected knee on most days in the 3 months beforeenrolment. The primary outcome measure was global assessmentof pain, analysed by an area under the curve technique. Theseauthors found no difference between glucosamine and placebogroups in the primary outcome measure or WOMAC scales,despite the fact that the study was adequately powered.Thus, whereas two studies (funded by a single company)concluded that glucosamine is better than placebo, a third study(funded by a different company) found no such difference. Thethird study was smaller (80 patients) and of shorter duration(6 months) than the first two. However, the first two studies hadmuch higher dropout rates (33–46%) in both the glucosamine andplacebo groups than the third (5 patients out of 80 dropped out),though statistical calculations allowed for this and still showed adifference between glucosamine and placebo in those studies.The opposition therefore concluded that, at best, the publisheddata could only show that glucosamine manufactured by oneparticular company has a mild beneficial effect in patients whohave mild symptoms in the first place. This is not sufficient evidenceto justify asking patients to spend their money on this product,especially as there is no clear rationale to explain its mode of actionin osteoarthritis.DiscussionContributions from the floor showed a range of opinions,underlining the difficulty of reaching a consensus about this issue.A number of speakers explained that they already recommendglucosamine to some patients with osteoarthritis because it is safeand may offer some symptomatic relief in patients who have fewother therapeutic options. This particularly applies to patients whoare highly symptomatic, but in whom structural damage is notsufficient to justify knee replacement surgery. These speakers feltthat the range of patients included in the trials of Pavelka et al. andReginster et al. was broad enough to be relevant to their ownpopulations of patients. The cost of purchasing glucosamine maybe a barrier for some patients, and may be considered beforerecommending it in individual cases.In contrast, some other speakers were troubled by the factthat most of the major studies supporting use of glucosaminewere funded by manufacturers of this product. Some felt that,in advising a patient to spend his or her money on glucosamine,rheumatologists might confer a degree of approval on this productthat is not justified by the evidence. Conversely, it could be arguedthat many drugs of undisputed efficacy are available today asa result of trials funded by the pharmaceutical industry. Thebeneficial effects of glucosamine seem to be relatively modest, andit may be unreasonable to deprive patients of this therapeuticoption just because the evidence is not yet perfect.Interestingly, the vote showed equal numbers for and againstthe motion, with several abstentions. We were unable to reacha clear decision and have therefore not adopted a policy onglucosamine. Individual doctors in our unit must continue tomake their own decisions about whether to recommend this

product to patients, and it is hoped that this debate will helpthem to make that choice.The authors have declared no conflicts of interest.References1. Chard J, Dieppe P. Glucosamine for osteoarthritis: magic, hype orconfusion? Br Med J 2001;322:1439–40.2. Bassleer C, Rovati LC, Franchimont P. Glucosamine sulfatestimulates proteoglycan production in human chondrocytes in vitro.Osteoarthritis Cartilage 1998;6:427–34.3. Shikhman AR, Kuhn K, Alaaeddine N, Lotz M. N-acetylglucosamineprevents IL-1_ mediated activation of human chondrocytes.J Immunol 2001;155:5155–60.4. McAlinden TE, Lavalley MP, Gulin JP, Felson DT. Glucosamineand chondroitin for treatment of osteoarthritis: a systematic qualityassessment and meta-analysis. J Am Med Assoc 2000;283:1469–75.5. Pavelka K, Gatterova J, Olejarova M, Machacek S, Giacovelli G,Rovati LC. Glucosamine sulfate use and delay of progression ofknee osteoarthritis. Arch Intern Med 2002;162:2113–23.6. Reginster JY, Deroisy R, Rovati LC et al. Long term effects ofglucosamine sulfate on osteoarthritis progression: a randomizedplacebo-controlled clinical trial. Lancet 2001;357:251–6.7. Hughes R, Carr A. A randomized, double-blind, placebo-controlledtrial of glucosamine sulfate as an analgesic in osteoarthritis of theknee. Rheumatology 2002;41:279–84.Debate: efficacy of glucosamine in OA of the knee 101

http://www.abstracts2view.com/eular/view.php?nu=EULAR05L1_2005SAT0227&terms=1 of 1 12/21/2006 9:25 AM[2005] [SAT0227] EFFECT OF GLUCOSAMINE SULFATE ON TOTAL JOINT REPLACEMENT, TIME TO SURGERY ANDOUTCOME PREDICTORS: 5-YEAR FOLLOW-UP OF A 3-YEAR TRIAL IN KNEE OSTEOARTHRITISK. Pavelka1, J. Gatterova 2 , G. Giacovelli 3 , M. Olejarova 2 , L.C. Rovati 3 1Department of Rheumatology, Institute ofRheumatology, Prague, 2Department of Rheumatology, Institute of Rheumatology, Prague 2, Czech Republic, 3Departmentof Clinical Pharmacology, Rotta Research Laboratorium-Rottapharm, Monza, ItalyBackground: Glucosamine sulfate prevented radiographic joint space narrowing (JSN) and relieved symptoms in two randomised,placebo-controlled, double-blind, 3-year trials in knee osteoarthritis (OA) (1,2).Objectives: To assess and characterize the effect of glucosamine sulfate on the incidence of joint replacement after a furtherlong-term follow-up.Methods: Knee OA patients from our 3-year study (2), who had been in the trial for at least 12 months and then followed bystandard care after discontinuation of the study medication, were sistematically contacted. One-hundred-thirty-six patients (67formerly on placebo and 69 on glucosamine sulfate), i.e. 78.6% of this original cohort, could be retrieved. Occurrence of jointsurgery was assessed by a standardised questionnaire, checked against patient medical records. Incidence of total kneereplacement was compared between the two former groups and within possible outcome predictors by the chi-square test, withcalculation of Relative Risk (RR). A survival analysis on time to surgery was performed by the Log Rank test. Finally, a subset of101 patients (47 and 54 from the two groups, respectively) accepted to perform also a standing AP knee radiograph according tothe standardised technique used in the trial, for measurement of medial tibiofemoral minimum joint space width (JSW) with a

magnifying glass by two readers, randomising the sequence of radiographs; comparisons were performed by ANOVA. Allassessments were double-blinded.Results: Median duration of follow-up after the trial was for additional 5 years (64 months, range 40-90 months). A total of 14patients, out of the 136 retrieved, had undergone knee replacement: 11/67 previously on placebo (16.4%) and 3/69 on glucosaminesulfate (4.3%), with a 73% decrease in risk with the latter (RR=0.27, 95%CI 0.08 to 0.91, p=0.021). The survival analysis alsopointed out a significant difference in favour of glucosamine sulfate in delaying the recourse to surgery (p=0.023). JSN>0.5 mmduring the former 3-year trial was a good predictor of knee replacement during follow-up, since these patients had a significantincrease in the risk of undergoing this surgery [RR=3.23 (1.15 to 9.02)]. Glucosamine sulfate had decreased by over 60% (from14% to 5%) the proportion of patients with JSN >0.5 mm during the trial.The former placebo patients in which a radiograph was taken at follow-up showed a significant JSN during the trial compared withthose on glucosamine sulfate [mean (and 95% CI) difference in JSW from baseline: -0.07 mm (-0.19 to 0.07) vs. 0.17 mm (0.03 to0.31), respectively; p=0.017], and still tended to have a greater JSN on the overall 8-year observation period [-0.62 mm (-0.82 to–0.41) vs. –0.47 mm (-0.66 to –0.28); NS: p=0.30].Conclusion: Treatment for up to 3 years with glucosamine sulfate decreased and retarded total knee replacement in knee OApatients during an additional follow-up of 5 years after drug withdrawal. This result might be explained by the effect on jointstructure achieved during treatment.References: 1. Reginster et al, Lancet 2001;357:251-6; 2) Pavelka et al, Arch Intern Med 2002;162:2113-23Osteoarthritis Clinical aspects and treatmentCitation: Ann Rheum Dis 2005;64(Suppl III):481Close Window

Glucosamine - Supplements http://www.supplementwatch.com/suplib/supplementPrintFriendly.asp?D...1 of 2 12/21/2006 8:29 AM<< Back to Review PrintGlucosamineDescription Glucosamine is an aminopolysaccharide (a combination of an amino acid -glutamine and a sugar - glucose). Glucosamine is concentrated in joint cartilagewhere it is incorporated in longer chains known as glycosaminoglycans and finallyinto very large structures known as proteoglycans. The proteoglycans function toattract water into the joint space for lubrication of the cartilage during movement.Claims Reverses osteoarthritisProtects joints and tendons from injuryDecreases inflammationTheory The principle behind glucosamine supplementation is that the glucosamine isdelivered to the joint space and incorporated into proteoglycans of joint cartilageto maintain structure and repair damage. Glucosamine may also stimulatechondrocytes (cartilage cells) to begin producing healthy new cartilage matrix(both collagen and proteoglycans).Scientific Support There are numerous European studies showing a clear benefit of glucosaminesupplements for relief of joint pain and stiffness associated with arthritis. Many ofthe studies have been criticized for lack of scientific control, short duration andsmall size, but recent meta-analyses of the smaller studies have supported thebeneficial role of glucosamine supplements as a safe and effective approach totreating osteoarthritis. In general 1-3 months of glucosamine supplementationseems to be more effective than a placebo and at least as effective as analgesicand non-steroidal anti-inflammatory drugs (NSAID), like acetaminophen andibuprofen, in reducing the joint pain of osteoarthritis. Until more rigorous studiesare conducted in the United States, the Arthritis Foundation has stated that itcannot recommend glucosamine supplements as a treatment for osteoarthritis, butthis stand has not stopped the Foundation from accepting financial support fromthe producer of the best selling brand of glucosamine supplements on the market– Rexall Sundown’s Osteo-Bi-Flex. Perhaps the supplements with the best clinicalsubstantiation are Dona from Rotta Labs and Cosamin from NutraMax Labs.Safety Occasional symptoms of gastrointestinal discomfort have been noted, but nosignificant adverse effects have been noted with glucosamine supplementation.Although there have been no long-term safety studies conducted in humans,animal studies on glucosamine have found it to be non-toxic. Diabetics may wantto exercise a degree of caution when using glucosamine supplements, as therehave been several animal studies and one small human pilot study that havesuggested an increase in blood sugar levels during regular glucosamineconsumption (though most of the animal studies have used injections ofglucosamine).Value Glucosamine supplements tend to be among the more expensive products on theshelf. A one-month supply of capsules can range from $15 to well over $100.Because they have to be consumed for 1-3 months before any noticeable benefit isapparent, you may need to invest a significant amount of money before yourealize any benefits. However, because arthritis pain is one of the most debilitatingconditions, most people dealing with such pain would gladly invest a dollar or soper day in a supplement that relieved their discomfort and helped repair theirdamaged cartilage tissue. For people with existing chronic joint pain, glucosaminesupplements are probably worth the significant dollar investment for the benefitsthat they deliver. For those individuals with intermittent joint pain or those withmore mild joint stiffness, the high cost associated with glucosamine supplementsmay not be justified - and the money might be better spent on other morerelevant supplements.Dosage No dose-response studies have been conducted with glucosamine supplements.Virtually all oral supplementation studies on glucosamine have used 1500mg perday - usually in 3 divided doses of 500mg each. While this level appears to be an

Glucosamine - Supplements http://www.supplementwatch.com/suplib/supplementPrintFriendly.asp?D...2 of 2 12/21/2006 8:29 AMeffective dose, there is no information to suggest that a higher does would workbetter or faster - or that a lower dose would be less effective. A commonsupplementation strategy, which can decrease the daily cost of supplements, is toconsume 1500mg of glucosamine per day for the first 60-90 days of your regimen,followed by a reduced intake of 250-750mg per day as a "maintenance level."Following the initial 60-90 day period, dosage levels can be increased or decreasedbased on individual pain and stiffness levels.RelatedSupplementsChondroitinReferences 1. Barclay TS, Tsourounis C, McCart GM. Glucosamine. Ann Pharmacother. 1998May;32(5):574-9. 2. da Camara CC, Dowless GV. Glucosamine sulfate forosteoarthritis. Ann Pharmacother. 1998 May;32(5):580-7. 3. Deal CL, MoskowitzRW. Nutraceuticals as therapeutic agents in osteoarthritis. The role ofglucosamine, chondroitin sulfate, and collagen hydrolysate. Rheum Dis Clin NorthAm. 1999 May;25(2):379-95. 4. Delafuente JC. Glucosamine in the treatment ofosteoarthritis. Rheum Dis Clin North Am. 2000 Feb;26(1):1-11. 5. Denham AC,Newton WP. Are glucosamine and chondroitin effective in treating osteoarthritis? JFam Pract. 2000 Jun;49(6):571-2. 6. Donohoe M. Efficacy of glucosamine andchondroitin for treatment of osteoarthritis. JAMA. 2000 Sep 13;284(10):1241;discussion 1242. 7. Houpt JB, McMillan R, Wein C, Paget-Dellio SD. Effect ofglucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. JRheumatol. 1999 Nov;26(11):2423-30. 8. Leeb BF, Schweitzer H, Montag K,Smolen JS. A metaanalysis of chondroitin sulfate in the treatment of osteoarthritis.J Rheumatol. 2000 Jan;27(1):205-11. 9. Leffler CT, Philippi AF, Leffler SG, MosureJC, Kim PD. Glucosamine, chondroitin, and manganese ascorbate for degenerativejoint disease of the knee or low back: a randomized, double-blind,placebo-controlled pilot study. Mil Med. 1999 Feb;164(2):85-91. 10. Mautone G.Efficacy of glucosamine and chondroitin for treatment of osteoarthritis. JAMA. 2000Sep 13;284(10):1241; discussion 1242. 11. McAlindon TE, LaValley MP, Felson DT.Efficacy of glucosamine and chondroitin for treatment of osteoarthritis. JAMA. 2000Sep 13;284(10):1241. 12. McAlindon TE, LaValley MP, Gulin JP, Felson DT.Glucosamine and chondroitin for treatment of osteoarthritis: a systematic qualityassessment and meta-analysis. JAMA. 2000 Mar 15;283(11):1469-75. 13. RindoneJP, Hiller D, Collacott E, Nordhaugen N, Arriola G. Randomized, controlled trial ofglucosamine for treating osteoarthritis of the knee. West J Med. 2000Feb;172(2):91-4. 14. Towheed TE, Anastassiades TP. Glucosamine and chondroitinfor treating symptoms of osteoarthritis: evidence is widely touted but incomplete.JAMA. 2000 Mar 15;283(11):1483-4.copyright supplementwatch Inc. 2006

Soy protein ingredients and their health benefitsSHANNON L. KOSKIProtient, Inc.1751 West County Road BSuite 200St. Paul, Minnesota 55113, USA

ABSTRACTThis paper is a literature review and summary of studies conducted worldwide evaluating the health benefits of soy protein ingredients. The focus is on soy proteins and isoflavones and their role in maintaining women's health, heart health, bone health, muscle mass and prostate health in men. In each case,consumption of soyfoods is attributed to positive changes in health attributes in men and/or women.

INTRODUCTIONIn supermarkets everywhere, retailers are reorganizing shelves to make room for soy containing foods. This trend can be attributed to the increased consumer acceptance of soy, which is linked to the growing awareness of soy as a healthy food ingredient. Soy as an ingredient comes in several forms including soy oil, lecithin, meal, flour, protein concentrates and isolates. The healthy attributes of soy have been linked to the isoflavones naturally occurring in soy in conjunction with the soy protein. Therefore, this paper will focus on the latter four soy ingredients (meal, flour, concentrates and isolates) as these are shown to result in the most health benefits.Soy isoflavones are phytochemicals that offer specific biological effects. They are considered to be possible selective estrogen receptor modulators but possess nonhormonal properties thatalso may contribute to their effects (1). Soybeans contain two primary isoflavones, genistein and daidzein. A third isoflavone, glycitin is present in smaller amounts. Typically, genistein is found at the highest level in soyfoods, although the source of beans and how they have been processed does have an effect on the ratio of isoflavones (2). Soybeans are the only food source that contains nutritionally significant amounts of isoflavones, adding to their allure. Isoflavones are not water soluble and can be lost during processing as they may be washed away during alcohol extraction. There can be as much as an eightfold variation in isoflavone content in soy ingredientsmaking it imperative that formulators consider isoflavone levels of an ingredient before choosing it for their soy food (2). The second constituent of high nutritional regard in soy is the protein component. Soy protein is a complete protein, meaning it contains all of the indispensable amino acids required by the body in the correct proportions and amounts to meet human needs for growth, maintenance and repair of living tissues. Soy protein is the only complete plant based protein which is available to those maintaining a vegetarian lifestyle and is equal in protein quality to milk, whey, meat and egg proteins.Soy protein and the component parts, the amino acids, serve as building blocks for synthesis of protein into skeletal muscles. Muscles need protein to repair, rebuild and grow. In accordancewith the guidelines given by WHO/FAO/UNU, soy protein used as a sole source of protein in the daily diet will support normal muscle formation and maintain nitrogen balance in both children and adults (3). A great deal of research has been conducted in both animals and humans to determine the healthy effects of soyfoods. Because of the chemical similarity of isoflavones to estrogen, much of the research has been centered on women's health issues where a variety of benefits have been shown. Some of these include reduction of menopausal symptoms and breast health. General population studies have also been conducted and have found that soyfoods may promote heart health and cholesterol reduction, bone health, muscle mass, and prostate health in men. Each of these topics will be discussed in detail, with only human studies included and cited as the animal studies are less relevant.

WOMEN'S HEALTHFor many women, menopausal hormonal changes lead to uncomfortable physical and psychological symptoms. An increasing number of women are avoiding oestrogen treatmentdue to side effects and fear of increased risk of cancer. Due to a much higher incidence of Western women reporting hot flashes than Asian women, it is thought that soy isoflavones

may exert oestrogenic effects. The effectiveness of phytooestrogen is supported by a prospective study of post menopausal Japanese women that suggests an inverse association between hot flashes and soyfood consumption. In this study, women taking 51mg/day isoflavones were half aslikely to have symptoms as those taking 20 mg/day (4). Nearly all studies reported a 20-30 percent reduction in symptoms in the placebo group, and additional reductions of 10-20 percentwere seen in intervention studies using soy foods, soy protein isolate and soy extracts providing 30-100 mg/day isoflavones (5). The epidemiologic data supporting an inverse association between phyto-estrogens and breast cancer risk are suggestive of benefits, but not strongly so. Data from a study conducted in China reports that women who consume greater quantities ofsoy foods as adolescents have lower breast cancer risk as adults (6). A study performed using Asian-American subjects confirmed these results. Thus, it appears that soy phytoestrogensare cancer preventative, particularly when consumed early in life (5).

HEART HEALTHThe effects of soyfoods on cardiovascular health and cholesterol levels are by far the most studied aspects of soy health effects. In human clinical intervention trials, soy product consumption reduces levels of total cholesterol and low-density lipoprotein cholesterol.Soy consumption also can improve plasma lipids while the isoflavones reduce low-density lipoprotein oxidation and improve vascular reactivity (7). In 1995, meta-analysis of thirtyeight controlled clinical trials examining the relationship between soy protein consumption and serum lipid concentration in humans was completed and prompted the US Food and Drug Administration to approve a health claim for the relationship between consumption of soy protein and reduced risk of coronary heart disease.

The results of this meta-analysis found that the consumption of soy protein rather than animal protein significantly decreased serum concentrations of total cholesterol, LDL cholesterol andtriglycerides without significantly affecting serum HDL cholesterol concentrations (8). This health claim has significantly raised awareness in the US of the healthy attributes of soyfoods. Another important study because of its size was conducted on Chinese women and confirmed aninverse relationship between soy intake and cardiovascular disease. 75,322 women living in Shanghai, China between the ages of 40 and 70 years participated in a study to examine therelationship between soyfood intake and incidence of coronary heart disease.After a mean of 2.5 years of follow-up, sixty two incident cases of coronary heart disease were documented. There was a clear monotonic dose relationship between soyfood intake andrisk of total coronary heart disease (P for trend=0.003) with an adjusted relative risk (RR) of 0.25 observed for women in the highest versus the lowest quartile of total soy protein intake.The inverse association was more pronounced for nonfatal myocardial infraction (RR=0.14; P for trend=0.001) for the highest versus the lowest quartile of soy intake (9). This study provides direct confirmation that soyfood consumption may reduce the risk of coronary heart disease.

MUSCLE MASSProtein plays an important role in building and maintaining muscle mass. Studies have shown that soy protein, a high quality protein, supports formation of lean body mass, enhances muscle recovery and reduces the oxidative stress or muscle inflammation in exercising individuals (13).Soy protein contains higher levels of the essential amino acids arginine and glutamine.Arginine promotes anabolic activity of muscles that result in muscle formation while glutamine buffers lactic acid build-up to reduce fatigue during and after exercise. In the past decadeseveral studies have been conducted in the United States and European Universities and Sport Physiology Research Institutes on the favorable effects of soy protein on lean muscle mass development, performance and chemical markers of muscle fatigue as well as muscle recovery time following strenuous training. The results of these studies comparing soy protein to whey protein or casein indicate that soy protein supplementation results in measurable effects in strength and endurance and afavorable effect on the chemical markers of muscle fatigue in athletes using soy versus other protein sources (13). In another study, lean body mass was examined in males from a university weight training class given daily servings of protein bars containing whey or soy (33 g protein/day, 9 weeks, n=9 for each protein treatment group).A control group did the training, but did not consume either type of bar. Both the whey and the soy treatment groups showed a gain in lean body mass, but the training-only group did not. Only the soy group showed the added benefit of preserving two aspects of antioxidant function, while

the whey and training only groups saw and increase in radical scavenging capacity (a negative antioxidant activity) (14).Thus, there are strong supporting results that soy is an appropriate protein source for improved muscle mass and potentially for improved antioxidant activity as well.

PROSTATE HEALTHData on soy effects in men's health is much more sparse compared to women, but several studies show promising results. Soyfoods are a unique dietary source of isoflavones, which have both hormonal and non-hormonal effects related to prostate cancer prevention. In vitro, the main soybean isoflavone, genistein, inhibits prostate cancer cell growth.Currently, there is limited epidemiologic data to indicate soy intake reduces cancer risk, but results from a pilot intervention trial suggest that isoflavones may be beneficial to prostatecancer patients. For several reasons, men concerned about their prostate health may consider incorporating soy into their diets (3).

BONE HEALTHAfter menopause, women experience up to a ten fold increase in the rate of bone loss (10). Since bone loss is generally thought to be related to a decline in estrogen levels, there has been great interest in the possibility that soy phyto-estrogens might exert similar effects as endogenousestrogen and prevent the development of osteoporosis. Due to the high intake of soyfoods in the Asia-Pacific diet, much data is available from the region on the effect of soy intake as related to bone mass. One study was conducted using a cross-sectional study of the effects of soybean protein intake on bone mineral density and biochemical markers in eighty five postmenopausal Japanese women.Stepwise multiple regression analyses showed that soy protein intake is significantly associated with the Z-score for lumbar spine bone mineral density (beta=0.225, p=0.04) and urinary deoxypyridinoline among four nutritional factors.These results suggest that high soy protein intake is associated with a higher bone mineral density and a lower level of bone resorption (11). Another study investigated the effect of soy isoflavone intake on the maintenance of peak bone mass in 132 Hong Kong Chinese women ages 30-40 years old. Baseline measurements of spinal bone mineral density were obtained as well as dietary intake of soy foods and other key nutrients including calcium were recorded.Repeated measurements were obtained yearly for three years. At the conclusion of the study, it was shown that soy intake had a significant effect on the maintenance of spinal bone mineral density in women 30-40 years of age (12).The evidence that isoflavones have clinically importantbenefits on bone health is suggestive but not conclusive, and more research is needed in this area (5)

CONCLUSIONThough stronger research and data exists in some areas more than others, soyfoods have been found to have advantageous health benefits for many ailments. Soy protein and isoflavones can help reduce menopausal symptoms in women as well as prevent breast cancer if consumed at an early age. Soy also is beneficial to maintain heart health and lowcholesterol, bone health, muscle mass and prostate health in men. Given the increasing number of products containing soy, and the improving flavor of such products, soyfoods should beincorporated into the diet of most adults for their numerous health benefits.

Rediff News: Protein Powder as a cure for Hair Loss

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Going bald? Try these solutions

Dr Parul Kolhe

August 09, 2005

Name the one hair problem that causes the most amount of anguish among men? You're right. It's baldness. In the past, men would simply accept it and get on with their lives.

But today's generation is more conscious about their looks. They demand explanations and, luckily for them, in some cases there are solutions as well.  

This is where we dermatologists can help

Blame it on testosterone

The basic cause of male pattern hair loss -- or Androgenetic Alopecia as it is technically known -- are the male hormones.

The hair's response to these hormones is genetically determined. The more baldness genes you inherit, the worse your problem. So, if your father and mother's family have the baldness gene, you are much more likely to develop this problem.

When will you hair begin to fall?

Once you reach adolescence and your male hormones activate, they start affecting your hair which is genetically programmed to fall in response to testosterone.

The hair fall may start as early as adolescence but becomes visible a bit later. This depends on factors like your initial hair density, the speed with which you are losing hair and how vigilant you are about your problem.

The loss of 50-70 hair strands a day is normal. Any more, and visible thinning is apparent.

Your hairline first begins to recede from the forehead and the sides. The next stage is thinning on the top of your scalp. The progressive final stages are when this receding hairline meets the baldness on top. Finally, only a thin fringe of hair around the sides and back of the head is left.

Most men realise they are faced with a balding problem when they are 25-35 years old but it is not uncommon to see this

problem manifesting itself much earlier these days.

Baldness vs   other types of hair loss

Hair loss could be caused by many other reasons -- the most common being stress, prolonged illness or poor nutrition.

Hair falls about eight to 10 weeks after the occurrence of these causes. If you have worked late nights and long hours on a project, been sick with typhoid or had any long illness or surgery, or have been on a strict diet two months ago, that could be the cause of your present hair loss.

This type of hair loss does not follow the pattern of frontal recession like male pattern baldness. It also stops after a few weeks of consuming a high protein nutritious diet, iron and multivitamin supplements and destressing.

Dieticians recommend protein powders like Nutrilite (an Amway product that costs Rs1,550) or Ensure (Rs175, available at all chemists).

Help is at hand 

Most men, especially those who fall in the younger age group, get extremely upset about male pattern balding. Don't worry, several solutions are available nowadays.

Get in touch with your dermatologist to assess the severity of your hair loss. S/ he will then get you started on a treatment programme (these medications need a prescription).

~ You may be started on a lotion called Minoxidil, available as Mintop (with all chemists, Rs 175 for two percent and Rs 375 for five percent) or Coverit (Rs 135 for two percent and Rs 300 for five percent).

~ Combinations of Minoxidil with other drugs are also available as Trigaine liquid (Rs180). This must be applied very carefully. Exactly one millilitre should be measured out and spread over the scalp twice a day.

 ~ Do not apply any hair oil as the medication will not get absorbed.

The medicine takes about six weeks to show its effect and will have to be used in the long term.

~ Oral medications like Finasteride may also be used to treat severe cases, but this MUST be taken under medical supervision.

The alternatives

~ Hair transplants are fairly common these days. They cost approximately between Rs 1 and Rs 1.5 lakhs and involve transplanting single hair strands from the back and side of the scalp to the front and top.

However, keep your expectations realistic -- you can't look as good as you did 10 years ago.

~ If that option is too expensive, hair weaves can be made on order (about Rs 7,000-Rs 15,000 depending on the sizeof your bald patch).

These are synthetic hair strands, carefully chosen to match your hair type, woven into a skin coloured mesh that approximates the shape and size of your bald patch and can be clipped or glued on your scalp.

They look quite natural and are indistinguishable from the real thing.

So, whatever your budget, there are ways to tackle this problem. Do not lose heart, because you CAN control that receding hairline.

Do you have a skin query for Dr Parul Kolhe? Write to us.

Dr Parul S Kolhe is an M B B S, DDV and DNB in dermatology.