PRODUCT CATALOGUE 2012 - Conseil –...

BioVectra Inc. [email protected] www.biovectra.com

PRODUCT CATALOGUE

2012

Bridging chemistry and biotechnology

Company Profile

BioVectra Inc. is an Eastern Canadian supplier to the global pharmaceutical and biotechnology industries,

operating from three, FDA-inspected facilities. This agile and steadily growing company has been in

business since 1970, and has an impressive track-record in the quality of services and products provided to our global customer base.

Our facilities are equipped to provide synthetic organic chemistry, natural extraction of bioactive

compounds from both plant and animal-based biomass sources, PEGylation and conjugation chemistry,

and fermentation of a variety of molecule types.

A key component of our service is our Quality history: to date, BioVectra has submitted 9 product filings, including DMF, VMF, and CMC section preparations for both the United States Food and Drug

Administration (U.S. FDA), and Health Canada. These filings have been made for both synthetic and

biologic molecules, and include a human injectable API, as well as a final drug product.

BioVectra is ‘bridging chemistry and biotechnology’’ – offering drug development companies a unique mix of skills that can be applied to molecules requiring more than one processing technique, and an ability to

be a full-service, drug development partner.

Contract Fermentation Services

We have produced recombinant proteins from E. Coli (three different expression systems in two different hosts), secondary

metabolites from fungal systems, and also, unique marine bacterial systems producing small molecule entities. Handling of

cytotoxic, clinical-scale fermentations can be managed to a containment level <1ug/m3 OEL. All downstream process design

is done on a project-specific basis, but BioVectra can work with various modes of process-scale chromatography, as well as

ultrafiltration and diafiltration.

BioVectra can also perform post-fermentation modifications unlike many other biologics CMO’s. BioVectra has two, 4000

Litre reactors, and can perform synthetic modification of molecules following primary fermentation. It has experience in

performing PEGylation, and conjugation with targeting agents, and can easily design process flow to allow for proper

containment and handling of these complex molecules, since its cGMP facility has each of these processing suites within one

overall cGMP facility.

Natural Extractions of APIs

Another basic competency of BioVectra is in the isolation, extraction, and purification of natural bioactives. Within its

completely segregated facility, animal-based bioextractions can be conducted, and BioVectra currently produces two

commercial API’s from animal-based biomass. All materials procurement and handling fall under strict BSE/TSE risk

prevention procedures.

Plant-based bioextractions are also an inherent skill in the BioVectra organization, and we can both develop and optimize

extraction processes, and undertake commercial-scale extraction at a processing level of 1000 Kg biomass/day.

MPEG reagents and PEGylation

We aim to be your MPEG supplier of choice, and we have been steadily building our experience in terms of product

development and manufacturing, to demonstrate our quality and capability in this area. We offer a product catalogue,

consisting of both low molecular weight, monodispersed PEGs, and higher molecular weight MPEG reagents, suitable for

direct conjugation to drug molecules.

To date, BioVectra has supplied MPEG and PEG reagents up to Phase III clinical development, and has submitted a DMF for

a custom MPEG reagent on behalf of a specific client. We have experience producing MPEG Propionaldehyde, Amine,

Maleimide, Epsilon Maleimide, Iodoacetamide, and Nitrophenyl Carbonate chemistries, to a high purity and low

polydispersity.

Products

Active Pharmaceutical Ingredients & Advanced Intermediates

PRODUCT NAME

13-Acetyl-9-Dihydrobaccatin III (9DHB)

Purity ≥ 80%

High purity intermediate

CAS #: 142203-65-4

13-Acetyl-9-Dihydrobaccatin III (9DHB)

Purity ≥ 95%


CAS #: 142203-65-4

API-Grade Paclitaxel (Semi-Synthetic)

USP-grade API suitable for formulation

CAS #: 33069-62-4

API-Grade Docetaxel (Semi-Synthetic)

API suitable for formulation

CAS #: 114977-28-5

10-Deacetylbaccatin III (10-DAB)


CAS #: 32981-86-5

Active Pharmaceutical Ingredients & Advanced Intermediates

Dihydrobaccatin III (9DHB)

Dihydrobaccatin III (9DHB)

Synthetic)

grade API suitable for formulation

Synthetic)

DAB)

AcO

CH3

OH

O

H OAc

OBz

CH3

CH3

AcO

OH

CH3

OH

AcO

CH3

OH

O

H OAc

OBz

CH3

CH3

AcO

OH

CH3

OH

NHO

O

CH3

CH3

CH3

O

O

OH

CH3

CH3

O

H OAcOBz

CH3

CH3

OOH

OH

CH3

HO

CH3

OH

O

H OAc

OBz

CH3

CH3

HO

OH

CH3

O

CATALOGUE

#

7030

7031

7034

7039

Please Inquire

1

Products

P

CO2H

CO2H

HO 2C

HCl

HO2CP

HO2C

CO2H

.ΗCl

C

N

N N

CH3

CH3

H3C

HCl

HS

SH

OH

OH

HS

SH

OH

OH

Bioprocessing Reagents

PRODUCT NAME CATALOGUE

#

Tris-(2-Carboxyethyl) Phosphine, Hydrochloride (TCEP-HCl)

Reagent used in the reduction of disulfide bonds

CAS #: 51805-45-9

AVAILABLE IN: 10g / 100g

1300

cGMP Tris (2-carboxyethyl) phosphine, hydrochloride (cGMP TCEP-HCI)

For the reduction of disulfide

CAS #: 51805-45-9

1301

1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide Hydrochloride (EDAC-HCl)

Water soluble crosslinker used to conjugate

proteins and polypeptides

CAS #: 25952-53-8

AVAILABLE IN: 25g / 100g / 1kg

1339

Dithioerythritol (DTE)

Reagent used for maintaining thiol groups in a reduced state during protein processing, isolation,

and denaturing

CAS #: 6892-68-8

AVAILABLE IN: 25g / 1kg

1360

Dithiothreitol (DTT)

Purity ≥ 99%

Reagent used for maintaining thiol groups in a

reduced state during protein processing, isolation,

and denaturing

CAS #: 3483-12-3

AVAILABLE IN: 5g / 10g / 25g / 100g / 1kg

1365

2

Products

HS

SH

OH

OH

HS

SH

OH

OH

HS

SH

OH

OH

O

CH2OH

H

H

H

OH

H

OH

OH H

S

CH3

CH3

O

CH2OH

H

H

H

OH

H

OH

OH H

S

CH3

CH3


#

Dithiothreitol - Molecular Biology Grade (DTT-

MBG)

Additional grade of DTT

Additional tests: Protease, Rnase, Dnase, ICP metals

CAS #: 3483-12-3

AVAILABLE IN: 5g / 25g / 100g / 1kg

1365MBG

Dithiothreitol - High Purity (DTT-HP)

Purity ≥ 99.5%


CAS #: 3483-12-3

AVAILABLE IN: 5g / 25g / 100g / 1kg

1369

Dithiothreitol - cGMP (DTT-cGMP)


Additional test: Residual solvents

CAS #: 3483-12-3


1370

Isopropyl-β-D-Thiogalactopyranoside, Dioxane Free (IPTG)

Galactosidase activator

CAS #: 367-93-1

AVAILABLE IN: 1g / 5g / 10g / 25g / 100g / 1kg

1882

Isopropyl-β-D-Thiogalactopyranoside, Non-Animal Origin (IPTG Non-

Animal)

Additional grade of IPTG

CAS #: 367-93-1


1900

3

Products

S

N

N

N

S

N

O3S

SO3 NH4+

NH4+

-

-

Cl

Cl

OH

SO3 Na+-

NN

NN

SO3

SO3

-

-

Na+

Na+

NN

NN

SO3X

SO3XX = H, Na

Clinical Diagnostic Raw Materials


#

2,2'-Azino-di-(3-Ethylbenzthiazoline Sulfonic Acid) Diammonium Salt (ABTS)

A substrate for the detection of peroxidase,

used in diagnostic and biotech assays

CAS #: 30931-67-0


1006

3,5-Dichloro-2-Hydroxy-Benzenesulfonic Acid, Sodium Salt (DHBS)

Hydrogen donor for photometric determination of

hydrogen peroxide, diagnostic and immunoassay

chromagen

CAS #: 54970-72-8

AVAILABLE IN: 100g

1357

5,5' -[3-(2-Pyridyl)-1,2,4-Triazine-5,6 Diyl]-bis-2-Furansulfonic Acid,

Disodium Salt

A substrate used for the detection of iron in clinical

reagents

CAS #: 79551-14-7


1522

3-(2-Pyridyl)-5,6-bis-(4-Phenylsulfonic Acid)-1,2,4-Triazine, Monosodium

Salt

Laboratory reagent used in determining iron levels

in human blood serum

CAS #: 69898-45-9


1542

4

Products

O2N NH

O

NH2

COOH

H2O

NO 2OP

O

O-

O-

Na+

Na+

6 H2O

NO2OP

O

O-

O-

CH2OH

CH2OH

NH3HOH2C

2

+

CO2HOP

O

OH

O-

NH3+

CO 2HOP

O

OH

O-

K +


#

L-γ-Glutamyl-p-Nitroanilide, Monohydrate (GPNA)

Substrate for γ-Glutamyl Transpeptidase

CAS #: 7300-59-6


1664

p-Nitrophenylphosphate, Disodium Salt, Hexahydrate (pNPP-Na)

A substrate for the detection of Alkaline

Phosphatase

CAS #: 4264-83-9


2370

p-Nitrophenylphosphate, Ditris Salt (pNPP-ditris)

A substrate for the detection of Alkaline

Phosphatase

CAS #: 68189-42-4


2372

Phosphoenolpyruvate, Cyclohexylammonium Salt (PEP-Mono)

A substrate for the detection of Carboxylase

CAS #: 10526-80-4


2552

Phosphoenolpyruvate, Monopotassium Salt (PEP-K)

A substrate for the detection of Carboxylase

CAS #: 4265-07-0

AVAILABLE IN: 1g

2553

5

Products


#

Phosphoenolpyruvate, Tricyclohexylammonium Salt (PEP-Tri)

A substrate for the detection of

Carboxylase

CAS #: 35556-70-8


2555

Enzymes


#

Adenosine Deaminase Derived From Bovine Spleen (ADA)

An enzyme used for the determination of adenosine in biological fluids, and for

biochemical transformations in process chemistry (transamination)

CAS #: 9026-93-1

A-020

Cholesterol Esterase Derived From Porcine Pancreas (CE)

An enzyme used in the clinical analysis of serum cholesterol

CAS #: 9026-00-0

C-040

Glutamate Dehydrogenase Derived From Bovine Liver (GLDH)

An enzyme used for in vitro diagnostic determination of blood urea nitrogen

CAS #: 9029-12-3

G-042E

Urease Derived From Jack Bean

For in vitro diagnostic use in the determination of urea nitrogen in biological fluids

CAS #: 9002-13-5

U-080

COOOP

O

O-

O-

NH3

+

3

6

Products

High Molecular Weight Vectra MPEG Derivatives


#

Vectra MPEG Amine 10kDa

MW: 10,000 Da

AVAILABLE IN: Please Inquire

6232


MW: 20,000 Da


6233


MW: 30,0000kDa


6234

Vectra MPEG Propionaldehyde 10kDa

MW: 10,000 Da


6241


MW: 20,000 Da


6242


MW: 30,000 Da


6243

Vectra MPEG Epsilon Maleimide 30kDa

MW: 30,000 Da


6265


MW: 20,000 Da


6266

H3COO

NH2

n

H3COO

NH2

n

H3COO

NH2

n

H3COO H

O

n

H3COO H

O

n

H3COO H

O

n

H3COO

NH

O

N

O

O

n

H3COO

NH

O

N

O

O

n

7

Products


#


MW: 10,000 Da


6267

Vectra MPEG Iodoacetemide 30kDa

MW: 30,000 Da


6293


MW: 20,000 Da


6294


MW: 10,000 Da


Please Inquire

Vectra MPEG p-Nitrophenyl Carbonate 10kDa

MW: 10,000 Da


Please Inquire


MW: 20,000 Da


6296


MW: 30,000 Da


Please Inquire

H3COO

NH

O

N

O

O

n

H3COO

NH

O

In

H3COO

NH

O

In

H3COO

O

O

O N

O

O

n

H3COO

O

O

O N

O

O

n

H3COO

O

O

O N

O

O

n

H3COO

NH

O

In

8

Products

Low Molecular Weight Monodisperse PEGs


#

PEG - Octaethylene Glycol (PEG 8)

n = 8

MW: 370.4

AVAILABLE IN: 5g

10110-0895

PEG - Dodecaethylene Glycol (PEG 12)

n = 12

MW: 546.7

AVAILABLE IN: 5g

10110-1295

PEG-28

n = 28

MW: 1251.5


10110-2895

MPEG - Heptaethylene Glycol Methyl Ether (Methoxy PEG 7)

n = 7

MW: 340.4


10111-0795

MPEG - Undecaethylene Glycol Methyl Ether (Methoxy PEG 11)

n = 11

MW: 516.6


10111-1195

Azido-PEG

n = 7

MW: 395.5


10113-0795

Azido-PEG

n = 15

MW: 747.9


10113-1595

OH

O

H

n

OH

O

H

n

OH

O

H

n

H3CO

O

H

n

OHO

N3

n

OHO

N3

n

H3CO

O

H

n

9

Products


#

PEG tBu-Propionate

n = 12

MW: 674.8

10139-1295

MPEG Propionic Acid

n = 11

MW: 588.7

11137-1195

MPEG Thiol

n = 6

MW: 356.6

11156-0695

MPEG Disulfide

n = 6

MW: 710.9

11157-0695

PEG Diamine

n = 18

MW: 897.1


12112-1895

Azido-PEG Amine

n = 5

MW: 350.4


12113-0595

Azido-PEG Amine

n = 10

MW: 570.7


12113-1095

Boc-Amino PEG Amine

n = 6

MW: 468.6


12114-0695

OHO O

O

n

n

H3COO OH

O

H3COO

SH

n

H3COO

S

n 2

OO

NH2NH2

n

OO

N3NH2

n

OO

N3NH2

n

OO

NHNH2

O

On

10

Products

n

OO

NH O

O

OH

O

OO OH

O

OH

On

n

OO

NH

O

S

NH NH

O

OH

O


#

Boc-Amino PEG Amine

n = 10

MW: 644.8


12114-1095

Biotin PEG Amine

n = 8

MW: 682.9

AVAILABLE IN: 100mg / 1g

12141-0895

Boc-Amino PEG Diglycolic Acid

n = 6

MW: 584.7


14131-0695

Boc-Amino PEG Diglycolic Acid

n = 10

MW: 760.9


14131-1095

Fmoc-Amino PEG Propionic Acid

n = 11

MW: 840

15137-1195

PEG Dipropionic Acid

n = 12

MW: 690.8

37137-1295

Biotin PEG Acid

n = 11

MW: 844


37141-1195

OO

NHNH2

O

On

n

OO

NHNH2

O

S

NH NH

O

n

OO

NHNH

O

O

O

OOH

O

n

OO

NHNH

O

O

O

OOH

O

11

Products

OO

SOH

On 2

OO

SO

O

N

O

O

n

2

n

OO

NHNH

O

S

NH NH

O

O

S

2

O

CH2OH

H

H

H

OH

H

OH

OH H

O NH

Br

Cl


#

PEG Thiol Propionic Acid

n = 7

MW: 458.6

37156-0795

PEG Propionic Acid Disulfide

n = 7

MW: 915.1

37157-0795

PEG-Succinimidylpropionate, Disulfide (PEG NHS Ester, Disulfide)

n = 7

MW: 1109.3

38157-0795

Biotin PEG Disulfide

n = 8

MW: 1540


41151-0895

Molecular Biology Reagents


#

5-Bromo-4-Chloro-3-Indolyl-β-D-Galactopyranoside (X-Gal)

A substrate for β-galactosidase, LacZ indicator and total coliform detection

CAS #: 7240-90-6

AVAILABLE IN: 500mg / 1g / 5g / 10g

1161

OO

SHOH

On

12

Products

NH

Br

ClOP

O

O-

O-

Na+

Na+

O

CH2OH

H

H

H

OH

H

OH

OH H

O NH

Br


#

5-Bromo-4-Chloro-3-Indolyl-β-D-Glucuronic Acid, Cyclohexylammonium Salt (X-Gluc)

Substrate for the detection of the β-glucuronidase

enzyme and in selection of E. coli in water and food testing

CAS #: 114162-64-0

AVAILABLE IN: 100mg / 1g / 5g

1167

5-Bromo-4-Chloro-3-Indolyl Phosphate, Disodium Salt (BCIP-Na)

Substrate for the detection of alkaline

phosphatase, frequently in immunodiagnostic applications

CAS #: 102185-33-1 AVAILABLE IN: 1g / 5g

1171

5-Bromo-4-Chloro-3-Indolyl Phosphate, p-Toluidine Salt (BCIP-T)

Substrate for the detection of alkaline

phosphatase, frequently in

immunodiagnostic applications

CAS #: 6578-06-9


1176

5-Bromo-3-Indolyl-β-D-Galactopyranoside (Bluo-Gal)

Laboratory reagent used in the determination

of positive clones of genetically altered bacteria

CAS #: 97753-82-7


1182

4-Methylumbelliferyl-β-D-Glucuronic Acid (MUG)

β-Glucuronidase substrate for the rapid

determination of E. coli in water and food testing

CAS #: 6160-80-1

AVAILABLE IN: 1g

2251

O

COO

H

H

OH

OH

H

H

OH H

O NH

Br

Cl

-NH3

+

NH

Br

ClOP

O

O-

OH

H3C NH3+

O

CH2OH

H

H

OH

OH

H

H

OH H

OO O

13

Products

N+

N

N

N

H3CO NO 2

SO3

SO3

NO 2H3CO

O

NH

Na+

-


#

Nitro Blue Tetrazolium (NBT)

Used to enhance the color development of BCIP

products in the determination of phosphatase

activity

CAS #: 298-83-9


2344

o-Nitrophenyl-β-D-Galactopyranoside (ONPG)

Substrate used in the detection of β-galactosidase

CAS #: 369-07-3

AVAILABLE IN: 5g

2360

Sodium 3,3′ -{1-[(Phenylamino)Carbonyl]-3,4-Tetrazolium}bis (4-Methoxy-

6-Nitro)Benzene Sulfonic Acid Hydrate (XTT)

Widely used to measure cell

proliferation in toxicity assays

CAS #: 111072-31-2


2525

Neurochemicals


#

Domoic Acid - Mytilus Edulis

A natural plant amino acid which acts as a neurotoxin

CAS #: 14277-97-5

AVAILABLE IN: 5mg / 20mg

1380

N

N

N+

N

O2N

N

N

N+

N

NO 2OCH3

H3CO

Cl-

2

H2O

CH3OH

O

CH2OH

H

H

H

OH

H

OH

OH H

O

O2N

CO2H

H3C

H3C

CO2H

H

NH

CO2H

14

Products

Yeast Genetics


#

5-Fluoroorotic Acid (5-FOA)

Used in the selection of orotidine-5′-phosphate

decarboxylase mutants in yeast research

CAS #: 703-95-7

AVAILABLE IN: 1g / 5g / 10g

1555

αscl-Pheromone (Alpha Mating Factor)

Inhibits DNA synthesis preventing cell division of mating type yeast cells

CAS #: 59401-28-4

AVAILABLE IN: 5mg

5945-5

NH

NH

O

O

F

CO2H

15

Capabilities

What Does BioVectra Specialize in?

• Scaling Projects from development to commercial-scale under appropriate cGMPs We have experience in working with customers from early process research to full commercial manufacturing, and everything

in between. Our organization is fully engaged in the Project Management structure and process; cross-functional teams are

assembled at project inception, and either assigned an R&D, or Manufacturing Project Manager as appropriate. If the

project is at an early-stage, the R&D lead remains in oversight of the process as it transfers and scales from lab to pilot to

manufacturing. BioVectra has filed 7 DMF's, 3 VMF's, 1 ANDA, and written CMC sections for both chemical and biologic

IND filings. We work closely with our clients to define the quality and regulatory requirements of each project, in terms of

scope and product definition.

• Small to Large Scale Fermentation Capabilities (up to 25,000 L) - Shaker flask to 25,000L commercial capacity

- Recombinant proteins (E. coli ), unique fungal and marine bacteria experience

- Production area inspected (2005) for an active DMF; process approved for commercial manufacture

- Large-scale chromatography, ultrafiltration

- 2 x 4000L chemical reactors for post-fermentation synthesis

- Ability to perform conjugation chemistries (PEGylation) and targeting chemistries

• Custom API Synthesis - Pilot equipment from 20L to 800L

- Large-scale equipment up to 4000L reactors

- Depth of experience in diverse synthetic chemistry

- Ability to handle cytotoxics and cytotoxic conjugates

- Experience in producing MPEGs and high-purity polymers

- Can perform post-fermentation or extraction chemistry within a single facility

• Plant bioactive Extraction & Purification BioVectra has experience in natural product isolation, extraction, and purification, that originates back to our beginnings as

a producer of a number of diagnostic enzymes from plant and animal-based biomasses. Since then, we have produced a

number of clinical and commercial API's and Intermediates from plant sources and have a strong competency in the area of

bioactive handling. Starting from our ability to use a full range of analytical techniques and method development experience,

we work with our clients to develop product characterization specifications, in and out, as well as potential process

improvements. We have experience in conducting solid/liquid separations, liquid/liquid separations, and solids processing

with a full range of downstream handling capability. Our process-scale equipment, the 'Littleford' polyphase

extractor/reactor/dryer with an 8000L capacity, can handle 1150Kg of dry product per batch. Our plant-extraction suite is a

self-contained, explosion-proof manufacturing unit within our cGMP facility; we can handle a full range of organic solvent

extractions and related process-scale column chromatography at a column capacity of 400L. We would welcome the

challenge of your extraction project, as our team understands how to structure the technical transfer, scale-up, and

regulatory support program to meet your clinical development goals.

• Large-molecule animal extraction & purification, under strict BSE-Free controls Our self-contained facility at 29 McCarville Street, Charlottetown, has been inspected by the U.S. FDA for a human

injectable API, and is specifically equipped to handle animal-based biomass extractions. This facility features:

- 4000 ft2 of total manufacturing space

- Refrigeration/Freezer storage

- Air-lock separation from primary processing and finishing suites

- Extraction throughput up to 300kg/biomass/day

- Lyophilization (40 ft2 shelf space)

- Flexible utilities for added equipment

- Dedicated to single product processing

• Synthetic modification of bioextracted compounds

• Process-scale chromatography

• Specialty, bioprocessing reagents (DTT, IPTG, DTE, TCEP, etc.)

• Bioconjugations, PEGylation and MPEG reagent production

Contact Us

Mailing Address:

BioVectra Inc.

11 Aviation Avenue

Charlottetown, PE

C1E 0A1 Canada

Tel: (902) 566-9116

Toll Free: (866) 883-2872

Fax: (902) 628-2045

Tel: (866) 883-2872, ext. 6248

Fax: (902) 628-2045

[email protected]

Tel: (866) 883-2872, ext. 6248

Fax: (902) 628-2045

[email protected]

For Desiree Quizon-Colquitt:

509 E. Ironwood Drive

Normal, IL 61761 USA

Tel: (309) 454-7919

Cel: (269) 720-2099

[email protected]

For Lee DesRosiers:

203 Chemin du Canal

Lachine, QC H8S 2P5 Canada

Tel: (514) 564-1664

Cel: (514) 246-5266

[email protected]

Facility Locations:

API Facility

11 Aviation Avenue

Charlottetown Airport Business Park

Charlottetown, PE

C1E 0A1 Canada

BioChem Facility

17 Hillstrom Avenue

West Royalty Business Park

Charlottetown, PE

C1E 2C2 Canada

Bioextraction Facility

29 McCarville Street

West Royalty Business Park

Charlottetown, PE

C1E 2A7 Canada

Distributors

Australia

(For Research-Scale Products & Bioprocess Reagents) ScimaR 4 Ruskin Close

Templestowe, Victoria 3106 Australia

T: (03) 9842 3386 / (800) 639-364 F: (03) 9842 3407 [email protected]

Republic of India

(For PEG Products & Services)

Austin Chemicals 1565 Barclay Boulevard

Buffalo Grove, IL 60089 USA

T: (847) 520-9600 F: (847) 520-9160 [email protected]

France & Belgium

GTH Chimie Fine - Fine Chemicals 72, avenue Charles de Gaulle 60260 LAMORLAYE France

T: +33 3 44 21 60 30 F: +33 3 44 21 60 31

M: +33 6 07 47 90 01 [email protected]

United Kingdom, Ireland, Austria & Switzerland

AS-Tec Chemicals Ltd. AS-Tec House, 5E, Barnfield Way, Millennium City Park, Preston PR2 5DB T: +44(0)1772 495123

F: +44(0)1772 496725 [email protected]

Japan

(For Research-Scale Products)

Nagase & Co., Ltd. Medical Care Products Division

5-1, Nihonbashi-Kobunacho Chuo-Ku, Tokyo 103-8355 Japan

T: +81 (03) 3665-3287 F: +81 (03) 3665-3752

[email protected]

United States of America

Doe & Ingalls of North Carolina, Inc. 1301 Person St.

Durham, NC 27703 USA T: (919) 598-1986

F: (919) 598-1707 [email protected]

People's Republic of China

(For PEG Products & Services)

Austin Chemicals 1565 Barclay Boulevard Buffalo Grove, IL

60089 USA T: (847) 520-9600

F: (847) 520-9160 [email protected]

BioVectra Inc.

11 Aviation Avenue Charlottetown, PE

C1E 0A1

T: (866) 883-2872 / (902) 566-9116 F: (902) 628-2045

[email protected]

www.biovectra.com

PRODUCT CATALOGUE 2012 - Conseil –...

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