ProductBrochure

©Copyright, Shimadzu Scientific Instruments, Inc., 2008 Printed in UKWindows® and Microsoft® are registered trademarks of Microsoft CorporationCLASS-VP® and Discovery VP® are registered trademarks of Shimadzu Scientific InstrumentsPsiPort™ is a trademark of Shimadzu Corporation

Empower™ and Waters® are registered trademarks of Waters Corporation

Founded in 1875 with headquarters in Kyoto, Japan, Shimadzu is a $2 billion multinational corporationwith three major divisions: Medical Diagnostics, Aerospace/Industrial, and Analytical Instruments. TheAnalytical Division is one of the world’s largest manufacturers of analytical instrumentation andenvironmental monitoring equipment. In addition to Japan, Shimadzu products are manufactured inChina, the Philippines, the U.K., and USA. International sales, service and technical support facilitiesare located in UK, Germany, Singapore, Australia, China, Brazil, and Turkey, with numerous offices anddistributors worldwide.

In 2006 Shimadzu UK became a wholly owned subsidiary, Shimadzu UK Limited, based in MiltonKeynes, with a responsibility of sales and service, local marketing and technical support of analyticalinstruments it’s aim is to keep focussed on the specific need of the analyst thus providing the bestpossible ‘solution tool’ for their discipline.

Innovative Research & DevelopmentAt Shimadzu, research and development represents the cornerstone of progress. From its inception,the Shimadzu Corporation has been investing resources to develop advanced technology to providesolutions for science, medicine, industry, and the environment. Many of our patented innovations haveresulted in new discoveries and increased productivity, and have improved the quality of life the world over.

Today, Shimadzu continues the tradition as a global leader in the development of solutions for theworld’s technology hurdles. In 2000, we established the Genomic Research Center in the U.K. andstarted contract biological analysis and trials for CO2 fixation technology. In 2001, we established lifesciences laboratories in Kyoto and Tsukuba to carry out medium and long-term R&D for biologicalinstruments and reagents. At the Technology Research Laboratories, which consists of five researchcentres located throughout Japan, we conduct research and development that results in original cutting-edge technology. In addition, we actively pursue joint research opportunities with universities,large corporations like Bristol Myers Squibb, and government agencies like the National Institutes of Health (NIH).

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Koichi Tanaka Mass Spectrometry Research LaboratoryHeaded by Koichi Tanaka, awarded the 2002 Nobel Prize in Chemistry, this laboratory conducts researchfor the development of new mass spectrometry techniques and equipment for analysing biologicalmacromolecules such as proteins. The aim is to broaden the scope of mass spectrometry by activelypursuing researchers and by participating in joint research projects with leading universities, researchinstitutes, and corporations. Under the guidance of Mr. Tanaka, the spirit of discovery and foundation forsuccess continues at Shimadzu.

Customer Training and Education CentreShimadzu’s prestigious UK offices located in Milton Keynes, include an extensive equipmentdemonstration showroom, a large fully equipped service workshop and customer training facilities.

Shimadzu offers scheduled training courses at competitive rates for advanced equipment and softwareuse as well as applications courses designed by our experts to meet your user’s requirements.

Product Service and SupportThe goal of the Shimadzu product support staff is to ensure our customers’ success with their instruments.Highly trained field service technicians, strategically located throughout the country, are equipped toenable fast and efficient response to any situation. Providing complete piece of mind with respect towarranty repair and support, on going annual preventative maintenance, emergency repair if you need itas well as validation services and user-training courses designed to meet your best expectations.

Shimadzu's Demonstration Facility in Milton Keynes

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Prominence HPLCBuilding on the success of the VP Series, Prominence delivers evenmore accurate and reproducible data while maintaining the flexibility forwhich Shimadzu HPLC instrumentation is known. The modular components interact with the precision of an integrated system whileallowing innumerable configurations–letting you design the system that best fits your needs. Central to the system is the CBM-20A, a single-point controller offering instrument control and monitoring throughyour web browser. The innovative design of the zero-sample-loss SIL-20 autosampler has virtually eliminated carryover without sacrificing the speed demanded by high-throughputlaboratories, offering a cycle time of just 10 seconds.Three pump models are available in the Prominence line, including theLC-20AB, a binary pump combining two of the LC-20AD dual micro-plunger pumps in a space-saving design. For a quaternary pumpingsystem, the new gradient elution valve is installed directly in the pump,reducing delay volumes and saving valuable bench space. The UVdetectors have been refined to be the world’s most sensitive detectorswith unmatched noise and drift specifications (ASTM Methods) and alinearity increase to 2.5AU. A standard temperature-controlled flow cell,improved optical components, and new signal processing technologies combine to yield this exceptional performance. TheProminence Photo Diode Array detector shares these enhancementswith the UV series and results in the world’s most sensitive PDA with linearity to 2.0AU. Forced air column ovens (85°C max temp), high-pressure column switching valves, and low-volume (<400 μL) vacuum degassersare all part of the Prominence series.

Prominence UFLCXR and Shim-pack XR-ODSII(Ultra Fast Liquid Chromatograph)Prominence UFLCXR and Shim-pack XR-ODSII have been developed torealize high speed and ultra high resolution. The new products arecompatible with high speed analysis using high viscosity mobile phase suchas water/methanol combination, and respond to a broader range of highspeed and high resolution applications. The biggest feature of theProminence UFLCXR is, keeping superior basic performance forrepeatability, low sample carryover and high sensitivity, in its maximumapplicable pressure 66MPa from 35 MPa in the Prominence UFLC system.Shim-pack XR-ODSII released at the same time also had its withstandpressure improved to 60 MPa inheriting concept of particle size 2.2um of theexisting Shim-pack XR-ODS, and 150mm length column for ultra highseparation is added to the line-up.

HPLC

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HPLC Front Ends for Mass SpectrometryShimadzu is a leader in HPLC Front Ends for Mass Spectrometry. Users can select from a variety of precise, reliable, and customisablemodular components, or choose a “turn-key” system to meet a specificrequirement. Choose your modular components from among sixautosamplers, including the World’s fastest, lowest carryoverProminence SIL-20A or the SIL-HT, six pumps, which deliver pulse-freeflows from 1 μL/min to 150 mL/min, and nine detectors, including theELSD-LTII. Single-point control is available for all components. Completesolutions include:• Multi-dimensional 2D Capillary-to-Microflow HPLC–offers automated

on-line Proteomics R&D• High-speed Multiplexed HPLC–offers parallel gradient analysis on up

to four columns• SIL-HT Dual Gradient System–offers single-point control of two

independent gradient profiles for alternating analysis (off-line column regeneration) or staggered gradients for rapid serial injections

Software Control – EmpowerTM

Control of Shimadzu’s Prominence Series high performance liquidchromatograph (HPLC) by Waters®’ EmpowerTM/EmpowerTM 2chromatography data system is now available through a collaborationbetween Waters and Shimadzu utilising the “Open Interface Portal (OIP)”for multi-vendor hardware control. Shimadzu Prominence nowseamlessly operates within the Empower software environment.

Full system control, including autosampler control, uses Empowersample set methods, and data processing is integrated with Empowersoftware so that the audit trail functions of Empower software are fullyutilised. This gives you full confidence in the compliance of the systemto regulations such as GMP and 21 CFR Part 11.

HPLC

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HPLC

High Performance Integrated HPLC• LC-2010AHT HPLC• LC-2010CHT HPLC

The LC-2010HT Series HPLC includes two fully integrated models: the LC-2010AHT for ambient and the LC-2010CHT for temperature-controlled samples. Sample injections can be made in as little as 15seconds with excellent carryover performance. Injection accuracy isless than 0.3% RSD. Increased capacity is provided for 1 mL, 1.5 mL, and 4 mL vials, plus 4 x 96 or 384-well titer plates. Setup andoperation have been simplified, with an advanced Graphical UserInterface (GUI) enabling analytical conditions to be set intuitively. Thebuilt-in validation functions save time, effort, and money by reducingoperator interaction during IQ, OQ, and PM functions. System stabilityperformance features can all be automatically checked and loggedusing the standard auto-validation routine.

HPLC Autosamplers• SIL-HTThe SIL-HT combines the extraordinary autosampler from the LC-2010HT with the full-featured VP series system controller. With its high capacity, the SIL-HT increases lab efficiency while its reduced injection time of ~15 sec for a 10 μL injection can increase thethroughput of many labs. Cross contamination is reduced by incorporating nontraditional wetted materials and a patented platinumneedle coating to reduce carryover–even with the most basic andhydrophobic compounds.

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Gas Chromatography Systems• GC-2010 High Speed GC• GC-2014 Flexible, Small Footprint GC

The GC-2010 combines ease-of-use with extraordinary speed and precision to meet all regulatory requirements and provide enhancedproductivity and flexibility for the widest range of applications. The GC-2010 offers up to four high-sensitivity detectors and a large, fast-heating oven. Third-generation AFC (Automated Flow Control) comes standard and ensures superior retention time stability andreproducibility, while 20 temperature ramps and constant linear velocityprovide the ultimate separation tools. High-speed GC is standard with upto a 6-fold decrease in analysis times.The highly flexible GC-2014 Series utilises the high-end technology ofthe GC-2010 to cover a wide range of applications from capillary topacked column analysis. AFC technology comes standard, offeringusers the precision of AFC, automatic and manual flow or pressurecontrol. Functionality can be expanded by installing up to four detectorsand three injectors. The GC-2014 provides complete self-diagnosticsfunctionality and complete logging functions, which are compliant withGLP/GMP requirements. GCsolution Data Station also fully controls andprocesses data for any analysis.

GC Autosamplers/Injectors• HT200H• AOC-5000• AOC-20i/sThe HT200H is a Headspace autosampler made to meet the needs ofstatic Headspace injection for GC analysis.The elegant swivel head design mimics the actions of manual injection.This removes the need for transfer lines and minimises dead volume andsample absorption. The autosampler does not require any bench spacebecause the unit can be mounted on top of the GC. The unit features a40 vial sample tray and a 6 position oven. This maximises the efficiencyof your analysis by incubating samples during analysis.The AOC-5000 provides powerful working capabilities, in liquid injectionmode, every single injection step, e.g. fill/inject speed, pre and post injectiondelay times, pre and post syringe cleaning, variable needle penetrationdepths, or standard addition is individually controlled through the ACO-5000’s advanced software package. LVI (Large Volume Injection) allows youto inject samples up to 500ul in a single stroke without the usual degradationin chromatographic performance.The AOC5000 also has the capability of performing Headspace and SPMEmodes of sample introduction. The automated syringe mechanism avoids theneed for a sample transfer line. The whole system is located on top of theanalyser and takes up no extra valuable bench space.The AOC-20i auto injector provides the highest degree of reliability.Minimising problems such as bent needles, evaporating samples, etc whilstproducing reproducible results. Simple periodic maintenance procedures,such as changing the injection port septa or syringe can be performed inyour lab without fear of adversely affecting the instrument performance.The AOC-20s auto sampler carousel and robotic arm provide sampletransport to the AOC-20i auto injector. It has a sample capacity of up to 1501.5ml vials. It can also accept 4.0ml vials using alternative trays. There areDual Tower versions of the auto sampler available giving it the power to injectsimultaneously onto two columns.

Gas Chromatography

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Gas Chromatography/Mass Spectrometry

Gas Chromatography/Mass Spectrometry Systems• GCMS-QP2010 Plus • GCMS-QP2010s

The GCMS-QP2010 Plus has the greatest sensitivity for any GC/MS with respect to OFN and provides acquisition speeds up to 50 scans persecond. The ability to use virtually any type of column, in EI, CI or NCImode over 1090 Daltons range, with a variety of inert reproducibleinjection systems, makes it the most versatile, accurate, and dependabletool for any analysis. Standard features include 20 temperature rampsand patented constant linear velocity for optimum separation. Design innovations include post-quadrupole focusing lenses, optimised ionoptics, and front access for easy maintenance, while the softwareincludes AART (Automatic Adjustment of Retention Time), FASST (FastAutomated Scan/SIM Technique), and COAST (Creation of AutomaticSIM [Scan/SIM] Table) functions.

Utilizing many of the high-end features of the GCMS-QP2010 Plus, the QP-2010s offers high throughput and excellent productivity, providing userswith an excellent performance-to-cost ratio. It features patented constantlinear velocity for optimum separation, 20 temperature ramps, and bothscan and SIM modes. The SIM mode enables monitoring of up to 64 setsof ions with up to 64 ions per set–potentially determining hundreds of compounds simultaneously. Classical spectrum permits rapid identification of unknowns using commercial libraries, making the QPSeries ideal for a variety of high-throughput applications.

Liquid Chromatography/Mass Spectrometry Systems• LCMS-2010EV • LCMS-IT-TOF • Discovery VP® MS• Prep LC/MS w/PsiPort™ Browser

The LCMS-2010EV is a fully flexible quadrupole MS detector optimizedfor HPLC uses including conventional HPLC, high-speed HPLC, 1-D and2-D-LC, as well as capillary and prep scale separations. It incorporates a drying gas system to create a finer spray mist for highsensitivity, especially for low-to-medium polarity compounds, while providing for high reliability, lower source contamination, and reducedadduct formation. The optical design incorporates patented ion focusing optics to preserve sensitivity by minimising unwanted fragmentation. The analyser includes an octopole for high-efficiency ion transmission, and pre-rods and true hyperbolic main rods for massanalysis. The electrospray (ESI) source (probe) features a metal capillary for reliability and to insure consistent electrical contact with thespray. Both the ESI probe and optional low flow rate APCI probe comeoffering low flow-rate compatibility with expanded operating ranges. Thedual source allows simultaneous ESI and APCI allowing more analytes tobe successfully ionised more of the time. All Shimadzu LC/MS modelssupport the Prominence HPLC and incorporate a multi-sequenceoperation mode, which enables simultaneous data collection with up to64 different monitored combinations within each analysis.

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Liquid Chromatography/Mass Spectrometry Systems continuedThe award-winning Shimadzu LCMS-IT-TOF couples atmosphericpressure ionisation with novel Ion-Trap (IT) technology along with a Time-of-Flight (TOF) mass analyser to deliver high mass accuracy and highmass resolution (10,000 at 1,000 m/z) independent of MS mode. It hasbeen designed to maximise sensitivity and selectivity by optimising theion transport to the TOF analyser and redefines the functions of thequadrupole ion trap. The ion trap is used to focus ions, provide multiplelevels of fragmentation, and function as an electronic gate to dischargeall ions into the TOF. It supports fragmentation, MSn analysis and a highprecursor ion selection (resolution > 1,000 at 1,000 m/z). Using theinformation rich MSn data, the new patent pending Formula Predictorsoftware identifies unknowns with greater certainty. Fast polarityswitching, combined with Compressed Ion Injection, Ballistic IonExtraction, and improved Dual-Stage Reflectron technology, creates atrue benchmark for biomarker discovery, metabolite identification, andnatural products research.

The Prominence system can be configured with a Shimadzu MassDetector, including any of the LCMS-2010 series instruments. Theincorporation of the MS allows anyone to easily use LC/MS for walk-awayanalysis of organic synthesis products. In an analytical mode, the LC/MScan be programmed for automatic operation and set to scan the desiredmass range. The system is available in several versions to allow forsimple analysis for compound confirmation, or with a Mass SamplingHPLC System for mass-directed or mass-informed fraction collection.

Shimadzu’s preparative LC/MS, using mass numbers as a trigger,precisely isolates target compounds, making it ideal for performinginvestigation and research of natural and synthetic compounds. OptionalPsiPort™ Software allows researchers to verify and purify synthesisedcompounds by simply entering the sample information, and alsoincorporates sample tracking and “open access” functions.

Mass Spectrometry

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AXIMA Performance™Axima Performance - a highly flexible research grade mass spectrometer – from highenergy MS/MS of proteomics and other biological and organic samples to uncompromisedanalysis of high mass intact proteins.True high energy MS/MS – CID with a laboratory frame collisionenergy of 20keV Optimal precursor ion selection resolution using revolutionary gatingtechnology.Outstanding sensitivity – uncompromised design, to ensure no MS/MS signal is discarded.

AXIMA Confidence™Taking MALDI-TOF MS Beyond the StandardPowerful MALDI-TOF performance for reliable mass information and MS/MS derivedstructural detail.A flexible system suited to the analysis of a wide variety of sample classes.Intuitive software incorporating data dependant workflows achieving maximum results withminimum user input.

AXIMA Assurance™High Performance Mass DetectionLinear MALDI-TOF mass spectrometry for reliable mass information.An affordable, robust option for all laboratories requiring routine analysis ofOligonucleotides, Proteins/Peptides, Polymers and small molecules.High sensitivity system using a variable repetition rate 50 Hz N2 laser and a variety oftarget formats to meet all sample throughput requirements

Life Sciences

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Automated LC-MALDI Plate SpotterAccuSpot automates LC micro-fractionation, spotting, and preparation forMS analysis. Used in tandem with any HPLC system for precise proteomeanalysis, AccuSpot enables spotting on up to nine microtiter plates in 96 or384 format or 18 2x2 (ABI) format plates. Spotting can be performed ineither continuous or time-specific mode, and users control spottingconditions from a PC. It features automatic addition of matrix solution and astandard CCD camera for monitoring the spotting operation. A “half-contactspotting method” utilizing plate sensors (patent pending) prevents platedamage and eliminates cross contamination.

CHIP-1000™Integrated MALDI imaging made simpleDiscover a completely integrated workflow designed to take the guess work out of tissueimaging.Reproducible automated matrix delivery directly to the sample surface using the CHIP-1000. Deposition of discrete droplets minimising diffusion and maintaining localisation ofcomponents within the tissue.Seamless export of sample location to the Axima™ MALDI mass spectrometer.Automated acquisition of MS data – profiling or Imaging.Visualisation of the spatial distribution of components of interest via intensity mappingsoftware.Easy export of data to alternative processing packages, including BioMAP. Reproducible automated matrix delivery directly to the sample surface using the CHIP-1000. Deposition of discrete droplets minimising diffusion and maintaining localisation ofcomponents within the tissue.Seamless export of sample location to the Axima™ MALDI mass spectrometer.Automated acquisition of MS data – profiling or Imaging.Visualisation of the spatial distribution of components of interest via intensity mappingsoftware.Easy export of data to alternative processing packages, including BioMAP.

Life Sciences

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Data Analysis

CLASS-Agent Integrated Data Management SoftwareCLASS-Agent software provides a scalable solution to 21 CFR Part 11compliance requirements for a wide range of laboratory instruments fromAA and Balances to TOC and UV-Vis. It incorporates audit trail andelectronic signature functions plus secure database archiving forShimadzu Instruments’ control software packages. CLASS-Agentprovides users with a network-based browser for review andauthorisation of data packages. Easy-to-use functions allow users topreview chromatograms, create graphs and reports, and visually overlay multiple files for batch review.

Web-Based Data Review and Acquisition Software for LC/MSIdeal for high-throughput or multi-user programs, PsiPort™ Browser web-based software operates on Microsoft® IE for LC/MS walk-up access,remote data review, and acquisition designed for automated compoundidentification, isolation (up to the gram scale) and/or purification.Supported by just one LC/MS administrator, researchers can view andtrack analytical results and fractions showing mass spectrum andassociated UV, PDA, or ELSD results for each collected product. PsiPortBrowser software supports the Gilson 215 as a fraction collector andautosampler.

Lab Solutions Software• GCsolution Software • GCMSsolution Software• LCsolution Software • LCMSsolution Software

Encompassing GC/MS, GC, LC, and LC/MS control software packages,powerful, easy-to-use Lab Solutions software can enable users tomaximise the full potential of their system quickly and efficiently. All setupand quantitative functions can be performed on one screen and Wizardslead the user through the process. It allows customised applicationsunder software control and provides universal reports for QA/QCverification and GLP/GMP compliance automatically. The systemadministration includes user administration, system policy setting, logbrowser, and audit trails, which support 21 CFR Part 11 compliance. LabSolutions software enables programmable scan and SIM modes andprovides full qualitative and quantitative support. Reports can becustomised to any format with no macros required.

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UV-Visible Spectroscopy• UV-2450 UV-Vis Spectrophotometer• UV-2550 UV-Vis Spectrometer

Superbly engineered for demanding applications, the UV-2550, with itsdouble-blazed grating, double monochromator (DDM) design, and theUV-2450 single monochromator system are ideal for resolving an array ofsample types. The UV-2550, with a unique combination of low stray light,wide dynamic range, and small beam size, performs flawlessly from smallsample volumes to highly absorbing samples. Think of the UV-2450 whensamples require ultra-small beam size and high sensitivity.

UV 1800In addition to achieving a resolution of 1 nm, the highest in its class, byusing a monochromator with a Czerny-Turner mounting, the UV-1800also features a compact, bright optical system. Having a resolution of 1nm makes it easy to satisfy the standards of wavelength resolutiondemanded by the European Pharmacopoeia. The UV-1800 alsoconforms to the specifications demanded by the JapanesePharmacopoeia in relation to wavelength accuracy and photometricaccuracy. Additionally, hardware validation based on the JapanesePharmacopoeia can be performed using validation software that isincorporated as a standard feature and an optical filter for wavelengthcalibration that is calibrated at a bandwidth of 1 nm.

Available as either a stand-alone instrument or a PC-controlledinstrument, the UV-1800 is USB-memory ready, which enables users tosave measurement data to highly versatile USB memory, and performdata analysis and printing using a PC.

UV-Vis-NIR and Deep UV Spectrophotometers • SolidSpec-3700• UV-3600

The new SolidSpec-3700 UV-Vis-NIR Spectrophotometers come in twomodels: the 3700 for standard applications and the 3700DUV for deepUV measurement to 165 nm. All UV-Vis-NIR models are equipped withthree detectors, which ensure high sensitivity during transmittance andreflectance, even in the switchover range, to significantly reduce noise.The 3700 units have large sample compartments for easy measurementwhile maintaining sample integrity. A wide variety of accessories,including the Automatic X-Y Stage for automated measurements, expandstheir applications.The UV-3600 combines research-grade UV-Vis or UV-Vis-NIR opticalperformance with the ease and familiarity of PC operation. Specialisedaccessory and software packages provide solutions in the analysis offilms, powders, coatings, plastics, and liquids.

UV-VIS Spectroscopy

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UV-VIS Spectroscopy

Compact Mini Series• UV Mini • BioMini

The compact, versatile, easy-to-use Shimadzu Mini UV-Visspectrophotometers provide performance features found only in moreexpensive instruments. Standard on-board application modes in the UVMini include photometric, spectrum, and quantitation. Optional programpacks are available to expand instrument functionalities. The BioMini is designed for bioscience applications. Standard on-boardapplication modes include nucleic acid analysis, protein analysis, andspectrum measurement. The nucleic acid module includes quantitationmethods for double and single-stranded DNA, RNA, and standardWarburg-Christian. DNA companion programs assist in easy calculationof molecular weight and molar extinction coefficients. DNA meltingcalculations provide information for optimisation of PCK andHybridisation. The Mini Series incorporates a universal sample compartment thataccommodates a complete line of accessories. UV Data Managersoftware provides unlimited data storage with expanded archiving andmanagement capabilities.

UV Probe Software for Windows®

UV Probe Software for Shimadzu’s full line of UV-Vis spectrophotometersand accessories offers intuitive operation with customised screens andreport generation, including multi-page reports. Validation featuresinclude audit trail for GLP compliance. A new user authentication toolprovides strict security with centralised management of ID codes andpasswords to ensure full compliance with 21 CFR Part 11 via UV ProbeAgent. Multiple Michaelis Menten calculations, including Hill andInhibitor tables, can be performed and saved in memory for easyretrieval. User-defined custom equations are also possible. An optionalprogram enables users to export UVPC file format data for color and filmthickness analysis.

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FTIR Spectrometers• IRPrestige-21• IRAffinity-1

Shimadzu’s IRPrestige-21 features a highly optimised, high-energythroughput optical system that results in a S/N ratio of 40,000:1. It offersexpansion capabilities to the Near IR, Mid IR, and Far IR ranges and the“Quick Start” automatic accessory function, which recognises installedaccessories and automatically sets appropriate measurement methods.Coupled with Advanced Dynamic Alignment, a triple protectioninterferometer, and temperature-stabilised DLATGS detector, theIRPrestige-21 is the ideal solution for a wide range of applications,including thin layers.The IRAffinity-1 is the most in-demand general-use instrument for FTIR,and was developed as the successor to the FTIR-8400S. The hardwarespecifications are significantly improved in comparison with the FTIR-8400S. For example, the S/N ratio, which is emphasized in FTIRselection, is 30,000:1 or better, the best in its class. The instrument alsofeatures a maximum resolution of 0.5 cm-1, and a built-in auto dryer. Inaddition, it has been miniaturized thanks to improvements to the opticalsystem, providing about a 20% reduction in width and installation spacein comparison with the FTIR-8400S.

Automated AIM-8800 FTIR MicroscopeThe AIM-8800 FTIR Microscope offers advanced features to enable fast,easy sample positioning and efficient analysis of microscopic defects orcontaminants in a wide range of materials. All microscope operations,including aperture setting, focusing, and positioning, are controlledautomatically on the PC screen. Each AIM-8800 system comesequipped with video display and screen capture capabilities via the on-board CCD camera. AIM View software can memorize X, Y, Zcoordinates with aperture size and position for up to 12 samplepositions. With the mapping module in IRsolution, complete automationis easily achieved. A range of accessories includes ATR and 4Xobjectives, sampling tools, and beam switching/reflectance kits.

IRsolution Software for FTIR OperationsPowerful IRsolution software provides quick and easy Windows®-basedsoftware control for the FTIR-8400S and IRPrestige-21. Fully secure andcompliant with GLP/GMP, ISO-9000 series, and FDA 21 CFR Part 11regulations, its versatility makes it ideal for use in high-level R&D and forroutine work within QA/QC departments or educational institutions.Functions include Peak detection, difference spectrum calculation,Kubelka-Munk conversion, and ATR correction.IRsolution software includes comprehensive help functions and apowerful report generator. Reusable print templates can be createdusing any data including the spectrum, calibration curve, quantitationresults, and peak pick tables.

FTIR/Fluorescence

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FTIR/Fluorescence

Fluorescence Spectrophotometers• RF-5301PC Fluorescence Spectrophotometer

Shimadzu opens up a new spectrum of fluorescence analysis with avariety of spectrofluorophotometers for applications from routine analysisto research. The high-throughput optical system in the RF-5301PC allowsthe measurement in seconds, and the narrow bandpass makes itpossible to distinguish fluorescent peaks from excitation wavelengths.Ideal for applications in such areas as pharmaceuticals andpharmacology, food science, and environmental monitoring, the RF-5301PC with Windows®-based software is the perfect partner for anylaboratory.

Fluorescence Software for Windows®

The Windows-compatible, full-featured Panorama software for the RF-5301PC enables multi-component sample analysis and provides three-dimensional spectral plots to facilitate a wide range of life scienceand environmental applications. Panorama software provides completeGLP/GMP compliance functions, including password protection andreport trails. Highly flexible data management capability includes datasharing, import and export, and customised report layouts. Super Ion Probe software provides an enhanced system for measuringintracellular ions with the RF-5301PC. Ion concentrations andintracellular pH can be measured using indicators such as Fura-2, Quin-2, or BCECF. This easy-to-use software for Windows permitssimultaneous measurement of up to four wavelength sets for multiplefluorescent probes.

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Multitype ICP Emission Spectrometer Shimadzu’s simultaneous ICPE-9000 can be used in application stagesfor a wide range of high-precision analytical assessments. Innovative,easy-to-use ICPEsolution Software features a Method DevelopmentAssistant that automatically selects optimal wavelength and allowsspectral interference correction for coexisting elements; a databasecalibration feature, and a Diagnosis Assistant. The ICPE-9000 utilizes a large-scale one-inch CCD detector withincreased pixel size and an Echelle spectrometer to enable high-speedmeasurement with high resolution. An extremely stable vacuumspectrometer equipped with semiconductor detectors, the first of its kindin an ICP emission spectrometer, demonstrates stable, sensitiveperformance over extended periods. The ICPE-9000’s innovative,vertical Mini Torch cuts cost by reducing consumption of argon gas tohalf that of conventional torches and minimises contamination andblockages.

Atomic Absorption (AA) Spectroscopy• AA-6800 Atomic Absorption Spectrometer• AA-6300 Atomic Absorption Spectrometer • AA-6200 Atomic Absorption Spectrometer• ASC-6100 Atomic Absorption Autosampler

The AA-6800 Series takes AA functionality and ease of operation to ahigher level. It was the first AA that automatically switched from flame tofurnace via the keyboard, eliminating time-consuming hardwarechanges and optical alignment. If high background is a problem in yourAA analysis, the EPA-approved self-reversal and deuterium backgroundcorrections are in the AA-6800 and AA-6300. The AA-6300 also includesa dual-detector system to ensure maximum sensitivity for all elements. The AA-6200 is the lowest cost automated flame/furnace AA on themarket. It includes flame and EX-7 graphite furnace analysis with truedouble beam optics, deuterium background as standard, a PC, and theunique ASC-6100 autosampler. The ASC-6100 autosampler is the only autosampler that can be used forflame and furnace analysis. In addition, it is the only AA sampling systemthat can mix any combination (up to five solutions) into a homogeneousmixture for furnace analysis. Newly designed flame and furnaceatomisation units ensure unmatched sensitivity and reproducibility.

WizAArd SoftwareWindows®-based AA Wizard software enables fast, easy setup ofinstrument and measurement parameters, and analysis procedures.Analysis results, conditions, and procedures can be viewedsimultaneously on the same screen. QA/QC functions, which conform toEPA methods and GLP, ensure data reliability.

Atomic Spectroscopy

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Atomic Spectroscopy - HPV-1 Camera

Energy Dispersive X-ray Fluorescence SpectrometerShimadzu’s EDX Energy Dispersive X-ray Fluorescence Spectrometer isused for trace and rapid analysis of elements within a sample. The EDXseries can be used for regulatory compliance (e.g. RoHS and ELV)and/or quantitative analysis and monitoring processes. For example, theEDX series can rapidly screen for elements controlled by the RoHS andELV directives. A non-destructive technique, the EDX can accommodate samples up to300 mm wide and 150 mm high, with an automatic opening/closing door.With Standard-less Quantitative Analysis Software, the EDX series can beused for various applications, as it can switch calibration curves based onsample type differences and automatically select the appropriatecalibration curve. In addition, it is equipped with different types of filtersthat reduce and eliminate background, characteristic lines, and otherforms of scattered radiation, and consecutively distinguish between different elements without using expensive standards.

HPV-1 HyperVision CameraShimadzu’s High-Speed Video Camera HyperVision HPV-1 offers world-class ultra-high-speed video recording of up to one million frames per second. The HPV-1 permits recording of ultra-high-speed phenomena with resolution and totalframe capture not previously possible, serving in a wide variety of fields requiringhypervelocity imaging: shock waves, ballistics, materials failure, aerodynamics, particleimaging velocimetry, micro-scale blast wave phenomena, fluid dynamics, nebulization,ignition and combustion, biomedical imaging research, neuroscience, biomechanics, andsports science.

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Combustion TOC-VC and Total Nitrogen (TN)Analysis SystemsThe TOC Visionary Series includes seven different models for TotalOrganic Carbon (TOC) as well as Total Nitrogen (TN) measurement. TheTOC-Vc Visionary Series utilises a platinum-aided catalytic combustiontechnique. Each unit can be operated stand-alone or PC-controlled.TOC Visionary Systems enable automatic multipoint calibration from asingle standard and an external sparge option can double samplethroughput.The total nitrogen option permits simultaneous TOC and TNmeasurements. An optional air purifier can eliminate the need for costlyand dangerous purified gases. A septum piercing autosampler acceptsfour vial sizes.

Wet Chemical TOC-VW Shimadzu’s TOC-VW can be operated as a UV/Persulfate TOC, aHeated/Persulfate TOC, or as a unique Heated-UV-Persulfate TOCsystem. The three oxidation methods ensure rapid breakdown of difficult-to-oxidize compounds and shorter analysis time. The analyser canhandle particulates up to 1.6 mm in diameter, the largest for anycommercial analyser. The TOC-VW has the lowest detection limit (0.5ppb) for any laboratory TOC on the market. The newly designed NDIRdetector has five orders of magnitude linearity. Over-range samples canbe compared with up to three calibration curves automatically.

Environmental Analysis

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Environmental Analysis

On-line Analysers: Total Nitrogen/TOC• TOC-4110 • TN-4110 • TOCN-4110• TOC-VCSH • TNPC-4110

The TOC-4110 Series includes one model dedicated for TOC, one forTN, and one that can simultaneously measure both TOC and TN. TheSeries offers a number of capital as well as operational cost-reducingfeatures. A single unit can analyse up to seven different streams. Theoptional “Sample Thief” eliminates the need for expensive filters whenanalysing particulated sample streams. The on-board air purifier eliminates the need for expensive and dangerous gas cylinders andpermits standard house air to be used as the carrier gas. For TOC/TNanalysers, the proven combustion oxidation method eliminates the needfor chemicals and reduces maintenance requirements. An online version of its powerful TOC-Vc Series Analysers, the TOC-VCSH is a process-type TOC that can simultaneously measureTOC and TN, with an optional TNM module. The unit enables automaticmultipoint calibration from a single standard, and is equipped with adetection limit of 4 ppb and measurement capability up to 25,000 ppm.Existing TOC-Vc lab units can be upgraded to the Online TOC-Vc.Incorporating many of the capital and operational cost-reducing features, the TNC-4110C Series Analysers are capable of measuring TN,and TOC in water.

TOC Accessories & AutosamplersShimadzu offers a number of high-performance, high-value accessoriesand autosamplers to meet a range of sampling needs, including: • Total Nitrogen Module, TNM• ASI-V Autosampler• SSM-5000A Solid Sample Module• OCT 8 or 16-Position Autosampler• Carrier Gas Purification Kit• Gas Sample Injection Kit

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Global ActivitiesShimadzu is a truly international company with sales and production facilities located throughout theworld. Our overseas network is segmented into North America, Central and South America, Europe,China, and Asia-Oceania. In each of these regions we have established unique business modelsdesigned to best respond to the particular requirements of varying cultures. We are actively workingtowards expanded internationalisation of technological development through greater cooperation inthe areas of research, development, and sales. Shimadzu is striving to grow our business in a manner that reflects the importance of our partnerships with our customers worldwide.

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Founded in 1875, Shimadzu Corporation, a leader in the development of advancedtechnologies, has a distinguished history of innovation built on the foundation ofcontributing to society through science and technology. We maintain a global network ofsales, service, technical support and applications centers on six continents, and haveestablished long-term relationships with a host of highly trained distributors located inover 100 countries. For information about Shimadzu, and to contact your local office,please visit our Web site at www.shimadzu.com.

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SHIMADZU UK LTD.Mill Court, Featherstone Road, Wolverton Mill South, Milton Keynes MK12 5RDPhone: 08708 375200, Fax: 08708 375211info@shimadzu.co.ukURL: www.shimadzu.co.uk