Processing PIB Demographics - ESMI · • SPM analyses Processing PIB ... – AAT comprehension...
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DIMI - Workpackage 8.2. - Leuven Parametric brain mapping of Abeta-amyloid deposition in AD using 11 C-PIB Neurology : R. Vandenberghe, M. Vandenbulcke, N. Nelissen Nuclear Medicine : K Van Laere, P. Dupont Radiopharmaceutical Chemistry : G. Bormans, A. Verbruggen, K. Serdons University Hospital and K.U. Leuven, Belgium PET • Siemens HR+ ECAT (3D mode) • 90 min. dynamic acquisition – 4 x 15 s, 4 x 60 s, 2 x 150 s and 16 x 300 s • 300 MBq iv (mean 230) • Arterial sampling, metabolite correction • FBP (attenuation, random and scatter correction) MRI • 1.5 T Siemens Sonata • T1w MR (MPRAGE) • BOLD-fMRI (associative-semantic paradigm) Scan protocol PIB • Sum frame 1-6 • Realign fr 9-26, sum as reference • Smooth 6mm • Kinetic modeling – Logan DVR (reference = cerebellar cortex) (Price et al., J Cereb Blood Flow Metab 2005, Lopresti et al., J Nucl Med 2005) • Mask • Normalize (SPM2, sum to PET template) • Smooth 12 mm • SPM analyses Processing PIB • 15 patients with early-stage AD – MMSE: 19 – 28, mean 24.6, SD 2.7 – 6 men, 9 women – 1 left-hander – Age: 65 – 87 years, mean 73.2, SD 6.8 – Education: 8 – 16 years, mean 11.9, SD 2.4 • 16 controls – 7 men, 9 women – 1 left-hander – Age: 59 - 89 years, mean 70.9, SD 7.5 – Education: 8 - 18 years, mean 12.9, SD 2.5 Demographics
Transcript of Processing PIB Demographics - ESMI · • SPM analyses Processing PIB ... – AAT comprehension...
DIMI - Workpackage 8.2. - LeuvenParametric brain mapping of
Abeta-amyloid deposition in AD using 11C-PIB
Neurology : R. Vandenberghe, M. Vandenbulcke, N. NelissenNuclear Medicine : K Van Laere, P. Dupont
Radiopharmaceutical Chemistry : G. Bormans, A. Verbruggen, K. Serdons
University Hospital and K.U. Leuven, Belgium
PET• Siemens HR+ ECAT (3D mode)• 90 min. dynamic acquisition
– 4 x 15 s, 4 x 60 s, 2 x 150 s and 16 x 300 s• 300 MBq iv (mean 230)• Arterial sampling, metabolite correction• FBP (attenuation, random and scatter correction)
MRI• 1.5 T Siemens Sonata • T1w MR (MPRAGE)• BOLD-fMRI (associative-semantic paradigm)
Scan protocol PIB
• Sum frame 1-6• Realign fr 9-26, sum as reference• Smooth 6mm• Kinetic modeling
– Logan DVR (reference = cerebellar cortex)(Price et al., J Cereb Blood Flow Metab 2005, Loprestiet al., J Nucl Med 2005)
• Mask• Normalize (SPM2, sum to PET template)• Smooth 12 mm• SPM analyses
Processing PIB
• 15 patients with early-stage AD– MMSE: 19 – 28, mean 24.6, SD 2.7– 6 men, 9 women– 1 left-hander– Age: 65 – 87 years, mean 73.2, SD 6.8– Education: 8 – 16 years, mean 11.9, SD 2.4
• 16 controls– 7 men, 9 women– 1 left-hander– Age: 59 - 89 years, mean 70.9, SD 7.5– Education: 8 - 18 years, mean 12.9, SD 2.5
Demographics
• CDR• CPM• TMT(A & B)• AVLT (TL, STPR, LTPR, T7, recog)• RVDLT (TL, recog) or Rey-Osterrieth complex figure (copy, immediate
recall, delayed recall)• VOSP number location• BORB-OD (easy & hard)• AAT
– Spontaneous speech (comm, art, aut, sem, fon, syn)– Naming– Comprehension (AWC, ASC, VWC, VSC)– Reading– Writing– Repetition– Token test
• BNT• AVF• PALPA 49• PPT
Neuropsychological protocol
0
2.5DVR
AD patient
control
PIB-PET
Patients
Controls
AD > controls
voxel-level Puncorrected < 0.001cluster-level Pcorrected < 0.05
2 sample t-test (SPM2)
amyloid deposition
cognitive decline
precipitating factor(s)
neuronal dysfunction& damage
Amyloid cascade hypothesis
amyloid deposition
cognitive decline
precipitating factor(s)
neuronal dysfunction& damage
Amyloid cascade hypothesis
Post mortem• No correlation in AD• Plaques in controls
amyloid deposition
cognitive decline
precipitating factor(s)
neuronal dysfunction& damage
Amyloid cascade hypothesis
In vivo correlation?
• Simple correlations (SPM2) of DVR with:
– AVLT TL– AVLT recognition– CPM– Token test– AAT comprehension– PALPA– BNT– AVF
No significant voxels at puc < 0.001
PIB-PET vs. neuropsych
Left STS
PIB-PET vs. BNT
Right STS
amyloid deposition
cognitive decline
precipitating factor(s)
neuronal dysfunction& damage
Amyloid cascade hypothesis
cognitive decline
amyloid deposition
cognitive decline
precipitating factor(s)
neuronal dysfunction& damage
A different hypothesis
cognitive decline
functionalreorganisation
amyloid deposition
cognitive decline
precipitating factor(s)
neuronal dysfunction& damage
A different hypothesis
cognitive decline
functionalreorganisation
Associative-semantic fMRI
3.9
5.7
T
R
left STS
DYSFUNCTION
right STS
FUNTIONAL REORGANISATION
fMRI vs BNT / fMRI vs PIB
Nelissen et al, Brain 2007;130:2055-69.
