Prize for TB low-cost point of care rapid diagnostic test Pierre Chirac Médecins Sans Frontières,...
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![Page 1: Prize for TB low-cost point of care rapid diagnostic test Pierre Chirac Médecins Sans Frontières, Paris, France Campaign for Access to Essential Medicines.](https://reader036.fdocuments.us/reader036/viewer/2022070307/551b7f7b550346a10a8b50bf/html5/thumbnails/1.jpg)
Prize for TB low-cost point of care rapid diagnostic test
Pierre Chirac
Médecins Sans Frontières, Paris, FranceCampaign for Access to Essential Medicines
![Page 2: Prize for TB low-cost point of care rapid diagnostic test Pierre Chirac Médecins Sans Frontières, Paris, France Campaign for Access to Essential Medicines.](https://reader036.fdocuments.us/reader036/viewer/2022070307/551b7f7b550346a10a8b50bf/html5/thumbnails/2.jpg)
Present TB diagnostic methods leave half of all patients undiagnosed !
• sputum smear microscopy:
sensitivity < 50%, especially not suitable for:
– children– HIV positive patients– extra-pulmonary TB
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Better diagnostic tools exist
• Improved sputum collection and microscopy methods
• Liquid and solid culture
• Colorimetric redox indicators
• IGRA’s• Molecular techniques
• Still lacking sensitivity and specificity
• Expensive
• Not suitable for the most peripheral settings: requires highly trained staff and/or highly equipped lab-infrastructure
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What do we need?
• More needs-driven research for new TB diagnostic tools, taking especially into account the situation at peripheral level
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Rapid, low cost, point of Care– Differentiate between active and latent TB
especially in high HIV prevalence areas– High sensitivity especially for smear
negatives and EP TB – Cheap– Easy to handle – Fast (results within hours)– Not sputum based / Usable for children– Suitable for follow up– Detecting Rifampicin resistance– ….
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How to facilitate the development of POC:
MSF + experts meeting on TB prize, Geneva - April 2008
• « Developing simple, point-of-care tests soon requires innovative strategies, both financial and scientific »
• « The most fruitful way forward is to work with a combination of different antigens that would optimise the sensitivity and specificity of any test »
• « That would require actors who work now separately to join together to share the current status of their individual research, sum up these results and perform further tests together »
• « Protecting knowledge through patent monopoly stands in the way of this kind of innovative collaboration »
• Industry interested if prize is big enough
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POC TB test : best candidate for a prize…
• The low-cost POC TB test is a perfect candidate for testing innovative R&D mechanisms and funding
• This would perfectly be in line with the « Global strategy and plan of action on public health, innovation and intellectual property » the WHA adopted in May 2008 at the end of the IGWG process:– « Explore and (…) promote a range of incentive schemes for
research and development including addressing (…) the de-linkage of the costs of research and development and the price of health products, for example through the award of prizes (…) »
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A promising proposal
• Prize Fund for Development of Low-Cost Rapid Diagnostic Test for Tuberculosis, sponsored by Bolivia and Barbados.
• Presented during the IGWG process and expected to be considered soon by WHO
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Grand Prix
Grand Prix of 100 million dollars for a TB test (every 7 years)
• feasible to manufacture for 1 $• feasible at POC in developing countries• results in 3 hours• sensitivity = X %• specificity = Y %
= needs first= innovation + Access
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Sub-prizes
Awards (1 to 10 millions) for
• Small technical challenges• Best contributions (every 2 years)• Incentives to collaboration and access to knowledge
= cash flow on short term= rewards incremental advance= rewards collaboration and open access
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Monopoly free
“Intellectual Property Rights For Grand Prix”
A licensing pool would be created for acquiringneeded rights for the relevant patents and know-how for the diagnostic test—the TB licensingagency (TBLA). In order to claim the Grand Prix, thewinner would have to grant licenses to all patentand know-how needed for competitive supply of thetest, worldwide.”
= no monopoly= competition for production
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Public funding
Government would contribute to the prize
• Participating high-income countries would be expected to contribute 90 percent of the funds
• Developing countries would be expected to contribute 10 percent
• = public responsibility• = equity
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Administration
• The prize would be placed in the WHO, but administered by a committee including several institutions and representatives of the interests of TB patients
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Outstanding questions
• Medical and operational specification• IP - rights• Price• Partners• How much money to be allocated?• Money coming from?• When ? • Who ?
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Invitation Any proposal on specifications,
please come back to us :
www.accessmed-msf.org
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Thank you