Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer...

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Principles of Oncology Professor Ravi Kant

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Transcript of Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer...

Page 1: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Principles of Oncology

Professor Ravi Kant

Page 2: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Concepts

• Cancer= Crab• Some Egyptian mumies have cancer• Rudolf Virchow-1821-1902- Omnes cellula e

cellula• Theodor Boveri-1914 chromosomal

abnormalities• Watson & Crick-1953- DNA

Page 3: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Apoptosis

Page 4: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Cancer cells →

• Undemocratic• Autonomous• Avoid Apoptosis• Neoangiogenesis• Invasion• Proliferation

Page 5: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Cancer cellls

• Genomic instability

Page 6: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Malignant transformation

Page 7: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Gompertzian curve

Page 8: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.
Page 9: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Kaplan-Meier Curve

http://en.wikipedia.org/wiki/Kaplan%E2%80%93Meier_estimator
Page 10: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Clinical implication of Gompertzian curve

Page 11: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Genetic Cancer

• Breast• Thyroid

Page 12: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Prevention of Cancer

• Diet• Life style

Page 13: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Early detection of cancer

• Screening- for cancer of • Oral: Intraoral examination• Breast: Mammography• Stomach: Upper GI endoscopy • Prostate: PSA level in serum

Page 14: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Diagnosis & Staging

Page 15: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.
Page 16: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Rx of Cancer

• Surgery• Radiotherapy• Chemotherapy• Isotope Therapy• Immunotherapy• Immuno-modulation• Receptor blockade of cancer

Page 17: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Team

• Multidisciplinary approach

Page 18: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.
Page 19: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.
Page 20: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Rx of

• T= Tumour• N= Node• M= Metastasis

Page 21: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Palliation

Page 22: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

End of life care

• ? Nobel prize

Page 23: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Quality of life

• Dignity

Page 24: Principles of Oncology Professor Ravi Kant. Concepts Cancer= Crab Some Egyptian mumies have cancer Rudolf Virchow-1821-1902- Omnes cellula e cellula Theodor.

Thanks


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