PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of...

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PRIMARY CARE FOR PRIMARY CARE FOR TRANSGENDER PEOPLE TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California, San Francisco

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Page 1: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

PRIMARY CARE FOR PRIMARY CARE FOR TRANSGENDER PEOPLETRANSGENDER PEOPLE

Lori Kohler, MDAssociate Clinical ProfessorDepartment of Family and Community MedicineUniversity of California, San Francisco

Page 2: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

The Audience

Clinicians Nurses Social Workers Health Educators Pharmacists Psychotherapists ?

Page 3: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

PRIMARY CARE FOR TRANSGENDER PEOPLE

Clinical Background Who is Transgender Barriers to Care Transgender People and HIV Hormone Treatment and Management Surgical Options and Post-op care Evidence? Transgender care in prison

Page 4: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Clinical Experience

Tom Waddell Health Center Transgender Team

Family Health Center

Phone and e-mail Consultation

California Medical Facility-Department of Corrections

Page 5: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

TRANSGENDER

refers to a person who is born with the genetic traits of one gender but the internalized identity of another gender

The term transgender may not be universally accepted. Multiple terms exist that vary based on culture, age, class

  

Page 6: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Transgender Terminology

Male-to-female (MTF)

Born male, living as female

Transgender woman

Female-to-male (FTM)

Born female, living as male

Transgender man

Page 7: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Transgender Terminology Pre-op or preoperative

A transgender person who has not had gender confirmation surgery

A transgender woman who appears female but still has male genitaliaA transgender man who appears male but still has female genitalia

Post-op or post operative A transgender person who has had gender confirmation surgery

Page 8: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

The goal of treatment

for transgender people is to improve their quality of life by

facilitating their transition to a physical state that more closely represents their sense of themselves

Page 9: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Christine Jorgensen

Page 10: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Old Prevalence Estimates

Netherlands:

1 in 11,900 males(MTF)

1 in 30,400 females(FTM)

United States:

30-40,000 postoperative MTF

Page 11: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

What is the Diagnosis?

DSM-IV: Gender Identity Disorder

ICD-9: Gender Disorder, NOS

Hypogonadism

Endocrine Disorder, NOS

Page 12: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

DSM-IV 302.85 Gender Identity Disorder

A strong and persistent cross-gender identification

Manifested by symptoms such as the desire to be and be treated as the other sex, frequent passing as the other sex, the conviction that he or she has the typical feelings and reactions of the other sex

Persistent discomfort with his or her sex or sense of inappropriateness in the gender role

Page 13: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

DSM-IV Gender Identity Disorder (cont)

The disturbance is not concurrent with a physical intersex condition

The disturbance causes clinically significant distress or impairment in social, occupational, or other important areas of functioning

Page 14: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Transgenderism

Is not a mental illness

Cannot be objectively proven or confirmed

Page 15: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,
Page 16: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

GENDER

SEXUAL ORIENTATION

GENDER IDENTITY

SEXUAL IDENTITY

AESTHETIC

SOCIAL CONDUCT

SEXUAL ACTIVITY

Assertive

Masculine

Dominant

Male

Passive

Submissive

Female

StraightLesbian/Gay

MaleFemale

Feminine

UnbridledMonogamous

Page 17: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,
Page 18: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Barriers to Medical Care for Transgender People

Geographic Isolation

Social Isolation

Fear of Exposure/Avoidance

Denial of Insurance Coverage

Stigma of Gender Clinics

Lack of Clinical Research/Medical Literature

Page 19: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Provider ignorancelimits access to care

Page 20: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Regardless of their socioeconomic status all transgender people are medically underserved

Page 21: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,
Page 22: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

The Number of Transgender People in Urban Areas is Increasing Due to:

natural migration from smaller communities

earlier awareness and self-identity as transgender

Page 23: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Urban Transgender Women

Studies in several large cities have demonstrated that transgender women are at especially high risk for:

Poverty HIV disease Addiction Incarceration

Page 24: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Limited access to Medical Care for

TransgenderPeople

Page 25: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Limited access to Medical Care for

TransgenderPeople

No Transgender Education in Medical

Training

No Clinical Research

Page 26: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Limited access to Medical Care for

TransgenderPeople

No Transgender Education in Medical

Training

TRANSPHOBIANo Clinical Research

Page 27: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Limited access to Medical Care for

TransgenderPeople

No Transgender Education in Medical

Training

TRANSPHOBIANo Clinical Research

No Health InsuranceCoverage

No Legal Protection

Employment Discrimination

Poverty

Lack of Education

Page 28: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Limited access to Medical Care for

TransgenderPeople

No Prevention Efforts

No Transgender Education in Medical

Training

TRANSPHOBIANo Clinical Research

No Health InsuranceCoverage

No Legal ProtectionNo Targeted

ProgramsFor Transgender

PeopleMental health

Substance abuse

Employment Discrimination

Poverty

Lack of Education

Page 29: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Limited access to Medical Care for

TransgenderPeople

No Prevention Efforts

No Transgender Education in Medical

Training

TRANSPHOBIANo Clinical Research

No Health InsuranceCoverage

No Legal Protection

SOCIAL MARGINALIZATION

Low Self Esteem

No Targeted Programs

For TransgenderPeople

Mental healthSubstance abuse

Employment Discrimination

Poverty

Lack of Education

Page 30: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Limited access to Medical Care for

TransgenderPeople

No Prevention Efforts

No Transgender Education in Medical

Training

TRANSPHOBIANo Clinical Research

No Health InsuranceCoverage

No Legal Protection

SOCIAL MARGINALIZATION

Low Self Esteem

HIV Risk Behavior

No Targeted Programs

For TransgenderPeople

Mental healthSubstance abuse

Employment Discrimination

Poverty

Lack of Education

Page 31: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

HIV RISK BEHAVIOR

Sex workDrug use

Unprotected sexUnderground hormones

Sex for hormonesSilicone injections

Needle sharingAbuse by medical providers

LOW SELF ESTEEM

Page 32: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Why Sex work?

Survival

Access to gainful employment

Reinforcement of femininity and attractiveness

Page 33: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

HIV RISK BEHAVIOR

SOCIAL MARGINALIZATION

LOW SELF ESTEEM

Sex workDrug use

Unprotected sexUnderground hormones

Sex for hormonesSilicone injections

Needle sharingAbuse by medical providers

LOW SELF ESTEEM

Page 34: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

HIV RISK BEHAVIOR

SOCIAL MARGINALIZATION

LOW SELF ESTEEM

INCARCERATION

Sex workDrug use

Unprotected sexUnderground hormones

Sex for hormonesSilicone injections

Needle sharingAbuse by medical providers

LOW SELF ESTEEM

Page 35: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

HIV RISK BEHAVIOR

SOCIAL MARGINALIZATION

LOW SELF ESTEEM

INCARCERATION

Sex workDrug use

Unprotected sexUnderground hormones

Sex for hormonesSilicone injections

Needle sharingAbuse by medical providers

LIMITED ACCESS TO

MEDICAL CARE

LOW SELF ESTEEM

Page 36: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Limited access to Medical Care for

TransgenderPeople

No Prevention Efforts

No Transgender Education in Medical

Training

TRANSPHOBIANo Clinical Research

No Health InsuranceCoverage

No Legal Protection

SOCIAL MARGINALIZATION

Low Self Esteem

HIV Risk Behavior

No Targeted Programs

For TransgenderPeople

Mental healthSubstance abuse

Employment Discrimination

Poverty

Lack of Education

Page 37: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Access to Medical Care for

TransgenderPeople

Prevention Efforts

Transgender Education in Medical

Training

TRANSGENDERAwareness

Clinical Research

Health InsuranceCoverage

Legal Protection

SOCIAL INCLUSION

Self Esteem

HIV Risk Behavior

Targeted Programs

For TransgenderPeople

Mental healthSubstance abuse

Employment

Self-sufficiency

Education

Page 38: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

HIV RISK BEHAVIOR

SOCIAL INCLUSION

SELF ESTEEM

INCARCERATION

Sex WorkDrug use

Unprotected sexUnderground hormones

Sex for hormonesSilicone injections

Needle sharingAbuse by medical providers

ACCESS

TO MEDICAL

CARE

SELF ESTEEM

Page 39: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Access to Cross-Gender Hormones can:

Improve adherence to treatment of chronic illness

Increase opportunities for preventive health care

Lead to social change

Page 40: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Transgender Women Need

Improved access to medical care, including hormones and surgery

Social support and inclusion

Job training and education

Culturally appropriate substance abuse treatment

Page 41: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Transgender Women Need

Legal Protection

Research to assess ways to reduce recidivism

Self esteem building

Targeted prevention efforts that address the social context that leads to diminished health and well-being

Page 42: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,
Page 43: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Harry Benjamin International Gender Dysphoria Association (HBIGDA)

Standards of Care for Gender Identity Disorders – 2001 Eligibility Criteria for Hormone Therapy

1.  18 years or older

2. Knowledge of social and medical risks and benefits of hormones

3. EitherA. Documented real life experience for

at least 3 monthsOROR

B. Psychotherapy for at least 3 months

Page 44: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Readiness Criteria for Hormone Therapy-HBIGDA 2001

Real life experience or psychotherapy further consolidate gender identity

Progress has been made toward emotional well being and mental health

Hormones are likely to be taken in a responsible manner

Page 45: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

HBIGDA Real Life Experience

Employment, student, volunteer

New legal gender-appropriate first name

Documentation that persons other than the therapist know the patient in their new gender role

Page 46: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Initial Visits

Review history of gender experience

Document prior hormone use

Obtain sexual history

Order screening laboratory studies

Review patient goals

Page 47: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Initial Visits Address safety concerns Assess social support system Assess readiness for gender

transition Review risks and benefits of

hormone therapy Obtain informed consent Provide referrals Screening labs

Page 48: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Physical Exam

Assess patient comfort with P.E.

Problem oriented exam only

Avoid satisfying your curiosity

Page 49: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Male to Female Treatment Options

No hormones

Estrogens

Antiandrogen

ProgesteroneNot usually recommended except for weight maintenance

Page 50: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Estrogen Premarin

1.25-10mg po qd or divided as bid

Ethinyl Estradiol (Estinyl) 0.1-1.0 mg po qd

Estradiol Patch 0.1-0.3mg q3-7 days

Estradiol Valerate injection 20-60mg IM q2wks

Page 51: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Transgender Hormone Therapy

Heredity limits the tissue response to hormones

More is not always better

Page 52: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Estrogen Treatment May Lead To

Breast Development Redistribution of body fat Softening of skin Emotional changes Loss of erections Testicular atrophy Decreased upper body strength Slowing of scalp hair loss

Page 53: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Risks of Estrogen Therapy Venous thrombosis/emboli (po)Venous thrombosis/emboli (po) Hypertriglyceridemia (po)Hypertriglyceridemia (po) Weight gain Decreased libido Elevated blood pressure Decreased glucose tolerance Gallbladder disease Benign pituitary prolactinoma

(rare) Breast cancer(?)

Page 54: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Spironolactone

50-150 mg po bid

Page 55: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Spironolactone May Lead To

Modest breast development

Softening of facial and body hair

Page 56: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Risks of Spironolactone

Hyperkalemia

Hypotension

Page 57: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

HIV and HORMONES There are no significant drug

interactions with drugs used to treat HIV

Several HIV medications change the levels of estrogens

Cross gender hormone therapy is not contraindicated in HIV disease at any stage

Page 58: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Drug InteractionsEstradiol, Ethinyl Estradiol, levels areDECREASED by:

LopinavirLopinavir CarbamazepineNevirapineNevirapine PhenytoinRitonavirRitonavir PhenobarbitalNelfinavirNelfinavir Phenylbutazone

SulfinpyrazoneBenzoflavoneSulfamidine

Rifampin Naphthoflavone Progesterone Dexamethasone

Page 59: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Drug InteractionsEstradiol, Ethinyl Estradiol levels areINCREASEDby:

NefazodoneNefazodone IsoniazidFluvoxamine FluoxetineIndinavirIndinavir EfavirenzEfavirenzSertraline ParoxetineDiltiazem VerapamilCimetidine AstemizoleItraconazole KetoconazoleFluconazole MiconazoleClarythromycin ErythromycinGrapefruit TriacetyloleandomycinAmprenavirAmprenavir FosamprenavirFosamprenavirAtazanavirAtazanavir

Page 60: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Drug Interactions

Estrogen levels are DECREASED by:

Smoking cigarettes Nelfinavir Nevirapine Ritonavir

Page 61: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Drug Interactions

Estrogen levels are INCREASED by:

Vitamin C

Page 62: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Screening Labs for MTF Patients

CBC Liver Enzymes Lipid Profile Renal Panel Fasting Glucose Testosterone level Prolactin level

Page 63: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Follow-up labs for MTF Patients

Repeat labs at 3, 6 months and 12 months after initiation of hormones and annually

Lipids

Renal panel

Liver panel

Prolactin level annually for 3 years

Page 64: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,
Page 65: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Women over 40 years old Add ASA to regimen

Transdermal or IM estradiol to reduce the risk of thromboemboli

Minimize maintenance dose of estrogen

Testosterone for libido as needed

Page 66: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Treatment Considerations- MTFs

Testosterone therapy after castrationLibidoOsteoporosisGeneral sense of well-being

Hair lossRogaine, proscar

Hgb and Hct will decrease-not anemia

Page 67: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Cosmetic Therapies

PigmentationHydroquinone 3-4% topical

Hair RemovalEflornithine cream ElectrolysisLaser

Page 68: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Follow-Up Care for MTF Patients Assess feminization Review medication use Monitor mood cycles and adjust

medication as indicated Discuss social impact of transition Counsel regarding sexual activity Complete forms for name change Discuss silicone injections Follow up labs

Page 69: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Health Care Maintenance for MTF Patients

Instruction in self breast exam and care

Mammography – after 10+ years

Prostate screening?

STD screening

Beauty tips

Page 70: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Surgical Options for MTFs

Orchiectomy (castration)

Vaginoplasty

Breast augmentation

Tracheal shave

Face reconstruction

Page 71: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Post-op Care

Encourage consistent dilation

Vaginal skin care and lubrication

Surveillance of vagina?

Protection from HIV infection and other STDs

Douche with vinegar and water

Page 72: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,
Page 73: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Morbidity and Mortality in Transexual Subjects Treated with Cross-Sex HormonesVan Kestern, et.al., Clinical Endocrinology, 1997

Retrospective study of 816 MTF and 293 FTM transexuals treated between 1975 and 1994

Outcome measure: Standardized mortality and incidence ratios calculated from the Dutch population

Page 74: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Morbidity and Mortality (cont)

Results In both MTF and FTM transexuals,

total mortality was not higher than in the general population

Venous thromboembolism was the major complication in MTF patients treated with oral estrogens

No serious morbidity was observed that could be related to androgen treatment in FTM patients

Page 75: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Hormones

are not the cause of every medical problem reported by transgender people

Page 76: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Hormone Therapy for Incarcerated Persons-HBIGDA 2001

People with GID should continue to receive hormone treatment and monitoring

Prisoners who withdraw rapidly from hormone therapy are at risk for psychiatric symptoms

Housing for transgender prisoners should take into account their transition status and their personal safety

Page 77: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Torey South v. California Department of Corrections, 1999

Transgender inmate on hormones since adolescence

Hormones were discontinued during incarceration

Represented by law students at UC Davis

Page 78: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

T. South v. CDOC, 1999

US District Court:

Prison officials violated South’s constitutional right to be free of cruel and unusual punishment by deliberately withholding necessary medical care

Page 79: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Gender Program, CMF

Gender Clinic

Transgender support group

Harm reduction education by inmate peer educators

Page 80: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Gender Clinic, CMF 7/00-8/03

25 clinic sessions

23 patient encounters/session, avg.

800 patient encounters

250+ unduplicated patients

Page 81: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Gender Clinic, CMF

50-70 inmates receiving feminizing hormones

60-70% HIV+

Majority are people of color

Majority committed nonviolent crimes

Page 82: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Identification of Transgender Inmates-Challenges

Strict grooming standards No access to usual feminizing

accessories No access to evidence of usual

appearance No friends or family to support

patient identity

Page 83: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Identification of Transgender Inmates-Challenges

Hormones as income or barter

Secondary gain in a man’s world

Temporary loss of social stigma and separation from family influence

Page 84: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Identification of Transgender Inmates-Challenges

The grapevine impedes clinician use of consistent subjective tests, lines of questioning

The grapevine creates competition and influences treatment choices

Page 85: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Hormones in Prison

Estradiol injections only, no po

Non negotiable forms avoid use as barter

Provide hormones despite prior use

Increase opportunities for education

Page 86: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Special Concerns

No access to bras Safety- showers, housing Vulnerability- sexual abuse Domestic Violence Visibility to corrections Empowerment as a woman in a

men’s facility

Page 87: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Gender Program Development

Medical staff training and collaboration Consistent delivery of care Privacy during clinic visits Collaboration with mental health

providers Parole planning and referral Duplication of model in other

correctional facilities Realistic HIV prevention efforts

Page 88: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Summary

All transgender people are medically underserved

Hormone treatment is not optional for transgender people and contributes to improved quality of life

There are many unanswered questions about long term effects of hormone therapy but the benefits outweigh the risks for most patients

Page 89: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Summary Inclusion of transgender issues in medical

training and health promotion efforts is the only ethical and compassionate option

Transgender women are at increased risk for incarceration. Programs to address their needs in correctional facilities must be developed

People who work in HIV prevention and care have unique opportunities to improve the lives transgender people

Page 90: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Alexander Goodrum

Page 91: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,
Page 92: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,
Page 93: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,
Page 94: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Selected On-line Resources

• www.hbigda.org

The Harry Benjamin website• www.symposium.com/ijt/

International Journal of Transgenderism• www.lorencameron.com

Photos of FTMs • www.lynnconway.com

Photos of MTFs, FTMs and much more

http://www.hbigda.org/
http://www.symposium.com/ijt/
http://www.lorencameron.com/
http://www.lynnconway.com/
Page 95: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

To Contact Me

• Email: [email protected]• Phone: (415)206-4941• Pager: (415)719-7329• Mailing Address:

Department of Family and Community Medicine

995 Potrero Ave.Ward 83San Francisco, CA 94110

mailto:[email protected]
Page 96: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,
Page 97: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

FTM and HIV Risk

SFDPH Transgender Community Health Project suggested a low prevalence of HIV among the 132 FTMs in the study

FTMs in SF do engage in survival sex, IDU, and sex with other men

No HIV prevention programs in SF target FTMs

Page 98: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Female to Male Treatment Options No Hormones

DepotestosteroneTestosterone Enanthate or Cypionate 100-200 mg IM q 2 wks (22g x 1 ½” needles)

Transdermal TestosteroneAndroderm or Testoderm TTS 2.5-10mg qd

Testosterone GelAndrogel or Testim 50,75,100 mg to skin qd

Page 99: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Testosterone TherapyPermanent Changes

Increased facial and body hair

Deeper voice

Male pattern baldness

Clitoral enlargement

Page 100: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Treatment Considerations- FTMs

Testosterone cream in aquaphor for clitoral enlargement

Estrogen vaginal cream for atrophy/incontinence

Proscar, Rogaine for hair loss

Page 101: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Testosterone Therapy Reversible Changes Cessation of menses Increased libido, changes in sexual behavior Increased muscle mass / upper body strength Redistribution of fat Increased sweating / change in body odor Weight gain / fluid retention Prominence of veins / coarser skin Acne Mild breast atrophy Emotional changes

Page 102: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Risks of Testosterone Therapy

Lower HDL Elevated triglycerides Increased homocysteine levels Hepatotoxicity (oral only) Polycythemia Unknown effects on breast,

endometrial, ovarian tissues Potentiation of sleep apnea

Page 103: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

DRUG INTERACTIONS Testosterone Increases the anticoagulant effect of

warfarin

Increases clearance of propranolol

Decreases blood glucose-may decrease diabetic medication requirements

Page 104: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

Screening Labs for FTM Patients

CBC

Liver Enzymes

Lipid Profile

Renal Panel

Fasting Glucose

Page 105: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

LABORATORY MONITORING FOR FTMs

3 Months after starting testosterone and every 6-12 months:

CBC (Hgb and Hct will go up)

Lipid Profile

+/-Liver Enzymes

Page 106: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

FOLLOW-UP CARE FOR FTMs

Assess patient comfort with transition

Assess social impact of transition

Assess masculinization

Discuss family issues

Monitor mood cycles

Counsel regarding sexual activity

Page 107: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

FOLLOW-UP CARE FOR FTMs Review medication use

Discuss legal issues / name change

Review surgical options / plans

Continue Health Care MaintenanceIncluding PAP smears, mammograms, STD screening

Assess CAD risk

Minimize maintenance dose of testosterone

Page 108: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

SURGICAL OPTIONS FOR FTMs

Chest reconstruction

Continue SBE on residual tissue

Hysterectomy/oophorectomy

Genital reconstruction

–Phalloplasty

–Metoidioplasty

Page 109: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

FTM Quality of Life Survey 2004E. Newfield, L. Kohler, S. Hart

On line survey with standardized QOL form (SF-36v2)

377 completed surveys in 6 months

Page 110: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

FTM QOL Survey Results

Diminished QOL among FTMs relative to men and women in US, especially related to mental health

FTMs who received testosterone or surgery had higher QOL scores than those who did not

Page 111: PRIMARY CARE FOR TRANSGENDER PEOPLE Lori Kohler, MD Associate Clinical Professor Department of Family and Community Medicine University of California,

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