Presented by ORNL–University Partnerships in Computational Biology Igor B. Jouline Joint Institute...
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Presented by
ORNL–University Partnerships in Computational Biology
Igor B. JoulineJoint Institute for Computational Sciences
The University of Tennessee–Oak Ridge National Laboratory
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ORNL–University partnerships in computational biology
• Biosciences Division
• Computer Science andMathematics Division
• Biosciences Division
• Computer Science andMathematics Division
• Joint Institute forComputational Sciences
• Joint Institute forComputational Sciences
• School of Biology
• College of Computing
•Center for Bioinformatics and Computational Biology
• School of Biology
• College of Computing
•Center for Bioinformatics and Computational Biology
• Graduate School of Genome Science and Technology
• Graduate School of Genome Science and Technology
• Joint Institute for Biological Sciences• Joint Institute for Biological Sciences
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ORNL–UT Graduate School of Genome Science & Technology
Structural Biology and Proteomics
Genetics and Genomics
http://gst.ornl.gov
Areas of Research and Education:
Computational Biology and Bioinformatics
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Protein sequences
Domainarchitectures
MiST: Microbial Signal Transduction Database
Modular Perl infrastructureXMLSQLLinux
GenomesMeta-
genomics(in progress)
HHMER
SMARTlibraries
Pfamlibraries
Signal transduction families signatures
Signaltransduction
families — MiST
Web interface
http://genomics.ornl.gov/mist
PostgreSQLrelational database
management system
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MiST: Visualization of signal transduction profiles in 176 microbial genomes
http://genomics.ornl.gov/mist
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Distribution of sensory (a) and regulatory (b) domains in microbial genomes
Ulrich et al. (2005) Trends Microbiol
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Computational microbial genomics: Poison + water = hydrogen
"The findings show the continued value of microbial genome sequencing for exploring the useful capabilities of the vast realm of microbial life on Earth," says Ari Patrinos, former director of the Office of Biological and Environmental Research, part of the U.S. Department of Energy's (DOE) Office of Science. DOE, which funded the study, is pursuing clean fuel technologies.
www.sciencedaily.com/releases/2005/12/051204103616.htm
Life in Hot Carbon Monoxide: The Complete Genome Sequence of Carboxydothermus hydrogenoformans Z-2901
Martin Wu, Qinghu Ren, A. Scott Durkin, Sean C. Daugherty, Lauren M. Brinkac, Robert J. Dodson, Ramana Madupu, Steven A. Sullivan, James F. Kolonay, William C.
Nelson, Luke J. Tallon, Kristine M. Jones, Luke E. Ulrich, Juan M. Gonzalez, Igor B. Zhulin, Frank T. Robb, and Jonathan A. Eisen
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Contacts
Igor B. Jouline (Zhulin) PhD.Joint Institute for Computational SciencesThe University of Tennessee — Oak Ridge National Laboratory
Associate ProfessorThe University of TennesseeUTK (865) 974-7687 [email protected]
Senior R&D Staff MemberOak Ridge National LaboratoryORNL (865) [email protected]
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