Presented by

ORNL–University Partnerships in Computational Biology

Igor B. JoulineJoint Institute for Computational Sciences

The University of Tennessee–Oak Ridge National Laboratory

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ORNL–University partnerships in computational biology

• Biosciences Division

• Computer Science andMathematics Division

• Biosciences Division

• Computer Science andMathematics Division

• Joint Institute forComputational Sciences

• Joint Institute forComputational Sciences

• School of Biology

• College of Computing

•Center for Bioinformatics and Computational Biology

• School of Biology

• College of Computing

•Center for Bioinformatics and Computational Biology

• Graduate School of Genome Science and Technology

• Graduate School of Genome Science and Technology

• Joint Institute for Biological Sciences• Joint Institute for Biological Sciences

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ORNL–UT Graduate School of Genome Science & Technology

Structural Biology and Proteomics

Genetics and Genomics

http://gst.ornl.gov

Areas of Research and Education:

Computational Biology and Bioinformatics

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Protein sequences

Domainarchitectures

MiST: Microbial Signal Transduction Database

Modular Perl infrastructureXMLSQLLinux

GenomesMeta-

genomics(in progress)

HHMER

SMARTlibraries

Pfamlibraries

Signal transduction families signatures

Signaltransduction

families — MiST

Web interface

http://genomics.ornl.gov/mist

PostgreSQLrelational database

management system

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MiST: Visualization of signal transduction profiles in 176 microbial genomes

http://genomics.ornl.gov/mist

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Distribution of sensory (a) and regulatory (b) domains in microbial genomes

Ulrich et al. (2005) Trends Microbiol

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Computational microbial genomics: Poison + water = hydrogen

"The findings show the continued value of microbial genome sequencing for exploring the useful capabilities of the vast realm of microbial life on Earth," says Ari Patrinos, former director of the Office of Biological and Environmental Research, part of the U.S. Department of Energy's (DOE) Office of Science. DOE, which funded the study, is pursuing clean fuel technologies.

www.sciencedaily.com/releases/2005/12/051204103616.htm

Life in Hot Carbon Monoxide: The Complete Genome Sequence of Carboxydothermus hydrogenoformans Z-2901

Martin Wu, Qinghu Ren, A. Scott Durkin, Sean C. Daugherty, Lauren M. Brinkac, Robert J. Dodson, Ramana Madupu, Steven A. Sullivan, James F. Kolonay, William C.

Nelson, Luke J. Tallon, Kristine M. Jones, Luke E. Ulrich, Juan M. Gonzalez, Igor B. Zhulin, Frank T. Robb, and Jonathan A. Eisen

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Contacts

Igor B. Jouline (Zhulin) PhD.Joint Institute for Computational SciencesThe University of Tennessee — Oak Ridge National Laboratory

Associate ProfessorThe University of TennesseeUTK (865) 974-7687 Ijouline@utk.edu

Senior R&D Staff MemberOak Ridge National LaboratoryORNL (865) 241-3697joulineib@ornl.gov

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