Presented by Andrew Cinderella - University of Delaware · 2013-02-12 · Presented by Andrew...
Transcript of Presented by Andrew Cinderella - University of Delaware · 2013-02-12 · Presented by Andrew...
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Presented by Andrew Cinderella
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Samuel Danishefsky� Born 1936 in Bayonne, NJ� B.S. from Yeshiva University 1956� PhD from Harvard 1962� NIH post-doc fellow at Columbia, Stork Lab� 1963-1980 University of Pittsburg� 1963-1980 University of Pittsburg� 1980-1993 Yale University� 1993-present Columbia UniversityAwards� Wolf Prize in Chemistry with Stork� Arthur C. Cope Award� Benjamin Franklin Medal in Chemistry� National Academy of Science’s Award in Chemistry� >480 publications
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Dynemicin A� Possible anti-tumor agent
� Binds to the minor-groove of the DNA double helix
� Most effective in rapid growth cells
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Retrosynthesis
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Approach
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Early Synthetic Steps
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Approach
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Attempted Routes
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Approach
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Path II Synthetic Steps
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Path II Synthetic Steps Cont.
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Approach
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Final Synthetic Steps
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Conclusion� Dynemicin A was successfully synthesized in 33 steps.
� Overall yield of 0.13%
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Questions???Thank you!!!