Presented By Alan Venook at 2014 ASCO Annual Meeting
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Transcript of Presented By Alan Venook at 2014 ASCO Annual Meeting
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<br />CALGB/SWOG 80405: Phase III trial of FOLFIRI or FOLFOX with Bevacizumab or Cetuximab for patients w/ KRAS wild type untreated metastatic adenocarcinoma of the colon or rectum <br />
Presented By Alan Venook at 2014 ASCO Annual Meeting
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Slide 2
Presented By Alan Venook at 2014 ASCO Annual Meeting
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CALGB/SWOG 80405: <br /> FINAL DESIGN
Presented By Alan Venook at 2014 ASCO Annual Meeting
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COLORECTAL CANCER IN 2004 <br /> IS THERE AN OPTIMAL 1ST LINE TREATMENT ?
Presented By Alan Venook at 2014 ASCO Annual Meeting
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2004: A lot can happen in 10 years
Presented By Alan Venook at 2014 ASCO Annual Meeting
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CALGB / SWOG 80405: <br /> WHY DID IT TAKE TEN YEARS?
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CALGB/SWOG 80405: Eligibility Criteria
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CALGB/SWOG 80405: Endpoints
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CALGB/SWOG 80405: Statistics
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CALGB/SWOG 80405: Statistics
Presented By Alan Venook at 2014 ASCO Annual Meeting
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Slide 11
Presented By Alan Venook at 2014 ASCO Annual Meeting
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Slide 12
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CALGB/SWOG 80405: Overall Survival <br />
Presented By Alan Venook at 2014 ASCO Annual Meeting
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CALGB/SWOG 80405: Progression-Free Survival<br />(Investigator Determined)
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Slide 15
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CALGB/SWOG 80405: Overall Survival<br />FOLFOX Treated
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CALGB/SWOG 80405: Overall Survival<br />FOLFIRI Treated
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Patients Rendered Disease-Free<br />Overall Survival
Presented By Alan Venook at 2014 ASCO Annual Meeting
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Grade 3-4 Toxicities<br />
Presented By Alan Venook at 2014 ASCO Annual Meeting
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Slide 20
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80405: Data Pending
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Quality of Life and Symptoms
Presented By Alan Venook at 2014 ASCO Annual Meeting
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Slide 23
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“Expanded RAS”
Presented By Alan Venook at 2014 ASCO Annual Meeting
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<br /> Correlative Studies<br /> Tumor / Plasma / Serum > 44000 samples<br />
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80405: Upcoming Presentations
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CALGB/SWOG 80405: Conclusions
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CALGB/SWOG 80405: Conclusions
Presented By Alan Venook at 2014 ASCO Annual Meeting
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CALGB/SWOG 80405: Conclusions
Presented By Alan Venook at 2014 ASCO Annual Meeting
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TAKE HOME MESSAGE
Presented By Alan Venook at 2014 ASCO Annual Meeting
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Value of publicly funded clinical research
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ACKNOWLEDGEMENTS / THANKS Collaborators
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ACKNOWLEDGEMENT / THANK YOU
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Slide 35
Presented By Alan Venook at 2014 ASCO Annual Meeting
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Slide 36
Presented By Alan Venook at 2014 ASCO Annual Meeting