PRESENT BY

ROZANA ABOALKHAIR

GLUCOSE NANOSENSOR TATTOO

OVERVIEW

• INTRODUCTION

• GLUCOSE NANOSENSOR TOOLS

i- INJECTOR

ii-NANOSENSOR TATTO

iii- IMAGING DEVICE

• CONCLUSION

Diabetes Has Become Epidemic • Every day,

3,600 new cases of diabetes are diagnosed.

580 people die of diabetes-related complications.

225 people have a diabetes-related amputation.

120 people with diabetes progress to end-stage renal disease.

55 people with diabetes become blind.

American diabetes association, May,2012.

GLUCOSE NANOSENSOR TOOLS

• Injector

• Nanosensor tattoo

• Imaging device

Trends in Molecular Medicine, Volume 16, Issue 12, 584-593, 23 September 2010

PLACEMENT IN SKIN

Skin Pharmacol Physiol,2009

PLACEMENT IN SKIN

Skin Pharmacol Physiol,2009

Nanosensors composed of a hydrophobic polymer containing:

• Lipophilic glucose recognition elements

(boronic acid derivatives, PhB(OH)2 )

• Fluorescent reporters. (alizarin, C14H8O4 )

Trends in Molecular Medicine, Volume 16, Issue 12, 584-593, 23 September 2010

NANOSENSOR TATTOO COMPONENTS

Imaging Device

Trends in Molecular Medicine, Volume 16, Issue 12, 584-593, 23 September 2010

CONCLUSION• minimize the need for the implantation of electrochemical sensors , which minimizes

patient inconvenience and pain.

• Can performed when the patient is sleeping.

• Provide a means to measure the glucose levels continuously instead of only specific time.

• It would be an additional cost of producing this smart tattoo, by thoroughly comparing the smart tattoo with other commercially available nanosensors.

• The tattoo, like most cutting-edge technologies have drawbacks, but can be turned around to full efficiency.

Reference • American Diabetes Association. (2012). "Diabetes Basics.”

• Cash, Kevin J., and Heather A. Clark. "Nanosensors and nanomaterials for monitoring glucose in diabetes." Trends in molecular medicine 16.12 (2010): 584-593.

• Card, Jeffrey W., and Bernadene A. Magnuson. "A review of the efficacy and safety of nanoparticle-based oral insulin delivery systems." American Journal of Physiology-Gastrointestinal and Liver Physiology 301.6 (2011): G956-G967.

THANK YOU…