Presentation NPS CMS - NPSeuronet...2016/09/28 · Presentation_NPS_CMS.pptx Author cristina...

Iden%fica%on and Assessment of New Psychoac%ve Substances: A European Network

Lisbon, 28th September 2016

RISK ASSESSMENT AND NEUROTOXICITY STUDIES OF THE NPS

In vivo behaviour – FOB review



6

3

24

26 31

30

101 98

81 74

48 41

24



07/2016

Running:

. MDMB-‐CHMICA

. Acetylfentanyl

Mephedrone; 2011

BZP; 2009

PMMA;2003

TMA-‐2;2004

2C-‐I, 2C-‐T-‐2, 2C-‐T-‐7;2004

10/2015 10/2015 5/2014 5/2014 5/2014

5/2014 1/2014 1/2014

Ketamine;2002

GHB; 2002

4-‐MTA; 1999

MBDB; 1999

EMCDDA RA

Produced :



Since the number of new psychoacMve substances keeps growing, biomedical data, based on systemaMc

pharmacological and toxicological studies, will rarely be available for these NPS, making the RA a difficult task, as

requested data on NPS is usually limited.

Lisbon, 28th September 2016 EMCES-‐Álvaro Lopes


Possible contribuMons :



Toxicants beside inducing histopathological changes, can also alter nervous system funcMon, for example

BEHAVIOR, in profound and varied ways.

Behavioral effects -‐ May be a reflecMon of changes in nerve cell communicaMon and integraMon as well as the morphological alteraMons

Moser, Tox Pathol, 2011;39:36-‐45



BEHAVIOR

SensiMve indicator / the ulMmate assay

Moser, Tox Pathol, 2011;39:36-‐45

Neuronal Func%on

IntegraMon and integrity

Nervous System



FOB

?

2000 -‐ ICH S7A guidelines

Irwin (1962, 1968) Irwin, S. Psychopharmacologia, 1968;13:222-‐257.

1975 NaMonal Academy of Sc, government and academic scienMsts and US EPA

1989 Guidelines

A series of tests based on Irwin screen, called the FuncMonal ObservaMon Babery (1989)

1998 -‐ US EPA Human Health 870 series test

1995; 1997 -‐ OECD 1996 – Red book


FOB

ü Ataxia ü Retropulsion ü ExploraMon ü Convulsions ü Excessive grooming

ü Flabened body posture ü HyperacMvity ü SalivaMon


ü Self-‐injury ü Stereotyped head weaving ü Stereotyped circular head movements

ü Stereotyped biMng ü Stereotyped licking ü SMmulaMon

ü Tremor

ü Straub tail ü  Circling



FOB ü  Circling



FOB (determined 15-‐20 min post-‐injecMon)

COC – cocaine; METH – Methamphetamine; MDMA – Methylenedioxymethamphetamine; 5-‐IT – 5-‐(2-‐aminopropyl)indole; 6-‐IT -‐ 6-‐(2-‐aminopropyl)indole; 3-‐FMC – 3-‐fluoromethcathinone; 4-‐FMC – 4-‐fluoromethcathinone; MDPV – Methylenedioxyphyrovalerone; Mephe – Mephedrone; Methe – Methedrone; Methy -‐ Methylone


Lisbon, 28th September 2016 CrisMna Sampayo-‐FFULisboa EMCES-‐Álvaro Lopes

Thank You

Presentation NPS CMS - NPSeuronet...2016/09/28 · Presentation_NPS_CMS.pptx Author cristina...

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