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Clemson UniversityInnovations

From Idea to Impact

Targeted ElastinRestoration Therapy

Lisa Perpall MS MBAeperpal@clemson.edu

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Clemson University Top 25 public university

Legacy in bioengineering and

biomaterials research

Clemson University Research

Foundation (CURF)

Bridges research and industry

Access to emerging technology Access to research resources

Introduction

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Clemson Biomedical Research Resources

Clemson, SC Basic Research Technology

Development(BS, MS, PhD)

Charleston, SCCU-MUSCBioengineering Alliance

Clinical ResearchResearch Training

Greenville, SC

Translational ResearchFrom Bench to Bedside

EducationIncubation

http://www.biomaterials.org/index.cfmhttp://www.clemson.edu/agforestryresearch/gh/images/biosys_jpg.jpg

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Featured Technology

Targeted Elastin RestorationTherapy

Clemson Inventors:Dr. Naren Vyavahare

Aditi Sinha

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Invention

Modified nanoparticles that target elastin fragments & deliver

therapeutic agents to stabilize and regenerate elastin

PEG-PLA nanoparticles with

surface bound antibody

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Application Example: Aneurysm (AAA)

Elastin degradation causesweakened vessel walls

Abdominal Aortic Aneurysm

(AAA)

15,000 deaths per year1

13thlargest cause of death1

Agents to prevent or treat earlystage AAA

Statins, anti-inflammatories,

MMP inhibitors, etc.

drug

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Nanoparticles injected into aneurysmal rats

Calliper IVIS used for real time imaging of

NPs in vivo

The Science

Elastin Targeting NP 24hControl PEG-PLA NP 24h

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The Science

Targeted sustained drug delivery of agents for prevention,

treatment, or regeneration MMP inhibitors

Anti-inflammatories

Elastin regeneration compounds (i.e. PGG)

Elastin

Targeting

NPs 24h

Aneurysmal aortaimaging @24 hrs

ControlPEG-PLA

NPs 24h

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(image from: www.beltina.org)

Application OpportunitiesTopical, Respiratory, or Injection Delivery

COPD

3rdleading cause of death2

2010 cost of COPD annually $49.9B

2

Treat/prevent loss of elastin in alveoli

Skin CareCosmetic

Anti-aging segment of facial skin care market$1.2B 20093

Topical product for skin rejuvenation

(www.celergenswiss.com)

1- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312219/#B4

2- American Lung Association www.lung.org3- Frost and Sullivan 2011

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312219/http://www.lung.org/http://www.lung.org/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312219/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312219/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312219/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312219/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312219/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312219/