Présentation des biotechnologies en Israël et du secteur médical en Israël
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Transcript of Présentation des biotechnologies en Israël et du secteur médical en Israël
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Prepared by A. Zeitoun, MD
Dr. Alain Zeitoun Pharma & Medtech
France - Israel
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Prepared by A. Zeitoun, MD
Israel economy, industrial production and Trade - Highlights
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Prepared by A. Zeitoun, MD
Israel at glance
• Population: 8 million
• Area: 22,145 sq.km
• GDP 2013: $291b, per capita: $36K
• 2010: +4.8%, 2011: +4.7%, 2012: +3.4%, 2013: +3.3%
• High-Tech exports: 2010: $44b, 2011: +4.3%, 2012: +3%
• Inflation: 2011: 2.2%, 2012: 2.2% - about 1% in 2014?
• Unemployment: 2012: 6.9%, 2013: 6.2%, slight increase in 2014
• OECD: 2010 full membership
• Nobel prize: 10 winners, 6 in science, 2 in economics
• DP 2011 rate of growth - global comparison: OECD member average:
1.9%, US: +1.7%, Japan: +0.3%, Germany: +3.0%, France: +1.6%
China+ 9.3%, India: +7.7%
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Prepared by A. Zeitoun, MD
Inflation Rate Rate of change in consumer price index
Source: Central Bureau of Statistics
Source: Bank of Israel
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Prepared by A. Zeitoun, MD
Corporate Tax 2012
Ireland
Chile
Greece
Iceland
UK
Finland
Netherlands
Austria
Israel
OECD average *
Canada
Italy
Norway
Spain
Australia
Germany
Portugal
Belgium
France
US
Japan
13%
17%
20%
20%
24%
25%
25%
25%
25%
25%
26%
28%
28%
30%
30%
30%
32%
34%
34%
39%
40%
Corporate Tax
Source: Israel Ministry of Finance
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Prepared by A. Zeitoun, MD
Total industrial production grew by 3.8%
Industrial Production Average Annual Growth - 2013 average relative to 2004 average
Source: Central Bureau of Statistics
Source: Israel Ministry of Finance
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Prepared by A. Zeitoun, MD
Exports of Goods and Services As a share of GDP
Effects of the global economic crisis
Source: Israel Ministry of Finance
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Prepared by A. Zeitoun, MD
Main Export Destinations As a share of total exports
Source: Central Bureau of Statistics
Source: Israel Ministry of Finance
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Prepared by A. Zeitoun, MD
Main Trading Partners $ US Billions, 2013
* The data on trade with Hong-Kong is added to the data regarding China
Source: Central Bureau of Statistics
Source: Israel Ministry of Finance
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Prepared by A. Zeitoun, MD
Israel’s Free Trade Agreements
1985
1992
1997
1997
1999
2000
2007
USA
EFTA
Turkey
Canada
Mexico
European Union (Association Agreement)
MERCOSUR
QIZ Agreements
2004
1998
Egypt
Jordan
Colombia* 2013
* Yet to be ratified
Source: Israel Ministry of Finance
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Prepared by A. Zeitoun, MD
Israel – HR stance
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Prepared by A. Zeitoun, MD
Unemployment and Participation As % of total labor force
Source: Central Bureau of Statistics
Since the 2nd quarter of 2009 unemployment is relatively decreasing, with a gradual increase in the participation rate since the beginning of 2010.
Source: Bank of Israel
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Prepared by A. Zeitoun, MD
Ease of Doing Business 2012
Source: The World Bank. 2012 report covers 183 economies.
Singapore
Hong Kong
New Zealand
USA
Denmark
UK
Korea
Ireland
Finland
Canada
Japan
France
Austria
Israel
South Africa
Italy
1
2
3
4
5
7
8
10
11
13
20
29
32
34
35
87
Ease of Doing Business Rank 2012
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Prepared by A. Zeitoun, MD
Dismissals during 2008/9 Global Crisis Employee Jobs in the Business Sector
5.4%4.9%
4.2%
3.3%
0.9%
-0.7%
-1.7%-1.8%
0.2%
2.8%
4.5%4.3%4.5%4.3%4.1%4.3%
2.8%2.4%
1.7%
Employee Jobs in Business SectorChange Rates, Each period Compared to the Parallel Period in a Previous Year
Source: Israel Ministry of Finance
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Prepared by A. Zeitoun, MD
Employment Flexibility During 2008/9 Crisis
80%
30%
7%
15%
6%
11%
Reducing Overtime
At the expense of employees' vacation days
Unpayment vacation
At the expense of employees vacation days
while lowering wages
Reducing job scopes while lowering wages
Efficiency Measures Taken by Industrial CompaniesTowards all Employees, Excluding Management
Source: Israel Ministry of Finance
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Prepared by A. Zeitoun, MD
Israel – innovation driven economy
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Prepared by A. Zeitoun, MD
Competitiveness Report 2013
Source: World Economic Forum 17
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Prepared by A. Zeitoun, MD
4.4
1.8
1.3
3.8
2.8
2.3
2.0
1.81.9
1.7 1.71.6
1.3
0
1
2
3
4
5
Isra
el
Fin
lan
d
Germ
an
y
Fra
nce
Belg
ium
EU
27
Czech
Rep
.
Un
ited
Kin
gd
om
Can
ad
a
Irela
nd
No
rway
Sp
ain
Italy
Israel is a World Leader in Science, Technology, and Innovation
Source: OECD. * International Institute for Management Development (IMD) Global Competitiveness Yearbook 2013. ** World Economic Forum (WEF)
Global Competitiveness Report 2013-2014.
Civilian R&D as % of GDP, 2011 1st in R&D expenditure as % of GDP*
1st in quality of scientific research institutions**
1st in public expenditure on education*
1st for innovative capacity*
2nd for entrepreneurship being widespread amongst
its managers*
5th in PCT patents applications per million
population**
6th for strength of investor protection**
6th for Nobel Prizes per capita in the fields of physics,
chemistry, physiology, medicine and economics since
1950* Source: Bank of Israel
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Prepared by A. Zeitoun, MD
Some High-Tech success stories
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Prepared by A. Zeitoun, MD
The Importance of High-Tech to Israel
• Main contributions to the economy – 40% of GDP annual growth, 50% of industrial exports
– 40% of VC investments ends as tax revenue, direct and indirect each US dollar invested in R&D contributes 6 US dollars to industrial product
• Most new employment comes from new small businesses – 3:1 ratio of direct and indirect employees to engineers
– employment growth rate is double that of the rest of the economy
• Suited to Israeli business culture – entrepreneurial culture – creative, persistent, innovative, win attitude
– large number of entrepreneurs and engineers per capital
– using limited resources cost effectively
• Magnet of attraction to foreign investors
• Second only to the US
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Prepared by A. Zeitoun, MD
Foreign companies invested in Israel - exple
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Prepared by A. Zeitoun, MD
Israel Life Science - overall
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Prepared by A. Zeitoun, MD
Israel Life Sciences Cluster
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Prepared by A. Zeitoun, MD
Expenditure on R&D - as % of GDP,2010
Source: Israel Ministry of Finance
In 2009, 62% of Israel’s civilian R&D spending (US$4.7bn) took place in Israeli foreign owned companies. In addition, 92% of exported R&D services (US$3.4bn) originated from these companies.
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Prepared by A. Zeitoun, MD
Technology Transfer Organizations (TTOs)
University-associated and hospital-linked TTOs provide a forum for connecting Israeli researchers and early stage projects with the industry through their commercialization efforts
• Hebrew University’s Yissum, founded in 1964. Yissum generates a similar output as its counterparts at MIT and Stanford, with 7,000 patents to date.
• Yeda Research and Development Company is responsible for technology transfer from The Weizmann Institute of Science.
• Hadasit, the TTO of Hadassah Medical Organization, has established a number of start-up companies, six of which have already gone public
• Ramot, the TTO of Tel Aviv University, recently joined forces with J&J to establish a joint research fund (metabolic disorders, CNS, cancer and stem cell research.
• The Technion Institute of Technology, largest center of applied research in IL. Recently, opened Mann Institute for R&D : biomedicine, medtech and life
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Prepared by A. Zeitoun, MD
Israel Life Science – Sectors and Stages
Source: ILSI/IATI database 2009
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Medical Devices companies - sectors
Source: ILSI/IATI database 2013
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Prepared by A. Zeitoun, MD
Biopharma companies - sectors
Source: ILSI/IATI database 2013
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Prepared by A. Zeitoun, MD
Main Medical Fields - companies
Source: ILSI/IATI database 2009
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Prepared by A. Zeitoun, MD
Life Sciences companies - # of employees
Source: ILSI/IATI database 2013
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Prepared by A. Zeitoun, MD
Life Sciences patents as % of total patents
Source: ILSI/IATI – USPTO 2007
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Prepared by A. Zeitoun, MD
Cumulative number of Life Sciences companies
Source: ILSI/IATI / IVC – 2012 analysis
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Prepared by A. Zeitoun, MD
Biopharma – main therapeutic areas
• CNS – Four Blockbuster drugs in market (Copaxone, Rebif, Exelon, Azilect) - 5 Additional drugs in clinical stages
• Regenerative medicine & Cell Therapy (20 active companies, 4 in clinical trials)
• Cancer - Cell Therapy, Monoclonal Antibodies, Small Molecules, Image Guided Technologies
• Inflammation & Autoimmunity
• Cardiovascular
• Infectious diseases, Vaccines
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Prepared by A. Zeitoun, MD
Stem Cells – strong specialty field
• Israel is one of the world centers for stem cells research and technology development.
• The Jewish religion does not hinder stem cell research – a significant plus.
• Israeli scientists are the most prolific authors on a per capita basis of published articles related to stem cell research.
• There are about 20 companies actively engaged in this new industry.
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Biopharma – some examples BioLineRx is a clinical-stage, traded biopharmaceutical development company that develops products suitable for the pharmaceutical market satisfying an unmet medical need or exhibiting advantages over current therapies.
CollPlant (CLPT) is a biotechnology company specializing in the development and commercialization of plant-derived functional recombinant human collagen formulated for a variety of medical solutions.
Can-Fite has developed a platform technology that targets the A3 Adenosine Receptor for treatment of cancer and autoimmune inflammatory diseases.
Gamida Cell is developing unique stem cells therapeutics, based on its proprietary stem/progenitor cells expansion technologies.
Rosetta Genomics is a leader in the development of microRNAbased diagnostics tests for personalized medicine.
And …Atox Bio (Infectious Diseases), Cellcure (stemcells in Parkinson), Biocancell (Gene therapy), BiondVax (Intra nasal vaccines for several flu strains), Compugen (therapeutic &diagnostic drug discovery)
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Prepared by A. Zeitoun, MD
Medical Device – main therapeutic areas
• Electro-medical & Surgical Devices
• Therapeutic and Rehabilitation Equipment
• Dentistry
• Medical Supplies
• Telemedicine
• Health IT
• Diagnostics – electronics and non-electronic
• Hospital Planning & Engineering Consulting Services
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Prepared by A. Zeitoun, MD
Medical Device – some companies Given Imaging - 1st ingestible video camera used to view the small intestine and diagnose disorders.
Peer Medical – 3D view endoscope to diagnose gastrointestinal polyps, which can develop into bowel cancer.
Insightec - Image Guided HIFUS (High Intensity Focused Ultrasound) and MRI guided non-invasive surgical procedure
Medinol - pioneered the development of closed cell stent design and many additional innovations to the field of heart catheterization.
GE Healthcare in Israel manufactured the world’s first miniaturized portable cardiac ultrasound system
Philips Brilliance CT scanner, developed in Israel takes a comprehensive picture of a patient in seconds instead of minutes.
And more: 3D Dental Mapping, Fixed non-cooled Magnet Open MRI, Simulators for Medical Procedures, Labor Monitoring, NiTiNOL Tooling, Intravascular miniaturized MRI imager, Spectral Imaging Device, Various Stents, Revolutionary Rectoscope, Implantable Insulin Generator, etc
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Itamar Medical produces innovative diagnostic devices based on proprietary technology to diagnose disorders associated with cardiovascular and autonomic nervous systems.
BioView delivers cell imaging technology platform and software package that combines morphological, immuno-staining and FISH information on the same cell, enabling physicians and researchers to efficiently and effectively improve the quality of patient treatment and care.
Impliant produces novel cushion-bearing materials and engineering combine to create long-lasting orthopedic implants for the hip, knee, shoulder, and spine.
Medical Device – some companies
Brainsway Ltd. is dedicated to the development and marketing of Deep TMS (Transcranial
Magnetic Stimulation) systems, novel, noninvasive medical device for treatment of a wide
range of neurological and psychopathological disorders.
HeadSense Medical Ltd. is develops disruptive products that will allow physicians and
patients to diagnose and monitor clinical parameters in an easier and cost-effective way.
HeadSense’s first product the HS-1000 is a non-invasive ICP monitor offering accurate and
continuous ICP monitoring.
IceCure (TASE: ICCM) is a medical device company focused on developing and marketing minimally invasive, office-based cryoablation treatment solutions for women’s tumors. The proprietary IceSense3™ Cryoablation System offers a comfortable, ultrasoundguided procedure to treat breast tumors.
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Israel Life Science – Government support
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Israeli Government Support
– The Law for the Encouragement of Capital Investments
– Tax exemption path for manufacturing facilities
– The Law for the Encouragement of Industrial R&D
– Increased grants and longer project support for Life Sciences
– Company-Company, Company-Consortia, Company-Academy support programs
– The Global Enterprise R&D Cooperation Framework
– Special tax benefits for R&D centers
– Tax exemption for venture capital investment
– Annual Government support for Int. R&D projects: $100m
– Grants - scale from 20% - 85% of budget + regional incentives
– Conditional : royalty payments 3% - 5% of future product sales
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Prepared by A. Zeitoun, MD
OCS Government Support Programs
Generic R&D
Magnet
Magneton
Competitive R&D
Industrial
R&D
Pre-Seed
Tnufa
Nofar
Technological Incubators
Cooperative R&D
Long-Range R&D
Seed Fund
Applied Academic Research
Basic R&D Market Proximity
Bi-national Funds
(Europe FP)
Inte
rnat
ion
al
Global Enterprises R&D Cooperation
Bi-national Agreements
Galileo
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Prepared by A. Zeitoun, MD
The Technological Incubators Program Government Response to Market Failure
Primary Objective
• Creating new startup companies that would not start otherwise
Secondary Objectives
• Transferring technology from research institutes into the industry
• Creating industrial R&D activity in peripheral regions
• Creating a technological entrepreneurial culture in Israel
• Providing deal flow for the venture capital industry
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What incubators provide to entrepreneurs?
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Incubator support
• Incubation Period: 2 years
• Average budget: ~$600K for 2 years
• Government grant: 85% of budget
• Incubator’s investment: 15% of budget
• Extended Support
• Biomed and Clean-Tech projects (3rd year)
• Projects initiated in Peripheral Incubators (Increased budget)
• Payback: 3% royalties from annual revenue
• Annual Government Budget to the Program: ~$ US 45 Million
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Incubators network
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Government funding vs. private investment 1991-2013 Private funding and VC leveraging government’s money
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OCS Grants by Technological Sectors, 2012
Source: Office OCS
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Prepared by A. Zeitoun, MD
Issue – funding of Biopharma Industry
The Problem:
• Over dependence on ICT and a lack of investment in the bio-tech and Life Science area
Solution:
• Significant encouragement for the bio-tech industry in Israel via public-private funding
Description:
• Public-private funds for bio tech. Government’s $104m leveraged with a minimum of $300m private funds.
Status:
• Several funds created, managed by VCs under supervision of Ministry of Industry
• Example: $200 m fund managed by Orbimed, mainly invested in NCE, 505(b)2 and diagnostic companies
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Prepared by A. Zeitoun, MD
The Problem:
• Not enough money is raised by SEED-stage companies.
• Not enough incentives for Early Stage investments
Solution:
• Allowing investment in an R&D-focused company to be reported as an expense on “day one”
• “Angel Law” – allows investment to be tax deducted
Description:
• Deducting this investment as an expense against income from all sources, spread over three years
Issue – Seed and Early Stages funding
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Prepared by A. Zeitoun, MD
Issues - Minorities & High-Tech Industry
Problem:
• Low rate of Arab minority, Ultra-orthodox employees in the high-tech industries
Solution:
• Incentives for high-tech employers to employ underrepresented communities
Description:
• Adjusting the Ministry of Industry’s support programs, which subsidize cost of salaries for high-tech industry
• Examining other options to encourage employment via the Chief Scientist’s programs, i.e. specific incubators
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Prepared by A. Zeitoun, MD
Israel Life Science – VC funding
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Prepared by A. Zeitoun, MD
15 Years of Venture Capital Activity at a Glance
• $20 billion invested in the VC sector
• $14 billion raised by Israeli VC funds
• M&A: $28 billion, IPO: $6 billion
• More than 5,000 startups established
• NASDAQ: 100 Israeli high-tech companies are listed
• Main contributor to the economy, GDP, export, employment
• Human capital emerged as Israel’s main resource
• Global recognition achieved as an innovative technology center
Source IVC 2012
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Prepared by A. Zeitoun, MD
High-Tech capital raising
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Prepared by A. Zeitoun, MD
Israel Life Science – M&A and IPOs
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Prepared by A. Zeitoun, MD
Israeli High-Tech Exit Highlights
• VC-Backed Exits up to $4.2 billion; account for 63% of total capital
• 2013 M&A deals totaled $6.3 billion
• Average M&A deal in 2013: $87 million
• 2013 IPO activity is back with $361 million raised by 8 companies
• Positive trends for 2014
Source: IVC Research Center
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Prepared by A. Zeitoun, MD
All Israel High-Tech exits 2004-2013
Source: IVC Research Center
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Prepared by A. Zeitoun, MD
Israel High-Tech exits by sector (%)
Source: IVC Research Center
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Prepared by A. Zeitoun, MD
Top 5 exits in 2013 by sector
Source: IVC Research Center
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Prepared by A. Zeitoun, MD
Deloitte – VC confidence survey
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Prepared by A. Zeitoun, MD
France-Israel Life Science Events and cooperation actors
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Prepared by A. Zeitoun, MD
Save the dates – Bio Events in Israel Opportunities to meet israeli companies and bio actors
French Israeli Forum on Medical Robotic
Tel Aviv March 23rd -24th 2015
Coordinated by Ubifrance, the Scientific Department of the French
Embassy & the Israeli Ministry Of Science & Technology (MOST)
Mixiii BIOMED by IATI - Israël 2015
Tel Aviv - May 12th -14th 2015
Organized by Israel Advanced Technologies Industries - French
Pavilion, individual meetings coordinated by Ubifrance Israel
MedInIsrael congress 2015
Tel Aviv - May 16th -19th 2015
Following Mixiii Biomed – focusind on Medical Devices + Health IT
coordinated by the Israel Export Institute -
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Prepared by A. Zeitoun, MD
A dedicated and adapted portfolio of services
Promote French know-how
Business forums, pavillons in international
Trade shows, targeted and qualified B2B
meetings
Supports the French Innovative
ecosystem (companies, start-ups,
clusters) in its international expansion
Technological partnerships meetings for
innovative companies
Partnership missions w. specialized clusters
UBIFRANCE
Supporting French
companies abroad
Providing operational
information about
upcoming markets and
opportunities,
Identification of the
key players in each
relevant market, raising
awareness about French
expertise,
Matching French
companies with the best
foreign partners.
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Prepared by A. Zeitoun, MD
France-Israel Technological partnerships and Innovation - bilateral framework !
A priority for both Israeli and French governments At the core of the French President’s State visit in Israel in 2013
Foster bilateral innovative R&D partnerships Since 2014 : 1 Bpifrance staff established within Ubifrance team in Tel Aviv.
FIRAD France-Israel Industrial R&D program
2 submission deadlines: End of May (over now), November 30th
A wide diversity of projects submitted, amongst which: E-health: solutions for breast cancer detection / Medical Device / New
Media: Real time web content enrichment and semantic analysis / Energy: fuel production re-using industrial heat
May 2014: 15 projects at the 1st Call
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Prepared by A. Zeitoun, MD
Teams covering all the process from match-making to funding
2 pilot organizations
1 support team based in Tel Aviv
2014: 2 dedicated managers representing French public institutions
Supporting and matching Israeli & French companies
…And a global coalition of institutions and networks
French Embassy in Israel, French & Israeli Ministries of Economy, Ubifrance, Tel Aviv University, French-Israeli High Council for
Science & Technology…
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Prepared by A. Zeitoun, MD
Save the date: French-Israeli Innovation Day
– Hosted alternatively by the French and Israeli Ministry of Economy
– 1d conf. + B2B sessions, 1d on-site business tours
– ID1: Paris, December 5, 2011 – 400 participants
– ID2: Tel Aviv, November 19, 2013 – 800 participants
Innovation Day 3: Paris - December 16,17 2014
– FinTech & e-Commerce
– e-Health & Personalized medicine
– Big Data & the City of tomorrow
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Prepared by A. Zeitoun, MD
The French networks’ access points
Anne BAER France-Israel Innovation and Technological partnerships expert, French Ministry of Foreign Affairs [email protected]
Aurélie GUTHMANN Country representative - Israel Bpifrance [email protected]
French companies Israeli companies
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Prepared by A. Zeitoun, MD
Important actor – Israel Advanced Technology Industries – IATI www.iati.co.il
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Prepared by A. Zeitoun, MD
IATI annual congress – Mixiii Biomed Israel Biomed / High-Tech congress – 12-14 May 2015
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Prepared by A. Zeitoun, MD
Israel Export Institute - MedInIsrael In conjunction w. Mixiii Biomed – 16-19 May 2015
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Prepared by A. Zeitoun, MD
Thank you – merci pour votre attention - toda
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