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MECHANISM

OF ACTIONOF GENERAL

(INHALEDANESTHETICS)

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Presynaptic Neuron

NO ANESTHETIC

Chloride ion channel

Potassium ion channel

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Presynaptic Neuron

 GA BA 

 r e c e p

 t o r

Chloride ion channel

GABAor

Glycine

Potassium ion channel

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Presynaptic Neuron

Chloride ion channel

Potassium ion channel

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Presynaptic Neuron

Chloride ion channel

Potassium ion channel

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Presynaptic Neuron

Chloride ion channel

Potassium ion channel

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

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Presynaptic Neuron

Chloride ion channel

ActionPotential

Binding of GABA causeschloride ion channel to open

CHLORIDE

Potassium ion channel

Leadin toH!PERPOLARI"ATION o#

 P O TA S S

 I U M

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Presynaptic Neuron

In presence of

INHALED ANESTHETIC

Chloride ion channelPotassium ion channel

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Presynaptic Neuron

 GA BA 

 r e c e p

 t o r

Chloride ion channel

GABAor

Glycine

Potassium ion channel

ANESTHETICS

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

P i N

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

P ti N

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

P ti N

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

P ti N

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

P ti N

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

Presynaptic Neuron

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

Presynaptic Neuron

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

Binding of GABA is enhanced yinhaled anesthetic resulting in a

greater entry of chloride ion

Presynaptic Neuron

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Presynaptic Neuron

Chloride ion channelPotassium ion channel

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GABA%receptor c$loride c$annel&!"here these anesthetic agents directly

and indirectly facilitate a GABA#$ediatedincrease in chloride %Cl&' conductance to

hyperpolari(e and inhiit neuronal$e$rane acti)ity*

Liand%ated pota&&i' c$annel&!"here these anesthetic agents increase

potassiu$ conductance to hyperpolari(eand inhiit neuronal acti)ity*

 

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 THAN+ ,O-.

/repared y0 1aria 2e 3* Espina