Preliminary Programme - ICRS 2009 · Ana-Isabel Torres, Luciano De Petrocellis and Vincenzo Di...

PHEASANT RUN S T . C H A R L E S , I L .

J U L Y 7 - 1 1 , 2 0 0 9

Buffet Breakfast (Atrium)

Didier M. Lambert,

Coco N. Kapanda,

Giulio G. Muccioli,

Geoffray Labar

and Jacques H. Poupaert

BIS[(DIALKYLTHIOCARBAMOYL)]DISULFIDE

DERIVATIVES AS POTENT AND SELECTIVE

MONOGLYCERIDE LIPASE INHIBITORS

John W. Huffman,

Valerie J. Smith,

Jianhong Chen,

Jenny L. Wiley

and Billy R. Martin

STRUCTURE-ACTIVITY RELATIONSHIPS

AT THE CB1 AND CB2 RECEPTORS FOR

1-ALKYL-3-(1-NAPHTHOYL-4

AND 8-HALOGEN SUBSTITUTED) INDOLES

Xiang-Qun (Sean) Xie,

Yuxun Zhang, Lirong

Wang, Jianzhong Chen,

Juerg Gertsch

and Dana E. Selley

DISCOVERY OF NEW CB2 LIGANDS

WITH NOVEL CHEMICAL SCAFFOLD

Michael Meyer, Betty Yao,

Anthony Daza, Yihong Fan,

Lanlan Li, Loan Miller,

Odile El Kouhen, Gin

Hsieh, Erica Wensink, Anita

Salyers, Prasant Chandran,

Michael Dart, Tongmei Li

and William Carroll

A-1036654, A NOVEL ORALLY

BIOAVAILABLE CB2-SELECTIVE AGONIST

EXHIBITING ANALGESIC ACTIVITY IN

RODENT MODELS OF OSTEOARTHRITIC

AND NEUROPATHIC PAIN

Aron H. Lichtman,

Anu Mahadevan,

Raj K. Razdan,

Sreenivasulu P. Naidu,

Steven G. Kinsey,

Bingjun Zhao, Hang Sun,

Dana E. Selley

and M. Imad Damaj

COMPARISON BETWEEN THE CB2

RECEPTOR AGONIST O-3223 AND THE

POTENT, MIXED CB1/CB2 RECEPTOR

AGONIST CP55,940 IN A BATTERY OF

NOCICEPTIVE ASSAYS

Jenny L. Wiley,

Pinglang Wang,

Anu Mahadevan,

Raj K. Razdan

and Billy R. Martin

PYRAZOLE CANNABINOIDS WITH

NON-CB1, NON-CB2 ACTIVITY

Zhuanhong Qiao,

Jian Cai,

William M. Pierce Jr.

and Zhao-Hui Song

DETERMINATION OF AN INTERNAL

DISULFIDE BOND IN THE SECOND

EXTRACELLULAR LOOP OF CANNABINOID

CB2 RECEPTOR BY MASS SPECTROMETRY

Mitzi Nagarkatti,

Rupal Pandey

and Prakash Nagarkatti

TARGETING CANNABINOID RECEPTORS

AS A NOVEL APPROACH TO PREVENT

GRAFT-VERSUS-HOST DISEASE

Orr Ofek,

Malka Attar-Namdar,

Esther Shohami,

Raphael Mechoulam

and Itai Bab

OSTEOBLASTIC CB2 CANNABINOID

RECEPTOR ACTIVATES GI PROTEIN-ERK1/2-

MAPKAPK2-CREB SIGNALING PATHWAY

Nancy E. Buckley,

Beverly McDowell,

Ehsan Taqavi

and Gideon Blumstein

DELTA-9-TETRAHYDROCANNABINOL,

CB2R AND IMMUNITY TO YEAST

INFECTION

Betty B Yao,

Odile El Kouhen,

Gin Hsieh, Yihong Fan,

Bradley A Hooker,

Loan Miller, David G

Witte, Lanlan Li,

Steve McGaraughty,

Kathleen Chu,

Madhavi Pai, Erica J

Wensink, Anita K

Salyers, Chang Z Zhu,

William A Carroll,

Michael J Dart

and Michael D Meyer

CB2 RECEPTOR-MEDIATED ANTI-

ALLODYNIC EFFECTS IN NEUROPATHIC

PAIN MODELS IS LIKELY MEDIATED

THROUGH NON-NEURONAL CELLS

Peter Nguyen, Cullen L.

Schmid, Kirsten M.

Raehal, Dana E. Selley,

Laura M. Bohn

and Laura J. Sim-Selley

BETA-ARRESTIN 2 REGULATES

CB1 RECEPTOR DESENSITIZATION

AND THC-MEDIATED

ANTINOCICEPTIVE TOLERANCE

Alex Straiker

and Ken Mackie

DIFFERENTIAL REGULATION OF DSI TIME

COURSE IN IDENTIFIED POPULATIONS OF

AUTAPTIC HIPPOCAMPAL NEURONS

Val J. Watts

and Julie A. Przybyla

EXPRESSION, LOCALIZATION, AND DRUG

MODULATION OF CANNABINOID CB1 AND

DOPAMINE D2 RECEPTOR HETERODIMERS

IN CATH.A DIFFERENTIATED

NEURONAL CELLS

Joel E. Schlosburg,

James J. Burston,

Steven G. Kinsey,

Lamont Booker,

Rehab A. Abdullah,

Jonathan Z. Long,

Dana E. Selley,

Benjamin F. Cravatt

and Aron H. Lichtman

BEHAVIORAL AND FUNCTIONAL

ADAPTATION OF THE ENDOCANNABINOID

SYSTEM FOLLOWING REPEATED

MONOACYLGLYCEROL LIPASE

(MAGL) INHIBITION

Xia Zhang

LONG-TERM DEPRESSION IN VENTRAL

TEGMENTAL DOPAMINE NEURONS

MEDIATES LEARNING TO ASSOCIATE

CANNABINOID EXPOSURE WITH

ENVIRONMENTAL CUES

Sachin Patel,

Philip J. Kingsley,

Ken Mackie,

Lawrence J. Marnett

and Danny G. Winder

REPEATED HOMOTYPIC STRESS ELEVATES

2-AG AND ENHANCES DEPOLARIZATION-

INDUCED SUPRESSION OF INHIBITION IN

BASOLATERAL AMYGDALA

Tiziana Rubino,

Natalia Realini,

Daniela Vigano’,

Guidali Cinzia

and Daniela Parolaro

URB597 RECOVERS SOME OF THE

SIGNS PRESENT IN THE DEPRESSIVE

PHENOTYPE INDUCED BY

ADOLESCENT EXPOSURE TO THC

“THE GLUTAMATE HOMEOSTASIS

HYPOTHESIS OF ADDICTION”

Medical University of South Carolina


Chris Henstridge,

Simon Arthur

and Andrew Irving

LACK OF SPECIFICITY FOR

CANNABINOID CB1 RECEPTOR

ANTAGONISTS: INTERACTIONS

WITH GPR55

Khalil Eldeeb,

Stephen Alexander,

David Pritchard

and David Kendall

LPI-EVOKED INCREASES IN

INTRACELLULAR CALCIUM

INCREASES IN MICROGLIAL

CELLS IN CULTURE

Ankur Kapur, Pingwei Zhao,

Haleli Sharir, Yushi Bai,

Marc G. Caron, Larry S. Barak

and Mary E. Abood

GPR55: TO BE OR NOT TO BE A

CANNABINOID RECEPTOR

Nariman Balenga,

Ralf Schröder,

Wolfgang Platzer, Julia Kargl,

Christopher M Henstridge,

Andrew J Irving, Evi Kostenis

and Maria Waldhoer

FUNCTIONAL SELECTIVITY OF

CANNABINOIDS ON THE NOVEL

CANNABINOID RECEPTOR GPR55

Takayuki Sugiura,

Atsushi Yamashita

and Saori Oka

LYSOPHOSPHATIDYLINOSITOL

INDUCES RAPID CYTOSKELETAL

REARRANGEMENTS AND

MORPHOLOGICAL CHANGES IN

HEK293 CELLS EXPRESSING

GPR55: FURTHER EVIDENCE

THAT LYSOPHOSPHATIDYL-

INOSITOL IS THE NATURAL

LIGAND FOR GPR55

Lisa A.Gauson,

Maria-Grazia Cascio,

Ruth A. Ross

and Roger G. Pertwee

CANNABIGEROL DISPLAYS

SIGNIFICANT POTENCY

AS A 5-HT1A RECEPTOR

ANTAGONIST

Sean D. McAllister, Darryl Lau,

Rigel T. Christian, Arash E.

Pakdel, Anne J. Zielinski,

Jasmine Lee, Dan H. Moore

and Pierre-Yves Desprez

CANNABIDIOL AS A NOVEL

INHIBITOR OF ID-1 GENE

EXPRESSION IN AGGRESSIVE

BREAST CANCER CELLS

Nicholas A. Jones,

Andrew J. Hill, Gary J. Stephens,

Claire M. Williams

and Benjamin J. Whalley

ANTICONVULSANT EFFECTS OF

CANNABIDIOL UPON

SPONTANEOUS EPILEPTIFORM

ACTIVITY IN ACUTE

HIPPOCAMPAL BRAIN SLICES

Tamás Bíró, Attila Oláh,

Balázs I. Tóth,

Gabriella Czifra,

Christos C. Zouboulis

and Ralf Paus

CANNABIDIOL AS A NOVEL

ANTI-ACNE AGENT?

CANNABIDIOL INHIBITS LIPID

SYNTHESIS AND INDUCES CELL

DEATH IN HUMAN SEBACEOUS

GLAND-DERIVED SEBOCYTES

Erin M. Rock,

Cheryl L. Limebeer,

Raphael Mechoulam

and Linda A. Parker

CANNABIDIOL (THE NON-

PSYCHOACTIVE COMPONENT OF

CANNABIS) MAY ACT AS A 5-

HT1A AUTO-RECEPTOR AGONIST

TO REDUCE TOXIN-INDUCED

NAUSEA AND VOMITING

Daniele De Filippis,

Giuseppe Esposito,

Mariateresa Ciprian,

Caterina Scuderi, Joris De Man

and Teresa Iuvone

CANNABIDIOL CONTROLS

INTESTINAL INFLAMMATION

THROUGH THE MODULATION OF

ENTERIC GLIAL CELLS

Julian Romero, Ana I Castillo,

Marta Moreno, Rosa M Tolon

and Jose Martinez-Orgado

CHARACTERIZATION OF THE

NEUROPROTECTIVE EFFECT

OF CANNABIDIOL AFTER

OXYGEN AND GLUCOSE

DEPRIVATION OF NEWBORN

MICE FOREBRAIN SLICES

INDIVIDUAL DIFFERENCES IN

RESPONSES TO DRUGS IN HUMANS

University of Chicago

Joshua A. Lile, Thomas H. Kelly

and Lon R. Hays

GABAA MODULATION OF THE

DISCRIMINATIVE STIMULUS

EFFECTS OF 9-THC IN HUMANS

Amanda Reiman CANNABIS AS A SUBSTITUTE FOR

ALCOHOL AND OTHER DRUGS

Andrea M Dlugos,

Ajna Hamidovic,

Colin A Hodgkinson,

David Goldman,

Abraham A Palmer

and Harriet de Wit

MORE AROUSED, LESS FATIGUED:

FAAH GENE POLYMORPHISMS

INFLUENCE ACUTE RESPONSE

TO AMPHETAMINE

José Alexandre S. Crippa,

Guilherme Nogueira

Derenusson, Thiago Borduqui

Ferrari, Lauro Wichert-Ana,

Fábio Duran, Rocio Martin-

Santos, Marcus Vinícius Simões,

Sagnik Bhattacharyya, Paolo

Fusar-Poli, Alaor Santos Filho,

Maria Cecília Freitas-Ferrari,

Philip K. McGuire, Antonio

Waldo Zuardi, Geraldo Busatto

Filho, Jaime Eduardo Cecílio

Hallak and Richard E. Musty

NEURAL BASIS OF ANXIOLYTIC

EFFECTS OF CANNABIDIOL (CBD)

IN GENERALIZED SOCIAL

ANXIETY DISORDER

Sara Jane Ward

and Ellen A. Walker

SEX AND CANNABINOID CB1

GENOTYPE DIFFERENTIATE

PALATABLE FOOD AND COCAINE

SELF-ADMINISTRATION

IN MICE

Daniel Thomas Malone,

Dennis Jongegan

and David Alan Taylor

THE EFFECT OF CANNABIDIOL

AND

9-TETRAHYDROCANNABINOL

ON SOCIAL INTERACTION

OF RATS

Kofi-Kermit Horton,

Sarah Bough,

Anushka Goonawardena,

John Sesay, Allyn Howlett

and Robert E. Hampson

CHRONIC RIMONABANT ALTERS

BEHAVIOR AND GENE

EXPRESSION IN HIPPOCAMPUS

DURING LEARNING

Emmanuel Shan Onaivi GENETIC BASIS OF

MARIJUANA USE

Notes:


Lourdes Ruiz-Valdepeñas,

José Antonio Martínez Orgado,

Cristina Otalora, Marta Moreno,

África Millán, Rosa María Tolón

and Julián Romero

CANNABIDIOL REDUCES

LIPOPOLYSACCHARIDE-INDUCED

VASCULAR DYSFUNCTION IN

THE MOUSE BRAIN: AN

INTRAVITAL MICROSCOPY STUDY

Stefania Petrosino,

Marcello Naccarato,

Daniela Pizzuti,

Marco Simonetto, Fabio Chiodo

Grandi, Gilberto Pizzolato

and Vincenzo Di Marzo

BLOOD ENDOCANNABINOID

AND

PALMITOYLETHANOLAMIDE

LEVELS IN HUMAN ISCHEMIC

STROKE

Ming Zhang, Martin W. Adler,

Mary Abood, Doina Ganea

and Ronald F. Tuma

THE COMBINATION TREATMENT

WITH A CB2 AGONIST AND

CB1 ANTAGONIST ATTENUATED

CEREBRAL ISCHEMIC INJURY

THROUGH DIFFERENT

MECHANISMS

Yosefa Avraham,

Nicholaos C Grigoriadis,

Iddo Magena,

Theofilos Poutahidis,

Lia Vorobiava, Yaron Ilan,

Raphael Mechoulam

and Elliot M Berry

CAPSAICIN AFFECTS BRAIN

FUNCTION IN A MODEL OF

HEPATIC ENCEPHALOPATHY

ASSOCIATED WITH FULMINANT

HEPATIC FAILURE IN MICE

Somnath Mukhopadhyay,

Ju-Ahng Lee

and Shailendra Devkota

ENDOCANNABINOID AND CB1

RECEPTOR-MEDIATED

REGULATION OF NEUROGENESIS

IN ZEBRAFISH

Geoffray Labar, Franck Borel,

Cédric Bauvois, Jean-Luc Ferrer,

Johan Wouters

and Didier M. Lambert

MOLECULAR INSIGHT INTO

MONOGLYCERIDE LIPASE, THE

ENZYME DEGRADATING

2-ARACHIDONOYLGLYCEROL

Jonathan Z. Long,

Daniel K. Nomura

and Benjamin F. Cravatt

MECHANISTIC

CHARACTERIZATION OF SELECTIVE


INHIBITION REVEALS DIFFERENCES

IN CENTRAL AND PERIPHERAL

ENDOCANNABINOID METABOLISM

Martin Kaczocha,

Sherrye T. Glaser, Janiper Chae

and Dale G. Deutsch

FAAH-2 IS A LIPID DROPLET-

LOCALIZED ENZYME

THAT MEDIATES

N-ACYLETHANOLAMINE

INACTIVATION

Patricia H. Reggio,

Dow P. Hurst

and Diane L. Lynch

THE ROLE OF FATTY ACID BINDING

PROTEINS IN THE LIFE CYCLE OF

ANANDAMIDE

Lina Thors, Staffan Tavelin

and Christopher J. Fowler

TEMPERATURE-DEPENDENT

AND SATURABLE UPTAKE OF

ANANDAMIDE BY SYNTHETIC

LIPOSOMES

Alessia Ligresti, Dolores Hernan

Perez de la Ossa,

Jesús Molpeceres, Rosario

Aberturas, Mª Esther Gil,

Aniello Schiano Moriello,

Ana-Isabel Torres,

Luciano De Petrocellis


NANOPARTICLE-MEDIATED

CELLULAR UPTAKE-CONTROLLED

RELEASE AS A TOOL TO STUDY

ANANDAMIDE MEMBRANE

TRANSPORT

Leonie Wyffels,

Giulio G Muccioli,

Coco N Kapanda,

Sylvie De Bruyne,

Didier M Lambert

and Filip De Vosa

RADIOSYNTHESIS AND IN VIVO

EVALUATION OF [11C]- BIPHENYL-

3-YL 4-METHOXYPHENYL-

CARBAMATE AS PET TRACER FOR

IN VIVO EVALUATION OF FAAH IN

THE BRAIN

AN EVALUATION OF BRAIN ENDOCANNABINOID

SIGNALING AND ADDICTION-RELATED BEHAVIORS

Scripps Institute

Rao Rapaka, Ph.D. and Vishnudutt Purohit, D.V.M., Ph.D.

National Institute on Drug Abuse

Notes:


Cheryl L. Limebeer,

Kiran Vimuri, Holly Bedard,

Klaus-Peter Ossenkopp,

Alexandros Makriyannis

and Linda A. Parker

NAUSEATING EFFECTS OF AM-251

MAY BE PRODUCED BY THE

PERIPHERAL INVERSE-AGONIST

PROPERTIES: EVIDENCE FROM THE

CONDITIONED GAPING MODEL

IN RATS

Vincenzo Di Marzo, An

Verrijken, Antti Hakkarainen,

Stefania Petrosino, Ilse Mertens,

Nina Lundbom, Fabiana

Piscitelli, Jukka Westerbacka,

Aino Soro-Paavonen, Isabel

Matias, Luc Van Gaal

and Marja-Riitta Taskinen

INSULIN AS A NEGATIVE

REGULATOR OF

PLASMA ENDOCANNABINOID

LEVELS IN

OBESE AND NONOBESE SUBJECTS

Stefan Engeli, Anne-Christin

Lehmann, Jana Böhnke,

Verena Haas, Jürgen Janke,

Anke Strauß, Alexander Zörner,

Dimitrios Tsikas

and Jens Jordan

INFLUENCES OF DIETARY FAT ON

THE PERIPHERAL ECS IN LEAN AND

OBESE HUMAN SUBJECTS

Yossef Tam, Jie Liu,

Sándor Bátkai,

Douglas Osei-Hyiaman,

Alexandros Makriannis,

V. Kiran Vemuri, Keith Sharkey

and George Kunos

ANTI-OBESITY EFFECTS OF A NOVEL

PERIPHERALLY ACTING NEUTRAL

CANNABINOID 1 RECEPTOR

ANTAGONIST IN MICE

Nina L. Cluny,

Catherine M. Keenan,

Marnie Duncan,

Alyson Fox, Beat Lutz

and Keith A. Sharkey

THE ACTIONS OF A PERIPHERALLY

RESTRICTED CANNABINOID

CB1/CB2 RECEPTOR AGONIST

ON EXPERIMENTAL

COLITIS IN MICE

W.-S. Vanessa Ho

and Neelam Parmer

N-ARACHIDONOYL GLYCINE ACTS

AS A VASORELAXANT VIA NITRIC

OXIDE AND LARGE CONDUCTANCE

CALCIUM-ACTIVATED POTASSIUM

CHANNELS

K. Starowicz, W. Makuch,

M. Osikowicz, S. Petrosino,

F. Guadagno, V. Di Marzo

and B. Przewlocka

ANANDAMIDE INJECTED

INTRATHECALLY INDUCES

ANALGESIA MEDIATED BY A

TRPV1-DEPENDENT MECHANISM

IN NEUROPATHIC RATS

Mauro Dionisi, Leonie Norris,

David Barrett,

Stephen Alexander

and Andrew Bennett

SUSTAINED INHIBITION OF FAAH

ACTIVITY ELEVATES

ENDOCANNABINOID TONE AND

ACTIVATES PPAR NUCLEAR

RECEPTORS IN HUMAN

NEUROBLASTOMA CELLS

Steven G. Kinsey,

Jonathan Z. Long, Scott T.

O’Neal, Rehab A. Abdulla,

Justin L. Poklis, Dale L. Boger,

Benjamin F. Cravatt


FAAH AND MAGL INHIBITION

REDUCE NEUROPATHIC PAIN VIA

DISCRETE RECEPTOR-SPECIFIC

MECHANISMS OF ACTION

Kay Ahn, Douglas S. Johnson,

Mauro Mileni, David Beidler,

Jonathan Z. Long, Michele K.

McKinney, Eranthie Weerapana,

Nalini Sadagopan, Marya

Liimatta, Sarah E. Smith, Scott

Lazerwith, Cory Stiff, Satwik

Kamtekar, Keshab Bhattacharya,

Yanhua Zhang, Stephen

Swaney, Keri Van Becelaere,

Raymond C. Stevens


DISCOVERY AND

CHARACTERIZATION OF A HIGHLY

SELECTIVE FAAH INHIBITOR THAT

REDUCES INFLAMMATORY PAIN

Ethan Russo, Stephen Wright,

Philip Robson and Colin Stott

DOUBLE-BLIND, RANDOMIZED

WITHDRAWAL CLINICAL

TRIAL OF SATIVEX IN CENTRAL

NEUROPATHIC PAIN

IN MULTIPLE SCLEROSIS

Sabatino Maione,

Enza Palazzo, Alessia Ligresti


EFFECT OF PHYTOCANNABINOIDS

ON SUPRA-SPINAL

ANTINOCICEPTIVE DESCENDING

PATHWAYS IN RATS:

INVOLVEMENT OF CANNABINOID,

TRP AND ADENOSINE RECEPTORS

“CANNABINOID RECEPTORS AND

HUNTINGTON’S DISEASE”

The University of Auckland

.

Marilena Pira, Paolo Lazzari,

Stefania Ruiu, Simone Tambaro,

Christian Dessì and Luca Pani

SYNTHESIS AND BIOLOGICAL EVALUATION OF

ANALOGUES OF THE CB1 ANTAGONIST N-

PIPERIDINYL-5-(5-CHLORO-THIOPHEN-2-YL)-1-

(2’,4’-DICHLOROPHENYL)-4-METHYL-1H-

PYRAZOL-3-CARBOXAMIDE

Jianhong Chen, John W. Huffman,

Jenny L. Wiley and Billy R. Martin

SYNTHESIS OF GEMINALLY DIMETHYL

SUBSTITUTED ANALOGUES OF ∆8-THC

William Courtney LIPINS, CANNABINS AND ENCANNINS:

TOWARDS A RATIONAL NOMENCLATURE

Michael Dart, Arturo Perez-

Medrano, Tongmei Li, Sridhar

Peddi, Teo Kolasa, Meena Patel,

Xueqing Wang, Derek Nelson,

Anthony Daza, George Grayson,

Bradley Hooker, Yihong Fan,

Lanlan Li, Loan Miller, Tiffany

Garrison, Odile El-Kouhen,

Madhavi Pai, Prasant Chandran,

Anita Salyers, Gin Hsieh, Betty Yao,

Michael Meyer and William Carroll

ISOTHIAZOLYLIDENE AMIDES: A NEW SERIES OF

SELECTIVE CB2 AGONISTS FOR PAIN

MANAGEMENT

Derek Nelson, Jennifer Frost, Karin

Tietje, Steven Latshaw, Alan

Florjancic, Megan Gallagher,

William Carroll, Michael Dart,

Anthony Daza, Bradley Hooker,

George Grayson, Lanlan Li, Yihong

Fan, Loan Miller, Odile El-Kouhen,

Tiffany Garrison, Betty Yao, Prasant

Chandran, Chang Zhu, Madhavi

Pai, Gin Hsieh

and Michael Meyer

THIOPHENE BISAMIDE CB2 AGONISTS

Rangan Maitra, Yanan Zhang,

Herbert H. Seltzman, Michael

Roche, Julianne M. Tajuba, Rodney

W. Snyder, Norman Gaudette,

Timothy R. Fennell

and Brian F. Thomas

SYNTHESIS AND PHARMACOLOGICAL

CHARACTERIZATION OF QUATERNIZED

SR141716 ANALOGS THAT ANTAGONIZE

CANNABINOID RECEPTOR 1

Yanan Zhang, Ann Gilliam,

Rangan Maitra, Julianne M. Tajuba,

M. Imad Damaj,

Herbert H. Seltzman

and Brian F. Thomas

DEVELOPMENT OF BIVALENT SR141716 LIGANDS

FOR CB1 RECEPTOR DIMERS

Joong-Youn Shim LIPID MEMBRANE STRUCTURE OF THE

CANNABINOID CB1 RECEPTOR SECOND

EXTRACELLULAR LOOP

Evangelia Kotsikorou,

Diane L. Lynch,

Dow P. Hurst, Mary E. Abood

and Patricia H. Reggio

CONFORMATIONAL ANALYSIS AND

MOLECULAR DYNAMICS STUDY OF 2-

ARACHIDONOYL-SN-GLYCERO-3-

PHOSPHOINOSITOL (2-AGPI) AND 1-STEAROYL-

SN-GLYCERO-3-PHOSPHOINOSITOL (LPI)

IN A POPC BILAYER

Qing-Rong Liu, Chun-Hung Pan,

Akitoyo Hishimoto, Chuan-Yun Li,

Zheng-Xiong Xi, Alvaro Llorente-

Berzal, Maria-Paz Viveros,

Hiroki Ishiguro, Tadao Arinami,

Emmanuel Shan Onaivi

and George R. Uhl

IDENTIFICATION OF NOVEL HUMAN AND

RODENT CB2 CANNABINOID RECEPTOR

ISOFORMS AND THEIR DIFFERENTIAL

REGULATION IN BRAIN

Tricia H. Smith, Maurice R. Elphick,

Deborah L. Lewis

and Dana E. Selley

CANNABINOID RECEPTOR INTERACTING

PROTEIN (CRIP1A) ATTENUATES CONSTITUTIVE

CB1 RECEPTOR SIGNALING

AND CB1 DOWNREGULATION

Saori Oka, Shinji Kimura,

Atsushi Yamashita

and Takayuki Sugiura

LYSOPHOSPHATIDYLINOSITOL INDUCES

RAPID PHOSPHORYLATION OF P38 MITOGEN-

ACTIVATED PROTEIN KINASE IN HEK293

CELLS EXPRESSING GPR55

Chris Breivogel and Deryck Hill THE COUPLING OF CB1 RECEPTORS

WITH BETA-ARRESTIN1 AND 2

Lawrence C. Blume,

Caroline E. Bass,

George D. Dalton, Dana E. Selley

and Allyn C. Howlett

CANNABINOID RECEPTOR INTERACTING

PROTEIN (CRIP) 1A: DEVELOPMENT OF

OVEREXPRESSING NEURONAL CELLS

AND ADENO-ASSOCIATED VIRAL DELIVERY OF

CRIP1A TRANSCRIPTS IN VIVO

David F. Woodward , Neil Poloso,

Jenny W. Wang, Thierry Jolas,

David Piwnica, Robert W. Carling,

Clive L. Cornell, Hans Fliri,

Jose Martos, Simon N. Pettit

and W. Daniel Stamer

EVIDENCE FOR A BIMATOPROST-SENSITIVE

PROSTAMIDE RECEPTOR IN HUMAN OCULAR

CELLS ASSOCIATED WITH CONVENTIONAL

OUTFLOW

Brian D. Hudson

and Melanie E.M. Kelly

SIGNALLING INTERACTIONS BETWEEN CB1

RECEPTORS AND 2 ADRENERGIC RECEPTORS IN

HUMAN TRABECULAR MESHWORK CELLS

Lesley A. Ford, Anke J. Roelofs,

Luisa Mowat, Daniel Simpson

and Ruth A. Ross

EXPLORING THE ROLE OF

NOVEL CANNABINOID RECEPTORS

IN BREAST CANCER METASTASIS

Marco Koch, Susanne Kreutz,

Charlotte Böttger, Chalid Ghadban,

Horst-Werner Korf

and Faramarz Dehghani

NEUROPROTECTIVE EFFECTS OF

PALMITOYLETHANOLAMIDE (PEA)

TREATMENT ARE MEDIATED BY PEROXISOME

PROLIFERATOR-ACTIVATED

RECEPTOR (PPAR)-ALPHA

Ashley Dorning,

Tibor Harkany and Andrew Irving

ALTERATIONS IN CB1 RECEPTOR

NEURONAL POLARITY AND

AGONIST-INDUCED INTERNALIZATION

DURING MATURATION IN VITRO

Sherrica Tai, Torbjörn U.C. Järbe,

Subramanian K. Vadivel

and Alexandros Makriyannis

DISCRIMINATIVE STIMULUS FUNCTIONS OF

METHANANDAMIDE AND Δ9-THC IN RATS:

TESTS WITH AMINOALKYLINDOLES

(WIN55,212-2 AND AM678) AND ETHANOL

W.-S. Vanessa Ho

and Thomas Spelman

THE PUTATIVE ENDOTHELIAL CANNABINOID

RECEPTOR ANTAGONIST, O-1918 INHIBITS

VASCULAR LARGE CONDUCTANCE CALCIUM-

ACTIVATED POTASSIUM CHANNELS

Ryan McLaughlin, Matthew Hill,

Kara Stuhr, Cecilia Hillard

and Boris Gorzalka

FORCED SWIM EXPOSURE ELICITS RAPID

ALTERATIONS IN CORTICOLIMBIC

ENDOCANNABINOID CONTENT

Josée Guindon, Pierre Beaulieu

and Andrea Hohmann

THE ROLE OF THE ENDOGENOUS CANNABINOID

SYSTEM IN PERIPHERAL ANALGESIA

Alex X Dong, Melanie EM Kelly

and Susan E Howlett

VASOACTIVE ACTIONS OF ABNORMAL

CANNABIDIOL AND 3-(5-

DIMETHYLCARBAMOYL-PENT-1-ENYL)-N-(2-

HYDROXY-1-METHYL-ETHYL)BENZAMIDE

IN RETINAL ARTERIOLES

Qing-song Liu, Bin Pan, Wei Wang,

Jonathan Z Long, Dalong Sun,

Cecilia J Hillard

and Benjamin F Cravatt

BLOCKADE OF 2-AG HYDROLYSIS BY

SELECTIVE MONOACYLGLYCEROL LIPASE

INHIBITOR JZL184 ENHANCES RETROGRADE

ENDOCANNABINOID SIGNALING

Marcoita Gilbert

and Ken Soderstrom

MORPHOLOGICAL CHANGES IN ZEBRA

FINCH TELENCEPHALON FOLLOWING

DEVELOPMENTAL CANNABINOID EXPOSURE

Sabrina Francesca Lisboa

and Francisco Silveira Guimarães

INFLUENCE OF ENDOCANNABINOIDS ON

FLIGHT REACTION INDUCED BY A NITRIC OXIDE

DONOR (SIN-1) ADMINISTRATION INTO THE

DORSOLATERAL PERIAQUEDUCTAL GRAY

Thomas F. Gamage,

Mary M. O’Connell, Mary E. Tokarz

and Jenny L. Wiley

CHANGES IN SENSITIVITY TO THC AFTER

REPEATED ADMINISTRATION IN MALE AND

FEMALE ADOLESCENT

AND ADULT RATS

Tiffany T.-Y. Lee,

Matthew N. Hill, Caitlin J. Riebe

and Boris B. Gorzalka

EXPOSURE TO ESCALATING DOSES

OF A CANNABINOID CB1 RECEPTOR

AGONIST DURING ADOLESCENCE

SUPPRESSES ADULT NEUROGENESIS

Michal Schechter, Or Raviv,

Albert Pinhasov, Aron Weller

and Ester Fride

BLOCKADE OF THE CANNABINOID

CB1 RECEPTOR IMPAIRS MATERNAL

BEHAVIOR AND OFFSPRING DEVELOPMENT

AND PERFORMANCE AT ADULTHOOD IN MICE

Gernot Riedel,

Susan McKillop-Smith

and Lianne Robinson

ACUTE AND CHRONIC HU210

TREATMENT DIFFERENTIALLY AFFECTS

SPATIAL LEARNING AND MEMORY

Peter J. McLaughlin, V. Kiran

Vemuri, Alexandros Makriyannis,

Janel K. Hodge, Joshua P. Bow,

Rikki Miller

and Joshua Staszewski

MICROANALYSIS OF FOOD-MAINTAINED

LEVER PRESSING DISTINGUISHES EFFECTS

OF THE CB1 ANTAGONIST AM 6527

FROM THOSE OF PREFEEDING

Antonio Luchicchi, Salvatore Lecca,

Giuliano Pillolla, Stefano Carta

and Marco Pistis

INHIBITION OF FAAH ANTAGONIZES COCAINE

AND NICOTINE EFFECT ON NEURONS IN THE

NUCLEUS ACCUMBENS SHELL IN THE RAT

D. Matthew Walentiny,

Robert E. Vann, Benjamin F. Cravatt,

Aron H. Lichtman, Jonathan Z. Long,

Joel E. Schlosburg and Jenny L. Wiley

DISCRIMINATIVE STIMULUS EFFECTS OF THC

IN FAAH KNOCKOUT AND WILD-TYPE MICE

Michael E Ballard,

Gillinder Bedi, David A Gallo

and Harriet de Wit

EFFECTS OF ACUTE Δ9-THC ON PERCEPTION

AND MEMORY IN HEALTHY VOLUNTEERS –

RELATION TO VALENCE, MOOD

Divya Ramesh, Joel E. Schlosburg,

Rehab Abdulla, Jonathan Z. Long,

Benjamin F. Cravatt


INDUCTION OF PHYSICAL WITHDRAWAL

THROUGH PROLONGED ELEVATIONS OF

ENDOCANNABINOIDS

John Sesay, Anushka V.Goonawardena,

Gernot Riedel

and Robert E. Hampson

PHARMACOLOGICAL ELEVATION OF

ANANDAMIDE IMPAIRS SHORT-TERM

MEMORY BY ALTERING HIPPOCAMPAL

NEUROPHYSIOLOGY

Ludovic Brodusch, Nicolas Wagener

and David Bearman

MEDICINAL CANNABIS: HOW CANNABINOIDS

CAN HELP TREATING ATTENTION DEFICIT /

HYPERACTIVITY DISORDER (ADHD)?

Philippe Lucas A PATIENT SURVEY OF CANADA’S

MEDICAL CANNABIS PROGRAM AND PRODUCT

Shimon Rabichev, Yael Winter

and Ester Fride

CANNABINOID CB1 RECEPTOR ANTAGONIST

BLOCKADE AT BIRTH MAY BE ASSOCIATED

WITH ADHD

Jeffrey Hergenrather

and David Bearman

THE AMERICAN ACADEMY

OF CANNABINOID MEDICINE

Shelley L. Amen

and Cecilia J. Hillard

CHRONIC COCAINE TREATMENT,

WITHDRAWAL AND CHALLENGE ELICIT BRAIN

REGIONAL ALTERATIONS IN ANANDAMIDE

(AEA) CONCENTRATION AND FATTY ACID

AMIDE HYDROLASE (FAAH) ACTIVITY

Vinod K. Yaragudri, Suham A. Kassir,

Basalingappa L. Hungund,

Thomas B. Cooper, John Mann

and Victoria Arango

SELECTIVE ALTERATIONS IN THE CB1 RECEPTOR

AND THE FATTY ACID AMIDE HYDROLASE

IN THE VENTRAL STRIATUM OF

ALCOHOLIC AND SUICIDE VICTIMS

Hiroki Ishiguro, Yasue Horiuchi,

Maya Ishikawa, Aoi Syu,

Minori Koga, Emmanuel Onaivi,

Makoto Takahashi, Akiyoshi Kakita,

Hitoshi Takahashi, Hiroyuki Nawa

and Tadao Arinami

BRAIN CANNABINOID CB2

RECEPTOR AND SCHIZOPHRENIA

Krishna Kaphle

and S. Gautam

CANNABIS SATIVA USE IN

FOOD CULTURE OF NEPAL

Linda Klumpers, Christine Roy,

Franck Poitiers, Sandrine Turpault

and Joop van Gerven

CB1-ANTAGONIST SURINABANT INHIBITS THC-

EFFECTS IN HUMAN THC-CHALLENGE TEST

Jennifer M. Vollmer, Daniel J. Fridberg,

Patrick D. Skosnik

and Brian F. O’Donnell

THE RELATIONSHIP BETWEEN

SCHIZOTYPAL PERSONALITY TRAITS

AND CHRONIC CANNABIS USE

Patrick D. Skosnik, Giri P. Krishnan,

Adam B. Steinmetz, Chad R. Edwards,

Jennifer M. Vollmer, William P. Hetrick,

and Brian F. O’Donnell

DISRUPTION OF THE GAMMA-BAND AUDITORY

STEADY-STATE EEG RESPONSE BY

CANNABINOIDS IN HUMANS

Yuki Yamasaki, Naoki Amada,

Akihito Watanabe,

Serena Deiana, Tetsuro Kikuchi

and Gernot Riedel

EFFECTS OF CANNABIGEROL (CBG)

ON CONDITIONED AVOIDANCE

RESPONDING IN RATS

Sharon Anavi-Goffer, Shimon Rabichev,

Hodaia Matan, Ken Mackie,

Ruth A. Ross and Ester Fride

POSTNATAL NMDA-INHIBITION

INDUCES ALTERATIONS IN CB1 RECEPTOR

EXPRESSION LEADING TO SCHIZOPHRENIC-LIKE

BEHAVIOUR IN ADULTHOOD

Christopher J. Roberts


SEXUAL DIMORPHISM IN CB1R-MEDIATED

RECOVERY FROM STRESS-INDUCED

HPA AXIS ACTIVATION

David Bearman

CLINICAL APPLICATION OF BASIC

RESEARCH:CANNABIS AND CANNABINOIDS IN

THE TREATMENT OF ADD/ADHD

David Alan Taylor,

Elaine Hoi Ling Wong,

Theo Mantamadiotis

and Daniel Thomas Malone

LACK OF BEHAVIOURAL

AND NEUROMOLECULAR EFFECTS OF

CHRONIC PUBERTAL WIN 55,512-2

TREATMENT IN ADULT RATS

Naoki Amada, Akihito Watanabe,

Yuki Yamasaki,

Serena Deiana, Tetsuro Kikuchi

and Gernot Riedel

EFFECTS OF AM281 AND CANNABIGEROL

PURIFIED FROM CANNABIS EXTRACTS

ON STEREOTYPED BEHAVIOUR

INDUCED BY APOMORPHINE

Tara Halpern, Mersiha Mehanovic,

Norman Schanz, Robert Benno

and Emmanuel Onaivi

CANNABINOID-INDUCED BEHAVIORAL

EFFECTS IN A MOUSE MODEL OF

AUTISM SPECTRUM DISORDERS

Bradley E. Alger

and Meina Wang

ACUTE RESTRAINT STRESS ENHANCES

HIPPOCAMPAL ENDOCANNABINOID FUNCTION

VIA GLUCOCORTICOID RECEPTOR ACTIVATION

Matthew N. Hill,

Cecilia J. Hillard

and Bruce S. McEwen

REMOVAL OF ADRENAL STEROIDS

MODULATES CORTICOLIMBIC

ENDOCANNABINOID SIGNALING

Notes:

Lalita D. Shrestha


STUDIES OF POST-TRANSLATIONAL

MODIFICATIONS OF NEURONAL


Eric L. Barker, Ekaterina A. Placzek,

Bruce R. Cooper, Andrew T. Placzek,

Julia A. Chester and V. Jo Davisson

LIPIDOMIC ANALYSIS OF ANANDAMIDE

METABOLITES REVEALS NOVEL

BIOTRANSFORMATION PATHWAYS

Seon A. Hepburn, John W. Huffman,

Dow Hurst, Patricia H. Reggio,

Jenny L. Wiley and Billy R. Martin

1-METHOXY ANALOGS OF CP-47,497

Bright Okine, Leonie Norris,

Annie Patel, Peter Christensen,

Steve Alexander,David Kendall,

David Barrett, Andrew Bennett

and Victoria Chapman

EFFECTS OF ACUTE VERSUS

REPEATED INHIBITION OF FAAH

ON ENDOCANNABINOID SYNTHESIS

AND CATABOLISM IN THE

MIDBRAIN AND LIVER

Natsuo Ueda, Jun Wang, Li-Ying Zhao,

Toru Uyama, Kazuhito Tsuboi

and Takeharu Tonai

AMINO ACID RESIDUES IMPORTANT FOR PH

DEPENDENCY AND PROTEOLYTIC MATURATION

OF N-ACYLETHANOLAMINE- HYDROLYZING

ACID AMIDASE (NAAA)

Michele K. McKinney


NEXT GENERATION MOUSE MODELS FOR

FATTY ACID AMIDE HYDROLASE

Jacqueline L. Blankman,

Gabriel M. Simon,

Michele K. McKinney


CHARACTERIZATION OF NOVEL MOUSE

BRAIN 2-AG HYDROLASES

Amy Sasman and Cecilia Hillard

CIRCADIAN PATTERNS IN MRNA

EXPRESSION AND ACTIVITY OF FATTY

ACID AMIDE HYDROLASE

Toru Uyama, Jun Morishita,

Xing-Hua Jin, Yasuo Okamoto,

Kazuhito Tsuboi and Natsuo Ueda

THE TUMOR SUPPRESSOR H-REV107 FUNCTIONS

AS PHOSPHOLIPASE A1/2 WITH A LOW

N-ACYLTRANSFERASE ACTIVITY

Nadine M. Ulloa and Dale G. Deutsch NAM INHIBITION OF MAGL: COMPARISON OF

A COLORIMETRIC AND RADIOMETRIC ASSAY

Stephen PH Alexander and Annie Patel

4-NITROPHENYLACETATE AS A POTENTIAL

SUBSTRATE FOR MAG LIPASE: INVESTIGATION OF

AN ASSAY SUITABLE FOR HIGH-THROUGHPUT

SCREENING USING RAT TISSUES

Alexander A. Zoerner, Frank M. Gutzki,

Maria T. Suchy, Bibiana Beckmann,

Stefan Engeli, Jens Jordan

and Dimitrios Tsikas

TARGETED STABLE-ISOTOPE DILUTION GC-MS/MS

DETERMINATION OF THE ENDOCANNABINOID

ANANDAMIDE AND OTHER FATTY ACID

ETHANOL AMIDES IN HUMAN PLASMA

Sherry Shu-Jung Hu,

Jonathan Long, Andy Arnold,

Jim Wager-Miller, Ben Cravatt,

Ken Mackie and Alex Straiker

MONOACYL GLYCEROL LIPASE (MGL) LIMITS THE

DURATION OF ENDOCANNABINOID-MEDIATED

DEPOLARIZATION-INDUCED SUPPRESSION OF

EXCITATION (DSE) IN AUTAPTIC HIPPOCAMPAL

NEURONS

Emmelie Björklund, Erika Norén,

Johanna Nilsson, Yanlin Hu,

and Christopher J. Fowler

THE PEROXISOME PROLIFERATOR-ACTIVATED

RECEPTOR LIGAND TROGLITAZONE IS A

POTENT INHIBITOR OF MONOACYLGLYCEROL

LIPASE

Philip J. Kingsley, Sachin Patel

and Lawrence J. Marnett

SIMULTANEOUS ANALYSIS OF 2-

ARACHIDONOYLGLYCEROL, ARACHIDONIC

ACID AND SELECTED DIACYLGLYCEROLS

BY LC-ESI-MS/MS

Maria Grazia Cascio, Lisa A. Gauson,

Lesley A. Stevenson, Ruth A. Ross

and Roger G. Pertwee

CANNABIGEROL BEHAVES AS A POTENT

ALPHA-2-ADRENOCEPTOR PARTIAL AGONIST

Samir A. Ross, Mohamed M. Radwan,

Safwat A. Ahmed, Desmond Slade,

Anwen Eslinger, Olivia Dale,

Susan Manly, Stephen Cutler

and Mahmoud A. ElSohly

BINDING AFFINITIES OF MINOR CANNABIS

CONSTITUENTS TO CB1 AND CB2 RECEPTORS

Dolores Hernán, Guillermo Velasco,

Mar Lorente, Sofía Torres,

Mª Esther Gil

and Ana-Isabel Torres

CHARACTERIZATION AND

IN VIVO EVALUATION OF A

CONTROLLED RELEASE DELIVERY SYSTEM

FOR Δ9-TETRAHYDROCANNABINOL

ADMINISTRATION

Serena Deiana , Akihito Watanabe,

Yuki Yamasaki, Naoki Amada,

Tetsuro Kikuchi and Gernot Riedel

EFFECTS OF TETRAHYDROCANNABIVARIN

(THCV) AND RISPERIDONE ON MK-801-INDUCED

SOCIAL RECOGNITION DEFICITS IN RATS

Colin Stott, Leo Ayerakwa,

Stephen Wright,

Tetsuro Kikuchi

and Geoffrey Guy

THE GENOTOXICOLOGY OF

PHYTOCANNABINOIDS

Alistair VW Nunn, Jimmy D Bell

and Geoffrey W Guy

FROM PLANT POLYPHENOL STRESS PATHWAYS

TO THE ENDOCANNABINOID SYSTEM:

CO-EVOLVED MODULATION OF BEHAVIOUR

AND BIOENERGETICS

Akihito Watanabe , Yuki Yamasaki,

Naoki Amada, Serena Deiana ,

Tetsuro Kikuchi and Gernot Riedela

EVALUATION OF THE PURIFIED THCV AND

PLANT EXTRACTS RICH IN THCV

IN THE MOUSE IRWIN TEST

Andrew J. Hill, Samantha E. Weston,

Nicholas A. Jones,

Elizabeth M. Williamson,

Gary J. Stephens, Benjamin J. Whalley

and Claire M. Williams

ANTI-CONVULSANT PROPERTIES OF

9-THCV IN ADULT RATS IN CHEMICALLY-

INDUCED SEIZURES

Imogen Smith, Sarah Bevan,

Ben Whalley and Gary Stephens

PHYTOCANNABINOID AFFINITIES AT CB1

RECEPTORS IN THE MOUSE CEREBELLUM

Jahan P. Marcu, Rigel T. Christian,

Anne Zielinski, Maxx P. Horowitz,

Darryl Lau, Dan H. Moore,

Pierre-Yves Desprez, Garret L. Yount

and Sean D. McAllister

PLANT WISDOM: CANNABIDIOL SYNERGIZES

WITH Δ9-TETRAHYDROCANNABINOL TO INHBIT

HUMAN GLIOBLASTOMA PROLIFERATION AND

SURIVAL

Somnath Mukhopadhyay,

Inneke Johnson, Susana C. Hilderbrand,

Tonya Gerald and David Tulis

CB2 CANNABINOID RECEPTOR-MEDIATED

S-NITROSYLATION OF MATRIX

METALLOPROTEINASE IN ENDOTHELIAL

CELLS: A NOVEL MECHANISM FOR THE

REGULATION OF ANGIOGENESIS

Filomena Fezza, Monica Bari,

Paolo Maturo, Valeria Gasperi,

Raffaella Docimo

and Mauro Maccarrone

ANANDAMIDE METABOLISM IN GINGIVAL

CREVICULAR FLUID AND PERIODONTAL TISSUE

Nissar A. Darmani,

Seetha Chebolu, Andrew P. Ray

and Yaozhi Wang

WIN55, 212-2 PREVENTS LEUKOTRIENE-INDUCED

VOMITING IN THE LEAST SHREW (Cryptotis parva)

Hodaya Dahan, Aron Weller

and Ester Fride

CANNABINOID CB1 RECEPTOR BLOCKADE AT

BIRTH CAUSES GROWTH FAILURE DUE TO ORAL

MOTOR WEAKNESS AND IS MEDIATED BY

PERIPHERAL MECHANISMS

Stefan Engeli, Matthias Blüher,

Andrea Bosse-Henck,

Sandor Batkai, Pal Pacher,

Judy Harvey-White,

George Kunos

and Jens Jordan

CIRCULATING ENDOCANNABINOIDS ARE

RELATED TO BLOOD PRESSURE IN PATIENTS

WITH OBSTRUCTIVE SLEEP APNEA

Fabiana Piscitelli, Angelo A. Izzo,

Raffaele Capasso, Stefania Petrosino


ALTERATIONS OF BASAL AND

FASTING/REFEEDING-REGULATED TISSUE

LEVELS OF ENDOGENOUS N-ACYL-

ETHANOLAMINE LIGANDS OF PPAR-

IN OBESE ZUCKER RATS

Amanda R. Jones, M. Jerry Wright Jr.

and Jenny L. Wiley

EFFECT OF HIGH-FAT DIET ON THE SENSITIVITY

TO DELTA-9-TETRAHYDROCANNABINOL IN

FEMALE LONG-EVANS RATS

Natalia Battista, Felice Francavilla,

Arcangelo Barbonetti,

Vassallo Maria Rosaria, Cinzia Rapino,

Carla Antonangelo,

Nicoletta Pasquariello,

Barbara Barboni

and Mauro Maccarrone

FERTILIZING ABILITY OF HUMAN

SPERM IS CONTROLLED

BY TRPV1 VANILLOID RECEPTOR

Luciano De Petrocellis,

Paola Grimaldi, Pierangelo Orlando,

Sara Di Siena, Francesca Lolicato,

Stefania Petrosino, Tiziana Bisogno,

Raffaele Geremia


CB2 RECEPTORS IN MOUSE MALE GERM CELL

DIFFERENTIATION

Caitlin J. Riebe, Tiffany T. Lee,

Matthew N. Hill

and Boris B. Gorzalka

ESCALATING ADMINISTRATION

OF CANNABINOIDS DURING ADOLESCENCE

AUGMENTS MALE COPULATORY

BEHAVIOR IN ADULTHOOD

Xiaofei Sun and Sudhansu K. Dey ABERRANT ENDOCANNABINOID SIGNALING

COMPROMISES EPIDIDYMAL FUNCTION

Mariateresa Cipriano, Caterina Scuderi,

Daniele De Filippis, Giuseppe Esposito,

Antonio Steardo, Vincenzo Di Marzo

and Teresa Iuvone

PALMITOYLTHENOLAMIDE CONTROLS BETA

AMYLOID-INDUCED GLIAL HYPERACTIVATION

Julie M. Ziobro, Robert E. Blair,

Laxmikant S. Deshpande

and Robert J. DeLorenzo

WIN 55,212-2 MEDIATED NEUROPROTECTION

AND PREVENTION OF EPILEPTOGENESIS

FOLLOWING GLUTAMATE-INJURY

IN AN ORGANOTYPIC HIPPOCAMPAL

SLICE CULTURE MODEL

Cristina Benito, Ana Isabel Castillo,


Alicia López, Cristina Otalora,

Rosa M. Tolón, José Martínez-Orgado,

Benjamin F Cravatt and Julián Romero

THE GENETIC ABLATION OF FAAH MODIFIES

THE ASTROCYTIC RESPONSE AGAINST BETA

AMYLOID PEPTIDE


Cristina Benito, Alicia López,

Cristina Otalora, Rosa M. Tolón,

Benjamin F. Cravatt and Julián Romero

THE SELECTIVE DELETION OF FAAH ALTERS THE

APPEARANCE OF BETA AMYLOID PLAQUES IN

AN ANIMAL MODEL OF ALZHEIMER’S DISEASE

Megan Dowie, Douglas McHugh,

Heather Bradshaw, Monique Howard,

Louise Nicholson, Richard Faull,

Anthony Hannan and Michelle Glass

MOLECULAR IMPACTS OF CHRONIC

CANNABINOID TREATMENT IN HUNTINGTON’S

DISEASE TRANSGENIC MICE

Carla Pisu, Stefania Marcello,

Paolo Lazzari, Giovanni Loriga,

Stefania Ruiu, Christian Dessì,

Matteo Falzoi, Luigi Pira

and Luca Pani

RECEPTORIAL AND PHARMACOLOGICAL

CHARACTERIZATION OF THE NEW

CANNABINOID AGONIST NESS040C5

Xueqing Wang, Teodozyj Kolasa,

Jennifer M. Frost, Meena V. Patel,

Steven P. Latshaw, Arturo Perez-

Medrano, Sridhar Peddi, William A.

Carroll, Michael J. Dart, Anthony Daza,

George Grayson, Yihong Fan, Loan

Miller, Lanlan Li, Bradley A. Hooker,

Tiffany Garrison, Odile F. El-Kouhen,

Prasant Chandran, Anita Salyers,

Madhavi Pai, Gin Hsieh, Betty Yao

and Michael Meyer

CYANOAMIDINE ANALOGS OF N-

THIAZOLYLIDENE CARBOXIMIDE: POTENT,

SELECTIVE CANNABINOID CB2 AGONIST AS

NOVEL PAIN THERAPEUTICS

Bo Liu, Keith Ryther, Xueqing Wang,

Anthony Daza, Lanlan Li,

George Grayson, Yihong Fan,

Loan Miller, Bradley Hooker,

Tiffany Garrison, Odile El-Kouhen,

Chang Zhu, Gin Hsieh, Betty Yao,

Michael Dart and Michael Meyer

STRUCTURE-ACTIVITY RELATIONSHIP STUDIES

ON A NOVEL SERIES OF IMIDAZOPYRIDINE

DERIVATIVES AS CANNABINOID RECEPTOR 2

(CB2) AGONISTS

Elizabeth J. Rahn, Ganesh A. Thakur,

Alexander M. Zvonok,

V. Kiran Vemuri,

Alexandros Makriyannis

and Andrea G. Hohmann

PHARMACOLOGICAL CHARACTERIZATION OF

PUTATIVE CANNABINOID CB2 AGONISTS FROM

THE CANNABILACTONE CLASS:

ANTINOCICEPTION WITHOUT CENTRAL

NERVOUS SYSTEM SIDE-EFFECTS

Lamont Booker, Steven G. Kinsey,

Kay Ahn, Benjamin F. Cravatt


FAAH INHIBITION REVERSES

LIPOPOLYSACCHARIDE-INDUCED

MECHANICAL ALLODYNIA

Christopher J. Fowler, Lina Thors,

James J Burston, Benedict J. Alter,

Michele K. McKinney,

Benjamin F. Cravatt, Ruth A. Ross,

Roger G. Pertwee, Robert W. Gereau

and Jenny L. Wiley

BIOCHANIN A: A NATURALLY OCCURRING,

PERIPHERALLY ACTING INHIBITOR OF FATTY

ACID AMIDE HYDROLASE

Joel Musee and Lawrence J. Marnett SUBSTRATE SPECIFICITY IN THE

ACTIVATION OF COX-2

Mark Ware, Tongtong Wang,

Stan Shapiro and Jean-Paul Collet

CANNABIS FOR THE MANAGEMENT OF PAIN:

ASSESSMENT OF SAFETY STUDY (COMPASS)

Mauro Maccarrone, Nicoletta

Pasquariello, Giuseppina Catanzaro,

Valeria Marzano, Daniele Amadio,

Daniela Barcaroli, Sergio Oddi,

Giorgio Federici, Andrea Urbani

and Alessandro Finazzi-Agrò

PROTEOMIC ANALYSIS OF

ANANDAMIDE-INDUCED APOPTOSIS

IN HUMAN NEURONAL CELLS

Luciano De Petrocellis,

Alessia Ligresti,

Aniello Schiano Moriello,

Marco Allarà, Pierangelo Orlando


EFFECT OF PHYTOCANNABINOIDS ON HUMAN

PROSTATE CARCINOMA CELLS

D. Petit, C. Kramer

and P. Bagavandoss

DIFFERENTIAL EFFECTS OF THE ANTIOXIDANTS

ALPHA TOCOPHEROL AND BUTYLATED

HYDROXYANISOLE (BHA) ON AM251-INDUCED

ENDOTHELIAL CELL GROWTH INHIBITION

Natsuo Ueda, Jun Wang,

Li-Ying Zhao, Toru Uyama

and Kazuhito Tsuboi

EXPRESSION OF ANANDAMIDE-RELATED

ENZYMES IN HUMAN PROSTATE CANCER CELLS

Laurie Hamtiaux, Laurie Hansoulle,

Giulio Muccioli and Didier M Lambert

DECREASE OF TUMOR CELL VIABILITY VIA

INHIBITION OF ENDOCANNABINOID

DEGRADATION BY URB597

R. Bryan Rock,

Shuxian Hu, Wen S. Sheng

and Phillip K. Peterson

WIN55,212-2 PROTECTS HUMAN DOPAMINERGIC

NEURONS AGAINST GP120-INDUCED DAMAGE

Thitirat Ngaotepprutaram,

Barbara L.F. Kaplan,

Robert B. Crawford,

and Norbert E. Kaminski

DELTA9-TETRAHYDROCANNABINOL (∆9-THC)

SUPPRESSES CD40 LIGAND (CD40L)

UPREGULATION IN ACTIVATED CD4+ T CELLS

Ehsan Taqavi, Gideon Blumstein

and Nancy E. Buckley

EFFECTS OF CHRONIC THC TREATMENTS ON

ADAPTIVE IMMUNE RESPONSES TO CANDIDA

ALBICANS INFECTED C57BL/6 MICE

Beverly McDowell

and Nancy E. Buckley

THE EFFECTS OF THC ON THE INNATE IMMUNE

RESPONSE TO SYSTEMIC CANDIDA ALBICANS

INFECTION IN MICE

Kristen Peskuski

PUTATIVE ABBERATION OF THE

ENDOGENOUS CANNABINOID SYSTEM:

A CASE STUDY

Weimin Chen, Peer W. F. Karmaus,

Barbara L.F. Kaplan


REDUCED CYTOTOXIC T LYMPHOCYTE (CTL)

EFFECTOR RESPONSES IN CANNABINOID

RECEPTORS 1 AND 2 DEFICIENT MICE IN VITRO

Peer Karmaus, Weimin Chen,

Barbara Kaplan and Norbert Kaminski

Δ9-TETRAHYDROCANNABINOL DIRECTLY

IMPAIRS CYTOTOXIC T LYMPHOCYTE EFFECTOR

FUNCTION DURING DIFFERENTIATION

Michiel GJ Balvers,

Kitty CM Verhoeckx, Jocelijn Meijerink,

Pierluigi Plastina

and Renger F Witkamp

FORMATION AND IMMUNE MODULATING

ACTIVITIES OF THE ETHANOLAMIDE FROM

DOCOSAHEXAENOIC ACID IN 3T3L1

ADIPOCYTES AND RAW 264.7 MACROPHAGES

Priyadarshini Raman, Barbara L.F.

Kaplan, Jerry T. Thompson,

John P. Vanden Heuvel


PEROXISOME PROLIFERATOR ACTIVATED

RECEPTOR IS ACTIVATED BY 15D-PGJ2-G,

A PUTATIVE METABOLITE OF

2-ARACHIDONYL GLYCEROL

Preliminary Programme - ICRS 2009 · Ana-Isabel Torres, Luciano De Petrocellis and Vincenzo Di...

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