Predicting Success with VV ECMO - Home - Critical …...Barbaro R et al. Am J Respir Crit Care Med...
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Predicting Success with VV ECMO Is there a “sure thing”? CCCF 2015 ECMO – Tuesday, October 27, 2015 Eddy Fan MD, PhD, FRCPC Critical Care Medicine Medical Director, Extracorporeal Life Support (ECLS) Program Director, Critical Care Research Mount Sinai Hospital and University Health Network Assistant Professor of Medicine Interdepartmental Division of Critical Care Medicine Department of Medicine, University of Toronto
Transcript of Predicting Success with VV ECMO - Home - Critical …...Barbaro R et al. Am J Respir Crit Care Med...
Predicting Success with VV ECMOIs there a “sure thing”?
CCCF 2015ECMO – Tuesday, October 27, 2015
Eddy Fan MD, PhD, FRCPCCritical Care MedicineMedical Director, Extracorporeal Life Support (ECLS) ProgramDirector, Critical Care ResearchMount Sinai Hospital and University Health Network
Assistant Professor of MedicineInterdepartmental Division of Critical Care MedicineDepartment of Medicine, University of Toronto
Disclosures/COI
• No relevant financial relationships with any commercial interests
Barbaro R et al. Am J Respir Crit Care Med 2015;191:894-901.
“ECMO is less a discrete intervention than a commitment by a large group of skilled individuals to provide ongoing
high-risk, high-tech life support at extraordinary cost of time, energy,
equipment, and money.”
John Lantos, Neonatal Bioethics: The Moral Challenges of Medical Innovation (2006)
Distelmaier K et al., Crit Care 2014;18:R24.
Hsiao CC et al., Ann Thorac Surg 2014;97:1939-1944.
PREDICTION SCORESPrediction of VV ECMO Success
Schmidt M et al., Intensive Care Med 2013;39:1704-1713.
Characteristic Score
Age (years)18-4950-59≥ 60
0-2-3
Immunocompromised -2
MV prior to ECMO< 48 hours48 hours – 7 days> 7 days
310
Acute respiratory diagnosis groupViral pnemoniaBacterial pnemoniaAsthmaTrauma/burnAspiration pneumonitisOther acute respiratory diagnosisChronic respiratory and non-
respiratory diagnosis
33
113510
Schmidt M et al., Am J Respir Crit Care Med 2014;189:1374-1382.
Characteristic Score
CNS dysfunction -7
Acute associated (non-pulmonary) infection
-3
NMBA before ECMO 1
NO before ECMO -1
NaHCO3 infusion before ECMO -2
Cardiac arrest before ECMO -2
PaCO2 (mmHg)< 75≥ 75
0-1
PIP (cm H2O)< 42≥ 42
0-1
TOTAL RESP SCORE -22 to 15
Schmidt M et al., Am J Respir Crit Care Med 2014;189:1374-1382.
ROC c = 0.74 (95% CI 0.72-0.76)
External validationc = 0.92 (95% CI 0.89-0.97)
Enger TB et al., Crit Care 2014;18:R67.
Volume-Outcome Relationship?
Barbaro R et al., Am J Respir Crit Care Med 2015;191:894-901.
LIMITATIONS AND FUTURE DIRECTIONS
Prediction of VV ECMO Success
• All patients already on ECMO at experienced centers
– Need to focus also on who to (or not to) offer VV ECMO
• Focus on longer-term mortality and morbidity
– Will be very useful in prognostication/decision-making when discussing treatment options with patients/family/surrogates
Fan E and Pham T., Am J Respir Crit Care Med 2014;189:1292-1294.
Peek GJ et al., Lancet 2009;374:1351-1363.
• HRQOL scores at 6 months were better than those reported in similar ARDS cohorts
– Physical function domains of the SF-36, including general health and vitality most affected
– Clinically-significant depression (4%) and anxiety (8%) were relatively low as compared to previous cohorts
Hodgson C et al., Crit Care 2012;16:R202.
Schmidt M et al., Intensive Care Med 2013;39:1704-1713.
Quill TE and Holloway R., JAMA 2011;306:1483-1484.
“Prediction is very difficult, especially if it’s about the future”
Niels Bohr (1885-1962)
