Pratik swarup das
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Transcript of Pratik swarup das
A Seminar onA Seminar onCO-PROCESSED EXCIPIENTCO-PROCESSED EXCIPIENT
Noida Institute of Engineering and Technology,Pharmacy Institute
Presented by Pratik Swarup Das
M.Pharm(Pharmaceutics),1st yr
Co-processing
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Co-processing is a process in which two or more excipients interacting at the sub particle level, the objective of which is to provide a synergy of functionality improvements as well as masking the undesirable properties of individual excipients.
The main aim of co‐processing is to obtain a product with added value related to the ratio of its functionality / price.
Need for developing Co-processed Excipients
The growing popularity of the direct‐compression
process & demand for an ideal filler–binder that can
substitute two or more excipients.
The ability to modulate the solubility, permeability, or
stability.
To address the issues of flowability, compressibility,
and disintegration potential.
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Properties
Improved Flow Properties
Improved compressibility
Absence of chemical change
Reduced lubricant sensitivity
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Steps in Co-processing of Excipients
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Example Name Supplier Ingredients %
Ludipress BASF Lactose 96.5PVP 3.5
Starlac 100 Meggle α Lactose monohydrate
85
Maize Starch 15Advantose FS SPI Fructose 95
Starch 5Xylitab 200 Danisco Xylitol 98
SCMC 2
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Modified MCC-Name Supplier Ingredients %
Avicel®
HFEFMC MCC 90
Mannitol 10ProSolv® JRS MCC 98
Colloidal Silicon Dioxide
2
Avicel® CE15 FMC MCC 85Guar gum 15
Avicel® DG FMC MCC 75DiCalcium Phosphate 25
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Advantages
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Provide a single excipient with multiple functionalities.
Better mouth feel and improved palatibility.
Removal of undesirable properties.
Improvement of organoleptic properties.
Conclusion
The concepts of advanced technologies have shown an
alternate path to obtain a new class of excipients known as
Co-processed excipients.
Their manufacturing is very simple with marginal cost of
production.
They serve as multipurpose excipients.
Provides a better option of Excipient selection to the growing
industries.
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References1. Chougule Ajay Subhash, Dikpati Amarita, Trimbake Tushar,
Formulation development technique of co-processed excipient, Journal Of Advanced Pharmaceutical Sciences, 2012,Vol.2, 231-249.
2. Ushari.S, Prasanthi C.H, Reassessment of novel co-processed multi-
functional excipient, International Research journal Of
Pharmaceutical and Applied Sciences,2013 ,122-128.
3. Marwaha Minakshi ,Sandhu Dipak, Marwaha Rakesh Kumar, Co-
processing of excipient: A review on excipient development for
improved tableting performance, International Journal Of Applied
Pharmaceutics, vol 2,41-47.11
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4. Aulton’s Michel E, The design and manufacture of medicine,churchill livingstone elsevier, third edition, 2007, 355-356
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