Practical Protocols – experience and evidence based routines

Practical Protocols – experience and evidence based

routines

Henrik Ekberg

Living Donor Kidney Transplantation - Protocols

Why do we need protocols?

• Every transplant centre needs to make decisions on their routine practice.

• The reason for this is that all patients should be given the best possible care.

• These protocols should be based on current transplantation research

• They should be updated at regular intervals.

• The objective is to reach the highest international standard of outcome after kidney transplantation.

How to make your own protocols

• The book is published in Chinese and in English.

• With the book you should find a CD.

• If you want to make a print out of the same text as in the book, use the pdf file.

• If you want to make your own protocols, similar to what we have suggested but with an update or with local application, use the Word file.

A message from The Transplantation Society

Professor Jeremy Chapman, President, TTS 2008-2010.

• “This book provides the practical elements needed for a modern transplantation programme.

• It is absolutely essential in today’s clinical transplant programmes that all the professional staff work as a unit.

• Without protocols covering the most important aspects of transplant care there is no cohesion or collaboration.

• These Practical Protocols provide all transplant units the opportunity to build their own protocols easily and on a sound basis of international best practice. “

Structure of the Transplant Centre

DirectorTransplant Centre

TransplantSurgery

Vice Director

Transplant Nephrology

Vice Director

Transplant Laboratories

Riskassessment Cardiology

TransplantCo-ordinator

Protocols

1. Kidney Recipient Work Up

2. Living Donor Work Up

3. Consent to Kidney Donation

4. Protocols for the Doctor: Admission of the Recipient Before Transplantation

5. Protocols for the Nurse: Admission of the Recipient Before Transplantation

6. Doctor’s Orders: Pre-operative Management in Kidney Transplantation

(1) Kidney Recipient work up

1. Cardiac evaluation

2. Parathyroid function

3. Glucose tolerance

4. APC resistance

5. Panel reactive antibodies

6. Dentist

7. Antibody screening (HIV, HBV, HCV, etc)

8. Vaccination

9. CT of iliac arteries

(2) Living Donor Work Up1. Informed consent2. Blood group test3. Electrocardiogram4. Clinical chemistry according to a specified list5. GFR6. Glucose tolerance test7. Echocardiogram8. Renal artery ultrasound9. Chest X-ray10. Myocardial scintigraphy (if > 50 yrs old)11. CT angiography of renal arteries12. Nephrologist’s decision13. Surgeon’s decision

More Protocols

7. Anaesthetist: Intra-operative Management in Kidney Transplantation

8. Post-operative Management After Kidney Transplantation

9. Routine Blood Samples After Kidney Transplantation For the Nurse in the Transplant Ward

10. Flow Chart of Events of Nursing After Kidney Transplantation

11. Flow Chart of Events of Nursing in Kidney Donation

12. Long-term Follow-up After Kidney Donation

13. Antibiotics and Kidney Transplantation

(14) Initial Immunosuppression After Kidney Transplantation

1. Normal risk patient (with basiliximab)

2. Normal risk patient (with no induction)

3. NODAT risk (steroid avoidance)

4. NODAT risk (low-dose steroids)

5. High risk (with basiliximab induction)

6. High risk (with ATG induction)

(14) Initial Immunosuppression After Kidney Transplantation

15 + 515 + 51010 for

1 week

then 0

15 + 515 + 5Prednisone

Mg/day

111111MMF g BID

543.5443.5Start dose

Mg BID for 70kg BW

0.070.060.050.060.060.05Start dose

Mg/kg BID

10 - 128 – 103 - 78 – 108 – 105 - 8Tac trough

ATGBasiliximabBasiliximabBasiliximabNoneBasiliximabInduction

High risk (2)

High risk (1)

NODAT (2)NODAT (1)Normal risk (2)

Normal risk (1)

Tacrolimus (target concentration 5 – 8 ng/mL)

MMF 750 mg x 2 (or azathioprine 75 – 100 mg x 1)

Prednisolone 5 mg at 8 am

Days 90 and after

Tacrolimus (target concentration 5 – 8 ng/mL)

MMF 750 mg x 2


Days 60-90

Tacrolimus (target concentration 5 - 8 ng/mL)

MMF 750 mg x 2


Days 30-60

Tacrolimus 0.05 mg/kg x 2 (target concentration 5 – 8 ng/mL)

MMF 1000 mg x 2

Prednisone 15 mg at 8 am and 5 mg at 8 pm

Day 4: basiliximab 20 mg IV

Every day after transplantation

(8 am and 8 pm) Days 1 – 30

Tacrolimus 0.05 mg/kg

MMF 1000 mg

Prednisolone 100 mg IV

In the evening(8 pm) of the day of transplantation

Methylprednisolone 500mg IV

Basiliximab 20 mg IV

At the start of transplantation in the operating room

Tacrolimus 0.05 mg/kg

MMF 1000 mg

Morning of the day of transplantation (6 am)

Tacrolimus 0.05 mg/kg (e.g. 3.5 mg)

MMF 1000 mg

Evening (8 pm) the day before transplantation

Final Protocols

15. Transplant Biopsy

16. Treatment of Acute Rejection

17. Long-term Follow-up After Kidney Transplant

18. Responsibilities of Surgeon and Nephrologist

19. The Gift of a Kidney

– Information for the Potential Donor

20. Further Reading

At your transplant center:

• Which protocols would you accept today as they are?

• Which protocols would you like to modify to make them applicable to your routines?

• Are there any protocols you would not use?

• Please, give me your comments and suggestions:

[email protected]

Practical Protocols – experience and evidence based routines

Documents

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