Practical dr magdy
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Slide (1):-Acute suppurative appendicitis
Naked eye :-Circular structure with bluish wall Organ :-T.S. of an appendix Comment :- 1-Lumen :-Necrotic debris,intact and dead
PNLs, 2-Mucosa :-Intact and ulcerated areas 3-Submucosa :-Edema ,dilated and congested
blood vessels , hyperplastic lymphoid follicles and PNL,s may extends to musculosa or serosa
Diagnosis :- Acute suppurative appendicitis
Slide (2):- Chronic inflammation
Organ :- Section in the skin Comment :- 1-Epidermis :- Thickened epidermis and keratin 2-Dermis :- -Arterioles :- Thickened and narrowed (EAO) -Peri-vascular cuffing by (lymphocytes ,plasma
cells and macrophages) -Increased fibroblasts and collagen.
Diagnosis :- Chronic inflammation in
skin
Slide(3):-Myocardial scarring Organ :- Section in heart Comment :- Intact cardiac muscles :- Running in different directions Infarction area :- Pale pink,fibrous tissue
area ,composed of wavy collagen,few fibroblasts and few dilated thin walled capillaries
Diagnosis:-
Myocardial scarring
Cell injury (degeneration)Water accumulation :-e.g Cloudy swelling of kidney Fat accumulation :-e.g fatty change of liver
Cloudy swelling :- Reversible cell damage characterized by mild
accumulation of water inside cells. Oragns affected :-Proximal convoluted tubules of
kidney ,liver and heartPathogenesis:-swollen mitochondria is fragmented
with resultant decreased production of ATP and consequent distrubed Na/K pump retention of Na and H2O inside cells .
Pathology Grossly :- The organ size :- Increased Colour :- Pale Consistency:- Soft
Cloudy swelling of kidney
Section in the kidney :- Glomeruli :- Normal Tubules :- -Lumen :- Narrowed and star shaped -Lining epithelial cells *Swollen *Conical (pyramidal ) shaped.Its apex
directed inward. *Pink and granular cytoplasm
(mitochondrial damage. *Intact rounded nuclei .
Diagnosis :- Cloudy swelling of the kidney
Slide(4):-Cloudy swelling of
kidney
Fatty change ,liverA condition characterized by accumulation of
triglyceride inside hepatocytesCauses:-1-Toxins->diphtheria 2-Chemicals as phosphorus
and CCL4Etiology:-1-Increased entrance of FFAheptocytes2-Increased synthesis of FA and decreasd its
oxidation 3-Increased estrification of FA4-Decreased formation of phospholipids5-Decreased excretion of phospholipids.
Specimen :- Section of liver Size :- enlargedSurface :-SmoothCapsule :-Thin ,stretched easilyStrepedColour :- YellowishBorders :- RoundedConsistency:- Soft
D13
Section in liver :- Liver cells :- Cytoplasm :- Contain large clear
vacuoles Nuclei :-Peripheral located
nuclei(signet ring appearance.Some intact liver cells are seen.Diagnosis :- Fatty changes of liver.
Slide(5):-Fatty changes of liver
Naked eye :-Rounded structure with intra-luminal thrombus (2nd rounded structure)
Section in blood vessel :- 1- The lumen of blood vessel :- -Filled by thrombus mass attached to the vessel wall at one point (head of the thrombus ) 2-The thrombus mass containing :-pale pink lines radiating from the head (lines of Zahn) and
contain in between meshwork of fibrin ,RBC,s and WBC,s.
Diagnosis :- Recent thrombus
Slide(6):-Recent thrombus
2nd of circular lesions
Naked eye :- 3rd rounded structure Section in an artery :- Intima :- Degenerated and elevated Subintima :- Fibro-fatty mass
containing , needle like crystals of cholesterol. and haylinized C.T ± calcification
Elastic lamina :-Fragmented Media opposite the lesion :- Atrophic . Diagnosis :- Atherosclerosis of an
artery
Slide(7):-Atherosclerosis
Atheroma
Calcification Media
crystals