[PPT]T Cell Development - The University of Vermontbwilcke/tumor.ppt · Web viewPrinciples of...
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Principles of Immunology Tumor Immunology 4/25/06
Transcript of [PPT]T Cell Development - The University of Vermontbwilcke/tumor.ppt · Web viewPrinciples of...
Word/Terms List AFP Benign Carcinoma CEA Leukemia Lymphoma Malignant Metastasis Neoplasm Oncogene Sarcoma Transformation TSTA
Tumor Immunology
Benign vs. malignant tumors
Types of neoplasms
Carcinomas Leukemias/lymphomas Sarcomas
Tumor-specific Transplantation Antigens
Origin of TSTAs
Point mutations Expressed by germ line cells Expressed by specific cell types Over expressed Post translation changes Viral oncogenes
Tumors and Evasion of the Immune System
Low immunogenicity
Modulation by antibodies
Tumor secreted suppressors