PPT Telaah Journal Sharania.pptx

8/17/2019 PPT Telaah Journal Sharania.pptx

1/17

TELAAH ARTIKELPENELITIAN

DESAIN KOHORT

Pembimbing:

dr. Djap Hadi S.,M.Kes

Disusun !e":

S"arania Mani#annan

$$%&'$( % $)&


2/17

TOPI*

Prospective Cohort Study of

Green Tea Consumption andColorectal Cancer Risk inWomen


3/17

PRO+LEM

• Tea and its constituents have shown

antioxidative, anti- inammatory, and

anticarcino!enic activities in numerous in vitro

and animal studies"

• #r!an sites that are accessi$le directly to orally

administered tea, such as di!estive tract, are

thou!ht to represent !ood tar!ets for potential

chemoprevention $y tea $ecause of the hi!h

$ioavaila$ility"


4/17

AIM

The inverse association with re!ular

tea drinkin! was o$served for $oth

colon and rectal cancers"This study

su!!ests that re!ular consumption

of !reen tea may reduce CRC risk in

women


5/17

DESIN

%nalitic

Prospective cohort study"


6/17

-ARIA+LE

&epende

nt

Colorectal

cancer inwomen

'ndepend

ent

Green tea

consumption


7/17

POPLATION DANSAMPLE(),*)+ women

$etween **and +... fromseven ur$ancommunities ofShan!hai

Women a!ed). to (.years at$aseline"


8/17

*RITERIAINKLSI/ :

demo!raphic characteristics, lifestyle and dietary ha$its,

medical history, and family history of cancer"

%nthropometric measurements, includin! current wei!ht,hei!ht, and circumferences of the waist and hips"

EKSKLSI/:

history of cancer, dia$etes, or familial adenomatouspolyposis, su$/ects with an extreme total ener!y intake

012.. or 34,2.. kcal5d, su$/ects lost to follow-up since

enrollment, or su$/ects who drank $lack or oolon! tea

re!ularly and exclusively"


9/17

METHODS AND

MATERIALS6uestionaires

The death certi7cate data, medical chartsfrom hospitals, endoscopy, radio!raphy0$arium-air dou$le contrast radio!raphyand computed tomo!raphic scans8 orultrasound"

*ON*EPTAL


10/17

*ON*EPTAL/RAME0ORK

Colorectal

CancerRisk in

Women

&rank tea

re!ularly 0atleast thriceper weeklastin! at

least months8

%!e shestarted such

ha$it

Type andamount of tea

Tea leavesconsumedpast year

Current statusof tea

consumption"


11/17

DATA ANAL1SIS

ST%T'ST'C %9%:'T';- multivariate

The Cox proportional ha


12/17

HASIL


13/17

R>S?:T


14/17

RESLT


15/17

*ON*LSION

'n this lar!e population-$ased prospective

cohort study, we found that re!ular

consumption of !reen tea was inverselyassociated with the risk of CRC, particularly

amon! women who maintained such ha$it

over time" The lon!er the duration oflifetime tea consumption, the lower was

the risk of CRC"


16/17

PROPOSITION

This prospective cohort study amon! women

in Shan!hai provides one of the stron!est

pieces of evidence in humans that re!ular

consumption of !reen tea may confer a

protection a!ainst CRC"

These 7ndin!s are consistent with data

from in vitro and in vivo experiments,

indicatin! that tea may serve as an

e@ective chemopreventive a!ent


17/17

T>R'A% ;%S'B

PPT Telaah Journal Sharania.pptx

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