PPT-"Boston Gulf War Illness Consortium" by Dr. Kimberly Sullivan

8/18/2019 PPT-"Boston Gulf War Illness Consortium" by Dr. Kimberly Sullivan

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Boston Gulf War Illness

Consortium

Kimberly Sullivan, Ph.D.

Boston University School

of Public Health

April

2016

http://www.va.gov/http://www.va.gov/


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25th Gulf War Anniversary

www.Liberationofkuwait.com


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ELEPHANT AND THE

BLIND MENCommonly

Reported

Symptoms

Fatigue

Joint pain

Headaches

Concentration

and memory

problemsGastrointestinal

problems

Skin Problems

Respiratory

problems

SEEING THE FOREST FOR THE TREES

GWI is a multi-symptom and multi-system illness

with different investigators studying separate

body systems for many years.

GWI consortium has a multidisciplinaryapproach to studying GWI.


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GWI Consortium (GWIC)

16

collaborators from 9 study sites including US and

Australia

Designed to bring preclinical (cell and animal) and

clinical (human) researchers together to speed

development of understanding pathobiology of GWI

and to develop treatments.

Our focus

-

study brain

-

immune

pathways and chronic

release of chemical messengers from immune cells of

the brain that lead to chronic

Neuroinflammation


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Primary Focus of GWIC Research Program

1) To identify objective biomarkers of

thepathobiology of GWI

2) To develop treatments for

GWI


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Specific Clinical Studies

Clinical Protocol in 300 GW veteran participants

Blood draw – inflammatory cytokines, chemokines

Structural MRI/DTI/fMRI

Neuropsychological assessment/questionnaires

Saliva samples – immune-genetic studies

Call Back Studies▪ CSF and blood study – Boston

PET pilot studies - Boston University, MGH

Stem cell study – Boston


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Current Treatment studies

1) D-cycloserine for cognitive improvement

2) Intranasal Insulin for cognitive improvement

3) Co-enzyme Q10 Phase III trial for reduced

fatigue and improved cognitive function


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Thank You

PPT-"Boston Gulf War Illness Consortium" by Dr. Kimberly Sullivan

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