Systemic Inflammations in Non Obese and Obese Uncontrolled Asthma
PP236-MON PROFILE LIPID DISORDERS IN OBESE MEXICAN CHILDREN
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S210 Poster presentations insulin resistance. The aim of this study was to characterise metabolic inflexibility via the dynamics of plasma levels of FFA after peroral MCT oil application in morbid obese type 2. diabetics Methods: FFA plasma levels were estimated in obese type 2. diabetics [n = 13, body mass index (BMI) > 35 kg/m 2 , age 37 64 y] via enzymatic method (kit Wako chemicals GmbH, Germany). Plasma levels of FFA were estimated before peroral application of 40 ml MCT (Nutricia), then in 30, 60, 120, 180, 240 and 1440 minute. During the examination ketone bodies and glucose were detected from the capillary blood. Data were statistically analyzed via Sigma Stat (One way ANOVA repeated measurement). The data are presented as mean±standard deviation. Results: After 40 ml MCT oil application a significant decrease of FFA plasma levels were detected (table 1). A significant correlation of plasma FFA and ketone bodies was found (r = 0.335, p < 0.03). Table 1. Dynamics of FFAplasma levels after MCT oil application Time (min) FFA (mmol/l) 0 0.92±0.15 30 0.79±0.13 60 0.69±0.11 120 0.61±0.15 180 0.58±0.13 240 0.64±0.09 1440 0.86±0.12 Conclusion: Peroral application of 40 ml of MCT oil in morbid obese type 2. diabetics was accompanied with significant decrease of FFA plasma levels maximum at the end of the third hour of testing. A significant correlation of plasma FFA and ketone bodies was found. Other examinations continue to characterize MCT-related plasma FFAdynamic of study group on conditions of decreasing metabolic inflexibility. Supported by MZ CZ DRO (FNHK) Disclosure of Interest: None Declared PP236-MON PROFILE LIPID DISORDERS IN OBESE MEXICAN CHILDREN V. Davila 1 , I. Martinez Del Rio Requejo 1 , J.A. Leyva Islas 1 , L. Hern´ andez-Amezcua 2 , O.O. Olea Salinas 3 . 1 Chilhood Obesity Clinic, 2 Lopez Mateos, Mexico DF, 3 Apoyo Metabolico Nutricio, Lopez Mateos, Mexico DF, Mexico Rationale: The prevalence of childhood obesity is increasing rapidly. Metabolic disorders are commonly present in obese children, especially lipid profile disorders/dyslipidemia; how- ever there is no data available on Mexican children, and obesity is not part of a routine evaluation of this population. Aim: To evaluate the association between obese (OB), overweight (OW) and non-obese (NO) prepubescent children with lipid measurements: Total Cholesterol (TC), High-Density Lipoprotein Cholesterol (HDL-C), Low-Density Lipoprotein Cholesterol (LDL-C) and Triglycerides. Methods: We evaluated 59 OB (Body Mass Index (BMI) >95th percentile), 17 OW (BMI >85 and <95th percentile) and 19 NO (>15 and <85th percentile) prepubescent children (44 males) aged 4 to 13. Anthropometry and lipid profile (TC, HDL-C, LDL-C and Triglycerides) in a fasting blood sample was measured and adjusted for age and sex. Statistical analysis was done with the SPSS 15.0 Analysis Program. Results: The prevalence of dyslipidemia was of 6.04% in OB children, compared to 3.66% in OW children and to 5.49% in NO children. There was a significant correlation between OB patients and dyslipidemia. The ANOVA and the Post Hoc DMS adjusted for age and sex showed a significant difference (p < 0.05) between the NO and the OB children for TC, LDL-C and HDL-C. For Triglycerides, there was a significant difference (p = 0.041) between the OW and the OB children. The most frequent dyslipidemia between NO and OB children was hypercholesterolemia. Conclusion: External body measurements of adiposity were associated with increased TC and triglycerides in OB children. The prevalence of dyslipidemia is high among OB children. These biomarkers, present in their youth, are considered to pose a greater risk of adverse cardiovascular outcomes in their adulthood. Control of and modifications to diet and physical activity should be implemented. Lipid profile must be measured as part of the routine tests in OB children. Disclosure of Interest: None Declared PP237-MON PREVALENCE OF RISK FACTORS FOR METABOLIC SYNDROME IN OBESE ADOLESCENTS M.E. Zaki 1 , H. El-Bassyouni 2 , M. El-Gammal 2 , S. Kamal 1 . 1 Biological Anthropology, 2 Clinical Genetics, National Research Centre, Cairo, Egypt Rationale: Obesity is a major and increasing health problem for society because it increases the risk of cardiovascular disease, type 2 diabetes mellitus, and hypertension. The purpose of this study was to assess the prevalence of metabolic risk factors that compose metabolic syndrome (MS) in a sample of Egyptian obese adolescents and to compare anthropometric and biochemical parameters in cases with one or two parameters of MS syndrome to those of patients who meet MS criteria. Methods: A descriptive, cross-sectional study was conducted on 300 obese adolescents, who participated in the project entitled “Obesity among Youth: Lifestyle and Genetic Factors” funded by the Science and Technology Development Fund. They were 120 males (40%) and 180 females (60%). Variables examined included body mass index (BMI), waist circumfer- ence (WC), waist to hip ratio (WHR), systolic and diastolic blood pressure (SBP and DBP), fasting blood glucose, choles- terol, triglycerides (Tg), high density lipoprotein (HDL), low density lipoproteins (LDL), insulin and insulin resistance (IR) measured by HOMA. Receiver operating characteristic curve (ROC) analysis was used to determine the predictive powers of anthropometric parameters associated with increased MS risk. Results: The overall prevalence of metabolic syndrome was 20%. Patients meeting three or more MS criteria had significant higher levels of BP, Tg, glucose, insulin and HOMA-R and low HDL level as compared to patients with 1 or 2 MS criteria. Area under the curve (AUC) for identifying of MS risk factors was the highest for WHR, followed by WC and BMI in both sexes. Conclusion: (1) The most prevalent metabolic risk factors that compose MS, excluding waist circumference because all our subjects were obese, was arterial hypertension, low HDL and
Transcript of PP236-MON PROFILE LIPID DISORDERS IN OBESE MEXICAN CHILDREN
S210 Poster presentations
insulin resistance. The aim of this study was to characterisemetabolic inflexibility via the dynamics of plasma levels ofFFA after peroral MCT oil application in morbid obese type 2.diabeticsMethods: FFA plasma levels were estimated in obese type2. diabetics [n = 13, body mass index (BMI) > 35 kg/m2, age37 64 y] via enzymatic method (kit Wako chemicals GmbH,Germany). Plasma levels of FFA were estimated before peroralapplication of 40 ml MCT (Nutricia), then in 30, 60, 120,180, 240 and 1440 minute. During the examination ketonebodies and glucose were detected from the capillary blood.Data were statistically analyzed via Sigma Stat (One wayANOVA repeated measurement). The data are presented asmean±standard deviation.Results: After 40 ml MCT oil application a significant decreaseof FFA plasma levels were detected (table 1). A significantcorrelation of plasma FFA and ketone bodies was found(r = 0.335, p < 0.03).
Table 1. Dynamics of FFA plasma levels after MCT oil application
Time (min) FFA (mmol/l)
0 0.92±0.1530 0.79±0.1360 0.69±0.11120 0.61±0.15180 0.58±0.13240 0.64±0.091440 0.86±0.12
Conclusion: Peroral application of 40 ml of MCT oil in morbidobese type 2. diabetics was accompanied with significantdecrease of FFA plasma levels maximum at the end of thethird hour of testing. A significant correlation of plasma FFAand ketone bodies was found. Other examinations continue tocharacterize MCT-related plasma FFA dynamic of study groupon conditions of decreasing metabolic inflexibility.Supported by MZ CZ DRO (FNHK)
Disclosure of Interest: None Declared
PP236-MONPROFILE LIPID DISORDERS IN OBESE MEXICAN CHILDRENV. Davila1, I. Martinez Del Rio Requejo1, J.A. Leyva Islas1,L. Hernandez-Amezcua2, O.O. Olea Salinas3. 1ChilhoodObesity Clinic, 2Lopez Mateos, Mexico DF, 3Apoyo MetabolicoNutricio, Lopez Mateos, Mexico DF, Mexico
Rationale: The prevalence of childhood obesity is increasingrapidly. Metabolic disorders are commonly present in obesechildren, especially lipid profile disorders/dyslipidemia; how-ever there is no data available on Mexican children, andobesity is not part of a routine evaluation of this population.Aim: To evaluate the association between obese (OB),overweight (OW) and non-obese (NO) prepubescent childrenwith lipid measurements: Total Cholesterol (TC), High-DensityLipoprotein Cholesterol (HDL-C), Low-Density LipoproteinCholesterol (LDL-C) and Triglycerides.Methods: We evaluated 59 OB (Body Mass Index (BMI)>95th percentile), 17 OW (BMI >85 and <95th percentile) and19 NO (>15 and <85th percentile) prepubescent children (44males) aged 4 to 13. Anthropometry and lipid profile (TC,HDL-C, LDL-C and Triglycerides) in a fasting blood sample was
measured and adjusted for age and sex. Statistical analysiswas done with the SPSS 15.0 Analysis Program.Results: The prevalence of dyslipidemia was of 6.04% in OBchildren, compared to 3.66% in OW children and to 5.49%in NO children. There was a significant correlation betweenOB patients and dyslipidemia. The ANOVA and the Post HocDMS adjusted for age and sex showed a significant difference(p < 0.05) between the NO and the OB children for TC,LDL-C and HDL-C. For Triglycerides, there was a significantdifference (p = 0.041) between the OW and the OB children.The most frequent dyslipidemia between NO and OB childrenwas hypercholesterolemia.Conclusion: External body measurements of adiposity wereassociated with increased TC and triglycerides in OB children.The prevalence of dyslipidemia is high among OB children.These biomarkers, present in their youth, are considered topose a greater risk of adverse cardiovascular outcomes intheir adulthood. Control of and modifications to diet andphysical activity should be implemented. Lipid profile mustbe measured as part of the routine tests in OB children.
Disclosure of Interest: None Declared
PP237-MONPREVALENCE OF RISK FACTORS FOR METABOLIC SYNDROMEIN OBESE ADOLESCENTSM.E. Zaki1, H. El-Bassyouni2, M. El-Gammal2, S. Kamal1.1Biological Anthropology, 2Clinical Genetics, NationalResearch Centre, Cairo, Egypt
Rationale: Obesity is a major and increasing health problemfor society because it increases the risk of cardiovasculardisease, type 2 diabetes mellitus, and hypertension. Thepurpose of this study was to assess the prevalence ofmetabolic risk factors that compose metabolic syndrome (MS)in a sample of Egyptian obese adolescents and to compareanthropometric and biochemical parameters in cases with oneor two parameters of MS syndrome to those of patients whomeet MS criteria.Methods: A descriptive, cross-sectional study was conductedon 300 obese adolescents, who participated in the projectentitled “Obesity among Youth: Lifestyle and Genetic Factors”funded by the Science and Technology Development Fund.They were 120 males (40%) and 180 females (60%). Variablesexamined included body mass index (BMI), waist circumfer-ence (WC), waist to hip ratio (WHR), systolic and diastolicblood pressure (SBP and DBP), fasting blood glucose, choles-terol, triglycerides (Tg), high density lipoprotein (HDL), lowdensity lipoproteins (LDL), insulin and insulin resistance (IR)measured by HOMA. Receiver operating characteristic curve(ROC) analysis was used to determine the predictive powersof anthropometric parameters associated with increased MSrisk.Results: The overall prevalence of metabolic syndrome was20%. Patients meeting three or more MS criteria had significanthigher levels of BP, Tg, glucose, insulin and HOMA-R and lowHDL level as compared to patients with 1 or 2 MS criteria. Areaunder the curve (AUC) for identifying of MS risk factors wasthe highest for WHR, followed by WC and BMI in both sexes.Conclusion: (1) The most prevalent metabolic risk factors thatcompose MS, excluding waist circumference because all oursubjects were obese, was arterial hypertension, low HDL and
