POWERWULF CLUSTERS World’s Leading Provider of

Turn-key Compute Solutions for NGS / Bioinformatics

ABOUT US Founded in 1989

Over 1000 PowerWulf Clusters Delivered World Wide

350+ PowerWulf Clusters Dedicated Compute

Appliances for NGS / Bioinformatics

Mission Statement

Tier 1 Manufacturing & Support at Commodity Price

Custom Configured Products Include

Turn key PowerWulf Compute Clusters

RaidStation Storage Solutions

High Performance Workstations & Servers

LIFE SCIENCE SUCCESS Selected by Roche / 454 and CLCbio as OEM Hardware Provider

Over 60% of ALL WORLDWIDE data off GS FLX Titanium Platform is analyzed on PSSC Labs Platform

Roche’s Success in this space linked directly to PSSC Labs PowerWulf Cluster solution CLCbio is a leader in genomics software solutions

Certified our PowerWulf Clusters and Servers Compatible with Life Technologies’ Bioscope & Illumina’s Casava Applications

Pacific Biosciences considering PSSC Labs as OEM Hardware Provider

Recent LARGE Cluster Wins Western Kentucky University – 5000+ Cores

PSSC Labs Selected after evaluation of Dell, HP, IBM OpenX.org – 7000+ Cores

PSSC Labs Selected after evaluation of Dell, HP, IBM MIT / Harvard / HHMI Neuroimaging Center

Largest GPU Cluster at MIT

Revolutionary POWERSERVE DUO TI2000 Perfect Cluster Building Block Tool-Free Design Power Saving Eco Friendly Features World Wide Support & Maintenance

NGS/BIOINFORMATICS EXPERIENCE Partnerships w/ leading Sequencing Platform Providers

Roche / 454 OEM Provider of GS FLX Titanium Cluster (www.pssclabs.com/roche)

Life Technologies Certified Cluster Solutions w/ Bioscope Preconfigured

Illumina Certified Cluster / Server Solutions w/ Casava Preconfigured

Pacific Biosciences Potential OEM Proider of off line cluster for new RS platform

Ion Torrent Certified Workstation w/ Ion Torrent Software

CLC Bio Selected as OEM Hardware Provider of Genomics Machine / Factory

WHY OUR SUCCESS IN NGS Delivery Fully Functional / Turn Key Systems

Biologist are typically not system administrators. Just need a system that works out of the box.

Superior Knowledge & Support You will have direct communication with the PSSC Labs Cluster

Engineer that built, tested and configured the system with your applications.

Our Remote Assist support provides greater more responsive support than any other vendor

We Understand Your Business Seqwright needs a knowledgeable cost effective hardware

provider that ensures they deliver their customer results on time, every time. Our systems are considered the industry’s most reliable with a failure

rate >0.01%. This is a direct result of our superior testing procedure

PERFORMANCE PSSC Labs Runs Benchmarks Provided

by Application to Certify SystemsTypical benchmarks include small and large

data sets for all pipeline steps (mapping, assembly, alignment)

Example WT Run is one of three stress tests we run to

certify our clusters for BioscopeResults: DURATION= 6 hours 36 minutes 44

secs Configuration: 8 Core (2.67 Ghz) / 48GB

Memory)

PERFORMANCE Information obtained from end users

Illumina / Casava UCI Irvine

We are sequencing Drosophila (fruity fly) samples. The genome is approximately 1.2 x 108 base pairs.

One lane of paired-end, 75bp data from an Illumina GA2 machine gives about 25X coverage of a genome. Roughly 35 million pairs of reads per lane or 2* 75 *35e6 =

5.25e10 base pairs of data. We sequence 3 lanes per sample. Pipeline involves a lot of

custom software to do our analyses, and we can entirely process a single sample in about 12 hours. This is much more than simply doing the alignments

System Configuration PowerServe Duo T2400 (Single SMP System) 8 Processor Cores / 2.4 Ghz 128 GB System Memory 40 TB USABLE High Speed Storage Space

PERFORMANCE Information obtained from end users

Illumina / Casava St. Radbound University

“Mapping one exome sample to the human reference takes about 8.5 hours using Bioscope 1.3”

System Configuration PowerWulf Cluster 64 Processor Cores / 2.53 Ghz / 8 Cores Per Node 4 GB Memory Per Core

PERFORMANCE CLC Bio Genomics Factory Comparison

PSSC Labs is OEM Provider of Genomics Factory

156 Cores (12 cores per node / 2.53 Ghz)4 GB of Memory Per CoreStated Performance on Website

Mapping, whole human genome, 15x coverage: 32 Full Human Genomes Per Week (2 x 100 basepair Illumina GA – data

Whole human transcirptome analysis (RNA-seq): 600 Samples per week (130 million 50bp SOLiD reads