Powerpoint
-
Upload
prezi22 -
Category
Health & Medicine
-
view
1.508 -
download
0
Transcript of Powerpoint
![Page 1: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/1.jpg)
NEUTROPHILIC DERMATOSES
Dr. Brandon Howell, PGY2Dermatology
![Page 2: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/2.jpg)
OBJECTIVES
• A case…
• Describe some neutrophilic dermatoses
• Nauseate the room with photographs
• Treat the case…
![Page 3: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/3.jpg)
A CASE…• 49F with T1N2 breast cancer
• Had chemo with taxotere causing neutropenia
• Received G-CSF (Neupogen) during neutropenic state
• Developed progressive bullous, necrotic soft tissue lesion at site of i.v. trauma
• Initially thought to be aggressive cellulitis
• Cultures negative, not antibiotic responsive
• Worsened post-debridement
![Page 4: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/4.jpg)
Neutrophilic Dermatoses
• Sweet’s Syndrome (1964 – Dr. Sweet)
• Pyoderma Gangrenosum (1930 – Dr. Brunsting)
• Erythema Elevatum Diutinum
• Neutrophilic Dermatosis of the Dorsal Hands
• Rheumatoid Neutrophilic Dermatosis
• Subcorneal Pustular Dermatosis
• Neutrophilic Eccrine Hidradenitis
![Page 5: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/5.jpg)
A SPECTRUM
• Some people present with overlapping presentations of these conditions
• E.g., Sweet’s and Pyoderma Gangrenosum
• E.g., Pyoderma Gangrenosum and Subcorneal Pustular Dermatosis
![Page 6: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/6.jpg)
Commonalities• Pustules, nodules, plaques, or ulcers• Neutrophilic infiltrate – can affect all skin
layers• General malaise, fever• Multi-system: Joint, kidney, lung, eye, etc.
• Cutaneous manifestations of systemic disease
![Page 7: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/7.jpg)
SWEET’S SYNDROME
• Classical
• Idiopathic
• Malignancy-associated (20%)
• Drug-Induced
![Page 8: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/8.jpg)
CLASSICAL
• Pregnancy (1st and 2nd trimester)
• Inflammatory bowel disease
• Post-streptococcal
• Upper respiratory tract infection
• Yersinia, toxoplasmosis, histoplasmosis, salmonella, tuberculosis
• Tonsillitis
• Vulvo-vaginal infections
![Page 9: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/9.jpg)
MALIGNANCY-ASSOCIATED
• Non-lymphocytic leukemia (AML, CML)
• Lymphoma
• Polycythemias
• Solid tumors: GU, GI, Breast
• May pre-date heme malignancy by 3 months to 6 years
![Page 10: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/10.jpg)
DRUG-INDUCED
• G-CSF, GM-CSF: at site of infusion or distant sites; even in neutropenic states
• Birth control pills• Trimethoprim-sulfamethoxazole• Minocycline• All-trans-retinoic acid (promyelocytic
leukemia)
![Page 11: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/11.jpg)
SWEET’S DIAGNOSTIC CRITERIA
Major Criteria• Abrupt onset of characteristic lesions• Diffuse neutrophilic infiltration + dermal edema
Minor Criteria
• Preceded by or associated with described clinical conditions
• Malaise and fever
• ESR >20, CRP +, peripheral leukocytosis, left shift
• Excellent response to systemic corticosteroids
•Both major + 2 minor criteria = diagnosis
![Page 12: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/12.jpg)
SKIN LESIONS
• Acute, tender, red
• Plaques, nodules, pseudovesicles, blisters, annular/arciform
• Occur on head, neck, legs, arms, dorsum hands/fingers, less frequent on trunk
• No pathergy
![Page 13: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/13.jpg)
SWEET’S SYNDROME
![Page 14: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/14.jpg)
![Page 15: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/15.jpg)
![Page 16: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/16.jpg)
![Page 17: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/17.jpg)
![Page 18: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/18.jpg)
CLINICAL PRESENTATION
• Fever (50%)
• Myalgia/Arthralgia/Arthritis (62%)
• Eye involvement (38%)
• Oral aphthous ulcers (13%)
• A recurrent condition
![Page 19: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/19.jpg)
LABS
• Moderate leukocytosis
• Elevated ESR
• Slightly elevated ALP
• ANCA positive in some
![Page 20: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/20.jpg)
SKIN BIOPSY
• Papillary and mid dermal edema
• Neutrophilic infiltrate with nuclear fragmentation
• No vasculitis in early lesions, but can occur
![Page 21: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/21.jpg)
SWEET’S SYNDROME
![Page 22: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/22.jpg)
SECONDARY CAUSE
• Age > 50
• Anemia
• Thrombocytopenia
• Bullous or necrotic lesions
![Page 23: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/23.jpg)
TREATMENT• Underlying cause
• Prednisone 1mg/kg/d x 2-6 weeks
• Topical/Intralesional a possibility
• Fever, leukocytosis, new skin lesions should subside within 72 hours
• Skin lesions clear in 3 to 9 days with residual milia or scar
• Alternates: Potassium iodide, colchicine, indomethacin, dapsone, CsA
![Page 24: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/24.jpg)
PYODERMA GANGRENOSUMInflammatory Associations
• IBD (UC & Crohn’s), Sarcoid, RA, Chronic/active hepatitis (HCV), Takayasu, HIV, SLE, PAPA syndrome (Pyogenic arthritis, PG and acne)
Pregnancy
Malignancy
• Non-lymphocytic leukemias (AML, CML), Polycythemias, Myeloid metaplasia, IgA monoclonal gammopathy
Drug
• G-CSF, GM-CSF, IFN, anti-psychotics
Idiopathic (50%)
![Page 25: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/25.jpg)
SKIN LESIONS• Tender, red• Macule, papule, pustule, nodule, bullae• Usually start as papulopustules (not plaques like
Sweet’s). Pustular especially in IBD.• Surrounding halo• Necrotizing extends peripherally to form necrotic
ulcer with purulent base and purple margin and surrounding erythema
• Small lesions may fuse together• Usually <10cm but may increase with pathergy• Also heal with scar• Can be confused with Erythema Nodosum and
Sweet’s early on
![Page 26: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/26.jpg)
ERYTHEMA NODOSUM
![Page 27: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/27.jpg)
PYODERMA GANGRENOSUM
![Page 28: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/28.jpg)
![Page 29: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/29.jpg)
![Page 30: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/30.jpg)
![Page 31: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/31.jpg)
![Page 32: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/32.jpg)
![Page 33: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/33.jpg)
![Page 34: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/34.jpg)
![Page 35: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/35.jpg)
![Page 36: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/36.jpg)
CLINICAL PRESENTATION
• Post-trauma (pathergy)
• Recurrent lesions (30%)
• Seronegative large joint arthritis (40%)
• Distal legs most common, but can be anywhere
• In IBD usually appears 5-10 years into disease course
![Page 37: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/37.jpg)
DIFFERENTIAL DIAGNOSIS
• Vasculitis
• Venous disease
• Factitial
• Spider bite
• Infections: deep fungal, mycobacteria, syphilis, gangrene, amebiasis
• “ulcerating lesions”
![Page 38: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/38.jpg)
LABS• Not very helpful
• Less systemic symptoms than Sweet’s
• SPEP etc. if suspect monoclonal gammopathy
• ANCA negative
• Historically, overlapped with “Malignant Pyoderma” which is C-ANCA positive—later considered to be cutaneous Wegener’s Granulomatosis
![Page 39: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/39.jpg)
SKIN BIOPSY• Evolves from supparative folliculitis to
form sterile abscess
• Dermal edema
• May involve subcutaneous fat
• +/- leukocytoclastic vasculitis (late)
• Suppurative granulomatous dermatitis
• Findings are not diagnostic. Need to rule out infectious etiology.
![Page 40: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/40.jpg)
PYODERMA GANGRENOSUM
![Page 41: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/41.jpg)
TREATMENT• Underlying cause
• Avoid trauma
• Topical/Intralesional steroid to abort early lesions
• Corticosteroids (1 mg/kg/d) x 3-4 weeks, plus CsA (if steroids ineffective) are first-line agents
• Infliximab first-line in IBD
• Reports of azathioprine, MMF, cyclophosphamide, IVIG, chlorambucil
• Thalidomide (in overlap with Behcet’s)
![Page 42: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/42.jpg)
TREATMENT
• Drug effect is independent of underlying cause
• Occlusive dressings to avoid infections
• No role for surgery
![Page 43: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/43.jpg)
EXTRACUTANEOUS PYODERMA GANGRENOSUM
• Joints
• Lungs (patchy infiltrates, interstitial pneumonitis)
• Heart
• GI, oropharyngeal
• Spleen
• Liver
• Eye
• Glans penis
![Page 44: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/44.jpg)
BACK TO THE CASE…
• Diagnosis: Pyoderma Gangrenosum
• Secondary to skin trauma (pathergy) and G-CSF therapy
• Treatment: Prednisone 1 mg/kg/d x 4 weeks, then taper by 5mg q week
• Lesion began to regress within 24 hours
![Page 45: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/45.jpg)
SUMMARY• Neutrophilic dermatoses are a spectrum of
disorders with overlapping disease associations and pathological features.
• One must consider pyoderma gangrenosum in the case of a spreading ‘sterile’ ulcer.
• Look at the big picture. What drugs was the patient on?
• Consult dermatology/plastics early to look for characteristic morphology before attempting debridement etc.
• Typically responsive to corticosteroids, but must search for underlying cause.
![Page 46: Powerpoint](https://reader035.fdocuments.us/reader035/viewer/2022070315/55506eceb4c9052d158b494d/html5/thumbnails/46.jpg)
REFERENCES
• Reichrath et al. Treatment recommendations for pyoderma gangrenosum: An evidence-based review of the literature based on more than 350 patients. JAAD 2005; 53: 273.
• Andrews et al. Diseases of the Skin. Clinical Dermatology. 2006.
• Habif et al. A color guide to diagnosis and therapy. Clinical Dermatology. 2004.