Pough Appendix 1w-plig/pdf/Pough Appendix 1, part 2.pdf · Pough Appendix 1 1 Biomedical...

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Pough Appendix 1 1 Biomedical Application of Cladistics SARS (Sudden Acute Respiratory Syndrome) virus Virion = nucleocapsid + viral RNA without lipid membrane. Corona virus fig 13.4 1. Viral glycoproteins bind to receptors on the host cell membrane. 2. Virus enters cell by endocytosis. 3. Viral RNA is released 4. Viral RNA makes viral mRNA 2 1 3 4 fig 13.4 5. Viral RNA makes more viral RNA 6. Viral RNA is translated into viral proteins 7. The virion is assembled 7 6 5 fig 13.4 8. Viral envelope glycoproteins are made on host ER and transported to the cell membrane via the Golgi apparatus. 9. New viruses are assembled by budding and are released. 8 6 fig 13.4 8. Viral envelope glycoproteins are made on host ER and transported to the cell membrane via the Golgi apparatus. 9. New viruses are assembled by budding and are released. 8 6 fig 13.4 • Virus RNA replication is prone to error (point mutations). • So viruses evolve rapidly. • Origin of a new pathogenic virus can be determined by analyzing base sequences. fig 13.4 Hong Kong Markets

Transcript of Pough Appendix 1w-plig/pdf/Pough Appendix 1, part 2.pdf · Pough Appendix 1 1 Biomedical...

Page 1: Pough Appendix 1w-plig/pdf/Pough Appendix 1, part 2.pdf · Pough Appendix 1 1 Biomedical Application of Cladistics SARS (Sudden Acute Respiratory Syndrome) virus Virion = nucleocapsid

Pough Appendix 1

1

Biomedical Application of Cladistics

SARS (Sudden Acute Respiratory Syndrome) virus

Virion = nucleocapsid+ viral RNA withoutlipid membrane.

Corona virus

fig 13.4

1. Viral glycoproteins bind toreceptors on the host cellmembrane.

2. Virus enters cell byendocytosis.

3. Viral RNA is released4. Viral RNA makes viral

mRNA

21

3

4

fig 13.4

5. Viral RNA makes more viralRNA

6. Viral RNA is translatedinto viral proteins

7. The virion is assembled7

65

fig 13.4

8. Viral envelopeglycoproteins are made onhost ER and transported tothe cell membrane via theGolgi apparatus.

9. New viruses are assembledby budding and arereleased.

8

6

fig 13.4

8. Viral envelopeglycoproteins are made onhost ER and transported tothe cell membrane via theGolgi apparatus.

9. New viruses are assembledby budding and arereleased.

8

6

fig 13.4

• Virus RNA replication isprone to error (pointmutations).• So viruses evolve rapidly.• Origin of a new pathogenicvirus can be determined byanalyzing base sequences.

fig 13.4

Hong Kong Markets

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