The Microbiome and Metagenomics Catherine Lozupone CPBS 7711 September 19, 2013.
Polysaccharide A a widely distributed immunoregulatory microbial product Matthew Rhodes and...
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Polysaccharide A a widely distributed immunoregulatory microbial product Matthew Rhodes and Catherine Lozupone University of Colorado, Denver Rocky Mountain Bioinformatics Conference December 11 th 2014 Mazmanian and Kasper 2006
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Transcript of Polysaccharide A a widely distributed immunoregulatory microbial product Matthew Rhodes and...
Polysaccharide Aa widely distributed immunoregulatory microbial product
Matthew Rhodes and Catherine LozuponeUniversity of Colorado, Denver
Rocky Mountain Bioinformatics Conference
December 11th 2014
Mazmanian and Kasper 2006
Mazmanian 2009
The Microbial Health Factor (PSA)
One bacterial molecule sufficient to mediate healthy immune response!!!
BAD GOODPSA
The B. fragilis PSA Operon
Coyne et al. 2001
E-ValueH
its to
wcf
RNext best hit in B. fragilis (PSB)
IL-10 Production Amongst PSA Producers
Red: PSA Black:No-PSA
0
200
400
600
IL-1
0 (p
g/m
l)
Neff unpublished