Polymerisation Chemistry. P4 – Case Studies Hyperbranched PMMA (HB-PMMA)Hyperbranched PMMA...
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Transcript of Polymerisation Chemistry. P4 – Case Studies Hyperbranched PMMA (HB-PMMA)Hyperbranched PMMA...
Polymerisation ChemistryPolymerisation Chemistry
P4 – Case StudiesP4 – Case Studies
• Hyperbranched PMMA Hyperbranched PMMA (HB-PMMA)(HB-PMMA)
• Hyperbranched aliphatic polyurethanes Hyperbranched aliphatic polyurethanes (HB-PU)(HB-PU)
• Highly syndiotactic PMMA and block Highly syndiotactic PMMA and block copolymers at r.t. (S-PMMA)copolymers at r.t. (S-PMMA)
• Novel polymer beads for solid-phase Novel polymer beads for solid-phase organic synthesisorganic synthesis
HB-PolymersHB-Polymers
• Tunable viscosityTunable viscosity• Modifiable solubilityModifiable solubility
characteristicscharacteristics• End-group dominatedEnd-group dominated
propertiesproperties• One-pot synthesisOne-pot synthesis• Reduced crystallinityReduced crystallinity• Increased blendIncreased blend
compatibilitycompatibility
HB-PMMAHB-PMMA
• Solution polymerisation of MMA as Solution polymerisation of MMA as batch model reactionbatch model reaction AIBN/xylenes; 20% MMA; time vs AIBN/xylenes; 20% MMA; time vs
conversion; validation dataconversion; validation data
• Solution polymerisation of HB-PMMA as Solution polymerisation of HB-PMMA as batch model reactionbatch model reaction Independently reproducedIndependently reproduced
• Scale-up of branching agentScale-up of branching agent
HB-PUHB-PU
• Small scale synthesis of HB-PUSmall scale synthesis of HB-PU• Effect of reaction parameters Effect of reaction parameters
investigatedinvestigated Time, temperature, addition sequence, Time, temperature, addition sequence,
catalyst, solventcatalyst, solvent
• Small scale synthesis of linear PU model Small scale synthesis of linear PU model polymerpolymer
S-PMMAS-PMMA
• Improved catalyst availableImproved catalyst available Better reaction control, higher Better reaction control, higher
syndiotacticitysyndiotacticity
Polymer BeadsPolymer Beads
• Successful catalyst optimisation (small Successful catalyst optimisation (small scale)scale) Homogeneous crosslinking possibleHomogeneous crosslinking possible
Immediate Targets IImmediate Targets I• PMMA scale-up reactor runsPMMA scale-up reactor runs• Model validationModel validation
Feedback loop establishedFeedback loop established
• Small scale HB-PMMA model reactionSmall scale HB-PMMA model reaction• HB-PMMA scale-up reactor runsHB-PMMA scale-up reactor runs• Implementation of new modelImplementation of new model
Immediate Targets IIImmediate Targets II
• Complete kinetic data set for HB-PUComplete kinetic data set for HB-PU• Small scale solution polymerisationSmall scale solution polymerisation
Conv., DoB, MW, MWDConv., DoB, MW, MWD
• Identify suitable matrix for MALDI-tofIdentify suitable matrix for MALDI-tof• Model implementation/validationModel implementation/validation
Funding OpportunitiesFunding Opportunities
• EPSRCEPSRC High-added value polymers (electronics, High-added value polymers (electronics,
biomedical, pharmaceutical (enabling))biomedical, pharmaceutical (enabling))
• MMIMMI LINK programme suggestedLINK programme suggested
• HuntsmanHuntsman HB-PU – Synthesis and scale-up technologyHB-PU – Synthesis and scale-up technology Sign of interestSign of interest
Funding OpportunitiesFunding Opportunities
• AveciaAvecia CombiChem Supports – Synthesis and scale-CombiChem Supports – Synthesis and scale-
up technology – immediate market potentialup technology – immediate market potential Initial discussion meeting 21.03.02Initial discussion meeting 21.03.02
• BP/DTIBP/DTI Photovoltaics/Molecular electronics Photovoltaics/Molecular electronics
contribution – IC Chem/ IC Physics initiativecontribution – IC Chem/ IC Physics initiative Discussions neededDiscussions needed
• Basic Technology Initiative 2Basic Technology Initiative 2ndnd call call Do programme objectives match P4 Do programme objectives match P4
philosophy?philosophy?
Department of Trade & Industry EPSRC
“The overall objective is to help the UK to become the world’s leading
manufacturing base of the next generation of complex, high value
chemicals”
4 key aims1. Reducing time taken to develop and make complex molecules
(using both chemical & biological processes)
2. Improving competitiveness by using innovative processes & technologies
3. Raising skills, particularly in SMEs, to rapidly adopt new processes & technologies
4. Increasing awareness of new technologies and emerging best practice through networking
1. Reducing time taken to develop and make complex molecules (using both chemical & biological processes)
2. Improving competitiveness by using innovative processes & technologies
3. Raising skills, particularly in SMEs, to rapidly adopt new processes & technologies
4. Increasing awareness of new technologies and emerging best practice through networking
Target Molecules
Pharmaceuticals including DNA active ingredients and
those derived from human genome work
Intermediates for pharmaceuticals
Additives and dyestuffs
Chemicals for electronics, battery systems, memory,
display and optical technologies
Agrochemicals
High performance materials for healthcare, packaging,
housing, clothing, transport, etc.
Pharmaceuticals including DNA active ingredients and
those derived from human genome work
Intermediates for pharmaceuticals
Additives and dyestuffs
Chemicals for electronics, battery systems, memory,
display and optical technologies
Agrochemicals
High performance materials for healthcare, packaging,
housing, clothing, transport, etc.
Technical Priorities
New chiral formation or separation technologies
New catalysis technologies
Novel chemical synthesis
Innovative separation & reactor technologies
New media, such as supercritical and ionic fluids
New chiral formation or separation technologies
New catalysis technologies
Novel chemical synthesis
Innovative separation & reactor technologies
New media, such as supercritical and ionic fluids
Technical Priorities
Enhanced fields such as photo, sonic, &
microwave
Biological processing
Innovative process design
Characterisation of reactions
Novel pilot plant
On-line analysis & control
Enhanced fields such as photo, sonic, &
microwave
Biological processing
Innovative process design
Characterisation of reactions
Novel pilot plant
On-line analysis & control
What can we support?
Scoping desk based research / survey /study < 4 months
< £50k
Pilot lab based research< 6 months< £100k
Demo plant based proof of performance< 12 months< £100k
Collaborative, pre-competitive researchCollaborative, pre-competitive research
Criteria for support of :
Min. One industrial and One research base partner
Pre-competitive research (not near to market)
Additionality (would not otherwise take place)
Exploitation (clearly identified route)
Overall limit 50% public funding (SMEs up to 60%)
Min. One industrial and One research base partnerGSK, Pfizer, AstraZeneca
Pre-competitive research Support performance and versatility, SPR tuned via
synthesisAdditionality
ConvincingExploitation
ClearOverall limit 50%
Should be possible
: CombiChem Supports
: Conducting Polymers
Min. One industrial and One research base partnerMerck, Avecia, SME?, IC Physics
Pre-competitive research Scale-up, SPRs, composition
AdditionalityConvincing
ExploitationNeeds to be worked out
Overall limit 50%Needs to be negotiated
Assessment Criteria :
Fit to aims and technical priorities (impact)
Quality of Science, Engineering & Technology
(excellence)
Collaboration (mix of partners & disciplines)
Management (project plan & milestones)
Exploitation (route to market & plan)
Approved projects
BRITEST Technology Transfer project
Chemicals Behaving Badly project
Chiral Separations Pilot study
Hyperbranched Polymers Pilot study
Contact Point
Richard BahuMMI Programme Coordinator
The Oxis PartnershipApril Croft
Faringdon RoadShippon, Abingdon
OxfordshireOX13 6LN
Tel/Fax: 01235 536766E-mail: [email protected]
Richard BahuMMI Programme Coordinator
The Oxis PartnershipApril Croft
Faringdon RoadShippon, Abingdon
OxfordshireOX13 6LN
Tel/Fax: 01235 536766E-mail: [email protected]