Polymerase δ and ε in colon cancer Aaron Stevens.

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Polymerase δ and ε in colon cancer Aaron Stevens

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Transcript of Polymerase δ and ε in colon cancer Aaron Stevens.

Page 1: Polymerase δ and ε in colon cancer Aaron Stevens.

Polymerase δ and εin colon cancer

Aaron Stevens

Page 2: Polymerase δ and ε in colon cancer Aaron Stevens.

Polymerase δ and ε contain both polymerase and exonuclease domains

Page 3: Polymerase δ and ε in colon cancer Aaron Stevens.

Polymerase δ and ε are the major replicative polymerases

Page 4: Polymerase δ and ε in colon cancer Aaron Stevens.

Pol δ and ε help repair damage

Page 5: Polymerase δ and ε in colon cancer Aaron Stevens.

Mutating the exonuclease domain leads to decreased survival rates

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Point mutations in Pol δ are found in colon cancer

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Mutating the exonuclease domain of Polymerase δ leads to cancer

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Page 9: Polymerase δ and ε in colon cancer Aaron Stevens.

References Biard Denis S.F. (2011). New Insight on Entangled DNA Repair Pathways:

Stable Silenced Human Cells for Unraveling the DDR Jigsaw, DNA Repair - On the Pathways to Fixing DNA Damage and Errors, Dr. Francesca Storici (Ed.), ISBN: 978-953-307-649-2, InTech, DOI: 10.5772/23681.

Prindle, M. J. and Loeb, L. A. (2012), DNA polymerase delta in dna replication and genome maintenance. Environ. Mol. Mutagen., 53: 666–682. doi: 10.1002/em.21745

Goldsby RE, Hays LE, Chen X, Olmsted EA, Slayton WB, Spangrude GJ, Preston BD. High incidence of epithelial cancers in mice deficient for DNA polymerase δ proofreading. PNAS.2002;99(24):15560–15565. doi: 10.1073/pnas.232340999.

Burgers P. M. (2009) Polymerase dynamics at the eukaryotic DNA replication fork. J. Biol. Chem. 284, 4041–4045

Albertson T. M., Ogawa M., Bugni J. M., Hays L. E., Chen Y., Wang Y.,Treuting P. M., Heddle J. A., Goldsby R. E., Preston B. D. (2009) DNA polymerase ϵ and δ proofreading suppress discrete mutator and cancer phenotypes in mice.Proc. Natl. Acad. Sci. U.S.A. 106, 17101–17104

Helmut Pospiech and Juhani E. Syväoja, “DNA Polymerase ε - More Than a Polymerase,”TheScientificWorldJOURNAL, vol. 3, pp. 87-104, 2003. doi:10.1100/tsw.2003.08

Cancer Genome Atlas Network (2012) Comprehensive molecular characterization of human colon and rectal cancer. Nature 487: 330–337

Q. Zhou, R. Effati, K. Talvinen, H. Pospiech, J.E. Syväoja, Y. Collan. Genomic changes of the 55 kDa subunit of DNA polymerase epsilon in human breast cancer. Cancer Genomics Proteomics, 5 (2008), pp. 287–292


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