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New article: Pollen and Vitamin in chronic prostatitis/chronic pelvic pain syndrome.

Commented and cured Vincent @Hupertan

Tags: chronic pelvic pain syndrome, chronic prostatitis, #chronicprostatitis, #pollen extract; #prostatitis syndrome; #prostatitissyndrome, #qualityoflife

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Pollen extract in association with vitamins provides early pain relief in patients affected by chronic prostatitis/chronic pelvic pain syndrome.

AbstractThe therapeutic efficacy for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is currently unsatisfactory. The aim of the present study was to assess the safety and efficacy of pollen extract in association with vitamins (DEPROX 500®) in males with CP/CPPS. All patients with a diagnosis of CP/CPPS attending the same urologic centre between March and October 2012 were enrolled in this randomised controlled phase III study. Participants were randomised to receive oral capsules of DEPROX 500® (two capsules every 24 h) or ibuprofen (600 mg, one tablet three times a day) for four weeks. The National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI), International Prostate Symptom Score and Quality of Well-Being (QoL) questionnaires were used. In the intention-to-treat analysis, 87 males (25 class IIIa and 62 class IIIb) with a mean age of 33.6±5.9 years were randomly allocated to the DEPROX 500® (n=41) or ibuprofen (n=46) treatment groups. At the follow-up examination (following one month of treatment), in the DEPROX 500® group, 31/41 patients (75.6%) reported an improvement in quality of life, defined as a reduction of the NIH-CPSI total score by ≥25%, compared with 19/46 (41.3%) in the control group (P=0.002). The greater improvement in the DEPROX 500® group compared with the ibuprofen group was statistically significant (treatment difference in the NIH-CPSI pain domain, -2.14±0.51, P<0.001; QoL scores, P=0.002). All patients were negative at the Meares-Stamey test evaluation. Adverse events were less frequent in the DEPROX 500® group than in the ibuprofen group. The DEPROX 500® treatment significantly improved total symptoms, pain and quality of life compared with ibuprofen in patients with CP/CPPS, without severe side-effects.

Cai T1, Wagenlehner FM2, Luciani LG1, Tiscione D1, Malossini G1, Verze P3, Mirone V3, Bartoletti R4.

Exp Ther Med. 2014 Oct;8(4):1032-1038. Epub 2014 Jul 24.

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RESULTS

76%

24%

DEPROX 500® group

QoL improvement-

41%59%

Ibuprofen group (Control)

QoL improvement-

At the follow-up examination (following one month of treatment), in the DEPROX 500® group, 31/41 patients (75.6%) reported an improvement in quality of life, defined as a reduction of the NIH-CPSI total score by ≥25%, compared with 19/46 (41.3%) in the control group (P=0.002).

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Comments by @hupertan

• Chronic syndrome of chronic prostatitis / pelvic pain (CP / CPPS) is a very difficult to treat satisfactorily very complex disease, although some patients respond to treatment;

• 3-As a rule: alpha blockers, antibiotics, anti-inflammatory, is not always effective;

• Evaluation of Meares-Stamey test is often negative and antibiotics should be considered with caution;

• Long treatment by anti-inflammayorees must be considered with caution because of side effects;

• A number of studies have shown the effectiveness of pollen extract should be taken into account and encourage large scale trials to test their effectiveness.

• Nevertheless, in some patients, this treatment could be offered.

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