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Stay Cool DuringMenopause For trade and professional use only

Menopause tablets are made from fresh organic sage leaves

Points to Remember1. 1 tablet per day.

2. Highly effective for relieving hot flashes and night sweats: Reduces both intensity and frequency.

3. Made from fresh organic plants for maximum efficacy.

4. To experience the full effect, a minimum of 8 weeks of treatment is recommended.

5. Menopause can be used for as long as necessary.

6. Sage is not known to work via estrogenic pathways and can be taken alongside HRT.

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References(1) ”Prevalence of hot flashes and night sweats around the world:

a systematic review” by Freeman EW and Sherif K. Climacteric 2007;10:197-214

(2) Bommer S, Klein P, Suter A. A multicentre open clinical trial to assess the tolerability and efficacy of Sage tablets in climacteric women with hot flashes. 57th GA congress, Geneva, 2009. Poster

Bioforce Canada Inc.66 Brunswick blvd., Dollard-des-Ormeaux

QC, Canada H9B 2L3 • 1-800-361-6320 www.avogel.ca • www.avogelinstitute.com

Nature made science

How does A.Vogel Menopause workSage (Salvia officinalis), the medicinal ingredient in Menopause has traditionally been used for hyperhidrosis (excessive perspiration) and hot flashes in menopause.

Sage leaf contains tannins, bitter principles (diterpenes), steroids, flavonoids and a volatile oil rich in terpenes (thujone, camphor, etc.). It is recognized for its carminative (relieving flatulence), antispasmodic, anti-inflammatory, astringent, and anti-microbial properties. The antispasmodic and astringent effects may explain its usefulness against excessive perspiration and hot flashes. Sage is not known to work via estrogenic pathways and can be taken alongside HRT.

A.Vogel Menopause offers a practical dosage of 1 tablet per day. Each tablet contains 3400 mg of fresh organically grown sage (Salvia officinalis) herb tincture (1:17 ratio).

Who should avoid Menopause?Menopause is not recommended during pregnancy and nursing. Sage might interfere with blood sugar control and should be avoided in case of epilepsy.

Though this isn’t its main mechanism of action, weak, almost negligible estrogenic activities in vitro have been identified. It is, therefore, in part regarded as a phytoestrogen like soy etc. Consequently, we cannot exclude a certain, even if negligible, action on estrogen receptors. Therefore, until the clinical significance of these weak in vitro findings is further elucidated, medical advice is recommended in cases of breast cancer, anti-estrogen therapy and high risk of breast cancer due to family history.

Results

Each woman experiences different stages, changes and symptoms during her menopausal transition. Some women may experience all the symptoms while others may just experience a few of them in different combinations.

Among the long list of menopausal symptoms, hot flashes are top ranking with prevalence rates of up to 88% in postmenopausal women in the US while night sweats affect 79%.(1)

Hot flashes are the body’s reaction to a decreased supply of hormone estrogen which occurs naturally as women approach menopause. In some women, estrogen decreases gradually, producing less hot flashes. But for others, the ovaries stop estrogen production abruptly (the same as in surgical meno- pause). For these women, hot flashes can be a real roller-coaster ride.

• After 4 weeks the average number of hot flashes had gone down by 50%

• After 8 weeks the average number of hot flashes had gone down by 64%

• The number of flashes was still decreasing during week 8, indicating that further reductions were most likely with continued treatment

The more intense the hot flashes, the better the results:• Mild flashes were reduced by 46%• Moderate flashes were reduced by 62%• Severe flashes were reduced by 79%• Very severe flashes were reduced

by 100%

In the patient diaries, the average highest number of mild hot flashes at week 0 was 59 per day. This is more than one hot flash every half hour around the clock! After 8 weeks of therapy, the average highest number of mild hot flashes was 7.6 per day.

Tolerability was rated as very good or good by 87.3% of the physicians as well as by 87.3% of the patients.

Research

A multi-centre clinical trial asses- sed the tolerability and efficacy of Menopause tablets in menopausal women experiencing hot flashes.(2)

This 8-week clinical trial investi- gated the safety and efficacy of a holistically standardized fresh herb sage extract, in a once-daily dosage in women aged between 50 and 65 who had been menopausal for at least 6 months and were experiencing at least 5 hot flashes daily.

Total Score of Average Intensity Rated Hot Flashes

TSIRHF

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14.6

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8.38.6

76.4 6

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