Plegable karen cano calle

KAREN CANO CALLEMedicine student

INTRODUCTION

The DNA repair is a setof processes that takecare the cell of theadverse events like asdefective proteinsynthesis

This defective synthesiscould result in a cellularaging or diseases

DNA REPAIRELSEVIER 25 (2015) 1-8

THE REPAIR OF OXIDIZED PURINES IN THE DNA OF HUMAN LYMPHOCYTES REQUIRES AN ACTIVATION INVOLVING NF-YA

MEDIATED UPREGULATION

THE REPAIR OF OXIDIZED PURINES IN THE DNA OF HUMAN LYMPHOCYTES REQUIRES AN ACTIVATION INVOLVING NF-YA MEDIATED

UPREGULATION

The elevated levels of 8-oxoG (amodificated base) increased GC-TA mutation frequenciesThe OGG1 (oxoguaninaglicosilasa) repair the oxidizedbases by Base excision repair(BER) and this one is the majorrepair glycosylase for 8oxoG ineukaryotic cells

THE REPAIR OF OXIDIZED PURINES IN THE DNA OF HUMAN LYMPHOCYTES REQUIRES AN ACTIVATION INVOLVING NF-YA MEDIATED UPREGULATION

NF-YA is a transcription factor and this one is responsible for the OGG1 regulation when the DNA is a risk of oxidation for example the exposure of cells to alkylating agent methyl methanesulphonate



The repair of OGG1 in primary human lymphocytes is very slow but can be a efficient repair with the activation by the phytohemagglutinin(PHA)

A shutdown of the global repair of oxidized purines in lymphocytes must be to a down-regulation of the OGG-1

In my opinion the regulation of the DNAacutes repair is a

essential factor in the maintenance of the DNAstability and this allows that the human organismcorrect the mutations that can be present by internalo external factors preventing these mutations lead tolife-threatening diseases

Student observation

MUTAGENESIS(2015) 30 (1) 129-137 OXFORD

Redox-linked effects of green tea on DNA damage and repair and influence of microsatellite polymorphism in HMOX-1 results of a human intervention trial

The green tea is a good antioxidant that can protect susceptible individuals at oxidative stress such as Type 2 diabetes patients

Acts taking part in the activation of Antioxidant(Electrophile) Response Element (ARE)


The nuclear transcriptionfactor (Nrf2 ) is a factorthat regulates theexpression of genesencoding cytoprotective

Reduced apoptosis

Increses the cellrsquos survival

Increased drug resistance

In the organism there are

various cytoprotective proteinslike the hOGG1 AND THE hemeoxygenase 1 (HMOX-1) the lastone is a importantcytoprotective protein and thisincreased indicated the responseto the oxidative stress

Redox-linked effects of green tea on DNA damage and repair and influence of microsatellite polymorphism in HMOX-1 results of a

human intervention trial



Is suggested that in the microsatellitepolymorphism of HMOX-1 in the GTrepeats is associated with a poorerprotective activity cells homozygous forshort (n lt 25) GT(n) were shown to havehigher HMOX-1 expression after oxidantchallenge than cells homozygous for long (nge 25) GT(n) (13)the people with a long GT do not respond

efficiently to increased oxidative stress

for my this type of investigations has a very

important relevance in the determination of thedifferent mechanism whereby the organiccompounds can prevent diseases and also we can toknow the reason whereby these compounds have noactivity in some people

Student observation

Medical utility

through the knowledge of the beneficial properties the natural compounds could

develop natural treatments that prevent diseases

This investigations could bring a new diagnostic methods for genetic disorders

trying to enhance the expression the factors involved in DNA repair could bring a cancer`s cure that donacutet affect the good cells

to improve the patientacutes quality life with diseases chronicles

Medical utility

httpwwwnaturecomnchembiojournalv10n7fig_tabnchembio1553_F1html httpomicsonlineorgdifferentiation-of-embryonic-stem-cells-and-oxidative-dna-damage-dna-repair-systems-2157-

7633S10-005phpaid=6278 httpmedmolesglosario57 Niture SK1 Jaiswal AKNrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis httpculturacolectivacomcampanas-publicitarias-para-la-prevencion-del-cancer-de-mama

httpcentromedicodepies mxprincipalsalud-de-sus-piespie-diabetico

MARTINEZSAacuteNCHEZMLinaGRISALESVARGASNataliaMONTOYATOROAndreacutesESIERRAPAMPLONAAnapaulinaORREGOQUEVEDOEstebanBIOLOGIacuteA MOLECULAR SEacutePTIMA EDICIOacuteNEditorialupbpaacuteg85-88

LIPENVONDERCarinaSAHUSanjeebSEIFERMANNMarcoTIWARIKVIJAY The repair of oxidized purines in the DNA of human lymphocytes requires an activation involving NF-YA-mediated upregulation of OGG1 Institute of Pharmacy and Biochemistry University of Mainz Staudingerweg 5 D-55099 Mainz Germany Institute of Molecular Biology D-55218 Mainz Germany

CHIWAISinYEUNGTFVincentCOLLINSRAndrewBENZIEFFIris Redox-linked effects of green tea on DNA damage and repair and influence of microsatellite polymorphism in HMOX-1 results of a human intervention trial

REFERENCES

THANKS

INTRODUCTION

The DNA repair is a setof processes that takecare the cell of theadverse events like asdefective proteinsynthesis

This defective synthesiscould result in a cellularaging or diseases





UPREGULATION










Student observation







Reduced apoptosis













Student observation

Medical utility






Medical utility







REFERENCES

THANKS





UPREGULATION










Student observation







Reduced apoptosis













Student observation

Medical utility






Medical utility







REFERENCES

THANKS









Student observation







Reduced apoptosis













Student observation

Medical utility






Medical utility







REFERENCES

THANKS







Reduced apoptosis













Student observation

Medical utility






Medical utility







REFERENCES

THANKS











Student observation

Medical utility






Medical utility







REFERENCES

THANKS

Medical utility






Medical utility







REFERENCES

THANKS






Medical utility







REFERENCES

THANKS







REFERENCES

THANKS

THANKS

Plegable karen cano calle

Health & Medicine

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