Platelets Presents to you by ABOUT DISEASE.CO TEAM.
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Transcript of Platelets Presents to you by ABOUT DISEASE.CO TEAM.
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Platelets
Presents to you by ABOUT DISEASE.CO TEAM
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Definition
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Platelets
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Platelets Size: 1 – 4 Micro meter in diameter Normal Count: 1, 50000 – 300,000 / cu mm or micro literLive span: 10 days Platelet membranes contain receptors for
Collagen ADP Vessel wall Von Willebrand factor Fibrinogen Glycoprotein
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Platelets cytoplasm contain Actin Myosin Thrombasthenin Glycogen Lysosomes Granules
I. Dense granules Contains non protein substances e.g. Serotonin, ADP, Ca and other nucleotides.
II. Alpha granules:Secrete proteins e.g. Clotting factors, platelet derivedgrowth factor (PDGF), Von Willebrand factor.
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Regulation of Platelet Production Thrombopoietin Erythropoietin Adrenaline Injury Hypoxia Smoking
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Thrombocytopenia
Decreased Number of platelets in the blood Causes.1. Idiopathic 2. Secondary
a. Pancytopenia b. Increased destruction of platelets c. Splenomegaly d. Leukemia
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Thrombocytosis
Increase no of platelets in the blood Causes. 1. After acute haemorrhage 2. Splenectomy 3. Polycythemia vera
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Hemostasis “Arrest of bleeding” is called hemostasis. It involves three steps 1. Vascular spasm
a. Inherent vascular response b. Sympathetically induced vasoconstriction
2. Formation of platelet plug a. Platelet adhesion b. Platelet activation c. Platelet aggregation
3. Clot formation a. Intrinsic system b. Extrinsic system
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Activated Platelets
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Platelet plug Formation
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Factors involved in Platelet Function
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Whenever the vessel is damaged, the net result is formation of prothrombin activator.
Prolthrombin activator is formed in two ways a. The extrinsic pathway b. The intrinsic pathway
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Intrinsic Pathway for initiating Clotting
Intrinsic pathway
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Extrinsic Pathway for initiating Clotting
Extrinsic Pathway
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Erythrocytes trapped in the fibrin
meshwork of a clot (Clot formation)
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Roles of Thrombin
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Concurrent Platelet Aggregation and Clot Formation
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Hemostasis
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Factors involved in Clotting
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Role of Factor XII
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Fibrinolytic system Plasminogen Activator Plasminogen Plasmin
Fibrin Fibrin Degradation Products
FDPs. Prevent platelet aggregation Inhibit thrombin formation Prevent fibrin polymerization Plasmin also digests factors I,II,V, VIII and XII.
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Endogenous factors involved in Fibrinolysis and Anticoagulation
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AB
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T D
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SE.C
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AEM
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