Placental Pathology - The role of the placenta in... · Placental Pathology Mirthe Schoots...
Transcript of Placental Pathology - The role of the placenta in... · Placental Pathology Mirthe Schoots...
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Placental Pathology
Mirthe SchootsPerinatal Pathologist UMCG Groningen, the Netherlands
11-10-2019
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Contents
• Placental examination
• Fetal hypoxia
• Placental lesions associated with fetal hypoxia
– Maternal vascular malperfusion
– Fetal vascular malperfusion
– Chronic villitis
– Chorioamnionitis
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Placental examination
• Macroscopy
• Microscopy
• Based on Amsterdam Placental Consensus Statement 2016
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Normal placenta
Color Atlas of Fetal and Neonatal Histology, LM Ernst ea, 2011
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Color Atlas of Fetal and Neonatal Histology, LM Ernst ea, 2011
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Normal histology
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Villous development
3e trimester
Distal villous immaturity, RW Redline, Diagnostic Histopathology 18:5, 2012
20-24 weeks
32-38 weeks
Term
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Gas and nutrient exchange
M.H. Schoots, et al., Oxidative stress in placental pathology, Placenta (2018), https://doi.org/10.1016/j.placenta.2018.03.003
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Normal spiral artery remodeling at implantation
Brosens ea. AJOG 2010Espinoza ea. J. Perinat 2006
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Fetal hypoxia
• Due to malperfusion of the parenchyma of the placenta
• Due to malperfusion of the umbilical cord
• Leading to fetal growth restricion
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Placental lesions
• Maternal vascular malperfusion
• Fetal vascular malperfusion
• Chronic villitis
• Chorioamnionitis
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Maternal vascular malperfusion
• Pre-eclampsia
• Hypertension during pregnancy
• HELLP-syndrome
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Burton ea. Placenta 2009
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Maternal Vascular Malperfusion
• Placental hypoplasia
– Weight <10th centile
– Thin umbilical cord (<10th centile / <8 mm diameter at term)
• Infarction
– Any preterm
– >5% of nonperipheral parenchyma at term
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Infarction
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Distal villous hypoplasia
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Increased perivillous fibrin deposition
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Retroplacental hemorrhage
Sampling and Definitions of Placental Lesions, TY Khong ea, Arch Pathol Lab Med, published online 2016
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Fetal vascular malperfusion
• Compromised fetal blood suply in the umbilical cord
• Severe chorioamnionitis
• Clotting disorders like thrombophilia
• Could lead to neonatal thrombosis of CNS, lungs and kidneys
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Thrombosis chorionic plate
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Thrombosis of stemvillus
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Avascular villi
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Chronic villitis of unknown etiology
• 5-10% placentas in uncomplicated pregnancy
• 34% complicated pregnancy (FGR)
• No infectious agent
• Maternal reaction to fetal antigens
• Recurrence risk to 20%
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Chorioamnionitis
• 20-24% of life birth and 67% of preterm birth
• Ascending intra-uterine infection
• Via maternal blood (sepsis)
• Premature rupture of membranes / premature birth
• Meconium release
• Sepsis of mother and or child
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Maternal respons
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Fetal respons
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Placental pathology and neonatal PH
• Possibly MVM associated with BPD
• Angiogenic factors in cord blood associated with BPD
• No studies yet to compare single placental lesions to BPD and PH
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Questions?
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Pathology & Medical Biology UNIVERSITY MEDICAL CENTER GRONINGEN
Literature
• Hampl V, Bibova J, ea: ‘Hypoxic fetoplacental vasocontstriction in humans is mediated by potassium channel inhibition’. Am J Physiol Heart Circ Physiol 283: H2240-H2249, 2002
• Yang WC, Chen CY, ea: ‘Angiogenic factors in cord blood of preterm infants predicts subsequently developing bronchopulmonary dysplasia’. Pediatrics and Neonatology (2015) 56, 382-385
• Yallapragada SG, Mestan KK, ea: ‘Placental villous vascularity is decreased in premature infants with bronchopulmonary dysplasia-associated pulmonary hypertension’. Pediatric and Developmental Pathology 19, 101-107, 2016
• Mestan KK, Gotteiner N, ea: ‘Cord blood biomarkers of placental maternal vascular underperfusion predict bronchopulmonary dysplasia-associated pulmonary hypertension’. The Journal of Pediatrics 2017;185:33-41