3rd Annual Pediatric PittNet Meeting

Please join us for our 3rd Annual Meeting on Thursday June 24, 2010 at Children’s Hospital in Lawrenceville. Based on feedback from last year’s meeting and the online provider survey, this year’s meeting will highlight: • an interactive workshop on communication about research • presentations about current and upcoming research studies and • a recognition ceremony for top referring individuals.

We’ll also have a prize drawing for practices—the more people attending from your practice, the better odds you’ll win!

And, of course, there will be time to catch up with friends, colleagues, and PIs—as we did at last year’s meeting (here are just a few of the photos from October 2009.)

We look forward to catching up with you on June 24!

Please RSVP today to: Abby.Trainer@chp.edu!

Volume 3, Issue 2 Summer 2010

UNIVERSITY OF PITTSBURGH CTSI PRACTICE-BASED RESEARCH NETWORK

The Paw: Pediatric pittnet

Director’s Note: So much to report; not enough space —here are the high points:

• Nader Shaikh’s Cold/Sinusitis study completed enrollment of 280 children ahead of schedule—thanks to our Pediatric PittNet nurses and lots of referrals from community providers.

• Screening for Jen Silk’s YES-D depression study has begun in selected practices; this will allow us to pilot depression • screening for children in primary care. • Tom Lynch will join the Pediatric PittNet leadership as the CCP

Physician Representative, assisting David Wolfson (CCP Liaison) in providing community input to network decision-making.

• Congratulations to Alejandro Hoberman who was named Vice Chair of Clinical Research for the Department of Pediatrics.

• This just in: on May 24, Dr. Andrew Wakefield was banned from practicing medicine by the British General Medical Council for his unethical behavior. (See our website for details.)

Hope to see you all on June 24! Evelyn

Current Network Membership

27 offices in 15 Pediatric PittNet

practices

6 counties in Western Pennsylvania

126 providers

153,000 patients

PittNet Staff: Medical Director

Evelyn Reis, MD

Co-Directors

Alejandro Hoberman, MD

David Brent, MD

Program Managers

Diana Kearney, RN, CCRC

Carrie Fascetti, LSW

Administration

Abby Trainer, BS

Data Manager

Kathy Colborn, BS

Network Research Nurses

Tracy Balentine, RN, CCRC

Annette Seelhorst, BSN, RN

Kristy Mackin, BSN, RN

Photos Top:

Tom Lynch (Kittanning) and Alejandro Hoberman (PI)

Middle:

Evelyn Reis, Lin Ewing (PI), and Paul Rowland (Pittsburgh Ped)

Bottom:

Mary Ann Haralam (PCC), Pam Heald (Mercy),

Kathy Kelly (Pittsburgh Ped), Donna Duchene (PCC),

and Heidi Clouse (Bass Wolfson)

Psychotherapy for Depressed Mothers of

Psychiatrically Ill Children

PI: Holly Swartz, MD

Depression is a prevalent illness in our society. One in five women will experience an episode of depression in their lifetime. Children of depressed parents are two to five times as likely to experience psychiatric disorders themselves compared to offspring of parents without depression. Psychiatric illness in children is less likely to remit if their mothers remain depressed. Unfortunately, depressed mothers with psychiatrically ill children are unlikely to find relief from available treatments because they do not seek them out. Novel interventions are required to address the needs of this non-treatment seeking population since conventional approaches do not facilitate treatment engagement.

This study, funded by the National Institute of Mental Health, is designed to evaluate the intergenerational impact of treating depressed mothers whose children suffer from psychiatric disorders. As part of the study, mothers will be offered 9 free talk therapy sessions. Who is being asked to participate? Mothers who are: • 18-65 years old • Overwhelmed • Experiencing distress and

hopelessness (symptoms of depression)

• Have a child between 7-17 years old who is in treatment for a psychiatric disorder

Featured Behavioral health research study

What are the procedures for the study and treatment provided? • Interviews with the mother

and child will be conducted at baseline, three, six, nine, and twelve month follow up visits

• Mothers will be randomly assigned to participate in either Brief Supportive Psychotherapy or in Interpersonal Psychotherapy for Depressed Mothers

• Acute treatment phase is 3 months, with nine therapy sessions offered during this period

• Therapy sessions can occur in home, over the phone, or at child’s clinic if needed

Mother and child will be compensated for study

participation If you think a patient may

be eligible, please call:

Stacy Martin Project Coordinator

412-246-5588 or martinse@upmc.edu

P A G E 2 T H E P A W : P E D I A T R I C P I T T N E T

NO NEW ACTIVE behavioral HEALTH research STUDIES at this time

overweight but do not have PCOS. Participants in this part of the study will also have comprehensive testing, but will not receive treatment. Who is being asked to Participate?

• Healthy Overweight Girls

• Healthy Overweight Girls

with PCOS (Symptoms of PCOS include

irregular periods, acne, and

unwanted hair growth)

• Ages 10-20 years

Participants will be compensated for

their time.

Please contact:

Julie Byrne, CRNP Study Coordinator

412-692-5239

Featured physical health research study

NEW ACTIVE physical HEALTH research STUDIES

Topic PI Research Study Contact

Physical Activity S. Lee Physical Activity in Youth 412-692-8199

Obesity, insulin resistance, and bone

metabolism in adolescents with PCOS:

Effects of insulin sensitizers versus oral

contraceptives

PI: Silva Arslanian, MD; Hala Tfayli, MD

This is a six months intervention

study that is looking to determine the best way to treat adolescent patients with PCOS.

Adolescents with PCOS in general have irregular periods, acne and excessive hair. They also tend to gain more weight and be more insulin resistant. Those young girls have higher risk of developing diabetes and metabolic problems as adults. Research regarding the best treatment of these girls is limited. The conventional way of treatment has been the use of an oral contraceptive pill. A newer approach to treatment is the use

of insulin sensitizers. Insulin sensitizers enable the body to use insulin more efficiently and can help with several aspects of PCOS. However we do not know at this point which treatment is better. What is the treatment? Participants in this study will be randomly assigned to receive either an oral contraceptive (Yasmin), or an insulin sensitizer (Avandia). Participants will undergo comprehensive testing, including tests for diabetes and cholesterol, tests for bone health, and tests for heart health. The tests will be done before initiation of treatment and at the end of the 6-months treatment. Participants will be seen on a monthly basis during the study to monitor their progress. The medication will be provided free of charge for the duration of the study. In order to better understand PCOS, we are also studying adolescent girls who are

V O L U M E 3 , I S S U E 2 P A G E 3

Mission Statement

To improve children’s health by facilitating the translation of research discoveries into pediatric practice through enhanced collaboration between investigators and practitioners.

“Having a clinical research nurse present in the office on a regular basis gives us an opportunity to stay up-to-date on the latest approaches to common clinical problems. The families we serve have often expressed how impressed they are that we stay so current.”

Dr. Labella - CCP Bass Wolfson

Children’s Community Pediatrics Allegheny Pediatrics Armstrong-Kittanning

Elderton Leechberg Sarver

Bass-Wolfson Squirrel Hill Cranberry

GIL Pediatrics East Side Murrysville

Norwin Pediatrics Monroeville Pediatric Association (MPA) Moon and Wexford Mt. Lebanon Pediatrics Mountain View Pediatrics and Blairsville Pediatrics Natrona Heights Pittsburgh Pediatrics

Center Ave Wexford

South Hills Pediatric Associates Brentwood Jefferson Hills

Waterdam and South Hills (Bethel Park) Children’s Hospital of Pittsburgh Primary Care Centers

Oakland Turtle Creek UPMC Mercy Health Center

Adolescent Medicine Clinic

PEDIATRIC PITTNET UNIVERSITY OF PITTSBURGH CTSI PRACTICE-BASED RESEARCH NETWORK 3414 Fifth Avenue- 3rd Floor Pittsburgh, PA 15213 Phone: 412-692-5900 www.PedsPittNet.pitt.edu

PittNet Practices

Immunization Education Videos Last year when we asked our community members to suggest a parent education topic appropriate for videos for our eMessage boards, the respond was unanimous: immunizations. So, we set out to create original videos which highlight the safety and efficacy of childhood vaccines. Thanks to Pediatric PittNet doctors, researchers, nurses, and parents who donated their time, we were able to film compelling messages for parents. We are happy to report that these videos are now complete—look for them soon on our website and eMessage boards.

To assess the impact of the videos, we will conduct a parent pre-/post-viewing survey on parental attitudes toward immunizations.

Stay tuned for results.

Dates to Remember Steering Committee meeting THURSDAY September 30, 2010

Protocol Submission Deadlines: TUESDAY July 13, 2010

Executive Committee will review protocols on July 27, 2010

TUESDAY August 10, 2010 Executive Committee will review protocols

on August 24, 2010

TUESDAY September 07, 2010 Executive Committee will review protocols

on September 21, 2010

Topic PI Research Study Contact ADHD C. Ladouceur Emotion regulation in High Risk of Bipolar Disorder 412-383-8135

Anxiety L. Giovengo Yoga for Kids 412-246-5771

Anxiety R. Dahl & N. Ryan Child Anxiety Treatment Study (CATS) 412-383-8182

Anxiety & Depression D. Brent Brief Cognitive Behavior Therapy for Depression and Anxiety in Primary Care 412-246-5283

Autism N. Minshew, C. Holland & B. Handen Autism Treatment Network (ATN) 412-235-5412

Autism N. Minshew Categorization & Facial Knowledge in Autism (PEAS) 412-246-5485

Autism N. Minshew Biological and Information Processing & Autism (ACE) 412-246-5485

Behavioral O. Bukstein TOSCA: Treatment of Severe Childhood Aggression 412-246-5661

Behavioral D. Kolko SKIP-Services for Kids in Primary Care 412-246-5888

Premature Birth B. Luna fMRI and DTI in Children with PVH/PVL 412-383-8180

Depression J. Silk & R. Dahl Youth Emotional and Social Development (YES-D) 412-383-5425

Depressed Moms H. Swartz Psychotherapy for Depressed Mothers of Psychiatrically Ill Children 412-246-5588

Healthy Children E. Szigethy Reducing Depressive Symptoms in Physically III Youth 412-692-5497

Healthy Children B. Luna Rewards Processing in Adolescence 412-383-8180

Healthy Children L. Pan Neural Circuitry & Early-Onset Suicide Attempt 412-246-5597

Healthy Young Moms J. South-Paul Mentoring support for young mothers 412-383-2366

PCOS D. Rofey Healthy Bodies, Healthy Minds: Helping Adolescents with PCOS 412-692-6564

PP Depression E. Moses-Kolko Women’s Postpartum Imaging Study 412-624-9152

PP Depression K. Wisner Transdermal Estradiol for Postpartum Depression 412-586-9072

PP Smoking M. Levine Postpartum Smoking Cessation (STARTS) 412-647-5767

Sleep, Activity, R. Dahl & D. Shaw Health Promotion: Sleep, Activity, and Emotion Regulation 412-624-9978

Pediatric PittNet active BEHAVIORAL HEALTH research STUDIES

412-692-5900 www.pedspittnet.pitt.edu

Topic PI Research Study Contact

Asthma S. Aujla Asthma 412-692-3154

Bone Metabolism M. Horwitz Bone Metabolism in Postpartum African-American Women 412-864-3265

Diabetes D. Becker Screening and Natural History of Type I Diabetes 412-692-5210

Healthy Controls S. Arslanian Metabolic Markers of Adult Morbidity in Black Children 412-692-8721

HPV/Cervical Cancer W. Doswell PDAC: Intervention Protecting Daughters Against Cancer 412-624-8977

Infant Formula T. Green Formula for Infants with Cows Milk Allergy 412-692-5677

Influenza M. Michaels Infant Tamiflu 412-692-6768

Obesity S. Lee Physical Activity in Youth 412-692-8199

PCOS S. Arslanian PCOS 412-692-5239

UTI with VUR A. Hoberman RIVUR — UTI with reflux 412-999-3277

UTI without VUR A. Hoberman CUTIE — UTI without reflux 412-999-3277

Vitamin D K. Rajakumar Vitamin D Insufficiency 412-692-5415

Obesity L. Ewing & P. Cluss HEALTH for Families 412-647-3179

Pediatric PittNet active PHYSICAL HEALTH research STUDIES

412-692-5900 www.pedspittnet.pitt.edu