Pink army july 31
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@ANDREWHESSELJULY 31 02010
a drug company for everyone
PINK ARMY COOPERATIVE
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http://ilovebacteria.com/Images/bacterialcell.jpg http://i.dell.com/images/global/products/314x314/desktop-studio-mini-left-314.jpg
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COMPILE
DESIGN
design/build/design/build/test cycletest cycle
EXECUTE
TEST
applications
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David Appleyard
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CANCER
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CANCER R&D IS
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Evolutionary distance
~ 4 billion yearstwo completely different species, far
removed,and bacteria are clonal
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many chemical compounds have antimicrobial activity without seriously harming human cells
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Evolutionary distance
max: patient’s agecancer cells are same species,
only recently diverged, and every divergence is unique, cells
continue to degrade over time (mixed)
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photo by billy hunt
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christa slotboom
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TARGETING FAST GROWING CELLS IS SO 1950there are plenty of normal cells that grow fast too, making treatments
needlessly harsh
ONE-SIZE-FITS-ALL DRUGMAKING IS ILLOGICALeach person’s DNA is different, their mutations are different, cancers are of
mixed cell types
CANCER RESEARCHERS DON’T MAKE DRUGS drug companies make drugs
A LOT OF RESEARCH ISN’T USEFUL there appears to be a near-infinite number of paths to cancer
CHANGE IS HARDcancer is industry with tremendous inertia
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THE IDEAL THERAPEUTIC
specific to the cancergentle
effectivemade quicklyinexpensive
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http://www.nature.com/horizon/chemicalspace/background/images/odyssey-f1.jpg
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Scientists
newdrug X
shareholders
Lawyers
MANUFACTURERS
clinical trials
Economists
physicians
Insurance companie
s
geneticists
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system is inherently limitedrequires blockbustersunable to accelerate
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RISK vs BENEFIT (n>1)
STATISTICAL ANALYSIS OF POPULATIONSrequires large markets failure is expensive politicalslow
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RISK vs BENEFIT (n=1)
no statistics – just direct observationsrisk benefit analysis always an individual decision
?
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isolate and
analyzedesign build test
failures
provide and
evaluate
SYNTHETIC BIOLOGY BIOFAB
results
COOPERATIVE
data sharing
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aims to bring together researchers, developers, cancer sufferers and supporters in a self-funded,
open-source therapeutic venture
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goal:not a new drug, but a completely new way
of making drugs
one that can accelerate and improve over time
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a significant step towards faster, better, cheaper cancer drugs
+ =
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diagnostics today, treatments tomorrow
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