Physics of Tablet Comp Action Copy
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PHYSICS OF TABLET COMPRESSION Introduction to Tablets : According to IP “tablets are solid dosage forms each containing a unit dose of one or more ingredients” Ninet y perce ntage of the drugs thar are administere d to produc e syste mic effect are throug h oral dosage forms. The advantage of the tablets and the capsules over liquid dosage forms includes elixirs, syrups,solutions is that the exact dose of the drug can be given to the patient. William Br ock edon got the fi rs t patent for tablet pr ess and showed a route for the fut ur e development. The main aim in using a tablet is to provide required amount and to dispense a unit dose of drug to patient. By the time it reaches the target action organ, the drug should not change chemically. And the amount of active ingredient varies a lot. E.g. L-thyroxine has 25ug of active ingredi ent wherea s amo xicilli n has about 1g of act ive ingr edient. The weight of the act ive ingredient ranges from 0.1 to 90% of the total weight of the drug. Tablets should be both physically and chemically stable. They should have capability to withstand the stress during packaging and transport. Physical stability is more important as its effects the bioavail ability of the tablet. In the tablet the drug should not undergo any chemical change and the effect of dug on the body must be an expected one. And the drugs have different physical and chemical properties like water solubility, crystalline nature etc. MANUFACTURE: There are three well known methods for the preparation of granules. I) Direct compression method: It is useful for the moderate dosage drugs. The diluents used should be inert. It should be compressed easily and it should loose this quality when drug and other excepients are added. Some of the materials for which this method is used are KCl, NaCl, NaBr But this is not used for most of the drugs because, the drug do not attain attraction forces on compression or the molecules will be covered by a layer of air. Advantages: Very less number of steps are involved. Disadvantages: The variations in particle size and density when compared to diluents leads to the formation of layers. This is problematic especially in case of low potet drugs. Most of the large dosage form
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