Photos from the conference

Photos from the conferencelntroduction - - - - - - - - ----- ------- - _._ - -- -

Photo series 1

Top left: Roger Mason, Klaus Kuettner; top right, standing: Thomas Andriacchi, Richard

Loeser; seated: Stefan Lohmander. Sue Eyre, Roger Mason, Inger Lohmander; middle: Jurgen

Mollenhauer, Gabriella Cs-Szabo; bottom left: Linda Sandell, Ernst Hunziker. Jenny Tyler,

Alan Grodzinsky; bottom right: Vince Hascall

483

Photos from the conference Introduction

Photo series 2

Top left: Vince Hascall, Klaus Kuettner, Elizabeth Dieppe; top right: Kathy Vukovich, Marliese

Annefeld, Hari Reddi, Anu Reddi; middle left: Joel Block, Richard Loeser, Warren Knudson,

Cheryl Knudson; middle right: Inger Lohmander, Stefan Lohmander; bottom left: Elizabeth

Dieppe, Paul Dieppe; bottom right: Tom White, Carol Muehleman, Klaus Kuettner, Julia

Freeman, Susan Chubinskaya

484

Photos from the conferencelntroduction

Photo series 3

Top left: Paul Dieppe, Robin Poole; top right, seated: Wolfgang Eger, Holger Koepp, Stefan

Soder; standing: Johannes Flechtenmacher, Bernd Rolauffs, Monika Schulze, Klaus Kuettner,

Matthias Aurich, Hans Hauselmann; middle left: Margaret Aydelotte, Klaus Kuettner; middle

right Ada Cole, AI/an Valdel/on, Arkady Margulis; bottom left: Mark Grabiner, Rick Sumner;

bottom right: Warren Knudson, Ted Oegema

485

Photos from the conferencelntroduction

Photo series 4

Top left: Klaus Kuettner. Verhonda Hearon Eggleston, Matthias Aurich, Erzsebet Kuettner. JiJr­

gen Mollenhauer; top right: Susan Chubinskaya, Klaus Kuettner. Carol Muehleman; middle

left: David Howell, Fred Woessner. Vince Hascall, Teresa Morales, Klaus Kuettner; middle

right: Fred Woessner. Nina Woessner. Klaus Kuettner. Eugene Thonar; bottom left: Erzsebet

Kuettner. Vince Hascall, Klaus Kuettner. Hari Reddi, Inger Lohmander; bottom right: Vania

Hascall, Hari Reddi, Vince Hascall

486

Photos from the conferencelntroduction

Photo series 5

Top left: "The Scoriers" (no names needed); top right Klaus Kuettner; middle left: Gene

Homandberg, Eugene Thonar; bottom left: Jill Urban, Alice Maroudas; bottom right: Robert

Sah. Cheryl Knudson, Teresa Morales

487

Index

actin 221

activin receptor-like kinase (ALK) 72,83

ADAM 280

ADAMTS 280

adduction moment 457

adult human normal cartilage 82

adult human articular cartilage 82,415

aggrecan 141,147,155,207,294,387

aggrecan solution properties, comparison

with hyaluronan 141

aging 248,249,409,417

AgKS, direct metabolic marker of joint

metabolism 454

alginate 77

alginate bead 429

ALK-l 72

ALK-2 83

ALK-3 83

ALK-6 83

alkali pH, effects on hyaluronan solution

properties 136

alkaline phosphatase 254

alphal(II) collagen (COL2Al) 72

amelogenin peptides, alternative premRNA

splice products 103

analgesic effect of hyaluronan 196

analyzer crystal 352

animal model 45,49

ankle 27, 353, 369, 429

ankle joint 27,353

ankle (talocrural) joint 27

anterior cruciate ligament (ACL) 461,465

apoptosis 256

applied stress 249

arthritic pain 197

articular cartilage 45, 67, 82,279, 351

articular cartilage collagen 279

atrophic destructive OA 357, 360

autologous chondrocyte transplantation (ACT)

67,68

automated electron tomography (AET) 124

autoradiography, quantitative 400

basic calcium phosphate (BCP) 357, 359

biglycan 294, 369, 370

bikunin 207,208

bikunin-gene knockout mouse 209

biocompatible scaffold 423

biomechanical properties, cartilage 409

biomechanics 239,409,441

blood circulating system 211

blood vessel invasion 255

BMprrGF~ superfamily 214

BMP-2 261, 262

BMP-7/0P-l 77,178,220

body mass index 33

bone collagen 277

bone dust 357

bone marrow 68, 73

bone matrix 276

bone mineral density 359

bone morphogenetic protein (BMP) 5, 7, 63,

64,77,81,82,101,119,178,214,220,

227,261,262

489

Index

bone morphogenetic protein (BMP) family 81

bone morphogenetic protein (BMP) antagonist 7

bone morphogenetic protein (BMP) receptor 82

bone remodeling 46, 49

bone resorption 275

bone scintigraphy 358

brachypodism (bp) 214

brevican 147

calcified cartilage, zone of 254

calcium pyrophosphate dihydrate (CPPD) 356,

357

calcium pyrophosphate dihydrate crystal 356

calcium, effects on hyaluronan solution

properties 134

camptodactyly-arthropathy-coxa vara­

pericarditis syndrome 22

camptodactyly-arthropathy-coxa vara­

pericarditis protein (CACP) 159

cementum attachment protein (CAP) 104

cartilage 46,49,63,64,77,81, 82, 151, 154,

163,192,214,239,251,261,263,278,

285-287,309,353,369,402,403,409,415,

423,453

cartilage biomechanics 409

cartilage collagen 278

cartilage degeneration 353,369

cartilage degradation 49

cartilage destruction 261

cartilage development 214

cartilage differentiation 309

cartilage marker 285

cartilage matrix protein (CMP) 151

cartilage oligomeric matrix protein (COMP)

46,163,286,287,453

cartilage oligomeric matrix protein, assays 287

cartilage regeneration 81

cartilage repair 81, 263, 369,423

cartilage-derived morphogenetic protein

(CDMP-1) 63,64

cartilage-specific gene 309

casein kinase 223

490

cathepsin K 276

CD44 178,219,255

CD44-HA interaction, modification 211

CD44, short-tail 225

eDNA-array technology 293

cell culture model 163

cell expansion 67

cellularity 416

cementum attachment protein (CAP) 104

Cereberus, Xenopus gene 64

chondrocyte 67,77,178,392

chondroitin sulfate chain, bikunin 207

chondrophyte 358

chordin 64

chromosome 16p 43, 44

chrondrogenesis 91

chrondrogenesis, bone induction 101

COL2A1 72

collagen 45, 117, 119, 121, 155,249,250,

275-279,294,413,414

collagen II, III, IX, XI 278, 279

collagen catabolism 277

collagen cross-links 45,275

collagen early fibril (CEF) 121

collagen fibril 278

collagen fibrillogenesis 119

collagen network 249,413

collagen network stiffness 247,250

collagen network, tension 248

collagen network Pc, tension stiffness 250

collagen tension 249

collagenase 279,296

Collins grade 370

complex genetic disease 18,21,22

conditional gene targeting 216

confocal fluorescence recovery after photo-

bleaching (confocal-FRAP) 131

congenital hip dysplasia 411

continuum model 416

copers 461

CPPD 359

C-reactive protein 453

cross-linked telopeptide 276

cross-linking interaction 279

crystals, markers of disease 359

CTx immunoassay (cross-linked C-telopeptides

of type I collagen) 275

C-type lectin 147

cumulus oophorus, expansion of 209

cytoskeleton 221,222,226

decorin 294, 369, 370

de-differentiation 68

deformation, of cells and matrix 383

degenerative cartilage 82

dentin matrix protein (DMP2) 103

deoxypyridinoline 275

diagnosis of OA 299,409

differential gene trapping 310

differentiation 213

Diffraction Enhanced Imaging (DEI) 351

distal femur 413

dual-photon X-ray absorptiometry 365

dynamic compression 398

dynamic joint loading 457

dynamic knee stabilization 461

dynamic shear modulus 404

dysplastic joint 359

electrokinetic behavior, of cartilage 402

electron microscopy 121

ELISA 210

embryogenesis 5,213

endocardial cushion tissue 149

endochondral ossification 149

energy metabolism 391

explant culture 429

extracellular matrix (ECM) 5, 65, 117, 149,

213,147

extracellular matrix, organization of 149

fatigue 416

FCD 248

femoral condyle 412

femoral head 358,412

fibril 117

Index

fibroblast growth factor receptor-3 (FGFR3) 72

fibronectin fragment 78

fibronectin 78, 192, 194, 294

fibulin-1 147

fibulin-2 147

fixed charge density 383, 387, 388

fixed charge 387,413

fluid flow 383

fractal signature analysis 358

fragment of biglycan 370

fragment of decorin 371

gait testing 457

gelatinase A 244

gene targeting 155

GIcNAc, of HA 208

glycation, non-enzymatic 249,414

glycosaminoglycan (GAG) 387, 388, 397,402,

414,429

glycosaminoglycan, electrostatic interactions 402

gremlin, Xenopus gene 64

growth factor 261

growth law 416

growth plate 254

growth/differentiation factor 5 (Gdf5) 178

growth/differentiation factor 9 (Gdf9) 214

heart development 149

heavy chain 207

heparan sulfate, binding of matrilysin 242

hip 39---44, 303, 363, 367

hip OA 303, 363, 367

hip OA, genetic component/background 39---44

histopathological indices 414

human articular cartilage 27,429

Human Genome Project 17

humerus, distal 413

hyaline cartilage 355-360

hyaline cartilage defect 357

hyaline cartilage degradation 355, 358

491

Index

hyaline cartilage disease 360

hyalocyte 193

hyaluronan (HA) 131,132,134,136-138,141,

147,177-179,189,195,196,201,207,

209,210,213,219,453,455

hyaluronan levels, in sera of RA patients

209,210,455

hyaluronan-rich matrix 207

hyaluronan synthase (HAS) 178,213

hyaluronan synthase 2 (HAS2) 178

hyaluronan synthesis 195

hyaluronan, self diffusion 132

hyaluronanlaggrecan aggregates, cross-linking

147

hyaluronan-binding chondroitin sulfate

proteoglycan 207

hyaluronan, therapeutic use 201

hydration 251, 387, 388

hydraulic permeability 180,411

hydrodynamic radius (RH), of hyaluronan 138

hydrogen ion 391

hydrostatic pressure 383

hydroxylysylpyridinoline (HP) 46

hylan A 201

hylan B 201

hypertrophic bone response 356

hypertrophic chondrocyte 254

hypertrophic hip OA 303

hypertrophic OA 356, 357

hypertrophic osteophytosis 358

hypertrophic pathway 257

hypertrophy 254

IL-1 64, 178, 220

IL-1~ 78,86,429

IL-17 64

imaging 329, 351,442

immobilized joint 195

immuno-histochemistry 45, 85

in situ hybridization 45,71,83

in vitro expansion 72

India ink 414

492

instantaneous deformation (ID) 250

instantaneous deformation, increase 251

inter-IX-trypsin inhibitor (m) 178

inter-IX-trypsin inhibitor (m) family molecule

207

inter-IX-trypsin inhibitor (m) family molecule,

structure 208

inter-IX-trypsin inhibitor (m) family molecule,

intracellular assembly 208

intracellular composition 392

intracellular pH 392, 393

ionic environment 387

ionic strength 387, 388

joint degradation 303

joint development 214

joint space width (JSW) 363-366

joint space width, rate of decline 364

knee 27,369,429,456,465

knee OA 456

knee (tibiofemoral) joint 27

lactic acid 391

lamina splendens 192

limb development 214

locomotion mechanics 453

lubricating function 412

lubrication 160

Lubricin 22, 159

lysylpyridinoline (LP) 46

macrophage 262

magnetic resonance imaging (MRI) 339,357,

358

MAP kinase pathway 384

marked risk 43

marker, joint metabolism 453

marker, osteoarthritis 297

marker practicality 298

marrow oedema 357

matrilysin 242, 282

matrix accretion 411

matrix fragmentation 416

matrix metalloproteinase (MMP) 7,241,280,

281,295

matrix metalloproteinase 3 281

matrix metalloproteinase 7 (matrilysin) 282

matrix nano-electromechanics 397

mechanical compression 427

mechanical integrity 416

mechanical properties, of cartilage 403

mechanical stimuli 383

mechanoreceptor 199

mechanotransduction, cellular 383

megakaryocyte stimulating factor (MSF) 159

membrane patches, from oocyte 199

membrane transporter 384

Mendelian disease 17

mesenchymal stem cell 73

microenvironment 416

microfibril 124

migration 213

Milwaukee shoulder 357

mineralization 256

mitogen activated protein (MAP) kinase 388

molecular marker 72, 285

molecular polarity reversal 122

molecular switch region 123

monolayer culture 429

morphogenesis 214

MRI 339, 357, 358

multiple epiphyseal dysplasia 156

multiple markers, use of 300

nanoscale electrostatic repulsive interaction

384

national genealogy database 39

national registry 39

negative staining EM 147

neurocan 147

NHrPropeptide 5

NHE (Na+x H+ exchange), chondrocytes 392

noggin 64

Index

non-copers 461,465

NTx immunoassay (cross-linked N-telopeptide

fragments of type I collagen) 275

OA cartilage 82,251

oligosaccharide 222, 226

OP-l (BMP7) 77,178,220

osmolality 387, 388

osmolyte 393

osmotic pressure 383

osmotic pressure, GuHCl extracts 248

osmotic pressure, proteoglycan (PG) 247,402

osmotic swelling pressure, proteoglycan 402

osmotical compression 413

osteoarthritic samples 251

osteoclast 276

osteogenic protein-l 81

osteonectin 294

osteophyte 46, 261, 262, 357

osteophytosis 358

overweight 35

Paget's disease of bone 278

patella 412

periosteum 68, 73

permanent cartilage 254

permeability 414

PG 46,71,77,78,147,207,247,250,369,

402,430

PG synthesis 78

PG-M/versican 207

pH 387, 390-393

phenotypic stability 68

physical activity 33

physical forces and flows 383

physical regulation, of cartilage metabolism 398

pointed tips 119

poroelasticity 402

preovulatory follices 209

pressure 387,393,411

pressure gradient 411

protease 239

493

Index

proteoglycan (PG) 46,71,77,78,147,207,

247,250,369,402,430

proteolytic processing 152

pseudoachondroplasia (PSACH) 165

pseudogout syndrome 356, 357

PTH 257

PTHrp 257

pycnodysostosis 276

pyridinoline 275

pyrophosphate arthropathy 356

quadriceps 466

quantitative autoradiography 400

RA progression, degree 209

radiographic imaging 353

radiography 351

radiology 331

rapidly destructive hip OA 303

regeneration 411

regenerative medicine 65

remodeling 417

repair 411,417

risk factors, development of lower limb

osteoarthritis 31

risk factors, human osteoarthritis 4

RUNX2 254

scanning electron micrograph 415

scanning electron microscopy 45

scintigraphic subsets 358

scintigraphic subsets, extended pattern 358

scintigraphic subsets, tramline pattern 358

self-assembling peptide hydrogel 423

semi-quantitative histology 45

semi-quantitative RT-PCR 83

sera of OA patients 209

serum cartilage oligomeric matrix protein

288,289

serum concentration, SHAP-HA complex

209,210

serum factor 207, 208

494

serum factor, from blood 208

serum HA concentration 209,210,455

serum-derived hyaluronan-associated protein

(SHAP) 178, 207-210

SHAP-HA complex, levels in RA sera 209

SHAP-HA complex formation, possible pathway

208

shear modulus of cartilage 403

skeletal development 5

skeletal scintigraphy 358

small proteoglycan (PG) 369

stem cell 65

STIR sequence 357,360

strain 409, 411

streaming potentials and currents 383

stress 249, 409, 411

subchondral bone 253, 356-360

subchondral bone, blood flow 360

subchondral bone, density 358

subchondral bone response 357

subchondral bone response, crystals 356

subchondral cyst 356

subchondral marrow 357

subchondral sclerosis 358

superficial layer, of cartilage 192

superficial tangential zone (STZ) 417

superficial zone chondrocytes 159

superficial zone protein (SZP) 22, 159

superficial zone 251,412

surrogate marker, hip OA 367

surrogate parameter 49

swelling 387,388,413,416

swelling pressure 387

synchrotron 351

synovial cavity of the articular joint 207

synovial cell 159

synovial fluid 159, 177, 179, 190, 208

synovial interstitial matrix 180

synovial membrane 207

synovial tissue 193

synoviocyte 177, 180, 193

synovium 73, 177, 189

talus 412

telopeptide 275,280,281

telopeptidase 280

telopeptide domain epitope 281

tenascin-R 147

tensile 411, 412

tensile modulus 411

tensile strength 412

TGF~ 72,214,257,261-264

TGF~ superfamily 72,214

TGF~ type II receptor 263

tidemark 253, 255, 256

TIMP-3, binding to matrix 243

tip-to-tip fusion 123

tissue engineering 65, 411, 423

tissue engineering scaffold 423

tissue expansion 411

tissue layer 410

tissue repair 5

tracer diffusion, in hyaluronan solutions

137

transcription factor 91

transport pathway .'392

transporter 389, 392, 393

trauma 33

TSG-6 gene 209

type 2A procollagen 3

type II collagen 46, 281

type II procollagcn 64

type II receptor 83

type IIA procollagen 5

type IV collagen 64

type X collagen 254

Index

urea, effects on hyaluronan solution properties

139

urinary hydroxyproline 278

urinary trypsin inhibitor (UTI) 208

versican 147, 207, 294

viscoelastic properties 177

viscosupplement 177

viscosupplementation 201

Xenopus genes 64

x-ray 334,351

495