Pharmacology of Methadone and Physican-Pharmacist...
Transcript of Pharmacology of Methadone and Physican-Pharmacist...
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Pharmacology of Methadone and
Physican-Pharmacist Collaborative Care
Nicole Nakatsu, Pharmacist WRHA
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Conflict of Interest Disclosure • Consultant for: N/A
• Speaker for: N/A
• Received grant/research support from: N/A
• Received honoraria from: N/A
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Objectives Methadone Pharmacology
Adverse Effects
Drug Interactions
Dosing
Missed Doses
Overdose
Pharmacist-Physician Collaboration
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Methadone Developed in 1941 by IG Farbenindustrie
Post WW2 marketed in US by Eli Lilly as Dolophine for pain
1962 methadone used in Vancouver as part of withdrawal program
1963 Dole and Nyswander in New York began testing methadone for maintenance therapy
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Methadone Pharmacology Synthetic opioid
Structurally unrelated to opiates
methadone
morphine
heroin
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Methadone Pharmacology Agonist at the μ-opioid receptor
Uses- analgesia and withdrawal management in opioid dependent individuals
No rush/euphoria in stabilized patients
Blocks euphoria from heroin and other opioids
Excellent oral bioavailability
Long duration of action allows once daily dosing in methadone maintenance therapy (MMT)
Note: when used for pain dosing is typically TID
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Absorption Following oral dosing methadone is detected in the
plasma within about 30 minutes
Peak plasma levels 2-4 hours after ingestion
PO bioavailability is 90 %
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Distribution Highly protein bound to both plasma proteins and
tissue proteins
VD = 4-5L/kg
t½ = 22 hours (15-40 hours)
5-7 days to reach steady state with repeated dosing
Withdrawal typically suppressed for 24-36 hours with therapeutic doses
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Metabolism Primarily metabolized by cytochrome P450 3A4 to
the inactive metabolite EDDP
Also metabolized to a lesser extent by CYP 1A2, 2B6, 2C8, 2C9, 2C19, and 2D6
Weak inhibitor of 2D6
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Excretion Methadone is excreted both as unchanged drug and
as metabolites in urine and feces.
Amount of methadone excreted in urine increases as pH decreases.
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Adverse Effects Sweating –may be due to dose being too high or
too low
Sedation- tolerance develops to this side effect but caution is advised during initiation and with dose increases
Constipation-inhibits propulsive contractions of the intestines while increasing non-propulsive segmental contractions. Increases tone of anal sphincter. Need to treat with stimulant laxative that works at the myenteric plexus (ie. Senna, bisacodyl)
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Adverse Effects Weight gain- reported by many patients. Can cause
water retention and decreased metabolism.
Psychoactive effects- patients may experience some euphoria when starting on methadone or during dose increases. When stabilized methadone will block euphoria from other opioids.
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Adverse Effects Insomnia-generally improves as patient is
stabilized. Look into other causes of insomnia such (i.e. anxiety). Instruct patient on good sleep hygiene
Sexual problems-may decrease desire and/or performance. Once stabilized some patients may experience an increase in desire
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Adverse Effects Neuroendocrine- increased prolactin, affects HPA
and HPG axis but with chronic use tolerance develops to these affects. Most women will report normal periods once stabilized.
Dental-may inhibit saliva production which causes dry mouth and increased plaque production. Good oral hygiene practices should be encouraged.
Urinary-some people report difficulty voiding but tolerance usually develops quickly
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Adverse Effects QT interval- QT interval prolongation with high
doses.
ECG recommended for patients on high doses.
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Drug Interactions PHARMACOKINETIC INTERACTIONS
P450 3A4
Drugs that inhibit CYP 3A4 – decrease methadone metabolism. Interaction occurs quickly (1-2 days). Watch for signs of toxicity (sedation, respiratory depression)
Drugs that induce CYP 3A4 – increase methadone metabolism. Interaction is slow to occur with peak effect after 1-2 weeks. Watch for signs of withdrawal.
Antagonist/partial-agonists-precipitate withdrawal
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Drug Interactions Decrease plasma levels
Barbiturates
Carbamazepine
Ethanol (chronic)
St. John’s Wort
Nelfinavir*
Phenytoin
rifampin
Increase plasma levels
Amitriptylline
Ciprofloxacin
Clarithromycin
Erythromycin
Ethanol (acute use)
Fluconazole/itraconazole
Fluvoxamine
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Drug Interactions PHARMACODYNAMIC INTERACTIONS
Additive effects of drugs with similar side effect profile
Be very careful with other CNS depressants and methadone-increased risk of respiratory depression and sedation
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Dosing Start low and go slow!
15-30mg to start
Remember it takes 5 days for plasma levels to reach steady state
Increase by 5-10 mg every 3-5 days as tolerated. Avoid prescriptions that have dose increases without patient assessment.
Incomplete cross-tolerance
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Dosing Overdose can be fatal but opioid withdrawal is not.
Always balance risk versus benefit.
Patient should take dose at same time each day
Some patients are rapid metabolizers and may require split dosing (also pregnant women)
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Missed Doses/ Vomited Doses
Tolerance is lost relatively quickly
After 3 missed doses, the patient must have a dose reduction-requires a new prescription
Emesis must be witnessed by a health care professional
Within 15 mins-consider replacing 50-75% of dose
Within 15-30 mins-consider replacing 25-50% of dose
After 30 mins-do not replace
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Overdose CNS and respiratory depression
Treat with naloxone for a minimum of 24 hours with an additional 12 hours of monitoring
Can run as an infusion or give small bolus doses hourly
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Pharmacist-Physician Collaboration
Pharmacist is often the healthcare provider that the patient has the most contact with. Will see methadone patients a least once a week if not more.
Pharmacists develop a professional relationship with their methadone patients so they are able to assess their condition when they come in for their dose.
Pharmacists are in an excellent position to identify when patients may be needing more support or referral to other healthcare professionals.
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Collaboration Examples of situations that should be reported to
physicians:
patient exhibiting unusual or unacceptable behaviour
Patient has not picked up dose
Patient refuses part or all of their dose
Patient appears intoxicated or impaired
Patient vomits dose
Patient fails to provide lock box
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Collaboration A good working relationship is not only
professionally satisfying but is also good for patient care.
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Questions?