Pharmacogenomic Approach Paving the Way for Personal is Ed Drugs
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Transcript of Pharmacogenomic Approach Paving the Way for Personal is Ed Drugs
8/3/2019 Pharmacogenomic Approach Paving the Way for Personal is Ed Drugs
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PHARMACOGENOMIC APPROACH;
PAVING THE WAY FOR
PERSONALISED DRUGSFOR ASTHMA
BY
SAHITHI . GADDEK.V.S.R.SIDDARTHA COLLEGE OF PHARMACEUTICAL
SCIENCES ,
VIJAYAWADA.
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DEFINITION OF ASTHMA
• Asthma is a chronic inflammatory disorder of the airways ofthe lungs.
• Many cells and cellular elements including mast cells,eosinophils, T-lymphocytes, macrophages, neutrophills andepithelial cells are involved in the process.
• It affects nearly 155 million individuals across the world.
• In India 10-15% of the population particularly women andchildren were found to be affected by atopic asthma.
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CLASSIFICATION• It is classified as;
1. Atopic (symptoms are precipitated
by allergens)2. Non-atopic (symptoms are not
precipitated by allergens)
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SYMPTOMS
• Wheezing (high pitched whistling soundswhen breathing out-especially in children)
•
Breathlessness • Chest tightness
• Coughing
- these symptoms are particularlyobserved in night and in early mornings.
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Causes for asthma • The infiltration of leukocytes
particularly eosionphils in to the
lungs and release of vaso activemediators from mast cells set thestage for asthamatic inflammation.
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Two functional alterations aretypically associated with
asthma;• These include variable air way obstruction of
bronchial hyper responsiveness. The narrowingof the airways is associated with smooth muscle
contraction, airway wall thickening, edema andincreased mucus secretion.
• Along with these there is a denudation of theair way epithelium and collagen deposition
beneath the basement membrane.
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BIOCHEMICAL PATHWAYSINVOLVED IN THE
PATHOGENESIS OF ASTHMA
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• Studies over last 25 years have clearlydemonstrated that both genetic and environmental factors determine the
phenotypic expression of asthma.
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• Asthma is a complex disorder of multi
factorial origin.• Atopic asthma in children is found to be
strongly familial and genetic basis.
•
In addition to genes of asthmaenvironmental factors such as allergens,food, childhood viral infection, alsoplays a significant role in causingasthma.
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Genes contributing to asthma
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CURRENT MODE OF
ASTHMA THERAPY• Large number of drugs are available for
the treatment of asthma.
•
Theanti-leukotrienes
are the newest class ofanti asthmatic drugs available. They helpto control symptoms of asthma.
• Corticosteroids are the anti inflammatory
drugs of choice.
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FUTURE PERSPECTIVE
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ACKNOWLEDGEMENT • A.PRAMEELA RANI
• N.KANAKA DURGA DEVI
• K.NAVEEN BABU
• KVSR SIDDARTHA COLLEGE OF PHARMACEUTICALSCIENCES,
VIJAYAWADA.
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