MICROBIOLOGICAL RESULTS

STILL WAITING?

WAITING FOR MICROBIOLOGICAL TEST RESULTS FOR WFI AND PURIFIED WATER IS NOW A THING OF THE PAST

JMAR INTRODUCES

• CONSTANT WATER QUALITY AWARENESS

• REAL-TIME BIOBURDEN MEASUREMENT

• INCREASED PROCESS CONTROL

• ONLINE MINUTE BY MINUTE ANALYSIS

• IMMEDIATE MEASURABLE ROI

• LOW ENERGY CONSUMPTION (300 WATTS)

Benefits:Continuous monitoring detects biological contamination of WFI or purified water in real time

Significantly lowers costs by reducing product loss and product recalls due to contamination

Monitors effectiveness of water purification processes

Automated system offeres low mainenance and low cost of ownership

Features:Total sytem flow 100ml/min

Inspection volume rate ~ 1 ml per minute (1.4 liters per day)

Requires no consumables or reagents for detection

Automatic cleaning

KBERG CONSULTANTS

4234 MASSEY PRESERVE TRAILRALEIGH, NC 27616 USA

PHONE (910)232-0342STEW@KBERG.INFOWWW.KBERG.INFO

STEWART JASON KOHNBERG

BioSentry’s real-time results equal real savings for

pharmaceutical manufacturers. The real-time

data provided by BioSentry has the potential to

increase productivity, reduce �nished product

release time, as well as lower lot rejection rates.

While BioSentry does not replace conventional

methods of testing , its advanced monitoring

technologies can reduce the number of overall

conventional tests needed every year resulting in

substantial consumable cost and labor savings for

manufacture rs.

BioSentry’ s compact, reagent free, and energy

e�cient design saves on operating costs around

the clock. Its multiple purchase incentives,

comprehensive training, and dedicated support

team make keep initial costs low and result in a

quick return of investment.

If you would like to learn more about BioSentry, or

discuss exactly how BioSentry can save you

money , please contact us at (858)946-6800 or visit

us on the web at www.jmar.com.

Returning Real-Time Results

No longer does the pharmaceutical industry have

to wait for microbiological test results for WFI and

puri�ed water. BioSentry not only reduces the wait

for microbial contamination results, it eliminates it.

With real-time, on-line capabilities

BioSentry allows users to

monitor the biological activity

of a water source from

anywhere in the world

at any time of day.

Whether you are across the

lab or across the globe,

BioSentry will alert you

the moment contamination occurs.

Returning Real Savings

Pharmaceutical manufacturers are �nally able to

integrate the power of state-of-the-art technology

with long standing scienti�c methods to assure

continuous water purity. JMAR’s BioSentry is the

only rapid microbiological method (RMM) of detec-

tion that o�ers real-time, on-line, monitoring for

microorganisms in process water.

Cost of capital

Net present value

Return on investment

Payback (in years)

298%

12%$2,312,057

0.29

ROI Measures

Sample Business Senerio

Reduction in Lot rejections (assumes impovement by 1 bactch)

Reduction in investigation cycle time from process excursions(manpower and Lab resources)

Loss of productivity due to line down time(assumes 1 batch produced)

Reduction in cycle time during production line restart after maintenance

Loss of productivity during production line restart(assumes 1 batch produced)

Reduction in rework, reprocessing, and repeat testing

Total Annual Benefits

Implementation �lter

Total Benefits Realized

BENEFIT DRIVERS YEAR0 1

$400,000

$50,000

$400,000

$50,000

$400,000

$30,000

$1,330,000

60%

$798,000

Initial InvestmentInitial investment (assume 3 unitis to support operstions)

Implementation Costs (Quali�cation and regulatory costs)

Ongoing support costs

Training costs

Other costs

Total Costs

$0

$0

$5,000

$5,000

$0

$10,000

$120,000

$100,000

$0

$10,000

$0

$230,000

0 1

REAL-TIME RESULTS, REAL SAVINGS

REAL-TIME RESULTS, REAL SAVINGS

KBERG CONSULTANTS(910)232-0342

www.kberg.info