Pharm 1.16 Antibiotic Cheat Sheet - Dr. C's Nursey Stuff...inhibit metabolism ANTIBIOTIC CHEAT SHEET...
Transcript of Pharm 1.16 Antibiotic Cheat Sheet - Dr. C's Nursey Stuff...inhibit metabolism ANTIBIOTIC CHEAT SHEET...
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Gram PositiveGram Negative
How and Where Various Antibiotics Work
Gram +Penicillins (Amoxicillin)Gram + (Strep, Syphillis)Disrupts synth of peptidoglycan
Macrolides (azythromycin, erythromycin)Gram + (URI’s, Strep, Staph)Inhibits protein synth
Lincosamides (clindamycin) Step, StaphInhibit protein synth
Gram -Aminoglycosides (streptomycin, tobramycin, gentamicin) Gram - Psuedomonas - TBInhibit protein synth
Gram + and -Tetracyclines
Outer membrane
Ribosome
DNA
Cell wall
Folic acid
Cell membrane
Lipoproteins
Peptidoglycan
Periplasmicspace
Cutoplasmicmembrane
Lipopolysaccharides Porin Protein
(tetracycline, doxycycline)Broad spectrum (Gram +/-, atypicals)Inhibit protein synth
CephalosporinsDisrupts synth of peptidoglycan1st gen: Gram + (Ke�ex)2nd gen: Gram - > Gram + (Cefzil)3rd gen: Gram - > Gram + Pseudomonas (cefdinir)4th gen: Pseudomonas (Cefepime)5th gen: MRSA (Ceftobiprole)
Fluoroquinolones(Cipro�oxacin, Levo�oxacin)Broad spectrumInhibit DNA synth
Sulfonamides(TMP-SMZ)UTIsInhibit DNA synth
Carbapenems (meropenem)Broad spectrumDisrupts synth of peptidoglycan
Metronidazole (Flagyl)Anaerobes, protozoaDisrupts DNA
Inhibition ofprotein synthesis
Inhibition ofnucleic acid synthesis
Inhibition of cell wall synthesis Disruption of cell
membrane function
Block pathways andinhibit metabolism
ANTIBIOTIC CHEAT SHEET
ANTIBIOTIC MOA